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# Metagenics Institute

Your trusted health, nutrition, and personalized lifestyle medicine resource

## Sitemaps

- [XML Sitemap](https://www.metagenicsinstitute.com/sitemap.xml): Contains all public & indexable URLs for this website.

## Posts

- [Creating Synergy Between Allopathic and Integrative Medicine](https://www.metagenicsinstitute.com/creating-synergy-between-allopathic-and-integrative-medicine-2/) - Frank Lipman, MD works to bring new modalities into partnership with Western medicine using an evidence-based approach. In this episode, Dr. Lipman explores a new hybrid path between allopathic and Functional Medicine to discover a higher potential for health and happiness. The post Creating Synergy Between Allopathic and Integrative Medicine first appeared on Metagenics Institute.
- [Creating Synergy Between Allopathic and Integrative Medicine](https://www.metagenicsinstitute.com/creating-synergy-between-allopathic-and-integrative-medicine/) - Frank Lipman, MD works to bring new modalities into partnership with Western medicine using an evidence-based approach. In this episode, Dr. Lipman explores a new hybrid path between allopathic and Functional Medicine to discover a higher potential for health and happiness.
- [An Affordable Approach to Integrative Medicine (Even in Challenging Cases)](https://www.metagenicsinstitute.com/an-affordable-approach-to-integrative-medicine-even-in-challenging-cases-2/) - The cost of obtaining personalized care can be extremely high for patients, both in terms of seeking care from practitioners as well as in getting advanced laboratory testing done. Michael Ruscio, DNM, DC knows how to solve this problem. He shares his insights and utilizes a common-sense approach on how to make personalized medicine more
- [An Affordable Approach to Integrative Medicine (Even in Challenging Cases)](https://www.metagenicsinstitute.com/an-affordable-approach-to-integrative-medicine-even-in-challenging-cases/) - The cost of obtaining personalized care can be extremely high for patients, both in terms of seeking care from practitioners as well as in getting advanced laboratory testing done. Michael Ruscio, DNM, DC knows how to solve this problem. He shares his insights and utilizes a common-sense approach on how to make personalized medicine more
- [Pregnancy: An Integrative Medicine Perspective](https://www.metagenicsinstitute.com/pregnancy-an-integrative-medicine-perspective-2/) - The foundation for our health starts during pregnancy and delivery, but the medical system in the United States performs shockingly less effectively during this crucial period than many third-world countries. Leslie Stone, MD, IFMCP and Emily Rydbom, CN, BHCN, CNP explore exciting possibilities with the potential to radically improve pre- and perinatal care and give
- [Pregnancy: An Integrative Medicine Perspective](https://www.metagenicsinstitute.com/pregnancy-an-integrative-medicine-perspective/) - The foundation for our health starts during pregnancy and delivery, but the medical system in the United States performs shockingly less effectively during this crucial period than many third-world countries. Leslie Stone, MD, IFMCP and Emily Rydbom, CN, BHCN, CNP explore exciting possibilities with the potential to radically improve pre- and perinatal care and give
- [A New Perspective on Alzheimer’s Disease](https://www.metagenicsinstitute.com/a-new-perspective-on-alzheimers-disease-2/) - Lisa Mosconi, PhD, a brilliant neuroscientist, reveals the latest research on Alzheimer’s disease and on the disproportionate rate that women are affected by Alzheimer’s, depression, and anxiety. Get the surprising new estimates regarding the role of genetics, as well as a comprehensive list of what to watch for now and what testing to explore. The
- [A New Perspective on Alzheimer’s Disease](https://www.metagenicsinstitute.com/a-new-perspective-on-alzheimers-disease/) - Lisa Mosconi, PhD, a brilliant neuroscientist, reveals the latest research on Alzheimer’s disease and on the disproportionate rate that women are affected by Alzheimer’s, depression, and anxiety. Get the surprising new estimates regarding the role of genetics, as well as a comprehensive list of what to watch for now and what testing to explore.
- [Connecting Methylation to Gut & Immune Health](https://www.metagenicsinstitute.com/connecting-methylation-to-gut-immune-health-2/) - Kara Fitzgerald, ND helps us understand methylation and its effects on modulating gene expression and impacting immune health. She’ll also provide a primer on the herbal bioactive constituents in the hops plant and give us a sneak peek into her current gut health study and its relationship to genetic expression. The post Connecting Methylation to
- [Connecting Methylation to Gut & Immune Health](https://www.metagenicsinstitute.com/connecting-methylation-to-gut-immune-health/) - Kara Fitzgerald, ND helps us understand methylation and its effects on modulating gene expression and impacting immune health. She’ll also provide a primer on the herbal bioactive constituents in the hops plant and give us a sneak peek into her current gut health study and its relationship to genetic expression.
- [The Elimination Diet Unlocks Priceless Data about the Individual](https://www.metagenicsinstitute.com/the-elimination-diet-unlocks-priceless-data-about-the-individual/) - The elimination diet gives specific experiential evidence about reactions to foods that can motivate people to make changes. As with most protocols, the challenge is compliance. Join us as Deanna Minich, PhD, CNS, FACN, IFMCP provides the three key principles to share with patients before starting them on an elimination diet.
- [The Elimination Diet Unlocks Priceless Data about the Individual](https://www.metagenicsinstitute.com/the-elimination-diet-unlocks-priceless-data-about-the-individual-2/) - The elimination diet gives specific experiential evidence about reactions to foods that can motivate people to make changes. As with most protocols, the challenge is compliance. Join us as Deanna Minich, PhD, CNS, FACN, IFMCP provides the three key principles to share with patients before starting them on an elimination diet. The post The Elimination
- [Intermittent Fasting: Examining Effects on Metabolism and Detoxification](https://www.metagenicsinstitute.com/intermittent-fasting-examining-effects-on-metabolism-and-detoxification-2/) - Get the inside scoop from Sara Gottfried, MD on the latest research on intermittent fasting, time-restricted eating, and the relationship to your metabolism and detoxification abilities. Explore several periodic fasting regimens and how to implement them. The post Intermittent Fasting: Examining Effects on Metabolism and Detoxification first appeared on Metagenics Institute.
- [Intermittent Fasting: Examining Effects on Metabolism and Detoxification](https://www.metagenicsinstitute.com/intermittent-fasting-examining-effects-on-metabolism-and-detoxification/) - Get the inside scoop from Sara Gottfried, MD on the latest research on intermittent fasting, time-restricted eating, and the relationship to your metabolism and detoxification abilities. Explore several periodic fasting regimens and how to implement them.
- [Cracking the Code on Balancing Appetite, Energy, and Weight](https://www.metagenicsinstitute.com/cracking-the-code-on-balancing-appetite-energy-and-weight-2/) - Alan Christianson, NMD specializes in natural endocrinology with a focus on thyroid disorders. In this episode, Dr. Christianson explores a 28-day approach to weight management designed to reset the metabolism. The post Cracking the Code on Balancing Appetite, Energy, and Weight first appeared on Metagenics Institute.
- [Cracking the Code on Balancing Appetite, Energy, and Weight](https://www.metagenicsinstitute.com/cracking-the-code-on-balancing-appetite-energy-and-weight/) - Alan Christianson, NMD specializes in natural endocrinology with a focus on thyroid disorders. In this episode, Dr. Christianson explores a 28-day approach to weight management designed to reset the metabolism.
- [The Role of Insulin in Balancing Sex Hormones](https://www.metagenicsinstitute.com/the-role-of-insulin-in-balancing-sex-hormones-2/) - While hundreds of millions of dollars are spent annually to balance hormones through replacement therapy, practitioners may be failing to assess the hormone that makes the biggest difference. Filomena Trindade, MD, MPH is a leading expert on hormones, with surprising and critical research on insulin’s role in the hormonal symphony. The post The Role of
- [The Role of Insulin in Balancing Sex Hormones](https://www.metagenicsinstitute.com/the-role-of-insulin-in-balancing-sex-hormones/) - While hundreds of millions of dollars are spent annually to balance hormones through replacement therapy, practitioners may be failing to assess the hormone that makes the biggest difference. Filomena Trindade, MD, MPH is a leading expert on hormones, with surprising and critical research on insulin’s role in the hormonal symphony.
- [Unraveling the Invisible Epidemic of Anxiety in Men](https://www.metagenicsinstitute.com/unraveling-the-invisible-epidemic-of-anxiety-in-men-2/) - Myles Spar, MD, MPH, an integrative medicine practitioner who specializes in men’s health, clarifies the difference between the anxious state men have grown accustomed to and being in a flow state that brings focused effectiveness and helps men create the results they want to produce without wreaking havoc on their health and happiness. The post
- [Unraveling the Invisible Epidemic of Anxiety in Men](https://www.metagenicsinstitute.com/unraveling-the-invisible-epidemic-of-anxiety-in-men/) - Myles Spar, MD, MPH, an integrative medicine practitioner who specializes in men’s health, clarifies the difference between the anxious state men have grown accustomed to and being in a flow state that brings focused effectiveness and helps men create the results they want to produce without wreaking havoc on their health and happiness.
- [Can We Predict, Detect, and Mitigate Disease Through Epigenetic Approaches?](https://www.metagenicsinstitute.com/can-we-predict-detect-and-mitigate-disease-through-epigenetic-approaches/) - Florence Comite, MD, a leading force in precision medicine, has the data on why Father Time strips away the genetic gifts Mother Nature gives us and what we can do about it.
- [How Practitioner-Patient Relationships Can Replace the Pill-for-Every-Ill Model](https://www.metagenicsinstitute.com/how-practitioner-patient-relationships-can-replace-the-pill-for-every-ill-model/) - Jen Landa, MD has escaped the pill-for-every-ill model and created partnerships with her patients to form lasting health. Explore the upside of breaking free from the allopathic model to enjoy better outcomes for practitioners and patients alike.
- [Doctor Becomes Patient: A Catalyst for Practicing Personalized Medicine](https://www.metagenicsinstitute.com/doctor-becomes-patient-a-catalyst-for-practicing-personalized-medicine/) - Jill Carnahan, MD walked away from a high-salary position as a director at a well-known medical facility to start her own personalized lifestyle medicine practice. Learn why she took this step, how she transitioned away from allopathic medicine smoothly, and how we can all support this emerging shift in medical care.
- [Challenging Degenerative Disease: How Much Healing Is Possible?](https://www.metagenicsinstitute.com/challenging-degenerative-disease-how-much-healing-is-possible/) - Terry Wahls, MD challenges the conventional medical view that MS is progressive and degenerative and shares her personal journey with MS, which is a shining example that healing is possible. This riveting story reveals how a once-conservative academic internal medicine doctor came into direct conflict with the very material she was meant to teach her

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## Articles

- [The Science of Magnesium](https://www.metagenicsinstitute.com/articles/the-science-of-magnesium/) - Explore how magnesium glycinate and magnesium citrate support stress relief, sleep quality, and muscle recovery through science-backed mechanisms.
- [Nutritional Ketosis May Preserve Brain Health via Increasing NAD+/NADH Ratio](https://www.metagenicsinstitute.com/articles/nutritional-ketosis-may-preserve-brain-health-via-increasing-nad-nadh-ratio/) - Consumption of MCT oil increased the level of ketone bodies in the brain and compensated for the brain glucose deficit in patients with Alzheimer’s disease (AD)
- [Impact of Ketogenic Diet on Body Composition with Resistance Training](https://www.metagenicsinstitute.com/articles/impact-ketogenic-diet-body-composition-resistance-training/) - The ketogenic diet in male athletes engaging in regular resistance training may impact body mass optimization, particularly fat mass & visceral adipose tissue.
- [Exogenous Ketone Salts Impact Blood Ketone Levels](https://www.metagenicsinstitute.com/articles/consumption-ketone-salts-transiently-increases-blood-ketone-levels-healthy-volunteers/) - A ketogenic diet is a dietary approach that promotes nutritional ketosis by restricting carbohydrates and increasing the intake of fat with adequate consumption of protein.
- [Can Genes Influence the Way People Respond to a Ketogenic Diet?](https://www.metagenicsinstitute.com/articles/genes-influence-ketogenic-diet/) - Many factors underlie the variability of response to a ketogenic diet including lifestyle factors and their interaction with genetic factors.
- [A 2’-Fucosyllactose Prebiotic Formula Improved Symptoms and Gut Bacteria in Patients with Gastrointestinal Disorders](https://www.metagenicsinstitute.com/articles/prebiotic-improves-gut-bacteria/) - Prebiotics are types of food ingredients that are nondigestible by humans and broken down by human gut bacteria into compounds that are beneficial for humans.
- [Vitamin D in Women: Q&A](https://www.metagenicsinstitute.com/articles/calling-all-women-for-the-411-on-vitamin-d-commonly-asked-questions-answers/) - Vitamin D has gained popularity in the public due to the numerous research studies and news headlines misinformation exists & practical recommendations are lacking
- [Specialized Pro-Resolving Mediators Supplementation in Adults With Obesity](https://www.metagenicsinstitute.com/articles/spm-obesity-clinical-trial-study/) - Specialized pro-resolving mediators communicate with immune cells, telling them the inflammatory process is no longer needed and to finish the job.
- [Pasteurized Akkermansia Muciniphila Supplementation: Exploring Potential Benefits in Overweight and Obese Individuals](https://www.metagenicsinstitute.com/articles/akkermansia-muciniphila-supplementation-exploring-potential-benefits/) - Akkermansia muciniphila supplementation in overweight and obese cohorts seek to elucidate its potential impact on metabolic parameters
- [Increased Dietary Fiber and Reduced Cardiac Health Risks](https://www.metagenicsinstitute.com/articles/increased-dietary-fiber-and-reduced-cardiac-health-risks/) - Recent data have indicated rates for cardiovascular disease (CVD) and coronary heart disease (CHD) are declining but still more than a third of all deaths in the US, and nearly half of the deaths in the EU, can be linked to heart disease. Fiber has long been proposed as a possible cardioprotectant; there have been
- [Magnesium, Carbs & Diabetes…Is There a Link?](https://www.metagenicsinstitute.com/articles/magnesium-carbs-diabetesis-link/) - Diets with poor carb quality are characterized by higher glycemic index (GI), higher glycemic load (GL), and lower fiber intake.
- [Biosynthesis of Pro-Resolving Lipid Mediators by Vascular Cells and Tissues](https://www.metagenicsinstitute.com/articles/biosynthesis-proresolving-lipid-mediators-vascular-cells-tissues/) - Inflammation plays a central role in the development and progression of vascular dysfunction including atherosclerosis and vascular restenosis
- [Siberian Rhubarb Extract (ERr 731®) Relieves Hot Flush Symptoms in Animals](https://www.metagenicsinstitute.com/articles/siberian-rhubarb-err-731-relieves-symptoms/) - Siberian rhubarb has been in use for treating menopause in Europe since the 1990s and is now gaining momentum in the global market.
- [Siberian Rhubarb Extract Alleviates Menopausal Symptoms in Indian Women](https://www.metagenicsinstitute.com/articles/siberian-rhubarb-menopause-indian-women/) - An extract from Siberian Rhubarb has been in use treating menopause for decades, and is now gaining popularity in more markets worldwide.
- [Are Diabetes Risk Reduction Recommendations Followed by the General Population?](https://www.metagenicsinstitute.com/articles/diabetes-risk-reduction-recommendations-followed-general-population/) - by Bianca Garilli, ND Guidelines for reduction of diabetes risk consist of recommendations such as: Losing 5-7% of your starting body weight if overweight Following a healthful diet by lowering caloric intake, choosing water in place of sweetened beverages, and reducing fat in the diet, particularly trans fat Engaging in 30 minutes of exercise 5
- [The “Heart” of the Problem is Not Fat but Inflammation, Some Argue](https://www.metagenicsinstitute.com/articles/heart-problem-not-fat-inflammation-argue/) - Regular brisk walking, eating real food (as opposed to highly processed food), and managing stress will effectively reduce inflammation and treat CAD.
- [Probiotic Strain B420 Increases Akkermansia muciniphila in Humans](https://www.metagenicsinstitute.com/articles/b420-akkermansia-muciniphila/) - Supplementation with probiotic strain B420 increased abundance of Akkermansia muciniphila, which is associated with lean body composition & improved metabolism.
- [How Genes Can Affect Your Patients’ Detox Function and Needs](https://www.metagenicsinstitute.com/articles/genes-affect-on-detox-function/) - Do we know which genes affect people’s detox function and need? How may clinicians use this information to personalize lifestyle recommendations to their patients?
- [Effect of Diet on Breast Cancer and Mortality in Postmenopausal Women](https://www.metagenicsinstitute.com/articles/effect-diet-breast-cancer-mortality-postmenopausal-women/) - Most women spend more than 1/3 of their lives in the postmenopausal phase, and one of the major health concerns for postmenopausal women is breast cancer.
- [Does Vitamin D Improve Chronic Pain?](https://www.metagenicsinstitute.com/articles/vitamin-d-improve-chronic-pain/) - The importance of vitamin D in diverse organ systems and biochemical processes is ever-growing with novel research findings.
- [Does Leptin Play a Role in Sleep Quality of those with T2D?](https://www.metagenicsinstitute.com/articles/leptin-play-role-sleep-quality-t2d/) - Leptin plays a key role in the regulation of energy balance, appetite and body weight through a negative feedback signaling pathway.
- [Growing Evidence Indicates Anxiety Linked to Diet](https://www.metagenicsinstitute.com/articles/emerging-evidence-indicates-anxiety-linked-diet/) - Research indicates that dietary patterns can correlate with anxiety symptoms and that a higher Western food consumption is associated with an increased risk for anxiety disorder.
- [Can Probiotics Help Reduce Stress?](https://www.metagenicsinstitute.com/articles/probiotics-help-reduce-stress/) - A recent publication using a robust clinical trial design demonstrated a probiotic strain that improved the stress response.
- [Early Data Suggest Peanut Allergy in Children May Benefit From Probiotic Immunotherapy](https://www.metagenicsinstitute.com/articles/early-data-suggest-peanut-allergy-children-may-benefit-probiotic-immunotherapy/) - Results from a recent small randomized clinical trial found that a combined probiotic and peanut oral immunotherapy (PPOIT) may potentially be an effective option to manage children with peanut allergy
- [Probiotic Use Reduces Risk of C. difficile Infections](https://www.metagenicsinstitute.com/articles/probiotic-use-reduces-risk-c-difficile-infections/) - Probiotics should be recommended in conjunction with antibiotic prescriptions in patients who are not immunocompromised or severely debilitated.
- [Study Shows Diet Beats Proton Pump Inhibitors in Management of Reflux](https://www.metagenicsinstitute.com/articles/study-shows-diet-beats-proton-pump-inhibitors-management-reflux/) - A recent, small, retrospective study undertaken by researchers from New York Medical College assessed the efficacy of totally dietary approach to manage reflux.
- [Hemp Oil Extract and Palmitoylethanolamide (PEA) Synergize to Enhance Pain Relief](https://www.metagenicsinstitute.com/articles/pain-relief-hemp-oil/) - During the past decade we've seen an increasing interest in cannabis-derived products for pain management with a better safety profile & adequate pain relief.
- [Does Abnormal Glucose Metabolism Impair Cognitive Function?](https://www.metagenicsinstitute.com/articles/abnormal-glucose-metabolism-impair-cognitive-function/) - In the United States more than 30 million people, approximately 10 percent of the population, have type-2 diabetes (T2D).1 Additionally, one in three adults in the US have prediabetes- that translates into over 84 million adults with hyperglycemia and an increased risk for frank diabetes. Diabetes is associated with other serious health concerns including high blood
- [Bariatric Surgery Reduces Cancer Incidence in Women](https://www.metagenicsinstitute.com/articles/bariatric-surgery-reduces-cancer-incidence-women/) - The latest findings from the landmark Swedish Obese Subjects (SOS) trial demonstrate that bariatric surgery significantly reduces the incidence of female-specific cancers.
- [Ketogenic Diet Provides Cluster Headache Relief](https://www.metagenicsinstitute.com/articles/ketogenic-diet-provides-cluster-headache-relief/) - Study provides evidence that diet-induced ketosis attenuates or resolves chronic cluster headache (CCH) attacks in patients who are responders to keto diet.
- [Exercise –at Any Intensity– Reduces Depression](https://www.metagenicsinstitute.com/articles/exercise-intensity-reduces-depression/) - In data from ~34k healthy Norwegian adults over 11 years, researchers found that regular leisure-time exercise was associated with reduced incidence of future depression.
- [Ketogenic MCTs Increase Brain Energy Metabolism in Alzheimer's](https://www.metagenicsinstitute.com/articles/ketogenic-medium-chain-triglycerides-increase-brain-energy-metabolism-alzheimers-disease/) - Blood & brain ketone uptake in MCT supplementation study of a ketogenic diet suggests partial metabolic rescue of the brain is possible in mild-to-moderate Alzheimer's disease.
- [Why Are Women at Increased Risk of Stroke?](https://www.metagenicsinstitute.com/articles/women-increased-risk-stroke/) - Women should be screened for stroke risk factors throughout their adult life, particularly during times of fluctuating hormone levels.
- [Can the Novel Coronavirus Be Passed from Pregnant Woman to Fetus/Newborn?](https://www.metagenicsinstitute.com/articles/coronavirus-pregnancy-transmission/) - The current pandemic has created anxiety and stress for women who are currently pregnant. Are they at increased risks of COVID-19 infection?
- [Patients with IBD Benefit from Autoimmune Food Plan](https://www.metagenicsinstitute.com/articles/ibd-patients-benefit-autoimmune-protocol-diet/) - More recently, the autoimmune protocol (AIP) has come into the spotlight as a potential dietary & lifestyle intervention approach that may improve IBD outcomes.
- [Early Natural Menopause Linked to Increased Risk for T2D](https://www.metagenicsinstitute.com/articles/early-natural-menopause-linked-increased-risk-t2d/) - Women who enter natural menopause before 45 years old have increased risks of cardiovascular disease and overall mortality compared with women whose onset of menopause is at 50-54 years of age.
- [A Proprietary Multistrain Probiotic Supplement Increased Health-Promoting Gut Bacteria in Healthy Adults](https://www.metagenicsinstitute.com/articles/multistrain-probiotic-benefit-gut-bacteria/) - Potential advantages of multistrain probiotic supplements are a broader spectrum of health benefits (compared to intake of a single probiotic strain).
- [Raw Fruits and Vegetables: Nature’s “Antidepressant”?](https://www.metagenicsinstitute.com/articles/raw-fruits-vegetables-natures-antidepressant/) - Various approaches focused on improving mental health exist in the medical community, from prescription medications to exercise. Food impacts mood, and mood impacts food choice
- [Catechins: Plant Flavonoids for Heart Health](https://www.metagenicsinstitute.com/articles/catechins-plant-flavanoids-heart-health/) - Growing epidemiological evidence has shown that plant-based dietary patterns (e.g. Mediterranean diet) are associated with improvements in cardiovascular health
- [Uncovering the Mechanisms Behind CoQ10's Anti-Inflammatory Properties](https://www.metagenicsinstitute.com/articles/uncovering-the-mechanisms-behind-coq10s-anti-inflammatory-properties/) - CoQ10 has been used to enhance energy, augment the immune system, act as an antioxidant and is commonly utilized for those with cardiovascular disease.
- [Healthy "ABCs" Lower CVD Risk in Patients with T2D](https://www.metagenicsinstitute.com/articles/achieving-abc-targets-lower-cvd-risk-t2d/) - A large population-based study of patients with type 2 diabetes (T2D) indicates that achieving a greater number of “ABC” targets (A: HbA1c; B: blood pressure; C: LDL-cholesterol) incrementally reduced the risk of cardiovascular disease (CVD). However, not all ABC risk factors were of equal importance in CVD risk reduction.1 For adults with T2D, the American Diabetes Association
- [BCAA (Leucine) Supplementation Increases Muscle Protein Synthesis in Healthy Women](https://www.metagenicsinstitute.com/articles/bcaa-leucine-supplementation-increases-muscle-protein-synthesis-healthy-women/) - Sarcopenia, the loss of muscle tissue associated with the aging process and increases the risk for morbidity through its association with chronic illnesses.
- [Food-Fortified Vitamin D3 More Effective than D2 at Raising Serum 25(OH)D Levels](https://www.metagenicsinstitute.com/articles/food-fortified-vitamin-d3-effective-d2-raising-serum-25ohd-levels/) - Vitamin D is essential for skeletal health and many emerging extraskeletal physiological processes but remains one of the most common micronutrient dietary gaps
- [Evidence Indicates Probiotics May Help Manage SIBO](https://www.metagenicsinstitute.com/articles/evidence-indicates-probiotics-may-help-manage-sibo/) - Probiotics have therapeutic potential to manage SIBO because they have been shown to inhibit translocation of bacteria.
- [Specialized Pro-Resolving Lipid Mediators in Metabolic Diseases](https://www.metagenicsinstitute.com/articles/resolvins-specialized-proresolving-lipid-mediators-potential-roles-metabolic-diseases/) - Patients with a variety of inflammatory conditions can benefit from SPMs and improved inflammation resolution.
- [Infection Regulates Pro-Resolving Mediators that Lower Antibiotic Requirements](https://www.metagenicsinstitute.com/articles/infection-regulates-pro-resolving-mediators-lower-antibiotic-requirements/) - SPMs are temporally regulated during infections and that they are anti-phlogistic, enhance containment and lower antibiotic requirements for bacterial clearance
- [SPM Levels Increase in Mothers and Newborns When EPA or DHA Rich Supplements Taken During Gestation](https://www.metagenicsinstitute.com/articles/spm-levels-increase-mothers-newborns-epa-dha-rich-supplements-taken-gestation/) - This study support further research assessing the effects of omega3 supplementation during pregnancy to reduce risk of various peripartum maternal health issues
- [Enhanced Bioavailability and Relative Distribution of Free (Unconjugated) Curcuminoids](https://www.metagenicsinstitute.com/articles/enhanced-bio-availability-relative-distribution-free-unconjugated-curcuminoids/) - Inflammation plays key role in many chronic conditions including IBD, arthritis, diabetes etc. Curcumin, as an active ingredient present in turmeric has long been known for its anti-inflammatory and antioxidative properties. However, due to its poor bioavailbility in humans (1-2%), there was a need for developing formulations that increased its bioavailability. Curcuminoids in plasma exist
- [Food Packaging Chemicals That Reduce Antibodies to Be Phased out](https://www.metagenicsinstitute.com/articles/food-packaging-chemicals-lower-antibodies/) - Removal of these substances from food packaging is an important step to improving overall public health.
- [Does Your Oral Microbiome Respond to Your Evening Cocktail?](https://www.metagenicsinstitute.com/articles/oral-microbiome-respond-evening-cocktail/) - The effects of alcohol consumption on the oral microbiome were assessed by comparing subjects in the moderate and heavy categories to non-drinkers.
- [Social Distance Today, Societal Existence Tomorrow](https://www.metagenicsinstitute.com/articles/social-distance-today/) - The US currently has over 300,000 reported cases, more than any other country in the world.
- [Debunking the Headlines on Aspirin Study (ASPREE)](https://www.metagenicsinstitute.com/articles/debunking-headlines-new-aspirin-study-aspree/) - The main hypothesis of the study was that daily low-dose aspirin would extend disability-free and dementia-free life in these healthy elder adults.
- [Why COVID-19 Is a Good Reason to Quit Smoking Now](https://www.metagenicsinstitute.com/articles/covid-19-smoking/) - Smokers were 1.4 times more likely to have severe symptoms of COVID-19 compared with nonsmokers.
- [Adding Antibody Testing Greatly Improves COVID-19 Diagnosis](https://www.metagenicsinstitute.com/articles/antibody-testing/) - Serological testing—detecting presence of antibodies against a specific antigen—is a highly valuable diagnostic tool that is fast, inexpensive, and efficient.
- [Are Children Less Susceptible to COVID-19?](https://www.metagenicsinstitute.com/articles/covid-19-children-risk/) - Children at all ages were susceptible to COVID-19, but their clinical symptoms were generally less severe compared to adult patients.
- [How Mathematical Model Simulation Helps Us See the Impact of Physical Distancing](https://www.metagenicsinstitute.com/articles/physical-distancing/) - Researchers estimate the trajectory of the ongoing outbreak and how lifting these physical distancing measures would affect the outbreak progression
- [Long Story Short: Americans Don't Get Enough Omega-3s](https://www.metagenicsinstitute.com/articles/long-story-short-americans-not-getting-enough-omega-3s/) - by Ashley Jordan Ferira, PhD, RDN You may have heard that many Americans are not getting enough vitamin D, calcium, potassium, etc. from their diet. But do you think about omega-3s as a nutrient gap? You should. Research from the National Health and Nutrition Examination Survey (NHANES) demonstrates that> 90% of Americans are not meeting recommendations
- [Novel Therapy for Migraines: Exogenous Ketones](https://www.metagenicsinstitute.com/articles/novel-therapeutic-approach-migraines-ketone-supplementation/) - A small, pilot study explored the effects of supplementing exogenous ketone salts in migraine patients, and results were promising.
- [Balanced, High-Fat Diet Exerts Race-Specific Cardiometabolic Benefits](https://www.metagenicsinstitute.com/articles/balanced-high-fat-diet-exerts-race-specific-benefits-premenopausal-women-obesity/) - by Lewis Chang, PhD Many nutrition studies utilizing a low fat diet for weight and health management have not consistently demonstrated reductions in cardiovascular events or mortality. In contrast, higher fat diets have netted improved body composition, diet adherence, and satisfying food preferences. However, it is still unknown whether there is an optimal diet composition
- [Keto-Mediet with Coconut for Healthy Brain Metabolism](https://www.metagenicsinstitute.com/articles/keto-mediet-coconut-novel-dietary-approach-help-combat-alzheimers-disease/) - This review article describes the value of a keto-mediet approach with coconut to support healthy brain metabolism, which underlies Alzheimer's pathology.
- [On the Growing Interest in Ketogenic Diet for Weight Loss and T2D](https://www.metagenicsinstitute.com/articles/growing-interest-ketogenic-diet-weight-loss-t2d-jama-perspective/) - by Lewis Chang, PhD An editorial perspective, recently published in the Journal of American Medical Association (JAMA) obesity-themed issue, helps to explain the growing interest in the ketogenic diet for weight and type 2 diabetes (T2D) management [1]. Many people successfully lose weight via diet over the short haul; however, because of physiological adaptations, it becomes much more difficult
- [Managing IBS with a Low FODMAP Diet](https://www.metagenicsinstitute.com/articles/managing-ibs-low-fodmap-diet-mechanisms-efficacy/) - by Ashley Jordan Ferira, PhD, RDN Most people have heard of, or know somebody who suffers from irritable bowel syndrome (IBS). IBS is not a single condition but rather a group of symptoms associated with the gastrointestinal (GI) tract that includes abdominal pain and changes in bowel movements such as constipation or diarrhea.1 IBS affects 10-15% of US
- [Proinflammatory Diet Linked to Increased Risk for Colorectal Cancer](https://www.metagenicsinstitute.com/articles/proinflammatory-diet-linked-increased-risk-colorectal-cancer/) - by Ashley Jordan Ferira, PhD, RDN Colorectal cancer (CRC) is the third leading cause of cancer-related death for men and women in the US.1 Chronic inflammation contributes to cancer development.2 Pro-inflammatory conditions, such as obesity and inflammatory bowel disease, have been associated with CRC risk.3-4 It is plausible that a dietary pattern that induces more inflammation could impact
- [Can a Healthy Diet Offset Obesity Genes?](https://www.metagenicsinstitute.com/articles/will-healthy-diet-offset-obesity-genes/) - by Bianca Garilli, ND Obesity has both genetic and environmental underpinnings. Research has elucidated key fat-regulating genes, one of which is the fat-mass and obesity-associated (FTO) gene located on chromosome 16q12.2. Single nucleotide polymorphisms (SNPs) on the FTO gene have been associated with an increased risk for obesity.1 Certain obesity-related SNPs have been shown to be
- [TV Time Worse for Cardiometabolic Health than Other Sedentary Behaviors](https://www.metagenicsinstitute.com/articles/tv-time-worse-cardiometabolic-health-sedentary-behaviors/) - Sedentary behaviors have been linked to obesity, diabetes, cardiovascular disease, and all-cause mortality. In terms of potential mechanisms, research has revealed associations between sedentary time and cardiometabolic risk factors, including higher waist circumference, higher blood pressure, unbalanced glucose and insulin metabolism, and unfavorable blood lipid profile.1 Television watching and its negative impact on health have
- [Stroke Risk Varies Based on Fasting Blood Glucose Levels](https://www.metagenicsinstitute.com/articles/risk-stroke-varies-fasting-blood-glucose-levels/) - by Bianca Garilli, ND Strokes are responsible for 1 out of every 20 deaths in the US – that’s ~ 140,000 Americans’ lives lost each year.1 Stroke is also a leading cause of serious, long-term disability.2 Diabetes mellitus is an independent risk factor for ischemic stroke, a form of stroke caused by inadequate blood supply (and therefore
- [Intermittent Fasting Improves Blood Insulin Sensitivity and Blood Pressure](https://www.metagenicsinstitute.com/articles/intermittent-fasting-improves-blood-glucose-control-blood-pressure/) - by Lewis Chang, PhD Intermittent fasting is an eating pattern where one alternates periods of eating and fasting. Overall, intermittent fasting has demonstrated efficacy in weight management and improvements in metabolism and body composition.1,2 However, it is unclear whether the observed metabolic benefits are the result of weight loss or due to other mechanisms. Also,
- [Women Eating a Healthy Diet Have Reduced Risk of Developing Rheumatoid Arthritis](https://www.metagenicsinstitute.com/articles/women-eating-healthy-diet-reduced-risk-developing-rheumatoid-arthritis/) - by Bianca Garilli, ND Women who consume increased amounts of antioxidants from fruits and vegetables as part of a healthy diet may reduce their risk of developing rheumatoid arthritis (RA). A 2017 prospective study by Hu Y, et al and published in the Annals of Rheumatic Diseases reviewed data from the Nurses’ Health Studies to evaluate the
- [Reducing Sugar Consumption Lowers Risk of Fatty Liver and Diabetes in Children](https://www.metagenicsinstitute.com/articles/reducing-sugar-consumption-lowers-risk-fatty-liver-diabetes-children/) - by Bianca Garilli, ND Insulin resistance (IR) develops as a response to long term elevation of insulin levels or hyperinsulinemia (HI) after exposure to chronic increases in blood sugar levels. Additionally, IR in conjunction with non-alcoholic fatty liver disease (NAFLD) and an increase in ectopic adipose storage including visceral adiposity tissue (VAT), are shown to
- [Ultra-Processed Food Consumption Associated with Cancer Risk](https://www.metagenicsinstitute.com/articles/ultra-processed-food-consumption-associated-cancer-risk/) - by Lewis Chang, PhD Ultra-processed foods, or highly-processed foods, are food products manufactured via multiple chemical or mechanical processes that are designed to make them convenient, affordable, palatable, and hygienic. Nutritionally, they tend to be loaded with added sugar, salt, and fat, and devoid of high-quality macronutrients, micronutrients, and fiber. Many ultra-processed foods also contain
- [Epigenetic Modulation of Key Gene Contributes to Multiple Sclerosis Risk](https://www.metagenicsinstitute.com/articles/epigenetic-modulation-key-gene-contributes-multiple-sclerosis-risk/) - by Lewis Chang, PhD Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) in which the immune system attacks and damages the myelin sheaths of nerve fibers in the brain and spinal cord.1 Common symptoms include cognitive difficulties, vision problems, fatigue, pain, motor problems, bladder dysfunction, and sexual problems. However, symptoms
- [Improving Metabolic Health Through Diets Depends on Genetic Background](https://www.metagenicsinstitute.com/articles/improving-metabolic-health-diets-depends-genetic-background/) - The struggle to find the best diet for weight management and metabolic health improvement has largely failed. This failure may imply that no diet fits all needs, which justifies a search for biomarkers that can predict success in weight loss and physiological response, and can allow the most efficient diet to be selected on an
- [Type 2 Diabetes Increases Risk for Hypertension, and Vice Versa](https://www.metagenicsinstitute.com/articles/type-2-diabetes-increases-risk-high-blood-pressure-vice-versa/) - by Lewis Chang, PhD Data from a recent epidemiological study revealed the bidirectional, pathogenic relationship between type 2 diabetes (T2D) and hypertension (HTN).1 Both T2D and HTN are important risk factors of cardiovascular disease. Previous epidemiological studies have shown that the presence of HTN predicts future T2D. An international team of researchers from Italy, Mexico
- [Is Baby’s Gut Bacteria Related to Cognitive Development?](https://www.metagenicsinstitute.com/articles/babys-gut-bacteria-influence-cognitive-ability-later/) - by Bianca Garilli, ND During the first years of life, an infant’s gut microbiota undergoes rapid colonization, and the microbial diversity of the growing infant results from exposure to a variety of sources.1 These microbiota sources are impacted by a variety of factors, including but not limited to: genetic underpinnings, the mother’s microbiota composition, method
- [Does Beverage Intake During Pregnancy Influence Childhood Obesity?](https://www.metagenicsinstitute.com/articles/can-childhood-obesity-reduced-lowering-intake-sugar-sweetened-beverages-pregnancy/) - The health and lifestyle choices a mother makes during pregnancy has immense impact on the unborn child during in-utero development and beyond. It is well known that drinking alcohol during pregnancy can lead to fetal alcohol syndrome; taking certain medications such as isotretinoin, a common acne drug, can lead to birth defects; and consuming inadequate
- [Sugar Intake in Pregnancy & Early Childhood Linked to Childhood Asthma](https://www.metagenicsinstitute.com/articles/maternal-consumption-high-sugar-fructose-containing-drinks-pregnancy-may-increase-risk-childhood-asthma/) - by Bianca Garilli, ND, IFMCP Within the past few decades the rates of obesity, metabolic syndrome and diabetes throughout the world have risen dramatically. Although there are many potential causes for this rise, one such contributor may be increased antenatal intake of sugary drinks.1 Intake of as little as 0.6 servings per day (standard deviation of
- [Multivitamin Use During Pregnancy May Reduce Risk of Autism](https://www.metagenicsinstitute.com/articles/multi-vitamin-use-pregnancy-may-reduce-risk-autism/) - by Bianca Garilli, ND, IFMCP Across the world autism spectrum disorder (ASD) rates vary greatly; making it difficult to confirm definitive numbers particularly in many countries that do not actively track rates or publicly report their statistics. However, data from countries such as Poland where it is reported that 3 in 10,000 children are diagnosed
- [Maternal DDT Metabolite Levels Associated with Autism in Offspring](https://www.metagenicsinstitute.com/articles/maternal-ddt-metabolite-levels-associated-autism-offspring/) - by Ashley Jordan Ferira, PhD, RDN Autism spectrum disorder (ASD) is an urgent public health concern affecting approximately 1 in 59 US children.1-2 This complex neurodevelopmental syndrome is 4x more common in boys than girls and impacts all racial, ethnic, and socioeconomic backgrounds, although ASD is more common in white > black > Hispanic children.1
- [Vitamin D3 & Autism: Does Supplementation Improve Symptoms?](https://www.metagenicsinstitute.com/articles/vitamin-d3-autism-supplementation-improve-symptoms/) - by Ashley Jordan Ferira, PhD, RDN Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome with significant social, communication and behavioral deficits and challenges.1 No cure exists for ASD, although early interventions (birth to 3 years) can yield developmental improvements.1 ASD impacts approximately 1 in 68 children in the US and is 4.5 times more
- [Pregnancy Hypertension to Chronic Hypertension – Weight Matters](https://www.metagenicsinstitute.com/articles/pregnancy-hypertension-chronic-hypertension-weight-matters/) - by Ashley Jordan Ferira, PhD, RDN An analysis of the Nurses’ Health Study II (NHS2) cohort revealed that women with a history of hypertensive disorders of pregnancy (HDP) who are also overweight or obese have a significantly increased risk of developing chronic hypertension (HTN) later in life.1 HDP includes pre-eclampsia and gestational HTN: obstetric complications increasing
- [Can Lifestyle Changes Protect from Unhealthy Pregnancy Weight Gain?](https://www.metagenicsinstitute.com/articles/can-lifestyle-changes-protect-unhealthy-pregnancy-weight-gain/) - by Bianca Garilli, ND Increased gestational weight gain (GWG) is of major concern due to its potentially negative impact on a mother’s long term health as well as the health of her newborn. Maternally, raised GWG is associated with postpartum weight retention and obesity later in her life; it may also lead to complications of
- [Resistance Exercise Reduces Depressive Symptoms in Adults](https://www.metagenicsinstitute.com/articles/resistance-exercise-reduces-depressive-symptoms-adults/) - by Christopher Moulton, PhD Depression is one of the most common mood disorders in the US and worldwide. In 2016 an estimated 16.2 million adults, or 6.7% of US adults, suffered at least one major depressive episode,1 while globally more than 300 million are afflicted.2 Further, depression is comorbid with numerous chronic disease states including
- [Yearlong Study Leverages Ketosis for Cardiometabolic Disease Management](https://www.metagenicsinstitute.com/articles/yearlong-study-leverages-ketosis-for-cardiometabolic-disease-management/) - by Lewis Chang, PhD A yearlong lifestyle intervention that utilized a ketogenic diet significantly improved HbA1c, body weight, and multiple cardiovascular disease (CVD) risk factors in patients with type 2 diabetes (T2D), according to data from a clinical study published in two journals.1,2 CVD is the leading cause of death among patients with T2D.3 As
- [Waiting Room Turned Classroom: Eating Plans Improve Diabetes Management](https://www.metagenicsinstitute.com/articles/waiting-room-turned-classroom-eating-plans-improve-diabetes-management/) - by Ashley Jordan Ferira, PhD, RDN Almost 10% of the US population has diabetes, with another 34% in a precarious state of prediabetes.1 These diagnoses are not destiny. Research demonstrates that lifestyle interventions, particularly those incorporating nutrition therapy, produce clinically meaningful improvements in diabetes.2 Integrating this research foundation into the clinical setting is key. A
- [Breastfeeding & Risk for Overweight in Infants](https://www.metagenicsinstitute.com/articles/breastfeeding-via-gut-microbiome-impacts-risk-overweight-infants/) - by Bianca Garilli, ND, IFMCP The Global Breastfeeding Collective (GBC), co-led by UNICEF and WHO, has a mission to rally political, legal, financial, and public support for breastfeeding, which will benefit mothers, children, and society. Seven key priorities have been set forth by the GBC to increase the rate of breastfeeding globally; their most recent
- [Possible Role of Microbiome in Reducing Salt-Sensitive Hypertension](https://www.metagenicsinstitute.com/articles/possible-role-microbiome-reducing-salt-sensitive-hypertension/) - Hypertension (HTN) affects more than a third (32.6%) of Americans and is a major risk factor for heart disease and mortality.1 Unfortunately, the exact mechanisms as to development and maintenance of this condition are yet to be understood. It has been suggested that HTN is associated with a fundamental defect in the ability for the kidneys to
- [Multi-Strain Probiotic Improves Insulin Resistance in Patients with Diabetes](https://www.metagenicsinstitute.com/articles/probiotics-impact-diabetes-study/) - RCT study in patients with type 2 diabetes demonstrated that a multi-strain probiotic improved insulin resistance and other glycemic and inflammatory markers.
- [Certain APOE Genotype Linked to Alzheimer's Disease Risk in Both Sexes](https://www.metagenicsinstitute.com/articles/certain-apolipoprotein-e-genotype-linked-alzheimer-disease-risks-sexes/) - Apolipoprotein E (APOE) is a type of apolipoprotein involved in various biological processes, including lipoprotein transport, immunoregulation, and even cognition. The gene that encodes APOE is called APOE gene and is polymorphic, with three major alleles (ε2, ε3 and ε4) producing 6 common genotypes (ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε3, ε3/ε4, and ε4/ε4). The ε3 allele is the most
- [Structured Nutrition Therapy with Diabetes-Specific Meal Replacement Improves T2D Outcomes](https://www.metagenicsinstitute.com/articles/structured-nutrition-therapy-approach-improves-type-2-diabetes-outcomes/) - by Ashley Jordan Ferira, PhD, RDN Diabetes has reached epidemic proportions in the US: 30 million US adults have diabetes (90-95% type 2 diabetes [T2D]), with another 84 million living with prediabetes.1 The most influential, modifiable risk factors for diabetes include overweight/obesity, lack of physical activity, and smoking.1 With diabetes-related medical costs and lost work/wages
- [Fish Oil Consumption Does Not Increase Bleeding Risk](https://www.metagenicsinstitute.com/articles/fish-oil-consumption-not-increase-bleeding-risk/) - by Lewis Chang, PhD Fish oil is rich in omega-3 fatty acids EPA and DHA. Increased intake of EPA and DHA is beneficial for cardiovascular health, cognitive function, mental health, maternal and child health, immunity and inflammation. EPA and DHA supplements are becoming more and more popular across a wide diversity of people; from healthy
- [Efficacy of Low-Carb Ketogenic Diet in Endurance Athletes](https://www.metagenicsinstitute.com/articles/athletic-performance-improved-low-carbohydrate-high-fat-ketogenic-diet/) - Study was conducted in endurance athletes to determine if a low-carbohydrate ketogenic diet would improve body composition and athletic performance outcomes.
- [Physical Activity Improves Physical Functioning, Reduces Disability in Older Adults](https://www.metagenicsinstitute.com/articles/physical-activity-older-adults-improves-physical-functioning-reduces-disability/) - by Bianca Garilli, ND Regular physical activity is a cornerstone of public health policy in most age groups, with the typical adult recommendation at > 150 minutes/week of aerobic exercise along with routine strength training or weight bearing exercise sessions. The benefits of consistent physical activity is well documented, including reducing risk of chronic illness
- [Yoga, Mindfulness Improve Children’s QOL](https://www.metagenicsinstitute.com/articles/school-based-yoga-mindfulness-improves-childrens-quality-life/) - by Ashley Jordan Ferira, PhD, RDN We are a stressed society, and our children are not immune. Stressors originating from home life and school (e.g. academic performance concerns, peer exclusion, social pressure, bullying, etc.) can result in negative short- and long-term consequences on children’s mental wellbeing, physical health and quality of life (QOL).1 It is
- [“The Biggest Loser”: Secret to Success 6 Years Later](https://www.metagenicsinstitute.com/articles/biggest-loser-secret-success-6-years-later/) - Study demonstrates how persistent increases in physical activity influence long-term weight loss success in 'The Biggest Loser' participants.
- [Lifestyle Modification vs. Medication for Sustainable Diabetes Prevention](https://www.metagenicsinstitute.com/articles/lifestyle-modification-vs-medication-sustainable-diabetes-prevention/) - by Ashley Jordan Ferira, PhD, RDN The global burden of diabetes is staggering, with an estimated 422 million adults living with the chronic disease.1 This prevalence has almost doubled since 1980 alongside the rise in obesity and has been dubbed the “diabesity” phenomenon.1 Diabetes and its myriad comorbidities (heart attack, stroke, kidney disease, nerve damage,
- [Lifestyle Interventions Reduce Odds of Undergoing C-Section](https://www.metagenicsinstitute.com/articles/lifestyle-interventions-reduce-odds-undergoing-c-section/) - Diet and exercise interventions during pregnancy helped women minimize excess gestational weight gain and lower the odds of caesarean section (C-section).1 Multiple clinical trials have previously demonstrated that diet, physical activity or the combination of both during pregnancy are beneficial in limiting excessive gestational weight gain. However, due to the relatively small sample sizes of
- [Energy Drinks: Ally or Enemy to Military Personnel?](https://www.metagenicsinstitute.com/articles/military-energy-drinks/) - Energy drinks are widely consumed in the general population, with higher consumption rates seen in military personnel. But, what are the health implications?
- [Updated (2017) Hypertension Guidelines from ACC/AHA](https://www.metagenicsinstitute.com/articles/new-hypertension-guidelines-released-acc-aha/) - by Ashley Jordan Ferira, PhD, RDN Updated clinical practice guidelines from the 2017 American Heart Association (AHA) Scientific Sessions and co-published in Hypertension1 and the Journal of the American College of Cardiology2 by the American College of Cardiology (ACC) and AHA, revealed a new blood pressure (BP) classification system and updated hypertension (HTN) treatment recommendations, with a clear emphasis on lifestyle
- [Veterans' Dementia Risk Over 2x Higher with History of TBI](https://www.metagenicsinstitute.com/articles/veteran-dementia-tbi/) - The study examines the association between TBI/concussion severity, loss of consciousness (LOC) from the TBI event, and dementia diagnosis in veterans.
- [Breastfeeding Helps Seed Infant Gut Microbiota](https://www.metagenicsinstitute.com/articles/importance-breast-feeding-seeding-infant-gut-microbiome/) - by Bianca Garilli, ND Within the first few hours of birth, bacteria are introduced to the infant gut through multiple vectors including maternal skin and vaginal exposure, breast milk, and the external environment. These initial exposures leave a life-long bacterial footprint that can be detected into adulthood. The importance of early gut imprinting on long
- [Breastfeeding May Be Key to Solving IBD](https://www.metagenicsinstitute.com/articles/breastfeeding-may-key-solving-ibd/) - by Bianca Garilli, ND “Treat the gut” and “breast is best” are both common mantras in the Functional Medicine practitioner’s office offering insight into the primary location of foundational imbalance for many chronic illnesses (in the gut) as well as a potential mechanisms to prevent these imbalances in the first place (breastfeeding). Delving into both
- [Unhealthy Dieting Trends in US Teens](https://www.metagenicsinstitute.com/articles/unhealthy-dieting-trends-us-teens/) - by Ashley Jordan Ferira, PhD, RDN There is a paradox occurring in American youth: obesity and dieting. National statistics confirm that pediatric overweight and obesity rates are high, steadily rising over the past few decades.1 In fact, over 20% of the 12-19 age group in the US are obese, with higher prevalence in Hispanics and
- [Does Alcohol Change Gut Microflora and is the Change Reversible?](https://www.metagenicsinstitute.com/articles/alcohol-change-gut-microflora-change-reversible/) - A review published in Alimentary Pharmacology and Therapeutics showed alcohol consumption adversely altered gut microbiota and could lead to negative impacts on the liver. It is well known that alcohol intake directly and adversely affects the liver, but more recently, it has also been clinically shown to impact the gastrointestinal microbiota. To better elucidate this relationship the
- [Meal Timing Impacts Daily Rhythms of Human Salivary Microbiota](https://www.metagenicsinstitute.com/articles/meal-timing-impacts-daily-rhythms-human-salivary-microbiota/) - by Ashley Jordan Ferira, PhD, RDN The digestive system begins in the mouth, which is home to 700+ unique species of bacteria.1 Research has shown that salivary2 and gastrointestinal (GI)3-4 microbiota possess diurnal rhythms; whether these daily patterns are a result of circadian biology and/or eating behaviors is unknown. The composition of one’s habitual diet
- [Higher Dementia Incidence Linked to Air Pollution](https://www.metagenicsinstitute.com/articles/dementia-linked-to-air-pollution/) - Dementia risk factors are cumulative over a lifetime, thus reinforcing the importance of a healthy lifestyle & reduction in toxin exposures like air pollution.
- [Migraine Risk Impacted by Body Weight](https://www.metagenicsinstitute.com/articles/migraines-impacted-body-weight/) - A meta-analysis including 12 studies that included > 280,000 participants found that both obesity and underweight are associated with an increased risk for migraines.1 Prior research had indicated an association between higher weight and migraines and while exact mechanisms are not known, it has been postulated that overweight individuals may have increased adipose tissue secretion of pro-inflammatory
- [Ginkgo Biloba May Improve Cognitive Function after Acute Ischemic Stroke](https://www.metagenicsinstitute.com/articles/ginkgo-biloba-may-improve-cognitive-function-acute-ischemic-stroke/) - by Lewis Chang, PhD A randomized trial demonstrated that Ginkgo biloba extract (GBE) supplementation in combination with aspirin improved cognitive function after an ischemic stroke better than aspirin alone.1 Researchers from Nanjing University Medical School (Nanjing, China) conducted a randomized, open-label, single-blind trial.1 They enrolled 348 patients with an onset of acute ischemic stroke within
- [Novel Marine Oil Supplement Alters HDL Lipid Mediator Profile](https://www.metagenicsinstitute.com/articles/hdl-marine-oil/) - Short-term clinical study of novel marine oil supplement demonstrates impact on lipid mediator profile of HDL, with increase in certain pro-resolving mediators.
- [Plate Design Increases Fruit & Vegetable Consumption in Children](https://www.metagenicsinstitute.com/articles/plate-design-increases-fruit-vegetable-consumption-children/) - by Ashley Jordan Ferira, PhD, RDN Color your plate, so the slogan goes. A 2018 study took this advice literally, incorporating pictures of fruits and vegetables (F&V) into school lunch plates with the goal of improving F&V consumption in preschoolers.1 F&Vs are a low-calorie, nutrient-dense (macro-, micro-, and phytonutrients) food group, but the US is
- [Moderate Physical Activity Reduces Cardiometabolic Risk in Children](https://www.metagenicsinstitute.com/articles/moderate-physical-activity-reduces-cardiometabolic-risk-children/) - by Bianca Garilli, ND Obesity is not age-discriminate, affecting both adults and children quite dramatically over the past few decades. In the United States, nearly one in five children ages 6-19 years old are currently obese, resulting in both long-term health consequences and a financial burden to the individual, family and nation.1 One of the most
- [Mediterranean Diet May Delay Brain Aging](https://www.metagenicsinstitute.com/articles/mediterranean-diet-may-delay-brain-aging/) - by Lewis Chang, PhD The Mediterranean diet (MED), characterized by a high consumption of plant-based foods, less red meat, and using olive oil as the main source of fat, is one of the healthiest diets. A study found that MED might also prolong brain health and function in cognitively healthy middle-aged individuals.1 According to an
- [Antioxidant-Rich Diets & Diabetes Risk](https://www.metagenicsinstitute.com/articles/antioxidant-rich-diets-diabetes-risk/) - by Ashley Jordan Ferira, PhD, RDN Cellular oxidative stress, the balance between pro-oxidants and antioxidants, may contribute to the pathogenesis of chronic diseases.1 A nutrient-dense dietary pattern, particularly one containing fruits and vegetables, whole grains, nuts, and legumes, confers antioxidant activity in the body. This is important because prior research has demonstrated that increasing the
- [Sex Hormone Imbalance Increases Heart Disease Incidence in Post-Menopausal Women](https://www.metagenicsinstitute.com/articles/sex-hormone-imbalance-increases-heart-disease-incidence-post-menopausal-women/) - by Bianca Garilli, ND For women, the pre- and post-menopausal years represent a time of major change in many aspects of life including spiritual, emotional, and physical. From a physical perspective, shifting levels of sex hormones such as dehydroepiandrosterone (DHEA), testosterone, and estrogen play critical roles in the transition in and through menopause. It’s during
- [Diabetes Linked to Bone Deterioration in Postmenopausal Women](https://www.metagenicsinstitute.com/articles/bone-fractures-menopausal-t2d/) - Research in postmenopausal women with type 2 diabetes suggests there may be distortion and weakening in the bone architecture, increasing the risk of fracture.
- [Metabolic Syndrome in Military Personnel Post-Retirement](https://www.metagenicsinstitute.com/articles/mets-retired-military/) - The study examines metabolic syndrome prevalence to determine if physical fitness standards in the military continue to deliver health benefits post-retirement.
- [Metabolism of Exogenous Ketones Explored](https://www.metagenicsinstitute.com/articles/on-the-metabolism-of-exogenous-ketones-in-humans/) - A series of studies were conducted to research the metabolism of exogenous ketone esters vs. salts, assessing blood ketones and substrates in healthy adults.
- [Ketone Body Neutralizes Harmful Metabolite of Glucose Metabolism](https://www.metagenicsinstitute.com/articles/ketone-body-neutralizes-harmful-metabolite-glucose-metabolism/) - A study demonstrates a novel biological function of ketone bodies: neutralizing methylglyoxal (MG), which is known to be involved in aging and diabetes.
- [Exogenous Ketone Ester Drink Reduces Hunger](https://www.metagenicsinstitute.com/articles/exogenous-ketone-ester-drink-lowers-hunger-hormone-ghrelin/) - Exogenous ketone ester drink increased blood ketone levels to ketosis level and blunted post-meal ghrelin levels, with was associated with decreased hunger.
- [Exogenous Ketone Drinks: Short-Term Consumption Results](https://www.metagenicsinstitute.com/articles/short-term-effects-of-two-forms-of-exogenous-ketone-drinks-in-healthy-volunteers/) - Short-term consumption of exogenous ketone drinks in ester and salt forms were shown to raise ketone levels in blood within the range of nutritional ketosis.
- [Metabolic Changes in Athletes Following a Ketogenic Diet](https://www.metagenicsinstitute.com/articles/athletes-following-low-carbohydrate-ketogenic-diet-increased-fat-oxidation/) - A study in ultra-endurance runners demonstrated an increase in fat oxidation in athletes following a low-cardohydrate ketogenic diet vs. high-carbohydrate diet.
- [2017 Position Statement from ADA on Hypertension in Diabetes](https://www.metagenicsinstitute.com/articles/2017-position-statement-american-diabetes-association-ada-hypertension-diabetes/) - The 2017 American Diabetes Association (ADA) position statement on type 2 diabetes and hypertension provides key guidance for practitioners.
- [Lean and Obese Patients with NAFLD Share Clinical Features](https://www.metagenicsinstitute.com/articles/skinny-lifestyle-intervention-non-alcoholic-fatty-liver-disease/) - Lean & obese patients with NAFLD share cardiometabolic aberrations, which along with fat mass deposition may predict NAFLD risk better than BMI, total fat mass.
- [Vitamin D Metabolism in Adipocytes & Implications for Supplementation](https://www.metagenicsinstitute.com/articles/insights-vitamin-d-supplementation-obese-patients/) - by Ashley Jordan Ferira, PhD, RDN Vitamin D is essential- it helps absorb calcium, supports nervous and muscle tissue, and the immune system. Compared to normal-weight counterparts, vitamin D deficiency is more prevalent in those with obesity. In the US over one-third of adults meet obesity criteria.1 A study in The Journal of Clinical Endocrinology and Metabolism2 examined
- [Lean and Obese Patients with NAFLD Share Clinical Features](https://www.metagenicsinstitute.com/articles/skinny-fat-individuals-similar-risk-obese-nafld/) - by Bianca Garilli, ND Obesity is an established a predisposing factor for chronic disease processes including metabolic syndrome, type 2 diabetes (T2D), cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). These sequelae of obesity results from the relationship between excess adiposity, underlying inflammation and insulin resistance at the population level.1 More recently, however, research indicates there is more
- [Fitness Reduces Cardiometabolic Risk and Insulin Resistance in Children with Obesity](https://www.metagenicsinstitute.com/articles/fitness-reduces-cardiometabolic-risk-insulin-resistance-children-obesity/) - by Lewis Chang, PhD Body mass index (BMI) is positively associated with cardiometabolic risk and insulin resistance in children according to a recent population-based study, but cardiorespiratory fitness may mitigate risk.1 Swedish researchers from the Department of Biosciences and Nutrition at Karolinska Institutet (Huddinge, Sweden) and colleagues from Spain and Chile conducted a pooled study including
- [Active Lifestyle from Childhood to Adulthood Lowers Risk of Impaired Glucose Metabolism](https://www.metagenicsinstitute.com/articles/active-lifestyle-childhood-adulthood-lowers-risk-impaired-glucose-metabolism/) - by Bianca Garilli, ND Physical inactivity prevalence among adolescents aged 11-17 years was estimated to be 81% globally in 2010, where insufficient physical activity (PA) was measured as < 60 minutes of moderate-to-vigorous-intensity PA daily per WHO guidelines.1 As part of the 60 minute/day exercise recommendation, the US Department of Health and Human Services recommends
- [Clinical Care and Modifications for Atrial Fibrillation](https://www.metagenicsinstitute.com/articles/clinical-care-modifications-atrial-fibrillation/) - Atrial fibrillation, also referred to as AFib or AF, is the most common type of arrhythmia, characterized by an irregular heartbeat in the atria which reduces flow to the heart ventricles. AF may lead to blood clots, stroke or other heart complications, as well as increased mortality. It is estimated that 2.7 to 6.1 million
- [Summary of Practice Guidelines for Prevention of CVD in Individuals with T2D](https://www.metagenicsinstitute.com/articles/summary-practice-guidelines-prevention-cvd-individuals-t2d/) - It is estimated that by 2050, 1 in 3 U.S. individuals will have type 2 diabetes(T2D) and cardiovascular disease (CVD) is the most common cause of death for in these patients. Prevention of CVD among individuals with T2D is therefore of great public health importance. The scientific statements from the American Diabetes Association (ADA), American Heart
- [Hyperglycemia in Diabetes Linked to Poor Cognitive Function](https://www.metagenicsinstitute.com/articles/hyperglycemia-diabetes-linked-poor-cognitive-function/) - Abnormally high blood sugar in individuals with type 2 Diabetes (T2D) is associated with impaired cognitive performance, a Dutch epidemiological study finds.1 Hyperglycemia is known to cause various long-term complications such as damage to retina, nerve and kidney, cardiovascular disease, and infections. Dutch researchers from the Department of Internal Medicine at Maastricht University Medical Centre and
- [Female Infertility Associated with Increased Risk of Death from Endocrine Related Diseases](https://www.metagenicsinstitute.com/articles/female-infertility-associated-increased-risk-death-endocrine-related-diseases/) - A retrospective cohort study found that infertility in women was associated with an increased risk of death from certain endocrine related disease such as diabetes and breast cancer [1]. As infertility in women may be a sign of endocrine or inflammatory disruption, scientists have had concerns about its long-term effects on women’s health. Researchers from the Reproductive
- [Gut Microbiome Linked to Congestive Heart Failure](https://www.metagenicsinstitute.com/articles/gut-microbiome-health-link-congestive-heart-failure/) - Inflammation, pathogenic gut bacteria, and Candida species and markers of disease severity where analyzed in adults with stable mild, moderate and severe congestive heart failure (CHF). High levels of pathogenic bacteria including Campylobacter, Shigella, Salmonella, Yersinia enterocolitica, and Candida species were discovered in CHF patients when compared to normal control. Intestinal permeability (IP), right arterial pressure (RAP) and markers of inflammation,
- [Myo-Inositol + Folic Acid May Help Manage PCOS](https://www.metagenicsinstitute.com/articles/myo-inositol-folic-acid-may-help-manage-pcos/) - A 12-week randomized controlled trial (RCT) demonstrated that, compared with metformin, myo-inositol had beneficial effects on multiple parameters related to polycystic ovary syndrome (PCOS) 1. PCOS, an endocrine disorder characterized by infertility, menstrual dysfunction and metabolic disturbances such as insulin resistance and androgen excess, affects many women of reproductive age. Because insulin resistance has been shown
- [Gut Microbiota Metabolite TMAO Linked to CVD Events and Mortality](https://www.metagenicsinstitute.com/articles/gut-heart-link-gut-microbiota-derived-metabolite-tmao-linked-cvd-events-mortality/) - A new meta-analysis based on multiple cohort studies found that elevated concentrations of trimethylamine N-oxide (TMAO)—a gut microbiota-derived metabolite of choline, L-carnitine or betaine—were associated with increased risks of major adverse cardiovascular events (MACE) and all-cause mortality. 1 Choline, L-carnitine and betaine are metabolized by intestinal bacteria to form trimethylamine, which is then oxidized to
- [Novel Use for Oral Glutathione: Treatment of Nonalcoholic Fatty Liver Disease](https://www.metagenicsinstitute.com/articles/novel-use-oral-glutathione-treatment-nonalcoholic-fatty-liver-disease/) - by Bianca Garilli, ND Non-alcoholic fatty liver disease (NAFLD), characterized by fat accumulation in the liver not caused by alcohol consumption, affects up to 25% of people in the US.1 This is typically a silent disease, often not producing symptoms until its later stages when there is chronic liver injury; complaints can include fatigue, weakness, weight
- [Clinical Use of Peppermint for GI Health](https://www.metagenicsinstitute.com/articles/clinical-use-peppermint-gi-health/) - by Bianca Garilli, ND A member of the Lamiaceae flowering plant family, peppermint (Mentha piperita) is one of the most widely herbs used in today’s society. The peppermint plant is a mix of Mentha spicata (spearmint) and Mentha aquatica (watermint). This fragrant herb originates form the Mediterranean region and now grows wildly in many areas of
- [Risk for Congenital Malformation Increases with High Maternal BMI](https://www.metagenicsinstitute.com/articles/risk-congenital-malformation-increases-high-maternal-bmi/) - by Bianca Garilli, ND Obesity rates have reached epidemic proportions globally and have been shown to adversely influence many clinical markers of health However, the data are sparse with regards to the effect maternal obesity may have on fetal and neonatal outcomes. A recent report in Lancet, by Di Cesare et al, showed that the number of
- [Younger Adults and Stroke: Risk Rates Rising](https://www.metagenicsinstitute.com/articles/younger-adults-stroke-risk-rates-rising/) - by Bianca Garilli, ND Often considered a disease of the older population, recent reports are indicating that an estimated 10% of stroke victims are less than 50 years of age and, according to a recent study published in the Journal of the American Medical Association (JAMA), ischemic stroke rates have risen in young adults aged between 24-50 years.1
- [Obesity-Induced Insulin Resistance and Hepatic Steatosis are Alleviated by n-3 Fatty Acids: A Role for Resolvins and Protectins](https://www.metagenicsinstitute.com/articles/obesity-induced-insulin-resistance-hepatic-steatosis-alleviated-o-3-fatty-acids-role-resolvins-protectins/) - A 2009 publication, obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins can be downloaded here. In this paper, the authors discuss omega-3-polyunsaturated fatty acids (omega-3-PUFAs), which have well-documented protective effects that are attributed not only to eicosanoid inhibition but also to the formation of novel
- [Talking Health– Not Weight– is Key to Improving Weight Loss in Patients](https://www.metagenicsinstitute.com/articles/talking-health-not-weight-key-improving-weight-loss-patients/) - A recent article published in a recent edition of Preventing Chronic Disease: Public Health Research, Practice and Policy proposes a shift from discussing BMI and weight loss with patients in the provider’s office, to focusing on the topics of awareness and education surrounding healthy life habits, physical activity in particular. Authors Emily Dollar and team encourage an
- [Nearly 50% of Americans now Diagnosed with Diabetes or Prediabetes](https://www.metagenicsinstitute.com/articles/nearly-50-americans-now-diagnosed-diabetes-prediabetes/) - The Centers for Disease Control (CDC) recently released their latest National Diabetes Statistics Report— and the news is not optimistic. The report indicates that one in 10 (30.3 million) US adults has diabetes, while more than one in three–or 84.1 million–has prediabetes. What is even more disconcerting is that 90% of those with prediabetes are not
- [Novel Measurements to Assess Cardiovascular Disease Risk in Type 2 Diabetes](https://www.metagenicsinstitute.com/articles/novel-measurements-assess-cardiovascular-disease-risk-type-2-diabetes/) - by Bianca Garilli, ND The World Health Organization (WHO) estimates the total number of people living with diabetes in 2014 was 422 million, equal to approximately 8.5% of adults worldwide– a majority of whom were diagnosed with type 2 diabetes (T2D). These figures are a staggering increase from the estimated 108 million people, globally, who
- [Nutrition Awareness and Improved Lifestyle Behaviors Should Be Started Earlier](https://www.metagenicsinstitute.com/articles/nutrition-awareness-improved-lifestyle-behaviors-started-earlier/) - by Bianca Garilli, ND An article published in the New England Journal of Medicine reviewed data collected from 1998-2012 from adults in the Swedish National Diabetes Register with type 1 diabetes (T1D) and type 2 diabetes (T2D). Information was analyzed for various end points including overall mortality rate and incidence of cardiovascular disease (CVD) and coronary heart
- [Weight Loss Improves Diabetic Peripheral Neuropathy Scores](https://www.metagenicsinstitute.com/articles/weight-loss-leads-subsequent-decrease-diabetic-peripheral-neuropathy-scores/) - by Bianca Garilli, ND Diabetic peripheral neuropathy (DPN), a common complication of diabetes, leads to pain and loss of feeling in the hands, arms, feet and legs. The incidence of neuropathy is approximately 45% for patients with type 2 diabetes mellitus (T2D) and is responsible for more hospital admissions than all other diabetic complications combined;
- [Weight Management Program Led by Primary Care Physicians Successful in Diabetes Remission](https://www.metagenicsinstitute.com/articles/weight-management-program-led-primary-care-physicians-successful-diabetes-remission/) - by Lewis Chang, PhD One-year results from a new long-term clinical trial demonstrate that, compared with the usual guideline-based care, a more aggressive weight management program implemented at primary care practices can effectively help patients achieve type 2 diabetes (T2D) remission [1]. Researchers from Newcastle University (Newcastle City, UK) and University of Glasgow (City of Glasgow, UK)
- [The Nonnutritive Sweetener Paradox](https://www.metagenicsinstitute.com/articles/nonnutritive-sweetener-paradox/) - by Ashley Jordan Ferira, PhD, RDN Nonnutritive sweeteners were designed to limit caloric intake and assist in weight and blood glucose management,1 but recent findings linked nonnutritive sweetener use to higher adiposity and cardiometabolic risk.2 Nonnutritive sweeteners (NNS) including aspartame, sucralose and stevioside are zero- or low-calorie sugar substitutes commonly consumed in the US.3 Approximately 25% of children and 41% of
- [Chocolate and Nuts: Recipe for Lipid Profile Success?](https://www.metagenicsinstitute.com/articles/chocolate-nuts-recipe-lipid-profile-success/) - by Ashley Jordan Ferira, PhD, RDN Heart disease is the #1, equal opportunity, killer in the US.1 Suboptimal diet quality, including low nut consumption, is also a leading cause of death.1 Observational and interventional studies have demonstrated that chocolate and almonds, separately, yield cardiometabolic benefits. Numerous nutritional bioactives exist in these foods, but the key players are thought
- [Intake of Antioxidants β-Carotene and Vitamin E Associated with Lower Risk for Parkinson’s Disease](https://www.metagenicsinstitute.com/articles/intake-antioxidants-β-carotene-vitamin-e-associated-lower-risk-parkinsons-disease/) - by Lewis Chang, PhD It has been suggested that oxidative stress contributes to the pathogenesis of Parkinson’s disease (PD), an age-related neurodegenerative disorder of the central nervous system affecting movement. As antioxidants may offset oxidative stress and damage to neurons, scientists have been interested in whether antioxidant consumption would reduce the risk of PD. Researchers
- [FDA Approves Blood Test for Concussion Diagnosis](https://www.metagenicsinstitute.com/articles/fda-approves-blood-test-concussion-diagnosis/) - by Ashley Jordan Ferira, PhD, RDN As part of its Breakthrough Devices Program, the FDA authorized marketing for the Brain Trauma Indicator, the first blood test to evaluate mild traumatic brain injury (TBI) in adults.1 What is TBI? TBI, also known as “concussion,” occurs following a bump, blow or jolt to the head or penetrating
- [Association of Vasomotor and Other Menopausal Symptoms with Risk of Cardiovascular Disease](https://www.metagenicsinstitute.com/articles/association-vasomotor-menopausal-symptoms-risk-cardiovascular-disease/) - Menopausal transition represents a critical period in women’s lives that marks an increase in cardiovascular disease (CVD) risk. Traditional CVD risk factors, such as reduced glucose tolerance, increased blood pressure and endothelial dysfunction, tend to become very present during menopausal transition and post-menopausal years which can partly explain the augmentation in CVD risk among women.
- [Acupuncture is Safe and Effective in Reducing Vasomotor Symptoms](https://www.metagenicsinstitute.com/articles/acupuncture-safe-effective-reducing-vasomotor-symptoms/) - by Lewis Chang, PhD Hormone therapy may be the most effective treatment for reducing vasomotor symptoms. But for many symptomatic perimenopausal and postmenopausal women, the risk of hormone therapy outweighs the benefit. One of the non-pharmacological options that many women consider is acupuncture. However, there has not been a systematic review of randomized clinical trials
- [Lifestyle Changes Can Improve Long-Term Brain Health in Adults](https://www.metagenicsinstitute.com/articles/lifestyle-changes-can-improve-long-term-brain-health-adults/) - by Bianca Garilli, ND A Presidential Advisory on brain health was recently released by the American Heart Association/American Stroke Association in September 2017. The goals of the publication were to provide a definition of “optimal brain health” in adults, and guidance on how to maintain brain health through the years. From these data, the following
- [Does Metabolic Syndrome Increase the Risk for Sudden Cardiac Death?](https://www.metagenicsinstitute.com/articles/metabolic-syndrome-increase-risk-sudden-cardiac-death/) - by Bianca Garilli, ND Metabolic syndrome (MetS) is defined by a group of markers including elevated blood pressure, increased fasting blood glucose and dyslipidemia along with increased levels of adiposity, particularly central fat deposition. It is estimated that MetS affects 1 in 3 Americans with a higher prevalence in women than in men. MetS is
- [Probiotics and Omega-3s May Help Manage NAFLD](https://www.metagenicsinstitute.com/articles/probiotics-omega-3s-may-help-manage-nafld/) - Results from a supplementation trial demonstrated that the combination of probiotics and omega-3 fatty acids reduced the risk for steatosis (fatty liver) in patients with nonalcoholic fatty liver disease (NAFLD)1. Previous research has shown that modulation of the gut microbiota via probiotics supplementation may have beneficial effects on the gut-liver axis and metabolic and immunologic responses,
- [Are Fetal and Postnatal Exposures to Heavy Metals Associated with Autism Development?](https://www.metagenicsinstitute.com/articles/fetal-postnatal-exposures-heavy-metals-associated-autism-development/) - by Bianca Garilli, ND Recent research continues to support the idea that both a genetic and environmental component may be potentially associated with the development of autism spectrum disorder (ASD). Heritability is high in ASD as can be seen from family and twin studies. It is most certainly polygenic (multiple genes may contribute to ASD risk rather than there
- [DASH-ing for Improved Outcomes in PCOS](https://www.metagenicsinstitute.com/articles/dash-ing-improved-outcomes-pcos/) - Polycystic Ovarian Syndrome (PCOS) is one of the most common endocrine disorders for reproductive aged women in the US with a prevalence of 4-12%; in the EU, the prevalence ranges from 6-8%. This syndrome is characterized by irregular menses, hyperandrogenism, and polycystic ovaries. On clinical examination, PCOS is usually noted by complaints of oligomenorrhea or
- [More Awful Truth about Artificially Sweetened Beverages (Diet Soda)](https://www.metagenicsinstitute.com/articles/awful-truth-artificially-sweetened-beverages-diet-soda/) - Artificially sweetened beverages (ASBs) are non-caloric soft drinks sweetened by non-nutritive sweeteners instead of sugars. For consumers interested in losing weight, improving glycemic control, or simply reducing sugar consumption, ASBs are thought to be healthier alternatives to sugar-sweetened beverages. However, epidemiological evidence has begun to show that ASBs are by no means harmless. For example,
- [Artificial Sweeteners Impact Glucose Response – and Not in a Good Way!](https://www.metagenicsinstitute.com/articles/study-shows-artificial-sweeteners-quickly-alters-glucose-response-not-good-way/) - Consumption of non-caloric artificial sweeteners (NAS) commonly found in diet sodas had a deleterious impact on postprandial glycemic response in healthy subjects, a double-blind randomized trial found.1 Artificially sweetened beverages (ASBs) are thought to be healthier than sugar sweetened beverages because they contain little or no sugar. However, an increasing number of large-scale epidemiological studies
- [Optimal Brain Health with 7 Simple Steps: Advisory from Heart and Stroke Groups](https://www.metagenicsinstitute.com/articles/optimal-brain-health-7-simple-steps-advisory-heart-stroke-groups/) - The American Heart Association (AHA) and the American Stroke Association (ASA) recently compiled their joint guidance that outlines 7 factors to be implemented in maintaining optimal brain health in adults. The joint advisory board notes that a healthy lifestyle benefits the brain as much as the body. Both the brain and the heart need adequate
- [Significant Longitudinal Associations between HbA1c Levels and Cognitive Decline](https://www.metagenicsinstitute.com/articles/significant-longitudinal-associations-hba1c-levels-cognitive-decline/) - by Lewis Chang, PhD Decline in cognitive ability progresses over a long period of time and is a risk factor for dementia. The link between type 2 diabetes (T2D) and dementia has been well documented. Mechanistically, T2D may directly induce amyloid accumulation and indirectly increase microvascular disease of the central nervous system. However, the link
- [Less Diverse Gut Microbiota in PCOS Linked to Hyperandrogenism](https://www.metagenicsinstitute.com/articles/less-diverse-gut-microbiome-pcos-linked-hyperandrogenism/) - by Lewis Chang, PhD The majority of women with polycystic ovary syndrome (PCOS) have metabolic abnormalities. Because reduced diversity in the gut microbiome has been associated with metabolic disorders, researchers have hypothesized that women with PCOS may also exhibit reduced diversity in their gut microbiota, which may be linked to other hormonal imbalances including increased
- [Both Vegetarian and Mediterranean Diets Improve Body Weight and Blood Lipids](https://www.metagenicsinstitute.com/articles/vegetarian-mediterranean-diets-improve-body-weight-blood-lipids/) - by Lewis Chang, PhD A new dietary intervention trial demonstrated that a low-caloric lacto-ovo vegetarian diet and low-caloric Mediterranean diet were equally effective in reducing body weight and fat mass in healthy individuals, with different beneficial effects observed for blood lipids.1 Previous epidemiological studies and meta-analyses of clinical trials have found various health benefits associated
- [Low-Fat, Plant-Based Diet Reduces T2D Risk in Obese Individuals](https://www.metagenicsinstitute.com/articles/low-fat-plant-based-diet-reduces-t2d-risk-obese-individuals/) - by Bianca Garilli, ND It is estimated that over 9% of the US population or 30.3 million people have diabetes, and 23% of these are undiagnosed.1 The pathogenesis of diabetes includes the development of insulin resistance in muscle and liver cells, followed by impairment of pancreatic beta-cell function. Eventually, there is beta-cell failure due to
- [Results from PURE Multi-National Cohort Study Challenge Current Dietary Guidelines](https://www.metagenicsinstitute.com/articles/results-pure-multi-national-cohort-study-challenge-current-dietary-guidelines/) - Findings from the Prospective Urban Rural Epidemiology (PURE) Study—which consisted of more than 135,000 individuals from 18 low-, middle- and high-income countries from five continents—showed that: (1) high carbohydrate intake was linked to worse total mortality, whereas high fat intake was linked to lower risk; (2) reducing saturated fat intake and replacing it with carbohydrate was linked
- [Dentists Identify and Treat Diabetes](https://www.metagenicsinstitute.com/articles/dentists-identify-treat-diabetes/) - by Bianca Garilli, ND A diagnosis of type 2 diabetes (T2D) is typically made through the following measurements and is most commonly screened for and diagnosed by primary care providers during annual exams: Hemoglobin A1c (HbA1c) ≥6.5% or Fasting plasma glucose (FPG) ≥126 mg/dl (7.0 mmol/l) or 2-h plasma glucose ≥200 mg/dl (11.1 mmol/l) during
- [Health Benefits of Blood-Type Diet Found to be Unrelated to Individual’s Blood Type](https://www.metagenicsinstitute.com/articles/health-benefits-blood-type-diet-found-unrelated-individuals-blood-type/) - by Lewis Chang, PhD Based on the theory that each blood type (i.e., O, A, B, and AB type) represents distinct genetic traits and ancestral dietary habits, the popular “blood-type diet” advocates eating according to one’s blood type to achieve optimal health. For example, individuals who are type O (“the hunter”) would benefit most from
- [Patients with Diabetes Account for 25% of Emergency Room Visits](https://www.metagenicsinstitute.com/articles/patients-diabetes-account-25-emergency-room-visits/) - by Bianca Garilli, ND In 2015, the prevalence of diabetes in the United States was 30.3 million Americans or 9.4% of the population.1 In the same year, over 12 million emergency department (ED) visits or 25% of total ED visits were made by patients with diabetes aged 45 and older. This number is 6 times higher
- [Is Obesity Passed on from Mother to Child?](https://www.metagenicsinstitute.com/articles/obesity-passed-mother-child/) - by Bianca Garilli, ND The rise in childhood overweight and obesity has been dramatic over the past three decades, with the number of overweight children tripling in that time frame, resulting in approximately 1 in 5 children (17%) in the US now estimated to be overweight.*1 Furthermore, while more children are becoming overweight, the heaviest children
- [Healthy (vs. Unhealthy) Plant-Based Diets Associated with Lower All-Cause Mortality](https://www.metagenicsinstitute.com/articles/healthy-vs-unhealthy-plant-based-diets-associated-lower-cause-mortality/) - by Lewis Chang, PhD A plant-based diet emphasizes a high intake of plant foods and limits or eliminates the intake of animal products. Research has demonstrated various health benefits of plant-based diets, such as lower risks of obesity, high blood pressure, and type 2 diabetes. However, studies that examined their effects on all-cause mortality have
- [Not All Fats are Created Equal: Lipidomics Associated with Obesity and Insulin Resistance](https://www.metagenicsinstitute.com/articles/not-fats-created-equal-lipidomics-associated-obesity-insulin-resistance/) - by Bianca Garilli, ND It has been said that an ounce of prevention is worth a pound of cure. In the case of the growing obesity epidemic and the concurrent increase in insulin resistance (IR) and type 2 diabetes (T2D), it is important to understand the relationship between obesity and IR, and to identify biomarkers
- [Stanford’s Low-Fat vs. Low-Carb Comparison Trial Underscores Importance of Robust Study Design](https://www.metagenicsinstitute.com/articles/stanfords-low-fat-vs-low-carb-comparison-trial-underscores-importance-robust-study-design/) - by Lewis Chang, PhD As the prevalence of obesity continues to increase worldwide, the search for the most effective diet(s) for weight loss continues. Whether one diet is better than another—such as the low-carb vs. low-fat diet approach—is still being hotly debated. Regardless, researchers have noticed substantial inter-individual differences in weight loss success (or failure)
- [Potential Contribution of Dietary Trehalose to C. diff Epidemic](https://www.metagenicsinstitute.com/articles/potential-contribution-dietary-trehalose-c-diff-epidemic/) - by Lewis Chang, PhD Clostridium difficile, or "C. diff", is a bacterium that can cause infection in at-risk individuals, triggering symptoms ranging from mild diarrhea to severe pseudomembranous colitis. Major risk factors for C. diff infection include depletion of protective gut microorganisms due to antibiotics use (e.g. fluoroquinolones), compromised immune system, age, healthcare environment, and
- [Blood Biomarkers to Help Diagnose and Guide Appropriate Treatment in TBI](https://www.metagenicsinstitute.com/articles/blood-biomarkers-to-help-diagnose-and-guide-appropriate-treatment-in-tbi/) - by Bianca Garilli, ND Traumatic brain injury (TBI) research has grown rapidly in the past decade as awareness of the high prevalence and its potential devastating consequences have become clearer.1 TBI may result in varying degrees of paralysis, loss of consciousness, amnesia and even death. Death was the most common outcome for those diagnosed with
- [Waist-to-Hip Ratio, but not BMI, Related to Major Cardiovascular Events in Women](https://www.metagenicsinstitute.com/articles/waist-hip-ratio-not-bmi-related-major-cardiovascular-events-women/) - by Bianca Garilli, ND Body mass index (BMI) is used in the medical community for defining anthropometric height/weight characteristics.1 An individual’s BMI categorizes them as normal, overweight or obese and is often used as a risk factor for various chronic health issues including coronary artery disease (CAD).1 It has become apparent however that BMI is
- [Mediterranean Diet Modulates Human Gut Microbiota](https://www.metagenicsinstitute.com/articles/mediterranean-diet-modulates-human-gut-microbiota/) - by Lewis Chang, PhD Gut microbiota, a community of trillions of microorganisms living in the gastrointestinal tract, play an important role in health and disease in humans. A loss in species richness and diversity in the microbiota has been associated with many metabolic disorders and disease states.1 Nutrition can have a significant impact on the
- [Is All Obesity Created Equal?](https://www.metagenicsinstitute.com/articles/obesity-created-equal/) - by Bianca Garilli, ND As the rise in obesity continues globally, questions remain: do all people with obesity have increased risk of long-term chronic health conditions, or whether is there a subset of individuals who are healthy despite having obesity? In fact, the concept that “not all obesity is created equally” is emerging in the
- [Added Sugars from Diet Linked to Frailty in Older Adults](https://www.metagenicsinstitute.com/articles/added-sugars-diet-linked-frailty-older-adults/) - by Lewis Chang, PhD Frailty, characterized by exhaustion, reduced physical activity capacity, slow gait speed, unintentional weight loss, and muscle weakness, is a major health concern associated with aging that increases the risk of disability, institutionalization, and death in older adults.1 It is important to identify modifiable risk factors associated with frailty so that prevention
- [Are Body Mass Index and Waist Circumference the Best Predictors of Cardiometabolic Risk?](https://www.metagenicsinstitute.com/articles/body-mass-index-waist-circumference-best-predictors-cardiometabolic-risk/) - by Bianca Garilli, ND Body mass index (BMI) is frequently utilized in clinical practice to assess for risk of cardiometabolic disease (CMD). High BMI measurements are associated with insulin resistance along with other markers of CMD such as elevated blood glucose and triglycerides, low HDL cholesterol, and elevated blood pressure.1 By way of review, a
- [Moderate Exercise Benefits Post-Concussive Symptoms & Cognitive Function in Youth](https://www.metagenicsinstitute.com/articles/moderate-exercise-benefits-post-concussive-symptoms-cognitive-function-youth/) - by Ashley Jordan Ferira, PhD, RDN Mild traumatic brain injury (TBI), AKA “concussion,” results from an impact to the head (e.g. bump, blow, jolt) that disrupts normal brain function or consciousness.1 Concussions in youth are more common than you may think. In 2016, 19.5% of US adolescents reported at least 1 diagnosed concussion during their

## Blogs

- [Zinc Is Essential for Immune Functions](https://www.metagenicsinstitute.com/blogs/zinc-for-immune-functions/) - Activation of inflammasomes is part of the innate immune defenses that leads to amplification of downstream inflammatory and immune responses.
- [Four Ways to Support Immune Health](https://www.metagenicsinstitute.com/blogs/immune-health-support/) - When used appropriately, nutritional supplements address common nutritional deficiencies and provide a targeted boost, particularly during cold and flu season.
- [The Role of Specialized Pro-Resolving Mediators (SPMs) in Inflammation & Cellular Resilience](https://www.metagenicsinstitute.com/blogs/spms-inflammation-resilience/) - Colleagues review research on specialized pro-resolving mediators (SPMs) in inflammation resolution and cellular resilience.
- [What Does the Omega-3 Index Tell You About Your Heart Health?](https://www.metagenicsinstitute.com/blogs/omega-3-index-tell-heart-health/) - Evidence points towards the greater benefit of achieving a healthy omega-3 index score in individuals who are already at high risk for a cardiovascular event.
- [A Functional Medicine Reset for the New Year](https://www.metagenicsinstitute.com/blogs/a-functional-medicine-reset-for-the-new-year/) - Support your patients’ detox goals with this science-based guide to nourishing the body’s natural elimination pathways for a functional medicine reset.
- [Supporting Liver Health After the Holidays](https://www.metagenicsinstitute.com/blogs/supporting-liver-health-after-the-holidays/) - The liver’s detoxification system represents one of the body’s most elegant biochemical defenses; explore supporting liver health during the holidays.
- [Beyond Performance](https://www.metagenicsinstitute.com/blogs/beyond-performance/) - Discover how creatine supports women’s health across all life stages—boosting strength, bone density, cognition, and overall vitality.
- [The Hidden Fragility of Menopause](https://www.metagenicsinstitute.com/blogs/the-hidden-fragility-of-menopause/) - Explore how menopause impacts bone health and discover evidence-based nutrients, lifestyle strategies, and clinical insights to support skeletal strength.
- [Vitamin C and Immunity](https://www.metagenicsinstitute.com/blogs/vitamin-c-and-immunity/) - Explore how buffered Vitamin C supports immunity, reduces inflammation, and enhances T & B cell function for optimal clinical outcomes.
- [The Evolving Science of Pain](https://www.metagenicsinstitute.com/blogs/the-evolving-science-of-pain/) - Blog exploring the science of pain, including specialized pro-resolving mediators, drivers of inflammation, and botanicals that modulate pain targets.
- [Magnesium Deficiency: A Silent Epidemic?](https://www.metagenicsinstitute.com/blogs/magnesium-deficiency/) - Magnesium deficiency symptoms include, sleeplessness and muscle cramping. How do we determine if you are deficient and what can be done about it?
- [Beyond the Injection](https://www.metagenicsinstitute.com/blogs/beyond-the-injection-glp-1-nutritional-support/) - Explore GLP-1 nutritional support with science-backed solutions and research. Discover how targeted nutrients help support patients beyond the injection.
- [GLP-1 Receptor Agonists and Sarcopenia](https://www.metagenicsinstitute.com/blogs/glp-1-receptor-agonists-and-sarcopenia/) - Explore how GLP-1 receptor agonists impact muscle mass and learn science-based strategies to minimize sarcopenia risk and preserve metabolic resilience.
- [Neuroprotective Effects of the Ketogenic Diet (Part 2: Mechanisms and Evidence)](https://www.metagenicsinstitute.com/blogs/neuroprotective-effects-ketogenic-diet-part-2-mechanisms-evidence/) - Chronic consumption of refined sugar and starches results in systemic inflammation in the body that exacerbates neuroinflammation and plays a role in blood brain barrier disruption
- [Getting to Know the Ketogenic Diet and Its Clinical Applications](https://www.metagenicsinstitute.com/blogs/getting-know-ketogenic-diet-clinical-applications/) - The key to the ketogenic plan is the macronutrient content of fats, proteins, and carbohydrates rather than the mere removal of processed foods.
- [Keto Diet for Diabetes Management: Insights from Landmark Virta Study](https://www.metagenicsinstitute.com/blogs/keto-diet-diabetes/) - Top 4 insights from the Virta trial, a landmark study that assessed effectiveness and safety of the ketogenic diet for the management of type 2 diabetes.
- [Lactiplantibacillus plantarum 299v: A probiotic for IBS and Gut-Brain Axis Support](https://www.metagenicsinstitute.com/blogs/probiotic-lp299v-improved-ibs/) - The probiotic strain Lactiplantibacillus plantarum 299v is the focus of great discovery and shown to be effective in supporting good gut health in managing IBS.
- [Can We Disrupt Cognitive Decline with Personalized Lifestyle Medicine?](https://www.metagenicsinstitute.com/blogs/cognitive-decline-treatment/) - Evidence suggests that multi-component, lifestyle interventions can reduce the risk for accelerated cognitive decline & offer functional improvement.
- [The Ketogenic Diet: “Best Hits” of Early 2019](https://www.metagenicsinstitute.com/blogs/ketogenic-diet-science/) - In this blog, we highlight new science and clinical research on the ketogenic diet related to migraine, Alzheimer’s disease, schizophrenia, epilepsy, and more.
- [Your Next Happiness Project: Mind Your Plate! The Food-Mood Connection](https://www.metagenicsinstitute.com/blogs/food-mood-connection/) - More than fuel for our bodies, nutrients play a role in brain functions. Cumulative evidence shows an association between unhealthy diets and poor mental health
- [Hypertension: A Precision and Personalized Approach](https://www.metagenicsinstitute.com/blogs/hypertension/) - Precision medicine examines the underlying physiology of hypertension, looking at the arterial structure and function in very different ways.
- [Nutritional Resilience in the Age of GLP-1 Therapy](https://www.metagenicsinstitute.com/blogs/nutritional-resilience-in-the-age-of-glp-1-therapy/) - Discover science-based strategies to maintain nutrient sufficiency and metabolic resilience during GLP-1 therapy with expert clinical insights.
- [Probiotics in the Prevention and Management of Respiratory Tract Infections](https://www.metagenicsinstitute.com/blogs/probiotics-immune-defense/) - Probiotic supplementation can help with protection against various diseases, including respiratory infections, and bring about a well-balanced gut microbiota.
- [Nrf-2 and Sulforaphane—What You Need to Know](https://www.metagenicsinstitute.com/blogs/sulforaphane-nrf2-detoxification/) - Our bodies are equipped to handle biological/biochemical challenges via Nrf-2 transcriptional factor, which is involved in the regulation of antioxidant & anti-inflammatory properties.
- [When the Gut Says No](https://www.metagenicsinstitute.com/blogs/when-the-gut-says-no/) - Explore the GI effects of GLP-1 therapies and learn evidence-based strategies to reduce side effects, support tolerance, and protect gut and liver health.
- [Vitamin C: An Overview](https://www.metagenicsinstitute.com/blogs/vitamin-c-overview/) - Due to the result of random genetic mutations, humans have lost the ability to synthesize ascorbate in our livers, making vitamin C an essential micronutrient.
- [Stress and the Immune System: A Delicate Balance](https://www.metagenicsinstitute.com/blogs/stress-immune-system/) - This blog discusses the biological ways in which physiological & psychological stress impact the immune system, plus lifestyle approaches for stress management.
- [Is High Blood Pressure or Diabetes Linked to Increased Risks for COVID-19 Infection?](https://www.metagenicsinstitute.com/blogs/htn-immune-risk/) - Scientists have found that the novel coronavirus that causes COVID-19 infection binds and enters human cells via angiotensin converting enzyme 2 (ACE2) receptors on the cells.
- [COVID-19: Gastrointestinal Symptoms and Outcomes](https://www.metagenicsinstitute.com/blogs/covid-19-gi-symptoms/) - Gastrointestinal tissues are markedly involved in the progression of a subset of clinical cases, and the gut could be actively involved in viral pathogenesis.
- [United States Military Response in the Time of COVID-19](https://www.metagenicsinstitute.com/blogs/military-response-covid-19/) - One of the many groups greatly affected by the novel coronavirus, while also playing a major role in defeating this pandemic, is the United States military.
- [Flattening the Curve of COVID-19: Why slowing the spread will save lives](https://www.metagenicsinstitute.com/blogs/flattening-the-curve/) - With over 191,000 confirmed COVID-19 cases and more than 7,800 deaths epidemiologists are really urging social distancing in an effort to “flatten the curve.”
- [Metabolic Health: The Clinical Relevance of Obesity and Diabetes in COVID-19](https://www.metagenicsinstitute.com/blogs/obesity-and-diabetes-in-covid-19/) - Obesity is a risk factor associated with many chronic diseases and it poses a significant health concern during a pandemic particularly when half of the population is affected.
- [Vitamin C: Layers of Immune Function](https://www.metagenicsinstitute.com/blogs/vitamin-c-immune-function/) - Vitamin C (AKA ascorbic acid/ascorbate) plays an important role in immune function with Swiss Army knife-like utility.
- [A Few Additional Treatment Possibilities for COVID19 (SARS Cov-2) Addressing Furin-Like Cleavage and Pyroptosis (Caspase-1 Activation of Inflammasome NLRP3)](https://www.metagenicsinstitute.com/blogs/activation-of-inflammasome/) - The cytokine storm seen in SARS CoV-1 and CoV-2 might be due to chronic pyroptosis activation. However, known activators of NLRP3 in SARS-CoV differ from CoV-2.
- [Are You D-Prived? Vitamin D Deficiency and Why it Persists](https://www.metagenicsinstitute.com/blogs/vitamin-d-deficiency/) - Multiple factors affect the vitamin D status of an individual which can have an impact on their health. Adequate supplementation can help improve the status.
- [Stimulation of Inflammation Resolution May Avert Cytokine Storm and Improve Clinical Outcomes Associated with Current Pandemic, Prominent Researchers Proposed](https://www.metagenicsinstitute.com/blogs/inflammation-cytokine-storm/) - Specialized pro-resolving mediators are biosynthesized to actively orchestrate key resolution events of acute inflammation. These bioactive compounds, such as resolvins, promote macrophage clearance of cellular debris and counter the release of proinflammatory cytokines
- [Cytokine Storm in the Context of COVID-19](https://www.metagenicsinstitute.com/blogs/cytokine-storm/) - Cytokine storm refers to the protective immune response out of control, leading to unregulated release of excessive amounts of cytokines into system.
- [SARS-CoV-2 Effects in the Central Nervous System and the Mental Health Burden of COVID-19](https://www.metagenicsinstitute.com/blogs/covid-19-effects-cns-mental-health/) - While social distancing remains the recommendation to minimize even greater dissemination of the virus, it does not come without deleterious health consequences.
- [COVID-19 and Neurological Symptoms: Do We Know Enough?](https://www.metagenicsinstitute.com/blogs/covid-19-neurological-symptoms/) - It’s been hypothesized that the common labored breathing, as well as less frequent instances of asymptomatic hypoxemia in COVID-19, may be linked to SARS-CoV-2
- [Antiviral and Anti-Inflammatory Effects of Green Tea Extract (EGCG)](https://www.metagenicsinstitute.com/blogs/antiviral-green-tea-extract/) - The antiviral and anti-inflammatory effects of epigallocatechin gallate (EGCG) demonstrate its broad utility for human health.
- [Antiviral Lactoferrin Now Pitted Against COVID-19](https://www.metagenicsinstitute.com/blogs/antiviral-lactoferrin-covid19/) - Lactoferrin has many anti-inflammatory and even anticarcinogenic effects; what remains to be discovered is its specific activity against the pandemic virus.
- [Six Questions on COVID-19 Antibody Testing](https://www.metagenicsinstitute.com/blogs/covid-19-antibody-testing/) - Antibodies are proteins produced by our immune system in response to the presence of an antigen (AKA foreign substance, including pathogens such as SARS-CoV-2).
- [COVID-19 and Pregnancy: What Do We Know?](https://www.metagenicsinstitute.com/blogs/covid-19-and-pregnancy/) - Pregnant women contracting COVID-19 must still be cautious about their and their developing babies’ health, especially since treatment options are more limited.
- [6 Medicinal Mushrooms and Their Immunomodulatory Properties](https://www.metagenicsinstitute.com/blogs/medicinal-mushrooms-immunomodulatory/) - This article reviews what medicinal mushrooms are, common bioactives, and the research on six common varieties of medicinal mushrooms.
- [Immune Health and Metabolism Mediated by Gut Microbe Akkermansia muciniphila](https://www.metagenicsinstitute.com/blogs/gut-microbe-and-immune-health/) - Key microbial species in the intestinal microbiome have been associated with both metabolic disorders, immune health and immunological responses.
- [The Physiology of Nighttime Renewal](https://www.metagenicsinstitute.com/blogs/nighttime-hormonal-renewal/) - Explore how magnesium, Holy Basil, and zinc support nighttime hormonal renewal and immune recovery through stress, sleep, and circadian pathways.
- [Gut Resilience and Immune Support](https://www.metagenicsinstitute.com/blogs/gut-resilience-and-immune-support/) - Explore clinical evidence on synbiotics, Bacillus coagulans, B. subtilis, and chicory root, supporting gut microbiome diversity, immune balance, and digestion.
- [Comprehensive Probiotic Support for Women's Health](https://www.metagenicsinstitute.com/blogs/comprehensive-probiotic-support-for-womens-health/) - Explore clinically backed probiotic strains supporting women’s gut, immune, and vaginal, and urogenital health for whole-body wellness at every life stage.
- [The Science of Balance: How Nature’s Bioactive Compounds Support Women’s Health from Within](https://www.metagenicsinstitute.com/blogs/the-science-of-balance-how-natures-bioactive-compounds-support-womens-health-from-within/) - Women’s health is complex, influenced by hormones, digestion, metabolism, and stress. The science-backed ingredients explored in this article—saffron, licorice root, chromium picolinate, and vitamin B6—offer a natural way to support these vital functions.
- [Golden Milk: Trend or Age-Old Remedy?](https://www.metagenicsinstitute.com/blogs/golden-milk-trend-age-old-remedy/) - by Whitney Crouch, RDN, CLT What is Golden Milk? Popularized across social media, golden milk is a cross-cultural drink originating in Asian countries and consumed for its anti-inflammatory properties and pungent flavor. Also known as “golden milk latte” or “turmeric tea”, golden milk is made with freshly grated or ground turmeric, a pinch of freshly
- [Triple-Action Gut Health Support](https://www.metagenicsinstitute.com/blogs/triple-action-gut-health-support/) - by Kyle Perkovich, BS The gut, often referred to as the body’s “second brain,” is central to overall health, influencing everything from digestion to immune function, metabolism, and even mental health.1-3 Emerging research consistently demonstrates that a balanced and diverse gut microbiome is essential for overall health and a key aspect of every patient’s wellness. The
- [PMS Relief Through Science: Which Natural Supplements Actually Work?](https://www.metagenicsinstitute.com/blogs/pms-relief-through-science-which-natural-supplements-actually-work/) - PMS can feel like an unavoidable struggle, but the right approach can help make it more manageable. During the luteal phase of the menstrual cycle, hormonal fluctuations trigger the common symptoms of PMS.
- [Unlocking Better Sleep: The Power of Melatonin and Circadian Rhythms](https://www.metagenicsinstitute.com/blogs/unlocking-better-sleep-the-power-of-melatonin-and-circadian-rhythms/) - by Kyle Perkovich, BS Sleep determines everything – how we feel throughout the day, our mental and physical performance, and various aspects of our overall health.1 However, an estimated 50 to 70 million Americans struggle with sleep disorders, and one out of every three adults does not get the proper amount of sleep for their
- [Kava: A Holistic Approach to Enhancing Sleep and Reducing Anxiety](https://www.metagenicsinstitute.com/blogs/kava-enhancing-sleep-and-reducing-anxiety/) - by Kyle Perkovich, BS The pursuit of effective, natural remedies for sleep disturbances and anxiety is increasingly critical. Among various options, kava—a traditional herbal ingredient rooted in Pacific Island cultures—stands out for its potential therapeutic benefits. Known scientifically as Piper methysticum, kava has been celebrated for centuries for its sedative properties1. Only in recent years
- [Navigating Iron Needs: Understanding Iron Supplementation for Women](https://www.metagenicsinstitute.com/blogs/navigating-iron-needs-understanding-iron-supplementation-for-women/) - Iron is a vital nutrient that serves as a fundamental component of heme and various coenzymes, playing critical roles in essential biochemical pathways.
- [The Role of Phytonutrients in Weight Management: Harnessing the Power of Plants](https://www.metagenicsinstitute.com/blogs/phytonutrients-in-weight-management/) - A diet centered around plant-based foods such as fruits, vegetables, and fiber-rich cereals provides essential phytonutrients, including vitamins, carotenoids, polyphenols, and minerals.
- [Synergy in Gut Health](https://www.metagenicsinstitute.com/blogs/synergy-in-gut-health/) - by Kyle Perkovich, BS In the intricate ecosystem of the human gut, a new frontier is emerging, marked by the strategic paring of probiotics and prebiotics working synergistically to help provide optimal gut health and well-being. This combination, known as synbiotics, is gaining prominence for its potential to enhance gut health and immune function. As
- [Akkermansia muciniphila: Your Next-Generation Bacteria for Metabolic Health](https://www.metagenicsinstitute.com/blogs/akkermansia-muciniphila-bacteria-for-metabolic-health/) - Akkermansia muciniphila, is a tiny hero that lives in our gut and promotes our health and wellbeing. It’s time to get to know this hero better.
- [Omega-3 Role in Coronary Heart Disease](https://www.metagenicsinstitute.com/blogs/omega-3-chd/) - This article will review the flawed studies that have been reported and comb through the best science to put in perspective the omega-3 role in coronary heart disease.
- [Are All Calories Created Equal?](https://www.metagenicsinstitute.com/blogs/calories-created-equal/) - Evidence from this study, current research on healthy calories and fat consumption plus the new dietary guidelines indicate that in order to improve our health, we need to stop being afraid to eat fats.
- [SIBO: Addressing and Managing Nutritional Deficiencies](https://www.metagenicsinstitute.com/blogs/sibo-nutritional-deficiencies/) - With SIBO we see an overgrowth of bacteria in the digestive tract which throws off the delicately balanced orchestra of breaking down and absorbing food.
- [Bacterial Vaginosis (Part 2 of 3)](https://www.metagenicsinstitute.com/blogs/bacterial-vaginosis-risk-factors/) - Bacterial Vaginosis (BV) is associated with a significant negative impact on self-esteem, sexual relationships, and quality of life.
- [Bacterial Vaginosis (Part 3 of 3)](https://www.metagenicsinstitute.com/blogs/bacterial-vaginosis-alternative-treatments/) - Multiple clinical trials can be found supporting the use of probiotics for the treatment of Bacterial Vaginosis.
- [Bacterial Vaginosis (Part 1 of 3)](https://www.metagenicsinstitute.com/blogs/bacterial-vaginosis-symptoms/) - Bacterial vaginosis is the often silent, sometimes maddening, and quite common vaginal microbiome dysbiosis that affects 29.2% of women in the United States.
- [Demystifying Modified Citrus Pectin: What Is the Evidence?](https://www.metagenicsinstitute.com/blogs/demystifying-modified-citrus-pectin-evidence/) - by Christopher Moulton, PhD Pectin is a complex and heterogeneous aggregation of polysaccharides first isolated from plant matter in 1825 by French chemist and pharmacist Henri Bracconot.1 Pectin is the major constituent of all plant primary cell walls, contributing to the plant’s structural integrity and providing a barrier to the external environment. Consequently, pectin is
- [Vitamin D and Immune Health](https://www.metagenicsinstitute.com/blogs/vitamin-d-immune-health/) - Low levels of vitamin D in the blood (25-hydroxyvitamin D) are associated with higher risks of acute upper and lower respiratory tract infections such as flu
- [Exploring Medicinal Properties of Andrographis](https://www.metagenicsinstitute.com/blogs/andrographis-medicinal-properties/) - Andrographis and it's major compound, andrographolide, have been largely overlooked in Western medicine despite their safety and a wide therapeutic range.
- [Powerful Immune Influencers: Omega-3 Fats and Specialized Pro-Resolving Mediators (SPMs)](https://www.metagenicsinstitute.com/blogs/powerful-immune-influencers-spms/) - Specialized pro-resolving mediators (SPMs) have big impacts on our immune system and play an important role in the activity of immune cells.
- [Coenzyme Q10 (CoQ10)—When and When Not to Use It with Your Patients](https://www.metagenicsinstitute.com/blogs/coq10-supplementation-benefits/) - CoQ10 is an antioxidant that we get by eating oily fish, organ meats & grains. CoQ10’s job is to help us make energy and protect cells from free radicals.
- [Asthma, Inflammation, and Specialized Pro-Resolving Mediators (SPMs)](https://www.metagenicsinstitute.com/blogs/asthma-inflammation-resolution-spms/) - Since asthma is an inflammatory condition, supplementing the diet with SPMs may also reduce symptoms of asthma and resolve the underlying inflammation
- [The Role of the Endocannabinoid System and Palmitoylethanolamide in Managing Pain and Addiction](https://www.metagenicsinstitute.com/blogs/pea-opioid-treatment/) - The endocannabinoid system (ECS) and Palmitoylethanolamide (PEA) play an important role in various processes, from anti-inflammatory to neuroprotective actions.
- [Dealing with Dyslipidemia via Targeted Nutrition](https://www.metagenicsinstitute.com/blogs/dealing-dyslipidemia-via-targeted-nutrition/) - by Annalouise O’Connor, PhD, RD Dyslipidemia is defined as an abnormal level of lipids in the blood and is often described most simplistically as greater levels of total or low-density lipoprotein (LDL), the “bad” cholesterol or particle number, or lower levels of high-density lipoprotein (HDL), the “good” cholesterol. Dyslipidemia is linked with cardiovascular risk and
- [LDL Cholesterol: Particle Number & Size Matter](https://www.metagenicsinstitute.com/blogs/ldl-particle-number/) - It’s only after modification that the LDL becomes atherogenic and induces the inflammation, oxidative stress and immune dysfunction in the blood vessel.
- [Probiotic Strains NCFM and Bi-07 Reduce Pain Post-Colonoscopy](https://www.metagenicsinstitute.com/blogs/probiotic-strains-ncfm-bi-07-may-help-pain-post-colonoscopy/) - Recently, a combination of probiotic strains consumed post-colonoscopy was evaluated for the endpoints of bloating, abdominal pain, and altered bowel function.
- [Impact of Probiotics & Other Key Factors on the Common Cold](https://www.metagenicsinstitute.com/blogs/impact-probiotics-factors-common-cold/) - Targeted probiotic supplementation is a wise approach in support of immune health, but certain probiotic strains are more effective than others and have disease-specific effects.
- [Exercise: Impact on the Gut-Brain Axis](https://www.metagenicsinstitute.com/blogs/gut-brain-axis-exercise/) - Exercise triggers a stress response in the body, impacting the gut-brain axis. Learn what can be done to help support the gut-brain axis.
- [Probiotics: What They Are and How to Use Them Effectively](https://www.metagenicsinstitute.com/blogs/probiotics-benefits/) - Probiotics follow the conventional naming structure of bacteria that uses the phylogenetic system. Specific identification characterizes the type of bacteria by the larger category of genus, then the subcategory of species, and finally to the more detailed level of the strain.
- [Microbiome Diversity: Is it Clinically Meaningful?](https://www.metagenicsinstitute.com/blogs/microbiome-diversity/) - This article reviews microbiome diversity as one of the potential therapeutic targets and reviews the available evidence to support its clinical application.
- [Probiotics: an effective solution for chronic digestive conditions?](https://www.metagenicsinstitute.com/blogs/chronic-digestive-conditions/) - The overall impact of chronic digestive conditions requires clinicians be equipped with relevant nutritional strategies to help patients manage symptoms.
- [Lactoferrin—an Iron-Binding Glycoprotein on First-Line Defense in the Innate Immune System](https://www.metagenicsinstitute.com/blogs/lactoferrin-immune-defense/) - Supplementation with human or bovine lactoferrin have been used experimentally to aid in vulnerable populations such as infants and pregnant women.
- [Cannabis: Science First?](https://www.metagenicsinstitute.com/blogs/cannabis-science/) - Insights from Daniele Piomelli, MD, PhD, PharmD on the science and history of cannabis are explored in this blog.
- [Function Informs Behavior](https://www.metagenicsinstitute.com/blogs/function-informs-behavior/) - Our behavior is the fifth function—it is the expression of the activity and reserve in the other four functional capacities.
- [Functional Medicine and Women’s Health, Part 1: Thyroid, Adrenals & Excess Estrogen](https://www.metagenicsinstitute.com/blogs/functional-medicine-womens-health-interview-joel-evans-md-part-1-thyroid-adrenal-function/) - Estrogen in the body is made by an enzyme called aromatase. That enzyme takes androgens, like testosterone or androstenedione, and converts them into estrogens.
- [3 Reasons Lack of Sleep May Cause Weight Gain](https://www.metagenicsinstitute.com/blogs/3-reasons-lack-sleep-may-cause-weight-gain/) - If you’re trying to maintain a healthy weight, counting sheep may be as important as counting the carbs on your plate or weight repetitions at the gym. Because, while physical activity and a balanced diet are key factors, sleep may be the most overlooked aspect of your weight management plan. Can you sleep your way
- [Added Sugars Negatively Impact Immune System](https://www.metagenicsinstitute.com/blogs/added-sugar-intake/) - Many Americans are exceeding recommendations for added sugar intake. Learn about the immune health consequences of excessive consumption of added sugars.
- [Quercetin and Immune Health](https://www.metagenicsinstitute.com/blogs/quercetin-and-immune-health/) - A major health benefit of quercetin comes from its antioxidant (antioxidative) and anti-inflammatory properties.
- [7 Underlying Causes of SIBO That You Might Be Missing](https://www.metagenicsinstitute.com/blogs/7-underlying-causes-sibo-might-missing/) - SIBO stands for Small Intestinal Bacterial Overgrowth. Normally, the bulk of our gut microbiome resides in the large intestine.In SIBO, we see an overgrowth of bacteria in the small intestine.
- [Diet Influences Telomere Shortening: Eating Your Way to the Fountain of Youth?](https://www.metagenicsinstitute.com/blogs/diet-influences-telomere-length-eating-way-fountain-youth/) - Telomeres serve as a cell’s “biological clock” influencing the lifespan of the cell and organism. The shorter the telomere, the shorter the remaining lifespan.
- [Sleep Disorders in Veterans Impact Physical and Psychological Health](https://www.metagenicsinstitute.com/blogs/sleep-disorders-veterans/) - This blog explores the role that sleep disorders in the military veteran population are playing in chronic illness.
- [Hormonal Triggers of Migraines in Women](https://www.metagenicsinstitute.com/blogs/migraine-triggers/) - This blog explores the role that hormones, specifically the menstrual cycle and perimenopause, play in triggering migraines, along with potential solutions.
- [Inflammation: The Good, the Bad, & the Ugly](https://www.metagenicsinstitute.com/blogs/inflammation-balanced/) - Timely, balanced inflammation is a good thing, but unresolved, chronic, low-grade inflammation fuels many chronic diseases. Learn how lifestyle approaches help.
- [Surviving and Mitigating Physician Burnout with Lifestyle Medicine](https://www.metagenicsinstitute.com/blogs/physician-burnout/) - Sara Gottfried, MD discusses the troubling epidemic of physician burnout and offers lifestyle medicine solutions to help healthcare practitioners survive.
- [The Endocannabinoid System: Components, Actions, and Optimization](https://www.metagenicsinstitute.com/blogs/endocannabinoid-system-components/) - This endocannabinoid system is a critical physiological system involved in balancing many functions in the human body.
- [Reversing Your Epigenetic Age-Is That Possible?](https://www.metagenicsinstitute.com/blogs/reversing-epigenetic-age/) - The investigators reported that classic cardiovascular disease risk factors such as smoking or type 2 diabetes were associated with acceleration of epigenetic age.
- [Hormones & Sleep: Is Perimenopause Keeping You Awake?](https://www.metagenicsinstitute.com/blogs/perimenopause-sleep/) - Woman’s physiological stages of life are often delineated by the various, unique phases and cycles associated with fertility, reproduction, and the hormones at work behind the scenes.
- [An Overview of Prebiotics – Part 1](https://www.metagenicsinstitute.com/blogs/overview-prebiotics-part-1/) - by Lewis Chang, PhD Series Part 1: An Overview on Prebiotics This multi-part series will help you understand what prebiotics are, what they do, and how they may improve the health of your patients. Based on published scientific literature, this series will also clarify common misconceptions surrounding prebiotics and summarize clinical evidence of specific ingredients
- [An Overview of Prebiotics – Part 2](https://www.metagenicsinstitute.com/blogs/overview-prebiotics-part-2/) - by Lewis Chang, PhD Series Part 2: An Overview on Prebiotics This multi-part series will help you understand what prebiotics are, what they do, and how they may improve the health of your patients. Based on published scientific literature, this series will also clarify common misconceptions surrounding prebiotics and summarize clinical evidence of specific ingredients
- [An Overview of Prebiotics – Part 3](https://www.metagenicsinstitute.com/blogs/overview-prebiotics-part-3/) - by Lewis Chang, PhD This multi-part series will help you understand what prebiotics are, what they do, and how they may improve the health of your patients. Based on published scientific literature, this series will also clarify common misconceptions surrounding prebiotics and summarize clinical evidence of specific ingredients with prebiotic properties Series Part 3: Regarding
- [Modulating Metabolic Detoxification Pathways with Nutrition and Lifestyle Strategies](https://www.metagenicsinstitute.com/blogs/metabolic-detoxification-pathways/) - Metabolic detoxification is highly nutrient-dependent, relying on a balanced input of macronutrients and micronutrients to function optimally.
- [Behind Closed Doors: Women, Anxiety, & the Search for Relief](https://www.metagenicsinstitute.com/blogs/women-anxiety-relief/) - Anxiety is common in women at many stages in life, but for many it creates feelings of shame. Identify the symptoms and learn the connection between anxiety & hormones.
- [My Heart is Racing! Should I Be Concerned?](https://www.metagenicsinstitute.com/blogs/heart-racing-concerned/) - Can CoQ10 cause irregular heart racing? Research indicates that supplementing with CoQ10 or magnesium may provide palpitation relief in some individuals.
- [The SIBO Dilemma: How the Optimistic “Magic Bullet” Falls Short  for Most Patients](https://www.metagenicsinstitute.com/blogs/the-sibo-dilemma-how-the-optimistic-magic-bullet-falls-short-for-most-patients/) - The key to successful SIBO treatment is to understand that remedies work best in combination, and the patient must follow a SIBO diet until SIBO is resolved.
- [Sarcopenia: Causes, Treatment, and Lifestyle Interventions](https://www.metagenicsinstitute.com/blogs/sarcopenia-muscle-aging/) - The definition of sarcopenia has three parameters: low muscle strength, low muscle quantity or quality, and low physical performance.
- [Back to School: Managing Schedules, Healthy Lunches, Exercise and Sleep](https://www.metagenicsinstitute.com/blogs/back-school-managing-schedules-healthy-lunches-exercise-sleep/) - Summer has ended and school is back in session- which means most of us are in the thick of balancing classes, healthy eating on the go, exercise and sleep.
- [Specialized Pro-Resolving Mediators (SPMs) and Osteoarthritis (OA)](https://www.metagenicsinstitute.com/blogs/spms-osteoarthritis-osteoarthritis-oa/) - There is strong evidence for the role of specialized pro-resolving mediators (SPMs) in resolving inflammation of the joints that is the hallmark of Osteoarthritis (OA).
- [Obesity & Environment: Obesogens, Hormones, and Weight](https://www.metagenicsinstitute.com/blogs/obesogens-obesity/) - Obesogens are chemicals that lead to weight gain, disrupt metabolism, and put patients at greater risk for obesity. Learn the research and clinical application.
- [A Quick-Start Guide to the Ketogenic Diet](https://www.metagenicsinstitute.com/blogs/quick-start-guide-ketogenic-diet/) - What is “ketosis,” and how can you get there? Many people associate ketosis with a popular ketogenic diet program as a way to lose a considerable amount of weight.
- [Talking Turkey: Tryptophan and Cardiovascular Disease Risk](https://www.metagenicsinstitute.com/blogs/talking-turkey-tryptophan-cardiovascular-disease-risk/) - by Ashley Jordan Ferira, PhD, RDN Turkey finds its way on the menu for most carnivores during the holiday season, but is also commonly consumed by many Americans throughout the year. This poultry meat has gained popularity for being a good source of tryptophan,1 an essential amino acid required for protein biosynthesis. Interestingly, most poultry and other
- [Once Upon a Time, I Had a Thyroid](https://www.metagenicsinstitute.com/blogs/thyroid-disease/) - This blog describes a clinical story of autoimmune thyroid disease and the challenging journey to find the correct diagnosis and true healthcare partners.
- [I’ll Take It with a Grain of Salt and Teaspoon of Coconut Oil](https://www.metagenicsinstitute.com/blogs/ill-take-grain-salt-teaspoon-coconut-oil/) - Coconuts and their oil are not menacing and can certainly fit into a healthful dietary pattern.
- [Debunking Vitamin D Myths: Part 1](https://www.metagenicsinstitute.com/blogs/vitamin-d-supplement-1/) - This blog series explores common myths about vitamin D. Part 1 examines whether you can meet your vitamin D needs from food alone, without a supplement.
- [Methylation and Bone Health](https://www.metagenicsinstitute.com/blogs/methylation-bone-health/) - Methylation is involved in DNA synthesis, metabolism of hormones, neurotransmitters, histamine & toxins, immune system regulation and cellular energy pathways.
- [What Do I Need to Know About COVID-19 mRNA Vaccines?](https://www.metagenicsinstitute.com/blogs/mrna-vaccines/) - Over the past decade research and technological innovations progressed rapidly in the field of vaccine development enabling mRNA as a promising therapeutic tool
- [Lactoferrin and Immunoglobulin-Rich Whey Protein Reduced Common Colds in Adults](https://www.metagenicsinstitute.com/blogs/lactoferrin-reduces-common-cold/) - Many natural supplements such as lactoferrin help us defend against the common cold by providing immune-enhancing ingredients.
- [Stress Adaptation with Ashwagandha](https://www.metagenicsinstitute.com/blogs/stress-adaptation-ashwagandha/) - Ashwagandha has been used in Ayurvedic medicine for centuries due to its various rejuvenating effects on the endocrine and immune systems.
- [Do These Microbes Make Me Look Fat?](https://www.metagenicsinstitute.com/blogs/microbes-make-look-fat/) - Newer research points to the benefits of providing beneficial microbes with prebiotics, or “substrates that are selectively utilized by host microorganisms conferring a health benefit.”
- [Menopause Belly: Why Fat Accumulates & How to Tackle It](https://www.metagenicsinstitute.com/blogs/menopause-abdominal-fat/) - Dr. Sara Gottfried addresses one of the biggest myths in women’s health. Learn why abdominal fat accumulates during menopause and what can be done about it.
- [The Nutritional Dynamic Duo: Vitamins D and K](https://www.metagenicsinstitute.com/blogs/the-nutritional-dynamic-duo-vitamins-d-and-k/) - Vitamins D and K are common nutrient gaps in the diet. Explore research on their independent and synergistic roles in bone and cardiovascular health.
- [Inflammation and Menopause: Cardiovascular Outcomes and SPMs](https://www.metagenicsinstitute.com/blogs/inflammation-menopause-cardiovascular-outcomes-spms/) - Physical activity, maintaining a healthy weight, and SPMs may improve women’s health in menopause, particularly related to inflammation.
- [3 Ways to Decrease Inflammation](https://www.metagenicsinstitute.com/blogs/3-ways-decrease-inflammation/) - Inflammation is the body’s natural response to fighting off potential health threats, but unhealthy lifestyle choices can stunt the resolution of your immune response.
- [Vascular Disease and SPMs](https://www.metagenicsinstitute.com/blogs/vascular-disease-spms/) - The resolution phase of inflammation is facilitated in the body by specialized pro-resolving mediators (SPMs) which include lipoxins, resolvins, protectins.
- [Metabolic Syndrome and Inflammation Resolution](https://www.metagenicsinstitute.com/blogs/metabolic-syndrome-inflammation-resolution/) - Following a Mediterranean diet, pro-resolving mediators from the fatty acids EPA and DHA have been shown to resolve the inflammation that is endemic in Metabolic syndrome.
- [Screen Time Negatively Affects Children’s Health](https://www.metagenicsinstitute.com/blogs/screen-time-children/) - Screen time is a hot topic for parents, healthcare practitioners, and educators. This blog explores the impact of screen time on children's health.
- [Can Lean Red Meat Fit into a Heart-Healthy Mediterranean Diet?](https://www.metagenicsinstitute.com/blogs/can-lean-red-meat-fit-heart-healthy-mediterranean-diet/) - By excluding processed red meat and clearly defining amounts of unprocessed meat to be consumed, the study tested the effects of low vs high intake of red meat.
- [Neuroprotective Effects of the Ketogenic Diet (Part 3: Specific Conditions)](https://www.metagenicsinstitute.com/blogs/neuroprotective-effects-ketogenic-diet-part-3-specific-conditions/) - by Milene Brownlow, PhD This 3-part blog series explores the history (Part 1), mechanisms and evidence (Part 2) underlying the neuroprotective effects of the ketogenic diet. In the final part 3, let’s investigate the current scientific evidence in support of the ketogenic diet (KD) as a therapeutic approach for specific neurological disorders. Preclinical study evidence
- [Anxiety Disorders in Women](https://www.metagenicsinstitute.com/blogs/anxiety-disorders-women/) - This foundational clinical review provides a deep dive into anxiety disorders in women - covering etiology, presentation, workup, and management options.
- [Weed, Seed, and Feed the Endocannabinoid System](https://www.metagenicsinstitute.com/blogs/endocannabinoid-system/) - This blog sheds light on endocannabinoid system (ECS) science, its roles in the body, and lifestyle strategies support your body’s internal homeostasis.
- [Metagenics Institute Response to the 2015-2020 Dietary Guidelines for Americans](https://www.metagenicsinstitute.com/blogs/2015-2020-dietary-guidelines/) - We've identified important components of a healthy lifestyle, such as new eating patterns and behaviors, and a variety of foods which are all nutrient dense.
- [SPMs: Critical Tool to Combat Inflammatory States](https://www.metagenicsinstitute.com/blogs/effective-way-managing-inflammatory-states-conditions/) - SPMs help facilitate the clearance of inflammatory components and thus resolve the inflammatory response.
- [SPMs and Inflammation in Aging](https://www.metagenicsinstitute.com/blogs/spms-inflammation-aging/) - In conditions as seemingly different as Alzheimer’s and arthritis, SPMs have been shown to improve inflammation resolution and improve patient outcomes.
- [The Undiscussed Side Effects of Birth Control Pills](https://www.metagenicsinstitute.com/blogs/birth-control-pill/) - Dr. Bronwyn Storoschuk examines lesser known side effects of birth control pills, including nutrient depletions, depression, gut health, endocrine effects, etc.
- [History of “Liquid Gold” and Its Comeback](https://www.metagenicsinstitute.com/blogs/history-liquid-gold-comeback/) - by Bianca Garilli, ND History of breast milk: then and now The “breast is best” and “liquid gold” taglines made their return to conventional pediatric conversations in recent years, diverging from a previous school of thought that led Western mothers to believe their naturally produced, free breast milk was inferior to factory made synthetic formulas
- [Intermittent Fasting Benefits: Exploring Emerging Research and Clinical Applications](https://www.metagenicsinstitute.com/blogs/intermittent-fasting-benefits/) - Intermittent fasting (IF) is nothing new, but what is new is research on the benefits of IF for health and longevity is beginning to tell an interesting story. 
- [Vitamin D and Polycystic Ovary Syndrome (PCOS)](https://www.metagenicsinstitute.com/blogs/vitamin-d-pcos/) - This blog examines the importance of vitamin D in the most common female endocrine disorder during reproductive years—polycystic ovary syndrome (PCOS).
- [Tips to Keep Your Brain Sharp with Age](https://www.metagenicsinstitute.com/blogs/alzheimers-blood-sugar/) - Many chronic diseases, like Alzheimer’s, stem from inflammation that begins years before the diagnosis. Blood sugar & lifestyle changes may prevent this.
- [The Gut-Brain Connection and Mental Health](https://www.metagenicsinstitute.com/blogs/gut-brain-stress/) - Science on the gut-brain connection is growing. This blog expores how gut health impacts brain homeostasis and mental health.
- [Birth Control Pills and Endocrine Disruption of the HPATG Axis](https://www.metagenicsinstitute.com/blogs/ocp-hpatg-axis/) - In this blog, Sara Gottfried, MD discusses the influence of oral contraceptive pills (OCPs), aka birth control pills, on endocrine disruption of the HPATG axis.
- [Physician Burnout: Exploring the Causes](https://www.metagenicsinstitute.com/blogs/physician-burnout-causes/) - In this blog, Sara Gottfried, MD explores multifactorial causes of physician burnout and provides pragmatic strategies to help manage burnout conditions.
- [Beyond HDL: New Insights into HDL Cholesterol Function in Cardiovascular Disease](https://www.metagenicsinstitute.com/blogs/hdl-cholesterol-function/) - by Mark Houston, MD and Sara Gottfried, MD A precision and personalized medicine approach to dyslipidemia and dyslipidemia- induced cardiovascular disease—including high LDL cholesterol, elevated triglycerides, low high-density lipoprotein (HDL) and HDL function, and other related cardiometabolic conditions such as insulin resistance and metabolic syndrome—is completely different from the conventional medicine approach. In this article,
- [Hemp Extract vs. CBD Isolate: Comparing Composition, Action, & Use](https://www.metagenicsinstitute.com/blogs/hemp-cbd/) - In this blog, Erik Lundquist, MD busts some myths about Cannabis and explores key differences between marijuana, hemp, and CBD in composition, action, and use.
- [Coronary Heart Disease: Precision and Personalized Medicine Approach](https://www.metagenicsinstitute.com/blogs/coronary-heart-disease/) - We have access to all the greatest technologies and drugs, we can measure anything and everything and yet the change in rates of coronary heart disease is flat.
- [Exercise, Hormones & Weight Loss: Q&A with Sara Gottfried, MD](https://www.metagenicsinstitute.com/blogs/exercise-weight-loss/) - Exercise is key to overall health, but the wrong approach can do more harm than good. Dr. Sara Gottfried discusses exercise, hormones, and weight loss.
- [Phytosterols and Inflammation: What’s the Story?](https://www.metagenicsinstitute.com/blogs/phytosterols-inflammation-whats-story/) - Obesity and cardiometabolic disease are metabolic perturbations associated with inflammation chronicity. The Western diet is typified by a surplus of calories, low nutritional quality, and high pro-inflammatory potential, thereby fueling excess adiposity, which further leads to inflammation. To break this obesity-inflammation cycle, adopting a healthful dietary pattern and incorporating regular physical activity is critical. Furthermore,
- [Postpartum Hormones Mediate Depression, Memory Changes, and More](https://www.metagenicsinstitute.com/blogs/postpartum-depression/) - Unique hormonal shifts are associated with childbirth. Postpartum hormones mediate physical and mental changes, including depression, memory changes, and more.
- [Probiotic Strains: Single vs. Multi-Is One Better Than the Other?](https://www.metagenicsinstitute.com/blogs/targeted-probiotic-strains/) - This article reviews the evidence that shows defined benefits of specific probiotic strains and the differences between multi- vs single-strain probiotics.
- [Safety and Tolerability of Probiotics](https://www.metagenicsinstitute.com/blogs/safety-of-probiotic/) - by Melissa Blake, ND Introduction As clinicians, we all want to make effective, safe recommendations, and the evidence of safety is an essential consideration prior to prescribing an intervention. Safety of probiotics is no exception. With evidence mounting on the many benefits and overall safety profile, it’s not surprising that probiotic supplementation quadrupled between 2007
- [Your Mom was Right - Eat your Beets, They’re Good for Your Heart](https://www.metagenicsinstitute.com/blogs/mom-right-eat-beets-theyre-good-heart/) - by Bianca Garilli, ND I have a patient who doesn’t like vegetables. In fact, this person is also not a fan of water (sans flavoring), exercise, nor high fiber foods such as legumes. This scenario is, in many ways, a perfect setup for a number of lifestyle-related chronic diseases, including hypertension. This patient has been
- [Q&A with Dr. Kaye: Keto Considerations for Hypothyroidism, Diabetes, Gallstones, and More](https://www.metagenicsinstitute.com/blogs/qa-dr-kaye-keto-considerations-hypothyroidism-diabetes-gallstones/) - Although the ketogenic diet has been used clinically since the early 20th century, with specific therapeutic use for seizure mitigation in children with intractable epilepsy, the “keto diet” is now discussed more broadly, having even entered colloquial use. With the ketogenic diet’s recent rise in mainstream popularity and increased clinical exposure, we compiled a Q&A
- [Reversing Cognitive Decline: Not Beyond our Reach](https://www.metagenicsinstitute.com/blogs/reversing-cognitive-decline-not-beyond-reach/) - by Kara Fitzgerald, ND It is plain myth that there is nothing that can be done to prevent, slow or even reverse the progress of cognitive decline or Alzheimer’s Disease. The Institute for Functional Medicine held a 3-day international conference earlier this month, attended in droves, diving into the body of evidence that demonstrates this, and
- [2:5 Intermittent Energy Restriction Diet Beneficial for Patients with T2D](https://www.metagenicsinstitute.com/blogs/25-intermittent-energy-restriction-diet-beneficial-patients-t2d/) - by Lewis Chang, PhD Intermittent Energy Restriction (IER) vs. Continuous Energy Restriction (CER) Excess energy intake over time contributes to weight gain and the obesity epidemic; therefore, restricting food intake is essential in weight management. Although cutting calories daily can be successful for short-term weight loss, the majority of individuals regain their lost weight in
- [Neuroprotective Effects of the Ketogenic Diet (Part 1: Historical Perspective)](https://www.metagenicsinstitute.com/blogs/neuroprotective-effects-ketogenic-diet-part-1-historical-perspective/) - by Milene Brownlow, PhD Nowadays, blogging about ketogenic diets hardly requires an introductory paragraph. Most of us are bombarded with newsletters, emails, and personal stories of how cutting back on carbs and increasing consumption of healthy fats yield remarkable benefits. The popularity of the diet is largely due to its effects on weight loss and
- [Will the Keto Diet Raise My Cholesterol Levels?](https://www.metagenicsinstitute.com/blogs/will-keto-diet-raise-cholesterol-levels/) - by Bianca Garilli, ND Although originally (and still) used as a therapeutic approach to reduce seizures in children with intractable epilepsy, nowadays the ketogenic diet is more well-known and broadly used for weight loss and cardiometabolic disease management. A question frequently asked when considering the implementation of a low-carbohydrate, high-fat diet is whether there are
- [Practitioner Burnout: Prevalence, Correlates, Impact, and Possible Solutions](https://www.metagenicsinstitute.com/blogs/practitioner-burnout-prevalence-correlates-impact-possible-solutions/) - by Bianca Garilli, ND The 2018 National Physician Burnout & Depression Report published by Medscape surveyed more than 15,000 physicians from 29 specialties on a wide array of topics, one of which was physician burnout.1 The topic of physician burnout has become increasingly important in medicine due to its impact on both the provider’s health
- [The Epigenetic Influence of the Mediterranean Diet](https://www.metagenicsinstitute.com/blogs/epigenetic-influence-mediterranean-diet/) - In recent years, dietary guidelines have turned from emphasizing low fat consumption to embracing dietary patterns that are comprised of “whole” and unprocessed foods, such as the Mediterranean diet. The Mayo Clinic indicates that the Mediterranean diet emphasizes plant-based foods, healthy oils, fish and poultry, and red wine in moderation, with limited consumption of salt and red
- [Depression and Anxiety: Genetic and Hormonal Underpinnings](https://www.metagenicsinstitute.com/blogs/depression-and-anxiety/) - Depression and anxiety, two of the most common mental health disorders, have unique genetic and hormonal underpinnings, some of which heighten risk in women.
- [DIM and Men: Prostate Cancer and Beyond](https://www.metagenicsinstitute.com/blogs/dim-prostate-cancer/) - This blog explores clinical insights for the nutritional bioactive 3,3’-diindolylmethane (DIM) in men’s health, including its role in prostate cancer and more.
- [Alopecia: Genes, Hormones, and More Causes of Hair Loss](https://www.metagenicsinstitute.com/blogs/alopecia-causes/) - Hair loss, or alopecia, is a common complaint by male and female patients. Genetics, hormones, stress, nutrition, and other causes of hair loss are explored.
- [How to Extract More Phytonutrients from Your Cruciferous Veggies](https://www.metagenicsinstitute.com/blogs/tips-to-extract-more-from-your-cruciferous-veggies/) - by Bianca Garilli, ND It’s a well-known fact that cruciferous vegetables, including broccoli, Brussels sprouts, cauliflower, cabbage, and many others, should be a major cornerstone of any healthy, nutrient-dense diet. Not as well known, however, is that the bioavailability of some of the most desired nutritional bioactives from the Brassica vegetables, including isothiocyanates (e.g. sulforaphane), will
- [Functional Medicine and Women’s Health, Part 2: PCOS & Preconception Care/Fertility](https://www.metagenicsinstitute.com/blogs/functional-medicine-womens-health-interview-joel-evans-md-part-2-pcos-preconception-care-fertility/) - Functional Medicine and Women’s Health: Interview with Joel Evans, MD Part 2: PCOS & Preconception Care/Fertility In this series, we sat down with Joel Evans, MD to talk about Functional Medicine options for common women’s health issues. Q: What is polycystic ovarian syndrome (PCOS), and what causes it? A: In order to understand polycystic ovarian syndrome, it’s
- [Lyme Disease: A Deep Dive on Symptoms and Treatment](https://www.metagenicsinstitute.com/blogs/lyme-disease-symptoms/) - In this foundational clinical review on Lyme disease, you will learn about early and late signs and symptoms, testing, diagnosis, testing, and treatments.
- [Modifying Habits is Key to Long-Term Weight Loss Maintenance](https://www.metagenicsinstitute.com/blogs/modifying-habits-key-long-term-weight-loss-maintenance/) - by Bianca Garilli, ND In individuals with overweight or obesity, it only takes a 5% reduction in body weight to create potentially significant improvements in LDL and total cholesterol, blood pressure, and blood glucose.1 The challenge in the weight loss field however, is often less about losing this initial 5% but rather maintaining the loss over
- [Nutrition and Supplementation for Endurance Athletes](https://www.metagenicsinstitute.com/blogs/nutrition-endurance-athletes/) - Endurance athletes are a unique breed of athlete. In this blog, Dr. Rob Silverman shares nutrition recommendations specific to their energy system and needs.
- [TBI in APOE ε4+ Veterans Ups Mental Health Disorders](https://www.metagenicsinstitute.com/blogs/tbi-allele-veterans/) - Study demonstrates that veteran & active duty APOE ε4+ allele carriers may be at higher risk for mental health sequelae following traumatic brain injury (TBI).
- [5 Foods for Joint Health](https://www.metagenicsinstitute.com/blogs/5-foods-joint-health/) - by Robert Silverman, DC, MS, CNS When your joints ache, don’t open the medicine cabinet for a pain pill. Instead, head to the grocery store to find healthful—and delicious—foods the support joint health instead. Sweet Potatoes The deep orange color of a sweet potato comes from the rich supply of beta-carotene it contains. Beta-carotene is
- [Targeting Midlife Weight Gain in Women with Lifestyle Modifications](https://www.metagenicsinstitute.com/blogs/targeting-mid-life-weight-gain-women-lifestyle-modifications/) - by Bianca Garilli, ND, IFMCP A common concern in peri- and postmenopausal years is weight gain, typically 1.5 pounds per year during the fifth and sixth decades of life and shown to be independent of a woman’s initial body size or race/ethnicity. It was previously believed that the increase in weight coincided with the onset
- [Group Lifestyle Programs Reduce Obesity and Prediabetes in Veterans](https://www.metagenicsinstitute.com/blogs/veterans-diabetes-lifestyle/) - Research examines the efficacy of group lifestyle programs to reduce the incidence of obesity, prediabetes, and metabolic syndrome for military veterans.
- [Obesity on the Rise in Active Duty Military & Veterans](https://www.metagenicsinstitute.com/blogs/obesity-epidemic-military-veterans/) - Obesity levels are quickly rising in both the active duty military and veteran populations. Effective programs targeting obesity prevention & treatment are needed.
- [Triclosan: Friend or Foe?](https://www.metagenicsinstitute.com/blogs/triclosan-friend-foe/) - A thought-provoking article in the July 22, 2016 Issue of Science posed the question “Is triclosan harming your microbiome”?1 The article concludes that the data is still mixed about the effects of triclosan on the microbiome, but begs some broader questions such as, “what is triclosan?” and “are there safety risks associated with it?” Triclosan, 2,4,4’
- [The Role of Endogenous Sex Hormones in the Development of Type 2 Diabetes](https://www.metagenicsinstitute.com/blogs/role-endogenous-sex-hormones-development-type-2-diabetes/) - Hormonal balance is recognized as a factor in the development of non-communicable diseases, such as type 2 diabetes. The topic is of particular interest regarding the health of peri- and post-menopausal women who experience changes in hormone levels during the menopausal transition and also have increased risk of developing non-communicable diseases, such as cardiovascular disease
- [There’s More to Precision Medicine than Genomics](https://www.metagenicsinstitute.com/blogs/theres-precision-medicine-genomics/) - by Kara Fitzgerald, ND Precision medicine, which encompasses the concepts of individual uniqueness and personalized healthcare solutions, has to-date been most focused on genetics. Genetic-based differences in tumor cells, for instance, is one example of how precision medicine has started to play out. Recently the team from the Microbiome Center at the University of Chicago
- [The Nutrition-Inflammation Connection](https://www.metagenicsinstitute.com/blogs/nutrition-inflammation-connection/) - by Nilima Desai, MPH, RD Research has established that inflammation is a risk factor for several chronic conditions such as diabetes, cardiovascular disease, arthritis, inflammatory bowel disease, and metabolic syndrome.1 But understanding how inflammation works can be overwhelming. Types of Inflammation Inflammation is classified as either acute or chronic. Inflammation is a natural and necessary
- [Optimizing the “Second Meal Effect” for a Healthy Glycemic Response](https://www.metagenicsinstitute.com/blogs/second-meal-glycemic-response/) - Blood glucose regulation helps control insulin resistance and may play a key role in the prevention and management of T2D and CVD.
- [Antibiotics: Effects & How to Restore Healthy Gut Bacteria](https://www.metagenicsinstitute.com/blogs/antibiotic-gut-bacteria/) - Exposure to antibiotics reduces the gut's healthy bacterial quantity and diversity. Learn the risks and how to recover gut health through nutrition and probiotics.
- [Clearing the Smoke Screen around E-Cigarettes](https://www.metagenicsinstitute.com/blogs/e-cigs-smoking-cessation/) - The history, use, safety, health effects, and research on smoking cessation effectiveness are explored for e-cigarettes (e-cigs).
- [Avoiding Loss of Lean Muscle Mass (Sarcopenia)](https://www.metagenicsinstitute.com/blogs/sarcopenia-muscle-mass/) - Approaches to combat sarcopenia, muscle mass loss with age, include resistance training exercise, supplemental BCAAs and HMB, vitamin D, and EPA and DHA.
- [Probiotic Therapy Influence on Healthy Microbiome](https://www.metagenicsinstitute.com/blogs/probiotic-microbiome-health/) - A look at its history, the role microbiome plays in human health, & the benefits of personalized probiotic therapy tied to specific strains of bacteria.
- [Gulf War Exposure Linked to Symptoms in Veterans](https://www.metagenicsinstitute.com/blogs/gulf-war-exposures-linked-to-morbidity/) - Exposures to environmental and chemical hazards while serving in the Gulf War linked to chronic multi-symptom illness (CMI).
- [Not Taking a Multivitamin? Here are 5 Reasons to Reconsider](https://www.metagenicsinstitute.com/blogs/not-taking-multivitamin-5-reasons/) - You try to eat well to feel good and stay healthy. While it’s optimal to get your daily nutritional needs from the foods you eat, it’s just plain difficult. There is conflicting information out there on the benefits of supplements, but the Dietary Guidelines for Americans 2015-2020 say that supplements may be useful for providing the nutrients you
- [Not all Plant-Based Diets are Created Equal: Discovering the Key to a Healthful Approach](https://www.metagenicsinstitute.com/blogs/not-plant-based-diets-created-equal-discovering-key-healthful-approach/) - by Bianca Garilli, ND In recent years, the benefits of adopting a plant-based diet to both prevent and treat cardiovascular disease has become well accepted in the health care community. Atherosclerosis is commonly associated with high dietary intake of animal products, fat and processed carbohydrates and continues to be the leading cause of mortality in
- [Apples, Brassica, and Squash, Oh My!](https://www.metagenicsinstitute.com/blogs/apples-brassica-squash-oh/) - The mornings are brisk and the sun is setting earlier- it’s definitely fall out there. With the seasonal change also comes a change in the local produce that is available. The markets start to fill with apples, pears, pumpkins, acorn squash, brussels sprouts, cauliflower, broccoli and other delightful fall produce. While we will miss the
- [Folic Acid Supplementation for Homocysteine Reduction](https://www.metagenicsinstitute.com/blogs/folic-acid-supplementation-homocysteine-reduction/) - The gene MTHFR is one of the best-known and most relevant genes in the growing field of nutrigenomics. According to the National Institutes of Health, MTHFR provides instructions for making an enzyme that plays a role in processing amino acids, as well as converting one form of folate to another, a process that is required to
- [When It Comes to Dietary Supplements, Quality Is Crucial](https://www.metagenicsinstitute.com/blogs/comes-dietary-supplements-quality-crucial/) - Dietary supplements are used by a majority of Americans on at least an occasional basis. The Dietary Supplement Health and Education (DSHEA) defines dietary supplements as“ vitamins, minerals, herbals and botanicals, amino acids, dietary substances to supplement the diet such as enzymes or tissues, or a concentrate, metabolite, constituent, or extract.” Supplements are popular across
- [Nutrition Prescriptions – An Opportunity to Induce Behavior Change and Improve Health](https://www.metagenicsinstitute.com/blogs/nutrition-prescriptions-opportunity-induce-behavior-change-improve-health/) - It is well known that nutrition plays a major role in the prevention and management of several chronic diseases, including type 2 diabetes and chronic kidney disease, as well as cardiovascular disease, metabolic syndrome, and overweight and obesity. Chronic disease is very common in the United States and nearly 70% of American adults are overweight or obese.
- [Phytosterols and Their Effect on Lowering Cholesterol Levels](https://www.metagenicsinstitute.com/blogs/phytosterols-effect-lowering-cholesterol-levels/) - Phytosterols, also referred to as plant sterols or stanols, are cholesterol-like molecules found in cell membranes of plants. Unlike cholesterol, however, the body cannot produce phytosterols. Therefore, their main source comes from plant-based foods, such as vegetable oils, nuts, seeds, legumes, and whole grains. There are multiple different types of phytosterols, but sitosterol, stigmasterol, and
- [Exercise and Heart Health](https://www.metagenicsinstitute.com/blogs/exercise-heart-health/) - Over the past several years, we have been instructed on the value of exercise and activity for our heart health. Statistics on the state of heart health in the US are sobering1: In the US, over 2000 people die from heart related illnesses every day (about one every 40 seconds) Every year over 735,000 Americans
- [A Functional Approach to Asthma and Allergic Sinusitis](https://www.metagenicsinstitute.com/blogs/functional-approach-asthma-allergic-sinusitis/) - by Kara Fitzgerald, ND Allergy season is in high gear. The trees are budding and pollen is bursting forth in Connecticut. As our winters are warmer, we’re also seeing allergies kick in sooner, perhaps with a higher intensity than in years past. While most of us are cracking our windows open and emerging from the winter cocoon
- [Key to Reducing Diabetes Risk: Color Your Plate with Polyphenols](https://www.metagenicsinstitute.com/blogs/key-reducing-diabetes-risk-color-plate-polyphenols/) - by Bianca Garilli, ND Polyphenol Overview Polyphenols are naturally occurring secondary metabolites found in plants. In nature they protect against ultraviolet radiation and play a role in defending against pathogens. Over 8,000 polyphenolic compounds have been identified from a large variety of plant species.1 Based on the structure and number of phenol rings they
- [Obesity in Hispanic US Youth and Targeted Lifestyle Intervention](https://www.metagenicsinstitute.com/blogs/obesity-hispanic-us-youth-targeted-lifestyle-intervention/) - by Bianca Garilli, ND Obesity, a preventable condition, has tripled worldwide since 1975, with 340 million children and adolescents between 5-19 years of age with overweight or obesity in 2016 according to the World Health Organization (WHO).1 In children and adolescents, BMI-for-age growth charts are used to determine weight status; >85th and
- [Healthy Aging: Functional Medicine Approach to Sarcopenia](https://www.metagenicsinstitute.com/blogs/healthy-aging-functional-medicine-approach-sarcopenia/) - by Melissa Blake, BSc, ND By 2020, more than 20% of the US population will be 65 and over.1 Healthy aging is and will continue to be an important focus in many Functional Medicine offices. Sarcopenia, the gradual loss of muscle mass that occurs in healthy adults as they age, begins after the age of
- [Healthy Weight Loss Preserves Muscle and Bone Mass](https://www.metagenicsinstitute.com/blogs/healthy-weight-loss-preserves-muscle-bone-mass/) - by Bianca Garilli, ND Globally, 39% of adults aged ≥18 years were classified as overweight and 13% obese in 2016, totaling a jaw-dropping 1.9 billion adults overall.1 With obesity rates soaring, tripling worldwide since 1975, most of the Earth’s population now lives in countries where overweight and obesity cause more morbidity and mortality than being

## Grand Rounds

- [From Bench to Bedside: SPMs for Perioperative Neurocognitive Disorders](https://www.metagenicsinstitute.com/grand-rounds/spm-neurocognitive-disorders/) - In this presentation, Niccolò Terrando, PhD shares research on the role of specialized pro-resolving mediators (SPMs) in perioperative neurocognitive disorders.
- [Real World Clinical Experiences with SPMs](https://www.metagenicsinstitute.com/grand-rounds/real-world-clinical-experiences-spms/) - Real World Clinical Experiences with SPMs presented by Cory Rice, DO This presentation by Dr. Cory Rice is entitled “Specialized Pro-resolving Mediators in Real World Clinical Practice.” This is part of our peer-to-peer knowledge sharing series. Incorporating SPMs in clinical practice for patients with chronic disease, particularly those who need nutritional support for lifestyle medicine.
- [Early Clinical Experiences with SPMs](https://www.metagenicsinstitute.com/grand-rounds/early-clinical-experiences-spms/) - Specialized Pro-resolving Mediators (SPMs) in Real World Clinical Practice presented by Jennifer Stagg, ND Jennifer Stagg, ND, is a healthcare practitioner in Connecticut who actively uses nutritional solutions to help her patients achieve better health. She frequently sees patients who are experiencing chronic inflammation. In this webinar, she describes her experience seeing patients who have

## MAPS

- [The Functional Medicine Approach to Stress](https://www.metagenicsinstitute.com/maps/the-functional-medicine-approach-to-stress/) - Dr. Joel Evans investigates the impact stress has on the body. He demonstrates how to support patients with a Functional Medicine approach.
- [Exploring Root Causes of Chronic Disease: Gut Health & Stress](https://www.metagenicsinstitute.com/maps/gut-health-stress/) - Jennifer Stagg, ND shares a new perspective on the root cause of chronic disease as well as the role of gut health and stress.
- [Drug Induced Nutrient Depletion](https://www.metagenicsinstitute.com/maps/drug-induced-nutrient-depletion/) - Nutrient depletion can lead to new and/or worsening symptoms. Suzanne Keyes, PharmD shares her experience helping patients find relief to their drug-induced nutrient-depletion symptoms.
- [Top 10 Supplements for Men](https://www.metagenicsinstitute.com/maps/top-10-supplements-for-men/) - Myles Spar, MD, MPH; Director of Integrative Medicine, Venice Family Clinic's Simms/Mann Health and Wellness Center When men come to your clinical practice, few are following proper nutrition, and often it is the women in their life have persuaded them to see a clinician. While those initial challenges exist, Dr. Spar explains that most men
- [Skin Health from the Inside Out](https://www.metagenicsinstitute.com/maps/skin-health/) - Dr. Coleman addresses how stress and emotional trauma can be an underlying cause of skin disorders and provides recommendations to help patients heal emotionally.
- [Ketogenic Q&A Part 4: Biohacking, Misconceptions, and the Future of the Ketogenic Diet](https://www.metagenicsinstitute.com/maps/ketogenic-qa-part-4-biohacking-misconceptions-and-the-future-of-the-ketogenic-diet/) - Dr. D’Agostino addresses common misconceptions surrounding the ketogenic diet and intermittent fasting, leveraging science to dispel myths.
- [Functional Medicine Approach to Hypertension](https://www.metagenicsinstitute.com/maps/functional-medicine-approach-hypertension/) - Mark Houston, MD, MS, FAHA, FASH, DABC; Internist & Cardiovascular Specialist; Director, Hypertension Institute and Vascular Biology Hypertension is not a disease. Dr. Mark Houston claims that hypertension is the manifestation of an abnormal vascular system. In this talk Dr. Houston gets back to the basics by looking at biochemical pathways and exploring what factors precipitate a hypertensive
- [MAPS Introduction and Overview](https://www.metagenicsinstitute.com/maps/maps-sizzle-video/) - We are proud to offer you the MAPS program, further supporting your personal educational journey as you strive to help patients live healthy lifestyles and reverse the growing trend of chronic illness and disease.
- [Autoimmunity: How to Restore Harmony in the Immune Orchestra](https://www.metagenicsinstitute.com/maps/autoimmunity-how-to-restore-harmony-in-the-immune-orchestra/) - Susan Blum, MD, MPH; Founder/Director Blum Center for Health In this course Dr. Blum shares her personal journey with autoimmune disease. She discusses her experience implementing a Functional Medicine approach in helping to not only solve symptoms, but also healing the root condition. Dr. Blum has made it her mission to help clinicians and patients
- [Methylation & Depression](https://www.metagenicsinstitute.com/maps/methylation-depression/) - According to the World Health Organization, 350,000,000 people suffer from depression—that is 5% of the world’s population. Betty Murray explains that 47% of our population has a mutation in the 5-MTHFR gene and that this genetic variance contributes to anxiety and depression. She dives into pertinent biochemical pathways and provides insights to improve the recognition
- [Fine-Tuning Patient Wellness Through Epigenetics and Methylation](https://www.metagenicsinstitute.com/maps/fine-tuning-patient-wellness-through-epigenetics-and-methylation/) - Aberrant DNA methylation patterns underlie disease and aging. While some DNA methylation marks are durable and not subject to environmental influence, in many other biological areas, DNA methylation is malleable, which unlocks the opportunity for epigenetic impact—modifying gene expression. In this MAPS talk, Dr. Kara Fitzgerald shares vanguard research and pragmatic clinical insights on the
- [Sequencing a Metabolic Detox Program](https://www.metagenicsinstitute.com/maps/metabolic-detox/) - After 20 years of medical practice Kristi Hughes, ND shares that metabolic detoxification is the area she is the most committed to and challenged by. Dr. Hughes’ patient population shows considerable range and complexity in their health conditions, so detoxification cannot be a one-size-fits-all treatment modality. In this talk Dr. Hughes walks you through her
- [Functional Medicine Approach to Dyslipidemia](https://www.metagenicsinstitute.com/maps/functional-medicine-approach-dyslipidemia/) - Mark Houston, MD, MS, FAHA, FASH, DABC; Internist & Cardiovascular Specialist; Director, Hypertension Institute and Vascular Biology The diagnosis, evaluation, and treatment of dyslipidemia have been misdirected for the past 30-40 years. Dr. Houston presents an evolutionary approach to managing dyslipidemia and dyslipidemia-induced vascular disease by challenging the use of LDL and triglycerides as markers of disease.
- [A Guide to Understanding the Ketogenic Diet (Part 1 of 3)](https://www.metagenicsinstitute.com/maps/guide-understanding-ketogenic-diet-part-1-3/) - In this video, Keto Diet Guide - part 1 of 3, Dominic D'Agostino, PhD discusses modified ketogenic diet macronutrient compositions to maintain ketosis.
- [A Guide to Understanding the Ketogenic Diet (Part 2 of 3)](https://www.metagenicsinstitute.com/maps/dominic-dagostino-keto-diet-p2/) - In this video, Keto Diet Guide - part 2 of 3. Dominic D'Agostino, PhD discusses how ketogenic diet influences neurotransmitters/energy metabolism in the brain.
- [How to Implement a Ketogenic Diet](https://www.metagenicsinstitute.com/maps/implement-ketogenic-diet/) - [Video] Dr. Keroack, MD - dicusses how to implement the ketogenic diet with success. What are the right foods and how can they be proportional to each patient?
- [Ketogenic Q&A Part 1: Introduction to the Ketogenic Diet](https://www.metagenicsinstitute.com/maps/ketogenic-qa-part-1-introduction-ketogenic-diet/) - [Video] In part 1 Dominic D’Agostino, PhD explains how ketones are generated and how it is used by the human body. Is ketosis is a natural process?
- [What is the Ketogenic Diet and How Does It Support Anti-Aging?](https://www.metagenicsinstitute.com/maps/what-is-the-ketone-diet-and-how-does-it-support-anti-aging/) - Ryan Lazarus, DC, MS, CNS, IFMCP In this preview of Dr. Lazarus’ talk on the ketone diet and anti-aging, he examines the body of research that demonstrates how the ketogenic food program effectively treats many metabolic conditions including metabolic syndrome, diabetes, Parkinson's disease, Alzheimer’s disease, and other neurodegenerative disorders. Dr. Lazarus provides insights on how
- [Understanding the Ketogenic Food Plan](https://www.metagenicsinstitute.com/maps/understanding-ketogenic-food-plan/) - Christopher Keroack, MD, IFMCP Adaptation is key to survival. In Dr. Keroack’s talk he shares his experiences helping patients follow a variety of dietary patterns and food plans. In his clinical practice, Dr. Keroack often uses the ketogenic diet. He shares how the body adapts to the ketogenic pattern of eating and the effects on
- [New HDL Cholesterol Concepts for Coronary Heart Disease](https://www.metagenicsinstitute.com/maps/new-hdl-cholesterol-concepts/) - Mark Houston, MD, MS, FAHA, FASH, DABC; Internist & Cardiovascular Specialist; Director, Hypertension Institute and Vascular Biology HDL cholesterol plays vital roles in lipid biology and coronary heart disease pathophysiology. The main function of HDL is to scavenge for and carry LDL cholesterol away from the arteries and back to the liver, for redistribution, metabolism,
- [Inflammation, Pain, and Candida](https://www.metagenicsinstitute.com/maps/inflammation-pain-candida/) - Scott Bergman, DC, CTN, DAAIM; Director, Chiro Kinetics Over 50% of US adults report experiencing pain. Musculoskeletal conditions are a major pain culprit. When the musculoskeletal conditions plus their comorbid conditions (e.g. obesity, diabetes, and heart disease) are considered, the associated costs are estimated to be $874 billion annually. Dr. Bergman explores a common, underlying
- [Why Look at Testosterone Levels for All Adult Male Patients](https://www.metagenicsinstitute.com/maps/why-look-at-testosterone-levels-for-all-adult-male-patients/) - Myles Spar, MD, MPH; Director of Integrative Medicine, Venice Family Clinic's Simms/Mann Health and Wellness Center Dr. Spar feels that medicine is missing the mark when it comes to the chronic disease burden in US men. Testosterone is a biomarker that should be a standard test for all adult men. In this talk Dr. Spar explores testosterone
- [Autoimmunity: A Functional Approach](https://www.metagenicsinstitute.com/maps/autoimmunity-functional-approach/) - Ryan Lazarus, DC, MS, CNS, IFMCP; Clinical Director/Owner Lazarus Wellness There is a silent epidemic in the United States. It has increased three-fold and affects 50-70 million people. There are over 100 types of it: autoimmune disease (AI). Dr. Lazarus examines the overwhelming impact AI is having on people all over our country. He provides clinical tools
- [Food as Medicine](https://www.metagenicsinstitute.com/maps/food-as-medicine/) - Deanna Minich, PhD, CNS, FACN, IFMCP; Nutrition Educator and Author In Dr. Deanna Minich’s talk, “Food as Medicine,” she identifies with clinicians who are newly embarking on their Functional Medicine journey. Many practitioners feel overwhelmed by the amount of research they feel they need to understand in order to get started with a new way of
- [Resolving Inflammation](https://www.metagenicsinstitute.com/maps/resolving-inflammation/) - Ryan Lazarus, DC, MS, CNS, IFMCP; Clinical Director/Owner, Lazarus Wellness Ryan Lazarus, DC contrasts conventional vs. Functional medicine approaches in the treatment of chronic inflammation, one of the most common chemical imbalances patients are facing today. Chronic inflammation exerts deleterious systemic effects in the body and is linked to most chronic diseases, such as neurodegenerative
- [Perinatal Care in the 21st Century: A Functional Medicine Approach](https://www.metagenicsinstitute.com/maps/perinatal-care-functional-approach/) - Leslie Stone, MD, IFMCP and Emily Rydbom, CN, BCHN, CNP Leslie Stone, MD has delivered thousands of babies during her 30-year practice in obstetrics and gynecology. This has given her great insights into common morbidities of pregnancy. In this MAPS talk, Dr. Stone examines variables that impact intrauterine health, including stress, nutritional deficiencies, and genetic variations, and
- [A Targeted Nutritional Approach to Pregnancy](https://www.metagenicsinstitute.com/maps/nutritional-approach-to-pregnancy/) - Emily Rydbom, CN, BCHN, CNP poses the question, “What do we know about the current care for pregnancy nutrition in the US today?” There are three basics we tell pregnant women: “Take your prenatal, don’t gain too much weight, and eat healthy foods.” Rydbom explains that although these recommendations sound like three simple tasks, if pregnant
- [Eating the Rainbow](https://www.metagenicsinstitute.com/maps/eating-the-rainbow/) - Deanna Minich, PhD, CNS, FACN, IFMCP; Nutrition Educator and Author In “Eating the Rainbow,” Dr. Deanna Minich explores the diverse, important roles that phytonutrients play in the body. Dr. Minich discusses different categories of phytonutrients and the foods they originate from, as well as how inflammation, insulin resistance, and stress responses are three primary areas where
- [Metabolic Detoxification and Group Visits](https://www.metagenicsinstitute.com/maps/metabolic-detoxification-and-group-visits/) - Erik Lundquist, MD; Family Physician; Medical Director/Owner, Temecula Center for Integrative Medicine Implementing nutritional metabolic detoxification programs with patients has been one of the most robust nutritional approaches that Dr. Lundquist has experienced for improving patient outcomes. Dr. Lundquist shares how metabolic detoxification works in his practice, the types of patients he helps detox, and the
- [A Guide to Understanding the Ketogenic Diet (Part 3 of 3)](https://www.metagenicsinstitute.com/maps/understanding-ketogenic-diet-3/) - Dominic D'Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida Dominic D’Agostino, PhD has been providing his expert perspective on all things keto in a series of discussions on the supporting science of the ketogenic diet. In the final part of this 3-part discussion, Dr. D’Agostino shares clinical and research
- [The Ketogenic Diet: An Introduction (Part 1 of 3)](https://www.metagenicsinstitute.com/maps/ketogenic-diet-introduction-part-1-3/) - Scott Bergman, DC, CTN, DAAIM; Ryan Lazarus, DC, MS, CNS, IFMCP; and Jeff Volek, PhD, RD Three key opinion leaders share their take on the philosophy behind the ketogenic diet and its therapeutic benefits, including macronutrient ratios, the process of ketosis, and the history of ketosis for human survival. They also provide thoughtful responses to
- [The Role of the Ketogenic Diet in Metabolic Health Optimization](https://www.metagenicsinstitute.com/maps/the-role-of-the-ketogenic-diet-in-metabolic-health-optimization/) - Dominic D'Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida In this MAPS talk, Dr. Dominic D’Agostino examines the role of the ketogenic diet in metabolic health optimization. We know that metabolic health correlates with overall health in the body, so by optimizing metabolic health, defined by a set of
- [Gut Basics: Treating Dysbiosis and Leaky Gut](https://www.metagenicsinstitute.com/maps/gut-basics-dysbiosis-leaky-gut/) - Susan Blum, MD, MPH; Functional Internist; Founder/Director, Blum Center for Health Research has shown that chronic inflammatory diseases have root causes that may include gut dysbiosis or leaky gut; practitioners need to treat these underlying conditions in order to address the chronic inflammation. Susan Blum, MD, MPH explains how these gut-related perturbations contribute to inflammation
- [Plantcentric Ketogenic Diet](https://www.metagenicsinstitute.com/maps/plantcentric-ketogenic-diet/) - Dominic D'Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida Dominic D’Agostino, PhD is a researcher in neuroscience, molecular pharmacology, and physiology who has conducted mechanistic and clinical research on the ketogenic diet and its health benefits. The ketogenic diet is a high-fat, moderate-protein, low-carbohydrate dietary approach associated with meat
- [5 Keys to Treating Hormones](https://www.metagenicsinstitute.com/maps/5-keys-to-treating-hormones/) - Filomena Trindade, MD, MPH; Family Physician, Saudade Wellness Center Hormones must be balanced and work together, and there is a stepwise approach to treating hormone imbalances. In this talk, Dr. Trindade shows practitioners specific hormones to consider when developing a stepwise patient management plan. Dr. Trindade covers insulin resistance, adrenals, thyroid, sex hormones, and metabolism
- [Hemp and the Endocannabinoid System](https://www.metagenicsinstitute.com/maps/hemp-and-the-endocannabinoid-system/) - More than 300 years after farmers had begun growing hemp as a staple crop in the United States, the endocannabinoid system (ECS) was discovered in the 1990s by researchers studying bioactive compounds in the Cannabis sativa plant. Since that time, cannabinoid receptors have been discovered in many different areas of the human body, such as the brain,
- [What Is Personalized Medicine?](https://www.metagenicsinstitute.com/maps/what-is-personalized-medicine/) - In this preview Dr. Jeffrey Bland speaks about the global challenge we are dealing with in our healthcare system. This new phenomenon does not come from infectious disease but rather is from the impact of our food and lifestyle. Dr. Bland jumps into the discussion of what personalized lifestyle medicine is and how this approach can radically
- [The Ketogenic Diet: Testing and Supplementation (Part 3 of 3)](https://www.metagenicsinstitute.com/maps/ketogenic-diet-testing-supplementation-part-3-3/) - Scott Bergman, DC, CTN, DAAIM; Ryan Lazarus, DC, MS, CNS, IFMCP; and Jeff Volek, PhD, RD Three key opinion leaders touch on the biological science behind ketosis as well as emerging scientific research that suggests the epigenetic benefits of a ketogenic lifestyle. To monitor progress during a ketogenic lifestyle plan, they explain how to check
- [The Ketogenic Diet: Connecting with Patients  (Part 2 of 3)](https://www.metagenicsinstitute.com/maps/ketogenic-diet-introduction-part-2-3/) - Scott Bergman, DC, CTN, DAAIM; Ryan Lazarus, DC, MS, CNS, IFMCP; and Jeff Volek, PhD, RD Three key opinion leaders explain the impact the ketogenic diet may have on various health conditions such as epilepsy, obesity, insulin resistance, and neurological disorders. They also explain why keto can be beneficial for athletes and how it may
- [Ketogenic Q&A Part 3: Exogenous Ketones](https://www.metagenicsinstitute.com/maps/ketogenic-qa-part-3-exogenous-ketones/) - In Q&A Part 3, Dominic D’Agostino, PhD explains a conundrum: the evidence basis and clinical benefits of the ketogenic diet for certain chronic disease states are well known, however, there are many individuals who are unable or unwilling to implement a ketogenic diet. To address this issue, Dr. D’Agostino and others are researching the impact
- [Ketogenic Q&A Part 2: Ketones, Fasting, and the Brain](https://www.metagenicsinstitute.com/maps/ketogenic-qa-part-2-ketones-fasting-brain/) - Dominic D’Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida In Q&A Part 2, Dominic D’Agostino, PhD focuses his discussion on the brain. Dr. D’Agostino explores misconceptions that exist regarding brain physiology, such as glucose dependency. He focuses on the neuroprotective effects of intermittent fasting, reducing glucose and insulin levels,
- [Omega-3 Fatty Acids and Coronary Heart Disease](https://www.metagenicsinstitute.com/maps/omega-3-fatty-acids/) - Mark Houston, MD, MS, FAHA, FASH, DABC; Internist & Cardiovascular Specialist; Director, Hypertension Institute and Vascular Biology Heart disease is the #1 cause of death in the US. Yet in recent years, there have been misleading and even inaccurate reports on the role of omega-3 fatty acids in primary and secondary prevention of coronary heart
- [Electrolytes: A Functional Medicine Approach](https://www.metagenicsinstitute.com/maps/electrolytes-a-functional-medicine-approach/) - Robert Silverman, DC, MS, CNS, CCN; Clinical Director/Owner, Westchester Integrative Health Dr. Silverman discusses what electrolytes are and how they function in the body. Specifically, he answers these fundamental questions: Why are electrolytes vital in sports drinks, and what other nutritional bioactives should be included? How are electrolytes valuable in the body’s metabolic detoxification processes?
- [Chronic Inflammatory Response Syndrome](https://www.metagenicsinstitute.com/maps/chronic-inflammatory-response/) - Erik Lundquist, MD; Family Physician; Medical Director/Owner, Temecula Center for Integrative Medicine In this talk, Erik Lundquist, MD explores chronic inflammatory response syndrome (CIRS), which is gaining traction among both integrative and traditional practitioners as we learn more about how mold and other biotoxins can impact our health. Home-building efficiencies over the past few decades
- [The 7 Systems of Health: A Holistic View of the Body](https://www.metagenicsinstitute.com/maps/the-7-systems-of-health-a-holistic-view-of-the-body/) - Deanna Minich, PhD, CNS, FACN, IFMCP; Nutrition Educator and Author In this combination of seven short video clips Dr. Deanna Minich explains how to use the spectrum quiz as a tool to help identify the system imbalances a patient may have, in order to better guide patients in the appropriate food and lifestyle choices that
- [Insurance-to-Cash Practice](https://www.metagenicsinstitute.com/maps/insurance-to-cash-practice/) - Cory Rice, DO; Internal Medicine Physician; Owner, Modern Medicine (Dallas, Forney) Dr. Rice says, “You can’t have an entity determining your financial worth and value that doesn’t understand what you are doing.” In this talk Dr. Rice explains how he was previously fully dependent on insurance reimbursement to sustain his medical practice and his businesses.
- [The Role of the Microbiome in Digestive Health](https://www.metagenicsinstitute.com/maps/the-role-of-the-microbiome-in-digestive-health/) - Daniel Kalish, DC; Founder, Kalish Institute It’s a central question that clinicians face with almost every Functional Medicine case involving the digestive tract: If a pathogen is present along with gut dysbiosis, do we try to eliminate the pathogen or work to reestablish healthy gut microbes? Daniel Kalish, DC provides clarity by first dividing normal, commensal
- [Lyme Disease: The Biomedical Approach](https://www.metagenicsinstitute.com/maps/lyme-disease-the-biomedical-approach/) - Karima Hirani, MD, MPH; Family Physician Hirani Wellness Medical Center There is no medical model for treating the growing epidemic of chronic Lyme disease in the US. Rather than relying on antibiotics, which are not effective for all patients with Lyme disease, Karima Hirani, MD, MPH treats patients with a more comprehensive, personalized approach by
- [Foundational Principles Utilizing Functional Medicine for Dementia and Alzheimer’s](https://www.metagenicsinstitute.com/maps/foundational-principles-utilizing-functional-medicine-for-dementia-and-alzheimers/) - Mark Hyman, MD; Family Physician; Author; Founder, The UltraWellness Center; Director, Cleveland Clinic Institute for Functional Medicine Dr. Hyman discusses his experience with a patient 20 years ago that completely changed the way he treats patients with dementia. In this talk Dr. Hyman explains how to approach this cognitive condition in a more holistic and systematic
- [Thyroid Disorders: A Functional Approach](https://www.metagenicsinstitute.com/maps/thyroid-disorders-a-functional-approach/) - Erik Lundquist, MD; Family Physician; Medical Director/Owner, Temecula Center for Integrative Medicine Dr. Lundquist explores a Functional Medicine approach to thyroid dysfunction and disorders. His goal is to explain the diverse thyroid hormone functions and feedback loops in the body. This knowledge is needed to glean context and effective approaches to treat your thyroid patients,
- [The Concussion’s Impact](https://www.metagenicsinstitute.com/maps/the-concussions-impact/) - Rob Silverman, DC, MS, CNS, CCN; Clinical Director/Owner, Westchester Integrative Health The brain is the most nutrient- and energy-dependent organ in the body. It consists of 60% fat and has 80 billion neurons on average. The brain utilizes 20% of the blood and oxygen in the body. Dr. Silverman examines the vulnerability of the brain and how a
- [The Athlete’s Advantage](https://www.metagenicsinstitute.com/maps/the-athletes-advantage/) - Rob Silverman, DC, MS, CNS, CCN; Clinical Director/Owner, Westchester Integrative Health Dr. Silverman has based his practice on athletes and supports them to achieve an athletic advantage. In this talk Dr. Silverman explores injury and the injury cycle. He focuses on three simple phases of care: acute, subacute, and wellness and prevention. This talk helps healthcare practitioners identify
- [HRT: Red Light, Yellow Light, Green Light](https://www.metagenicsinstitute.com/maps/hrt-red-light-yellow-light-green-light/) - Joel M. Evans, MD; OB/GYN Physician; Founder/Director, The Center for Functional Medicine Dr. Evans explores the Functional Medicine operating system as a framework to approach hormone replacement therapy during menopause. This framework utilizes a red light, yellow light, green light approach to the patient decision-making process. Dr. Evans reviews each patient category and covers insights
- [GERD, Heartburn, & Functional Dyspepsia](https://www.metagenicsinstitute.com/maps/gerd-heartburn-functional-dyspepsia-low-hanging-fruit-functional-medicine-approach/) - Erik Lundquist, MD; Family Physician; Medical Director/Owner, Temecula Center for Integrative Medicine Did you know that proton pump inhibitors (PPIs) are the third-most common prescribed medication, and over 110 million prescriptions are written every year? PPIs only temporarily relieve reflux symptoms and do not demonstrate efficacy in all patients. Additionally, side effects are common, including impacting
- [Fibromyalgia: A Functional Approach](https://www.metagenicsinstitute.com/maps/fibromyalgia-a-functional-approach/) - Erik Lundquist, MD; Family Physician; Medical Director/Owner, Temecula Center for Integrative Medicine In fibromyalgia there is a diagnosis of exclusion. Identifying the how, what, and why of this condition is challenging. Dr. Lundquist explains that fibromyalgia affects 6 million people, 1 out of 50 adults. He shares insights from case studies in patients with fibromyalgia and
- [The Functional Medicine Compass](https://www.metagenicsinstitute.com/maps/the-functional-medicine-compass/) - Joel Evans, MD; OB/GYN Physician; Founder/Director, The Center for Functional Medicine What if there were a robust, personalized way to tackle chronic disease? Dr. Evans makes the bold statement that he knows the way, and it is called the Functional Medicine approach. In this talk Dr. Evans shares the key components of Functional Medicine and how
- [Behavior Modification: Two-Minute Teachbacks](https://www.metagenicsinstitute.com/maps/behavior-modification-two-minute-teachbacks/) - BJ Fogg, PhD; Behavior Scientist; Author; Director, Stanford Behavior Design Lab Dr. BJ Fogg has been studying behavior change for over 20 years, which includes founding and directing the Behavior Design Lab at Stanford University; creating the Behavior Model, Fogg Method, and Fogg Choice Model; and working with over 40,000 people across the globe. In
- [How to Change Behavior and Achieve Life-Altering Results](https://www.metagenicsinstitute.com/maps/how-to-change-behavior-and-achieve-life-altering-results/) - BJ Fogg, PhD; Behavior Scientist; Author; Director, Stanford Behavior Design Lab BJ Fogg, PhD has been studying behavior change for over 20 years and has coached over 40,000 people in creating new habits in their life. Through his research and experience, he has created the Fogg Method, which includes three specific steps for behavior change.
- [The Future of Functional Medicine](https://www.metagenicsinstitute.com/maps/future-functional-medicine/) - In 1991 Dr. Jeffrey Bland initiated the concept of Functional Medicine that emerged out of inspiration of bringing physicians together to change the future of medicine. In this preview Dr. Bland shares the history of how Functional Medicine came to be and more importantly the future for Functional Medicine. Watch the full MAPS Talk presentation View Now
- [The Difference Between Functional and Personalized Medicine](https://www.metagenicsinstitute.com/maps/difference-functional-personalized-medicine/) - In this preview Jeffrey Bland, PhD, FACN, FACB, CNS discusses these two approaches to treatment of care in our healthcare system are not working separately, but together. Dr, Bland explores the reasons why understanding the definitions of these treatments of care are important to the forward movement of the medical system. Watch the full MAPS
- [Metabolic Detoxification](https://www.metagenicsinstitute.com/maps/metabolic-detoxification/) - Dr. Minich poses the question, “How do clinicians help reduce patients’ toxic burden in order to prevent and even reverse chronic disease?” In her experience working with Dr. Jeffrey Bland and developing the 28-day metabolic detox, she became very involved in toxicity research and came to understand how toxicity plays a key role in patient health.
- [Keto Diet: Brain Health & Cognitive Function](https://www.metagenicsinstitute.com/maps/keto-diet-brain/) - Dominic D’Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida The ketogenic diet was originally studied and used in patients with seizure disorders, such as epilepsy. The ketogenic diet was shown to be superior to anticonvulsant drug therapies for seizure reduction or remission in a large portion this patient population.
- [Treating Arthritis by Balancing the Gut Ecosystem](https://www.metagenicsinstitute.com/maps/treating-arthritis-balancing-gut-ecosystem/) - Susan Blum, MD, MPH; Functional Internist, Founder/Director, Blum Center for Health There are many types of arthritis including rheumatoid arthritis, which is an autoimmune disease. Common themes exist within autoimmune disease, including the presence of inflammation and presentation as a systemic condition. Dr. Blum discusses the health origins of arthritis and reviews research on the
- [Sports and the Ketogenic Diet](https://www.metagenicsinstitute.com/maps/sports-ketogenic-diet/) - Scott Bergman, DC, CTN, DAAIM; Director, Chiro Kinetics Dr. Bergman discusses inflammation and speaks about common inflammatory conditions and their underlying causes. Dr. Bergman suggests that the first place to start for patients with inflammatory dysfunction is the ketogenic diet. In this talk he will explore the biochemical process of the therapeutic ketogenic eating program and
- [A Functional Medicine Approach to Autism](https://www.metagenicsinstitute.com/maps/functional-medicine-approach-autism/) - P. Michael Stone, MD, MS, IFMCP A 2014 study estimates that one in 68 children are being diagnosed with autism. There are many programs that support these patients but very few treatment options. In Dr. P. Michael Stone’s talk he explores what may be happening in these unique individuals and how doctors can better support
- [Functional Medicine Approach to Coronary Artery Disease](https://www.metagenicsinstitute.com/maps/functional-medicine-approach-coronary-artery-disease/) - Mark Houston, MD, MS, FAHA, FASH, DABC; Internist & Cardiovascular Specialist; Director, Hypertension Institute and Vascular Biology The burden of coronary artery disease in the American patient population is significant, but treatment modalities have not changed. Dr. Houston explores what he feels will truly reduce the top five risk factors of coronary artery disease and improve
- [How Can You Completely Transform Your Practice?](https://www.metagenicsinstitute.com/maps/can-completely-transform-practice/) - Betty Murray, MSc, CN, IFMCP, Certified Nutritionist, Owner, Perfect Practice/Cofounder, Living Wellness Dallas The Wall Street Journal published a pertinent statistic: only 60% of physicians are happy with their practices. Insurance reimbursements are down, and the overall clinical and patient experiences are not what the doctors hoped for or envisioned. Murray imparts inspirational advice and shares simple
- [How Can You Utilize Social Media to Reach More Patients and Get Your Message Out?](https://www.metagenicsinstitute.com/maps/can-utilize-social-media-reach-patients-get-message/) - Dhru Purohit, Partner/CEO, Dr. Hyman Enterprises Dhru has been working with leading doctors across the nation, including Dr. Hyman, to build platforms to propagate doctors’ messages out into the world. Dhru motivates and inspires through his talk to gain fluency and confidence in utilizing social media to share your health and wellness messages out into
- [A Functional Medicine Approach to SIBO](https://www.metagenicsinstitute.com/maps/functional-medicine-approach-sibo/) - Monique Class, MS, APRN, FNP-BC, Family Nurse Practitioner, Center for Functional Medicine Although many patients experience small intestine bacterial overgrowth (SIBO), Monique explains that a SIBO diagnosis can often be overlooked in a clinical setting. Monique shares her journey and commitment in learning how to provide the best care to her patients with SIBO to
- [The Secret to a Clinician’s Success Begins with a Healthy Gut](https://www.metagenicsinstitute.com/maps/secret-clinicians-success-begins-healthy-gut/) - Bridget Briggs, MD There is real evidence supporting the link between most disease states and gut dysregulation. The gut is where 75-80% of the immune system resides. Dr. Briggs discusses the current research in this area and shares in-depth clinical pearls on how to support patients using the 5R gut restoration program. Watch the full MAPS
- [5 P’s of Medicine: The Predictive, Preventive, Personalized, Participatory, and Purpose-Driven Approach](https://www.metagenicsinstitute.com/maps/5-ps-medicine-predictive-preventive-personalized-participatory-purpose-driven-approach/) - Myles Spar, MD, MPH Myles Spar, MD, MPH shares his belief that the annual health check-up appointment is not designed to prevent disease and reduce mortality. He explains that disease prevention requires a more comprehensive medical approach than simply checking metabolic panels. Dr. Spar explores the 5 P’s of medicine, which include a predictive, preventive, personalized,
- [New Medicine, New Engagement: the Art of Connection and Facilitating Behavior Changes](https://www.metagenicsinstitute.com/maps/new-medicine-new-engagement-art-connection-facilitating-behavior-changes/) - Monique Class, MS, APRN, FNP-BC What’s the best way to create long-term change for patients? In Class' talk she shares some of the secrets she has learned in helping patients make recommended shifts and continue on their health journey for long periods of time. Class shares that these changes don’t only require shifts from the
- [Functional Medicine Made Easy](https://www.metagenicsinstitute.com/maps/functional-medicine-made-easy/) - Christopher Keroack, MD, IFMCP, Functional Internist, CEO, New England Center for Functional Medicine In this course Dr. Keroack shares a simple method to support the Functional Medicine decision-making process. He covers five key areas to include in the decision-making progression and explains how each area can impact patients’ overall health. Dr. Keroack also discusses five main
- [A Doctor’s Journey](https://www.metagenicsinstitute.com/maps/a-doctors-journey/) - Jeff Egler, MD, Family Physician, Parsley Health In Dr. Jeff Egler’s talk, “A Doctor’s Journey,” he speaks about his experiences as an educator at a prestigious medical school. In this module, he discusses how these experiences have shown him that the current medical system is broken and how he found himself moving toward a more functional
- [Type 2 Diabetes: Focusing on Insulin](https://www.metagenicsinstitute.com/maps/type-2-diabetesfocusing-on-insulin/) - Filomena Trindade, MD, MPH, Family Physician, Saudade Wellness Center Dr. Trindade explains that obesity, prediabetes, and/or diabetes are all clinical manifestations of insulin resistance. She will explore patient history, lack of sleep, heavy metals, microbiome, hormonal imbalances, infections, nutrient deficiencies, prescriptions drugs, and genetic predispositions to find the underlying cause of insulin resistance. Dr. Trindade will
- [Type 1 Diabetes: A Functional and Personalized Approach](https://www.metagenicsinstitute.com/maps/type-1-diabetes-functional-personalized-approach/) - Ryan Lazarus, DC, MS, CNS, IFMCP In Dr. Lazarus’ talk he shares a traumatic accident he experienced that made him a type 1 diabetic. He shares the real, daily struggles of the insulin-dependent patient. In his journey he has researched and studied how to help doctors and patients in their treatment protocols to achieve the best clinical
- [Transitioning Out of the Ketogenic Diet](https://www.metagenicsinstitute.com/maps/transitioning-ketogenic-diet/) - Christopher Keroack, MD, IFMCP The ketogenic food plan can facilitate significant improvements in weight management and chronic disease for patients. Transitioning out of the ketogenic dietary pattern is equally as important as the initiation. If the transition is implemented incorrectly, the improvements seen during the diet may be attenuated or lost. Dr. Keroack imparts a step-by-step
- [Simple and Effective Implementation Strategies for Ketosis](https://www.metagenicsinstitute.com/maps/simple-effective-implementation-strategies-ketosis/) - Ryan Lazarus, DC, MS, CNS, IFMCP If you had three wishes to improve your health, what would they be? Dr. Lazarus identifies the three main areas most patients desire improvement in: gain energy, lose weight, and improve the aging process. Dr. Lazarus discusses a therapeutic metabolic reboot via nutritional ketosis, when the body uses fat as alternative

## Podcasts

- [From Bench to Bedside](https://www.metagenicsinstitute.com/podcast/from-bench-to-bedside/) - In this presentation Niccolò Terrando, PhD shares research on the role of specialized pro-resolving mediators (SPMs) in perioperative neurocognitive disorders
- [Connecting Methylation to Gut & Immune Health](https://www.metagenicsinstitute.com/podcast/gut-immune-health/) - Kara Fitzgerald, ND provides an understanding of methylation and its influence on the health of the gut.
- [Challenging Degenerative Disease: How Much Healing Is Possible?](https://www.metagenicsinstitute.com/podcast/challenging-degenerative-disease-how-much-healing-is-possible/) - Terry Wahls, MD challenges the conventional medical view that multiple sclerosis is progressive and degenerative and shares her personal journey with MS.
- [Doctor Becomes Patient: A Catalyst for Practicing Personalized Medicine](https://www.metagenicsinstitute.com/podcast/doctor-becomes-patient/) - Listen to Dr. Carnahan's story on transitioning from allopathic medicine & how her experience with breast cancer influenced the way she practices medicine.
- [How Practitioner-Patient Relationships Can Replace the Pill-for-Every-Ill Model](https://www.metagenicsinstitute.com/podcast/allopathic-integrative/) - Listen to Dr. Landa's story on transitioning from allopathic to integrative medicine and how these changes impacted her at a personal & professional level.
- [Can We Predict, Detect, and Mitigate Disease Through Epigenetic Approaches?](https://www.metagenicsinstitute.com/podcast/applied-epigenetics/) - Florence Comite, MD explores gene variation and the benefits of precision medicine with an epigenetic approach.
- [Unraveling the Invisible Epidemic of Anxiety in Men](https://www.metagenicsinstitute.com/podcast/anxiety-mens-health/) - Myles Spar, MD discusses how being in a constant state of anxiety and stress can impact men’s overall health and happiness
- [The Role of Insulin in Balancing Sex Hormones](https://www.metagenicsinstitute.com/podcast/hormones-womens-health/) - Dr. Filomena Trindade discusses women's health and how anxiety disrupts the role of insulin, leading to possible hormone imbalance.
- [Cracking the Code on Balancing Appetite, Energy, and Weight](https://www.metagenicsinstitute.com/podcast/metabolism-health/) - Alan Christianson, NMD discusses a method to reset the metabolism, which he uncovered while making a shift in his own diet.
- [Intermittent Fasting: Examining Effects on Metabolism and Detoxification](https://www.metagenicsinstitute.com/podcast/intermittent-fasting/) - Dr. Sara Gottfried explores the latest research on intermittent fasting and time-restricted eating, and their effect on the metabolism.
- [The Elimination Diet Unlocks Priceless Data about the Individual](https://www.metagenicsinstitute.com/podcast/elimination-diet/) - Dr. Deanna Minich provides the three key principles to share with patients before starting them on an elimination diet.
- [A New Perspective on Alzheimer's Disease](https://www.metagenicsinstitute.com/podcast/alzheimers-disease/) - Lisa Mosconi, PhD explores recent research on Alzheimer's disease and the disproportionate rate that women are affected by Alzheimer's, depression and anxiety.
- [Pregnancy: An Integrative Medicine Perspective](https://www.metagenicsinstitute.com/podcast/genetics-pregnancy/) - Explore exciting possibilities with the potential to radically improve pre- and perinatal care and give the next generation a healthier foundation.
- [An Affordable Approach to Integrative Medicine (Even in Challenging Cases)](https://www.metagenicsinstitute.com/podcast/integrative-medicine/) - Michael Ruscio, DC leads the charge to make integrative medicine more affordable, effective, and practical
- [Creating Synergy Between Allopathic and Integrative Medicine](https://www.metagenicsinstitute.com/podcast/allopathic-integrative-medicine/) - Frank Lipman, MD offers insights on how to create a synergy between allopathic and integrative medicine models.

## Publications

- [Specialized Pro-Resolving Mediators (SPMs) Case Study](https://www.metagenicsinstitute.com/publications/specialized-pro-resolving-mediators-spms-case-study/) - Inflammation complicates the management of many conditions such as obesity and heart disease. The inability to resolve inflammation leads to progression and complications later on.
- [Herbal Therapies vs. Antibiotics for SIBO Management](https://www.metagenicsinstitute.com/publications/herbal-therapies-effective-antibiotics-sibo-management-fewer-side-effects/) - Small intestinal bacterial overgrowth (SIBO) has become a significant health problem seen in many clinical practices. The prevalence estimates for SIBO in patients with irritable bowel syndrome (IBS) range from 4-78% (higher prevalence in diarrhea-predominant IBS)1 and is thought to be almost as high in many other disorders of the digestive tract. Defined as an increase
- [Clinical Effects of a Novel Hops Extract & Undenatured Collagen (THIAA and UC-II)](https://www.metagenicsinstitute.com/publications/clinical-effects-novel-hops-extract-undenatured-collagen-thiaa-uc-ii/) - Hops-derived tetrahydroiso-alpha acids (THIAA) –have been shown to exhibit anti-inflammatory properties in vitro and to reduce bone cartilage degradation in mice models.
- [Exogenous Ketone Salts Increase Ketone Blood Levels in Healthy Adults](https://www.metagenicsinstitute.com/publications/exogenous-ketone-salts-increase-ketone-blood-levels-healthy-adults/) - Exogenous ketone supplementation, particularly with beta-hydroxybutyrate (βHB) salts enhance compliance for the ketogenic diet in order to induce and sustain ketosis.
- [Protein-Rich Hops Matrix Enhances Bioavailability of Xanthohumol: Clinical Study](https://www.metagenicsinstitute.com/publications/protein-rich-hops-matrix-enhances-bioavailability-xanthohumol-clinical-study/) - Xanthohumol (XN) is a flavonoid found in hops, the flowers of the hop plant Humulus lupulus. XN exhibits anti-inflammatory and antioxidant properties.
- [Innovative Structured Nutrition Therapy for Compromised Gut (IBS and IBD)](https://www.metagenicsinstitute.com/publications/innovative-medical-food-compromised-gut-ibs-ibd/) - This open-label, multi-clinic study in 12 patients with digestive disorders demonstrated that consuming 2 servings daily of an innovative structured nutrition therapy for 6 weeks: Reduced GI symptoms and improved overall GI quality of life Increased production of SCFA, including butyrate Increased levels of Bifidobacterium spp. Reduced potential harmful intestinal microbiota Despite the limited sample
- [ADA Poster: Novel Structured Nutrition Therapy for Glucose Control in T2D](https://www.metagenicsinstitute.com/publications/ada-2016-poster-novel-medical-food-glucose-control-t2d/) - The clinical results of a randomized controlled research study that showed a diabetes-specific nutrition formula for glucose control in combination with a structured dietary plan resulted in significant reduction in HbA1c levels and body weight in overweight and obese patients with type 2 diabetes (T2D) compared to an individualized dietary plan alone. The study, conducted
- [Glucose Toxicity and Insulin Resistance Disease](https://www.metagenicsinstitute.com/publications/glucose-toxicity-insulin-resistance-disease/) - Type 2 diabetes is an increasing global health issue, which benefits from ongoing research in medical nutrition therapy. All attempts to introduce a modified diet, reduced caloric intake and physical activity have been shown to assistance patients experiencing glucose toxicity. Impaired glucose tolerance causes many health issues, including cardiovascular disease. This review covers the criteria
- [Diagnosis and Management of Hyperglycemia Due to Carbohydrate Intolerance](https://www.metagenicsinstitute.com/publications/diagnosis-management-hyperglycemia-due-carbohydrate-intolerance/) - During periods of over-nutrition, excess energy is stored in white adipose tissue (WAT); continuing expansion of WAT may lead to obesity. Obesity alters the cellular physiology of adipocytes, the cells of WAT. In the context of obesity, adipocytes secrete elevated levels of free fatty acids and adipokines, but decreased levels of adiponectin. These pathophysiologic changes
- [‘Real World’ Practice-Based Research with Targeted Nutrition for Dyslipidemia](https://www.metagenicsinstitute.com/publications/real-world-clinical-results-proprietary-medical-food-dyslipidemia/) - Dyslipidemia is a prominent risk factor for atherosclerotic cardiovascular disease (CVD) and impacts over half of US adults. Lifestyle interventions, particularly those incorporating medical nutrition therapy, are essential in the management of dyslipidemia, to halt progression towards advanced CVD and metabolic disease. The primary objective of this multi-site, prospective case series was to measure changes
- [A Breakthrough Approach to Support Joint Health: Research Review](https://www.metagenicsinstitute.com/publications/breakthrough-approach-support-joint-health-research-review/) - This research review discusses how the combination of undenatured type II collagen and tetrahydro iso-alpha acids help revitalize joint function and support an active lifestyle. Arthritis is not a single condition. In fact, there are more than 100 different forms of arthritis. The 2 most common types of arthritis, whose main feature is joint pain,
- [A Systems Medicine Approach: Translating Emerging Science into Individualized Wellness](https://www.metagenicsinstitute.com/publications/systems-medicine-approach-translating-emerging-science-individualized-wellness/) - Clinicians and healthcare practitioners have a unique opportunity in advocating lifestyle medicine because patients see them as a reliable source of advice. However, there are still numerous technical and logistic challenges to overcome before personal “big data” can be translated into actionable and clinically relevant solutions. Clinicians are also facing various issues prior to bringing
- [Symptomatic Relief from SIBO with L. salivarius UCC118 Strain](https://www.metagenicsinstitute.com/publications/symptomatic-relief-sibo-l-salivarius-ucc118-strain/) - Daily consumption of the probiotic strain Lactobacillus salivarius UCC118 helped relieve severity of gastrointestinal (GI) symptoms associated with small intestinal bacterial overgrowth (SIBO), according to a pilot quality improvement study. The study participants (n=29) were recruited from patients who presented to the Cleveland Clinic Center for Gut Rehabilitation and Transplantation outpatient clinic (Cleveland, OH). Participants
- [The Microbiome: Achieving Balanced Gut Microbiota as a Pathway to Good Health](https://www.metagenicsinstitute.com/publications/microbiome-achieving-balanced-gut-microbiota-pathway-good-health/) - The microbial community in each of our bodies influences our physiology, metabolism and immune function, playing roles in both health and disease. This community of bacteria helps its human host digest food, synthesize certain vitamins, and protect against pathogenic bacteria. Recognizing the benefits of “good” microbes begs the question, what does the microbial population look
- [GI Mucosal Adherence Mechanisms of a Probiotic Lactobacillus Strain ](https://www.metagenicsinstitute.com/publications/gi-mucosal-adherence-mechanisms-probiotic-lactobacillus-strain/) - Lactobacillus salivarius UCC118 is a well-characterized and evidence-based probiotic strain. A feeding study led by Fergus Shanahan, MD and his research group at the University College Cork was conducted in patients with ulcerative colitis. This pilot-scale, open-label study aimed to determine the ability of L. salivarius UCC118 to adhere to human enterocyte epithelial cells. The bacterial
- [Nutritional Approach for Relief of Joint Discomfort: Illustrative Case Report](https://www.metagenicsinstitute.com/publications/nutritional-approach-relief-joint-discomfort-illustrative-case-report/) - This 12-week study evaluated the efficacy and safety of a nutritional product containing n-enriched tetrahydro iso-alpha acids and undenatured type 2 collagen in participants with chronic joint pain (including pain from symptomatic osteoarthritis and from rheumatoid arthritis). Tetrahydro iso-α acids (THIAAs), derived from Humulus lupulus (hops), have demonstrated anti-inflammatory effects in vitro and in an

## Pulse Patrol

- [The Keto Diet: Nuance in Practice](https://www.metagenicsinstitute.com/pulse_patrol/keto-diet-clinical-practice/) - Robert Silverman, DC & Deanna Minich, PhD infuse nuance & pragmatism into an important discussion on the ketogenic diet approach (“keto”) in clinical practice.
- [Improving Cognition with the Bredesen Protocol](https://www.metagenicsinstitute.com/pulse_patrol/improving-cognition/) - Amylee Amos, MS, RDN & Deanna Minich, PhD discuss nutrition & lifestyle factors in the Bredesen protocol to improve cognition in patients.
- [The Emotional Stress-Inflammation Link](https://www.metagenicsinstitute.com/pulse_patrol/emotional-stress/) - Jennifer Stagg, ND and Deanna Minich, PhD discuss the connection between emotional stress and health and the role that inflammation and oxidative stress play.
- [Detox Program Tips and Tools](https://www.metagenicsinstitute.com/pulse_patrol/group-detox-tips-tools/) - Drs. Tricia Paulson and Deanna Minich discuss detox, exploring tips for practitioners to structure a successful group detoxification program for their patients.
- [SIBO & The Connection to Sulfur](https://www.metagenicsinstitute.com/pulse_patrol/plp-eps-5-sibo-sulfur/) - Drs. Minich and Briggs explore the SIBO-sulfur link in this cutting edge discussion, where they use a personalized lifestyle medicine approach to examine SIBO.
- [The Resolution of Inflammation](https://www.metagenicsinstitute.com/pulse_patrol/omega3-spms-inflammation/) - Kara Fitzgerald, ND & Deanna Minich, PhD discuss inflammation resolution & how to provide clinical support to quench inflammation chronicity in your patients.
- [Optimizing Estrogen Detox](https://www.metagenicsinstitute.com/pulse_patrol/estrogen-detox/) - Carrie Jones, ND, MPH & Deanna Minich, PhD explore estrogen metabolism & detoxification pathways & how optimizing estrogen detox can impact hormonal symptoms.
- [Anti-Anxiety Food: Eat This, Not That](https://www.metagenicsinstitute.com/pulse_patrol/anti-anxiety-food/) - Ali Miller, RD details the impact of chronic stress on the gut microbiome and uncovers how glutamine depletion, impacts how we break down food.
- [Everyday Toxicity, Health, and CBD](https://www.metagenicsinstitute.com/pulse_patrol/cbd-health/) - Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Ann Shippy, MD Cannabidiol (CBD) seems to be everywhere these days, but how much of the available information is based on research, and how much is just hype? In this discussion, Deanna Minich, PhD, CNS, FACN, IFMCP queries her guest, Ann Shippy, MD, about the legality surrounding CBD, about
- [Thyroid Health: Treat the Patient, Not the Labs](https://www.metagenicsinstitute.com/pulse_patrol/thyroid-health/) - Erik Lundquist, MD and Deanna Minich, PhD discuss thyroid physiology, assessment, and clinical pearls for treating treating patients with thyroid dysfunction.
- [The Ketogenic Diet: Weight Loss and Beyond](https://www.metagenicsinstitute.com/pulse_patrol/personalized-lifestyle-pearls-eps-2-ketogenic-diet-weight-loss-and-beyond/) - Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Christopher Keroack, MD, IFMCP You may have heard about the ketogenic diet. This high-fat, low-carbohydrate, moderate-protein dietary pattern has experienced a revival of sorts in the mainstream media and dieting world. But, before “keto” was a contemporary fad, how was it used? In fact, there is ~100 years of
- [Metabolic Performance for the Ultimate Game…Life!](https://www.metagenicsinstitute.com/pulse_patrol/metabolic-performance/) - Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Scott Bergman, DC, CTN, DAAIM “Exercise breaks the body down. If we keep breaking it down, we never have the opportunity to repair.” – Dr. Scott Bergman In this discussion, Drs. Scott Bergman and Deanna Minich explore factors that impact metabolic performance, not just for athletic gain but for
- [The Hypothalamus & Hormone Balance](https://www.metagenicsinstitute.com/pulse_patrol/hypothalamus-hormone-balance/) - Deborah Maragopoulos and Deanna Minich discuss the neuro-immune-endocrine system & how the hypothalamus is at the core of many patients’ chronic health issues.
- [Anxiety & Women: Changing the Conversation](https://www.metagenicsinstitute.com/pulse_patrol/anxiety-and-women/) - Drs. Sara Gottfried and Deanna Minich explore how clinicians can help remove the stigma of anxiety and partner with women to identify root causes of anxiety.
- [Drugs vs. Personalized Lifestyle Medicine](https://www.metagenicsinstitute.com/pulse_patrol/personalized-lifestyle-pearls-episode-1-drugs-vs-personalized-lifestyle-medicine/) - Host: Deanna Minich, PhD, FACN, CNS Guest: Jeffrey Bland, PhD, FACN, FACB, CNS There has been considerable discussion recently as to what is the best approach in the management of early stage chronic disease- drugs or lifestyle? To help us answer that question, Drs. Deanna Minich and Jeffrey Bland discuss a recent New England Journal
- [Omega-3s, Let’s Get to the Heart of the Evidence](https://www.metagenicsinstitute.com/pulse_patrol/personalized-lifestyle-pearls-episode-3-omega-3s-lets-get-heart-evidence/) - Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Mark Houston, MD, MS, FAHA, FASH, DABC Drs. Mark Houston and Deanna Minich delve into the science and proper clinical use of omega-3 fatty acids for the prevention and treatment of heart-related conditions. Dr. Houston vets the methodology and validity of 3 major meta-analyses related to omega-3s and heart
- [Tackling Our Children’s Toxic Environment](https://www.metagenicsinstitute.com/pulse_patrol/personalized-lifestyle-pearls-episode-4-tackling-childrens-toxic-environment/) - Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Paul Thomas, MD, FAAP, ABAM, ABIHM Obesity and chronic disease are on the rise in our nation’s children. Prevalence of neurological and mood disorders is also increasing. Drs. Paul Thomas and Deanna Minich discuss how exposure to various toxic inputs from the environment and home are burdening our nation’s
- [PANDAS](https://www.metagenicsinstitute.com/pulse_patrol/personalized-lifestyle-pearls-pandas/) - Drs. Karima Hirani & Deanna Minich share clinical insights on pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS).

## Roundtables

- [Shifting the Paradigm from Blocking to Resolving Inflammation](https://www.metagenicsinstitute.com/roundtables/shifting-paradigm-blocking-resolving-inflammation/) - Specialized Proresolving Mediators from Blocking to Resolving Inflammation

## Video

- [Ketogenic Diet and Cancer Therapy](https://www.metagenicsinstitute.com/video/ketogenic-diet-and-cancer-therapy/) - Cancer researchers are interested in the potential benefits a ketogenic diet approach in cancer therapy. Why? Dr. Jeffrey Bland shares insights in this video.
- [Multi-Microbiome Effects: Probiotic Strategies to Target Next-Generation Microbes](https://www.metagenicsinstitute.com/video/multi-microbiome-probiotic-strategies/) - This presentation is an overview of specific microbiota, F. prausnitzii and A. muciniphila that have been described as next generation microbes and bioindicators of health
- [Clinical Minute Consult: Choosing a Probiotic](https://www.metagenicsinstitute.com/video/clinical-minute-consult-choosing-probiotic/) - In this video, Nikky Contractor, PhD discusses the most important factors for healthcare provider to consider when selecting a probiotic for their patient.
- [SPMs and Sjogren’s Syndrome](https://www.metagenicsinstitute.com/video/spms-and-sjogrens-syndrome/) - In this interview, Olga Baker, PhD, DDS, focuses on the treatment of Sjogren’s syndrome, discussing the limitations of current methods and the potential of SPMs like resolvin D1 to reduce inflammation and aid tissue restoration. Dr. Baker also expresses optimism about the future of research in this field, highlighting the importance of translating findings from
- [SPMs and Neuroinflammation Resolution](https://www.metagenicsinstitute.com/video/spms-and-neuroinflammation-resolution/) - In this interview, Valerio Chiurchiu, PhD addresses the crucial role of SPMs in neuroinflammation and brain health. He explains their critical function in resolving neuroinflammation and maintaining brain homeostasis, particularly highlighting their impact on neurodegenerative diseases such as MS and Parkinsons Disease. Dr. Chiurchiu also covers the therapeutic potential of SPMs for neurological disorders and
- [SPMs and Pain](https://www.metagenicsinstitute.com/video/spms-and-pain/) - In this interview, Dr. Ru-Rong Ji delves into the pain-relieving properties of SPMs, discussing their effectiveness in mitigating both inflammatory and neuropathic pain. He emphasizes the significance of SPMs in resolution pharmacology and their potential to reduce opioid dependency. Dr. Ji describes the successful application of SPMs in animal studies and their promising prospects for
- [Immunonutrition and SPMs in Surgery and Critical Care](https://www.metagenicsinstitute.com/video/immunonutrition-and-spms-in-surgery-and-critical-care/) - In this interview, Robert Martindale, MD, PhD, sheds light on the benefits of immunonutrition and SPMs in patient recovery post-surgery. He highlights how these nutritional strategies help modulate the immune response and improve outcomes for surgical and critical care patients. Dr. Martindale addresses the challenges of integrating such approaches into patient care. He also explores
- [Vascular Roles of SPM](https://www.metagenicsinstitute.com/video/vascular-roles-of-spm/) - In this interview, Michael Conte, MD, delves into the role of SPMs in treating vascular diseases. He highlights the potential of synthetic resolvin D1 analogues to improve the management of vascular injuries and control post-surgical inflammation. Dr. Conte also emphasizes the importance of future research on SPMs, particularly in enhancing surgical recovery and developing biomarkers
- [SPMs in Cardiology](https://www.metagenicsinstitute.com/video/spms-in-cardiology/) - In this interview, Magnus Back, MD, PhD delves into the role of SPMs in advancing cardiovascular disease treatment. He highlights their potential to enhance current therapies by effectively resolving inflammation. Dr. Back explains how insights from animal models are translating into human treatments, particularly focusing on the effects of SPMs on atheerosclerotic lesions and aortic
- [Resolvins in Atherosclerosis](https://www.metagenicsinstitute.com/video/resolvins-in-atherosclerosis/) - In this interview, Gabrielle Fredman, PhD delves into the role of SPMs, particularly resolvin D2, in the resolution of chronic inflammation in cardiovascular conditions such as atherosclerosis. She discusses how RvD2 facilitates the resolution of inflammation and the reduction of plaque formation, focusing on how it corrects imbalances in lipid mediators that fuel atherosclerosis. Looking
- [Metabolipidomics and SPMs: Pioneering Therapies](https://www.metagenicsinstitute.com/video/metabolipidomics-and-spms-pioneering-therapies/) - In this interview, Krishnarao Maddipati, PhD, discusses his research in metabolipidomics, focusing on the role of SPMs in cellular processes he calls "unalamation”. He highlights significant findings, including how dietary supplementation can boost SPM production, leading to innovative therapeutic strategies for managing diseases by harnessing the body's natural resolution mechanisms. Krishnarao Rao Maddipati, PhD, is
- [Aspirin-Triggered Resolvins and Lipoxin in Infection Clearance](https://www.metagenicsinstitute.com/video/aspirin-triggered-resolvins-and-lipoxin-in-infection-clearance/) - In this interview, Janos Filep, MD, PhD, discusses the role of aspirin-triggered resolvins and lipoxins in infection control, especially in sepsis. Dr. Filep is exploring how these molecules can restore immune function in patients with compromised phagocytosis. He also investigates the interaction between IFN-β and these mediators in clearing lung infections and outlines the challenges
- [SPMs in Asthma and RSV Infections](https://www.metagenicsinstitute.com/video/spms-in-asthma-and-rsv-infections/) - In this interview, Bruce Levy, MD discusses the scientific basis of SPMs in respiratory health, emphasizing their role in lung inflammation resolution, particularly for asthma and RSV infections. He notes the impact of lipoxin deficiency on asthma severity and how supplementation with these mediators offers therapeutic potential, promoting tissue repair and reducing lung damage. Dr.
- [SPMs in Oral Inflammation and Neurodegenerative Disease](https://www.metagenicsinstitute.com/video/spms-in-oral-inflammation-and-neurodegenerative-disease/) - In this interview, Alpdogan Kantarci, DDS, PhD, discusses the impact of SPMs on periodontal health and systemic inflammation. He reviews his research on SPMs and their role in linking oral inflammation to Alzheimer's disease, emphasizing their therapeutic potential. Dr. Kantarci also highlights the importance of nutrition in managing these conditions. Looking ahead, he discusses his
- [Advancing Wound Healing: Dr. Edward Botchwey's Intersection of Metabolomics, Bioengineering, and Rehabilitation Medicine](https://www.metagenicsinstitute.com/video/advancing-wound-healing-rehabilitation-medicine/) - Accelerating advanced wound healing is an emerging technology where metabolomics are used to identify insufficiencies in endogenous lipid mediators that may impact tissue healing.
- [Exploring SPMs in Aortic Valve Stenosis](https://www.metagenicsinstitute.com/video/exploring-spms-in-aortic-valve-stenosis/) - In this interview, Magnus Back, MD, PhD delves into the involvement of specialized pro-resolving mediators (SPMs) in the progression of aortic valve stenosis, and the reduced accumulation of omega-3. He also talks about his research on resolvins, their receptors, and ways to facilitate the resolution of inflammation without inducing immunosuppression. Additionally, Dr. Back discusses his
- [Advancing Periodontal Disease Treatment with Nutraceuticals and Inflammation Control](https://www.metagenicsinstitute.com/video/advancing-periodontal-disease-treatment-with-nutraceuticals-and-inflammation-control/) - In this interview, Thomas Van Dyke, DDS, PhD talks about the current role of nutraceuticals in managing inflammation associated with periodontal disease. He elaborates on the use of Omega-3s derivatives such as specialized pro-resolving mediators (SPMs) as an adjunctive therapy in periodontal disease. Additionally, Dr. Van Dyke explains the connection between periodontal infections and increased
- [SPMs and Omega-3 Metabolic Mysteries](https://www.metagenicsinstitute.com/video/spms-and-omega-3-metabolic-mysteries/) - In this interview, Dr. Makoto Arita sheds light on his recent research exploring the metabolites and metabolic pathways that contribute to the anti-inflammatory and inflammation-resolving properties of omega-3. He delves deeper into the nature of specialized pro-resolving mediators (SPMs) and how they are a cascade of metabolites. Dr. Arita also talks about various conditions, including
- [SPMs and Vulvar Disease](https://www.metagenicsinstitute.com/video/spms-and-vulvar-disease/) - In this interview, Megan Falsetta, PhD addresses the prevalence and characteristics of patients with vulvar disease. She discusses the role of inflammation in chronic vulvar pain. Dr. Falsetta highlights research findings indicating that exogenous specialized pro-resolving mediators (SPMs) have shown promising therapeutic effects in resolving pain in animal models. She expresses hope that SPMs might
- [Bridging Inflammation Resolution, Tissue Repair, and Obesity Management](https://www.metagenicsinstitute.com/video/inflammation-resolution-tissue-repair-obesity-management/) - In this interview, Matthew Spite, PhD discusses his research on the intersection of inflammation resolution via specialized pro-resolving mediators (SPMs) and tissue repair.
- [The Impact of SPMs on the Aging Process](https://www.metagenicsinstitute.com/video/the-impact-of-spms-on-the-aging-process/) - The role of SPMs in aging,the research and potential of using specialized pro-resolving mediators (SPMs) endogenously as a preventative measure against aging
- [Combating Inflammation in Diabetic Associated Atherosclerosis and Chronic Complications](https://www.metagenicsinstitute.com/video/combating-inflammation-in-diabetic-associated-atherosclerosis/) - Catherine Godson, PhD discusses the protective role of lipoxins against inflammation in diabetes associated atherosclerosis.
- [Pioneering Research on SPMs in Rheumatoid Arthritis Therapy](https://www.metagenicsinstitute.com/video/pioneering-research-on-spms-in-rheumatoid-arthritis-therapy/) - Research on the use of Maresins in treating rheumatoid arthritis patients and the clinical insights gained from the work of Dr. Jesmond Dalli and covers how specialized pro-resolving mediators (SPMs) offer a novel approach to pain therapy.
- [Exploring Cutting-Edge Medical Research: mRNA Vaccines, Cell-Based Therapies, and Insights into Long COVID and SPMs](https://www.metagenicsinstitute.com/video/exploring-cutting-edge-medical-research-mrna-vaccines-cell-based-therapies-and-insights-into-long-covid-and-spms/) - The development of mRNA vaccines, growth in cell-based therapies and expansion of interest in resolution biology. Dr. Levy describes the potential link between long COVID and dysregulation of resolution mediators.
- [Impact of Cytokine Storms in COVID-19 and Cancer](https://www.metagenicsinstitute.com/video/impact-of-cytokine-storms-in-covid-19-and-cancer/) - Dr. Panigraphy discusses how standard cancer treatments, including surgery and chemotherapy, may trigger cytokine storms
- [New HDL Cholesterol Concepts for Coronary Heart Disease [Full video]](https://www.metagenicsinstitute.com/video/hdl-cholesterol-chd/) - The main function of HDL is to scavenge for and carry LDL cholesterol away from the arteries and back to the liver, for redistribution, metabolism, and excretion.
- [Hiding in plain sight: HDL dysfunction](https://www.metagenicsinstitute.com/video/hdl-dysfunction/) - Understand components and mechanisms of HDL particles, reverse cholesterol transport, and how to treat dysfunctional HDL – an overlooked cardiovascular risk.
- [Endocannabinoid System (ECS) Signaling in Depressive Disorders](https://www.metagenicsinstitute.com/video/endocannabinoid-exercise-depression/) - The effect of exercise on the ECS, and how this may underpin some of the benefits of exercise in patients with depression and other mood disorders.
- [Detox Resource Hub](https://www.metagenicsinstitute.com/video/detox-resource-hub/) - We have compiled our most viewed detox blogs, webinars, and clinical tools on metabolic detoxification to help you keep up with the latest research on this topic that will enable you to help your patients’ live healthier, happier lives.
- [The Emerging Impact of Specialized Pro-Resolving Mediators (SPMs) on Tumor Size and Growth](https://www.metagenicsinstitute.com/video/spms-impact-tumor-growth/) - Dr Panigrahy outlines the reduction in metastases seen in preclinical cancer models, including pancreatic cancer, following treatments with various SPMs.
- [A Deep Dive into SPMs](https://www.metagenicsinstitute.com/video/a-deep-dive-into-spms/) - There is a growing body of research on the use of specialized pro-resolving mediators (SPMs) as a key therapy for many different conditions.
- [How Phytonutrients Help with Skin Health](https://www.metagenicsinstitute.com/video/phytonutrients-skin-health/) - Learn how we may support our skin by boosting skin’s antioxidant capacity via a phytonutrient-rich diet.
- [Integrative Medicine for Better Health](https://www.metagenicsinstitute.com/video/integrative-medicine-health/) - In this brief hallway chat, Mimi Guarneri, MD addresses how to manage stress and aging using integrative medicine and lifestyle approaches.
- [Inflammation Resolution & SPMs: Video Animation](https://www.metagenicsinstitute.com/video/specialized-pro-resolving-mediators-spms-effects-inflammation/) - This video highlights the difference between phases of inflammation resolution & the potential for inflammation to cause long-term damage to the body’s tissue
- [Recent SPM Research: Therapeutic Areas & Measurement](https://www.metagenicsinstitute.com/video/recent-spm-research-therapeutic-areas-measurement/) - Dr. Serhan discusses ongoing research centers that are conducting research to assess SPMs efficacy in a variety of health conditions.
- [Resolution Physiology: Then & Now, with Dr. Charles Serhan](https://www.metagenicsinstitute.com/video/resolution-physiology-now-dr-charles-serhan/) - Resolution is now known to be an active process with over 28 members of the specialized pro-resolving mediators (SPMs) superfamily playing critical roles.
- [Can SPMs be Used As Preventative Supplements in Healthy People?](https://www.metagenicsinstitute.com/video/can-spms-used-preventative-supplements-healthy-people/) - Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School how SPMs can be used as preventive dietary supplements in healthy people. Dr. Serhan responded that pre-clinical models indicate that SPMs can regenerate
- [What is the Potential Use of Supplements Enriched with SPMs?](https://www.metagenicsinstitute.com/video/potential-use-supplements-enriched-spms/) - In this video we ask Dr. Serhan, "What is the potential use of supplements enriched with SPMs for patients whose diets are deficient in essential fatty acids?" 3. Insights from the Metagenics Lifestyle Summit 2015: Charles Serhan, PhD
- [Where are SPMs Most Commonly Stored in the Body?](https://www.metagenicsinstitute.com/video/spms-commonly-stored-body/) - Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School about where SPMs are most commonly stored in the body. Dr. Serhan responded that there is no evidence that SPMs are stored in
- [What is the Average Time for Onset of Action for SPMs Following Ingestion?](https://www.metagenicsinstitute.com/video/average-time-onset-action-spms-following-ingestion/) - Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School about the time of onset of action for SPMs following their ingestion. Dr. Serhan responds that, in a limited study of humans, the
- [Leaky Gut Syndrome](https://www.metagenicsinstitute.com/video/leaky-gut-syndrome/) - Leaky gut syndrome is a condition some health practitioners claim is the cause of a wide range of serious conditions, including diabetes and multiple sclerosis.
- [Probiotics for Gut Health and Beyond: Video Animation](https://www.metagenicsinstitute.com/video/probiotics-gut-health-beyond/) - Adding probiotics to the diet can help support gut and overall health.
- [Skin Issues? Here are the Top 5 Foods to Avoid](https://www.metagenicsinstitute.com/video/skin-issues-5-foods-to-avoid/) - In this hallway chat, Ashley Koff, RD, addresses the gut connection to our skin health. She also demystifies the role of chocolate, dairy and sugar on skin issues, and provides practical tips on foods to avoid for acne and the scientific reason behind it.
- [What Does Your Gut Microbiome Say About You?](https://www.metagenicsinstitute.com/video/gut-microbiome/) - Dr. Singh discusses the importance of assessing the anti-inflammatory capacity of the gut microbiome, understanding the diagnostics, and remembering the lifestyle basics.
- [The Involvement of Endocannabinoid System (ECS) in Regulating Addiction and Reward](https://www.metagenicsinstitute.com/video/endocannabinoid-addiction-reward/) - The involvement of endocannabinoid system (ECS) in the role of CB1 receptors in regulating body weight and the critical differences of blocking CB1 receptors.
- [Start the Resolution: Stopping the Progression of Chronic Disease, Robert Martindale, MD, PhD](https://www.metagenicsinstitute.com/video/start-resolution-stopping-progression-chronic-disease-robert-martindale-md/) - Robert Martindale, MD delves into the unique roles that polyunsaturated fatty acids and specialized pro-resolving mediators, play in combating and resolving inflammation.
- [The Important Role that Specialized Pro-Resolving Mediators (SPMs) Play in Metabolic Health](https://www.metagenicsinstitute.com/video/spms-metabolic-health/) - The important role that specialized pro-resolving mediators play in adipose tissue and metabolic health & outlines future potential for SPM-based therapies
- [Vitamins D and K Go Hand-in-Hand](https://www.metagenicsinstitute.com/video/vitamin-d-and-k-video/) - Dr. Sara Gottfried explains the synergy of vitamins D and K in the body for bone and cardiovascular health. Implications for supplementation are explored.
- [Phytocannabinoids & the Endocannabinoid System: Video Animation](https://www.metagenicsinstitute.com/video/phytocannabinoids/) - In this video animation, you will learn about the role of phytocannabinoids, like cannabidiol (CBD), in the endocannabinoid system (ECS) and health.
- [Clinical Overview of SPMs and Application to Patient Care](https://www.metagenicsinstitute.com/video/clinical-overview-spms-application-patient-care/) - Resolution is an active process. Anti-inflammation is not equivalent to Pro-Resolution. SPMs are lipid compounds isolated in human tissues during inflammation.
- [The Oath](https://www.metagenicsinstitute.com/video/the-oath/) - Metagenics Institute was founded to help practitioners to fulfill their oath.
- [The Reality of Carbohydrate Intolerance](https://www.metagenicsinstitute.com/video/reality-carbohydrate-intolerance/) - The video reviews the day to day practices that cause the epidemic of carbohydrate intolerance. It discusses macronutrients and the implementation of medical nutrition therapy for diabetes prevention and treatment.
- [The Role of Specialized Pro-Resolving Mediators in Atherosclerosis](https://www.metagenicsinstitute.com/video/spms-in-atherosclerosis/) - Dr Gabrielle Fredman outlines the potential for specialized pro-resolving mediator (SPM) therapies in the management of vascular disease.
- [Latest Updates on Specialized Pro-Resolving Mediator (SPM) Science](https://www.metagenicsinstitute.com/video/updates-on-spm-science/) - Dr Serhan delivers a message on the state of resolution science today, and what is needed to advance SPM-based therapies in the future.
- [The Loss of Inflammatory 'Breaking Signals' in the Lung of Patients with Asthma](https://www.metagenicsinstitute.com/video/inflammatory-signals-asthma/) - How a defective resolution phenotype negatively impacts both adaptive and immune responses in individuals with asthma, leaving them vulnerable to infection.
- [Novel Clinical Insights on Inflammation: Resolving not Blocking](https://www.metagenicsinstitute.com/video/inflammation-resolving-not-blocking/) - Dr. Heyman explores the role of specialized pro-resolving mediators (SPMs) in the clinical management of chronic inflammatory conditions, such as chronic pain and fibromyalgia.
- [LDL Cholesterol: Particle Number & Size Matter for Coronary Heart Disease](https://www.metagenicsinstitute.com/video/ldl-cholesterol/) - Studies show that 50-70% of men have their first heart attack before they have any chest pain. 
- [What Are Some Examples Where SPM Biosynthesis Would be Challenged?](https://www.metagenicsinstitute.com/video/examples-spm-biosynthesis-challenged/) - NSAIDs lead to a decrease in acute inflammatory response, but persistence in the acute inflammatory response.
- [Clinical Applications of Specialized Pro-Resolving Mediators](https://www.metagenicsinstitute.com/video/spm-clinical-applications/) - SPMs and the positive results each individual has experienced from insomnia to periodontal pain.
- [Behaviors, Food, & Eating](https://www.metagenicsinstitute.com/video/behaviors-food-eating/) - Deanna Minich, PhD, CNS, FACN, IFMCP; Nutrition Educator and Author There is an overwhelming amount of information being thrown at your patients about food. This creates anxiety, stress, and confusion during meal times. Dr. Deanna Minich refers to this as “analysis paralysis.” In the world of food there is a need for more fun, creativity,
- [SPMs Now: Measurement in the Human Body](https://www.metagenicsinstitute.com/video/spms-now-measurement-human-body/) - In the 4th part of the SPM interview series with Charles Serhan, PhD, DSc, he answers the question: “Besides peripheral blood, can pro-resolving mediators be measured in other tissues? If so, which ones?” Dr. Serhan shares current research findings on SPM measurement in the human body, demonstrating several human tissues and fluids where SPMs have
- [Potential Effects of HMOs on Adult Gut Microbiome](https://www.metagenicsinstitute.com/video/potential-effects-hmos-adult-gut-microbiome/) - Lars Bode, PhD: Potential Effects of HMOs on Adult Gut Microbiome Lars Bode, PhD discusses the health benefits of Human Milk Oligosaccharides (HMOs) and how research has shown ways HMOs can effect the adult microbiome. Positive effects are seen specifically in breastfed infants, where it has been identified to raise levels of two prime fucosyllactose (2′FL).
- [Human Milk Oligosaccharides: Natural Prebiotics and More -Part 1](https://www.metagenicsinstitute.com/video/human-milk-oligosaccharides/) - [Video - 20min.] Human Milk Oligosaccharides (HMOs) - Part 1 of 2. UCSD Prof. of Pediatrics explains the role of HMOs as prebiotics and anti-adhesion molecules.
- [Human Milk Oligosaccharides: Natural Prebiotics and More -Part 2](https://www.metagenicsinstitute.com/video/human-milk-oligosaccharides-natural-prebiotics-2/) - [Video - 25min.] Human Milk Oligosaccharides (HMOs) - Part 2 of 2. UCSD Prof. of Pediatrics explains the role of HMOs and their potential in medicine.
- [Dietary Effects on the Microbiome](https://www.metagenicsinstitute.com/video/dietary-effects-on-the-microbiome/) - [Video] Lars Bode, PhD presentation covers objectives such as identifying early feeding as a driver for microbiome development & compares HMOs with infant formula.
- [Are All Formulations of Specialized Pro-Resolving Mediators (SPMs) Supplementation the Same?](https://www.metagenicsinstitute.com/video/formulations-spm-supplementation/) - 15. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD In this short video, Dr. Charles Serhan discusses the differences between specialized pro-resolving mediators (SPMs) formulations for clinical application. He indicates that different product formulations must be assessed for efficacy for specific uses. Further, SPMs themselves are natural molecules and are
- [Weight Management: Is Fat the Secret Weapon? (Part 2)](https://www.metagenicsinstitute.com/video/introduction-nutritional-ketosis-clinical-applications-fat-secret-weapon/) - In Part 2 of this 2-part series, ketogenic diet expert Jeff Volek, PhD, RD, reviews the critical need for nutritionally based management options in obesity treatment. Dr. Volek discusses the ketogenic diet and its safety, efficacy, and outcomes in patients with obesity. In this presentation you will learn how to personalize and implement a safe
- [Intro to Nutritional Ketosis and Clinical Applications (Part 1)](https://www.metagenicsinstitute.com/video/introduction-nutritional-ketosis-clinical-applications/) - In Part 1 of this 2-part series, Jeff Volek, PhD, RD reviews the concept of ketogenesis, nutritional ketosis, and keto-adaptation. He discusses the utility of ketogenic diets in clinical practice and the potential benefits of the ketogenic approach to enhance physical performance, manage inflammation, and improve lifespan. Dr. Volek is a Professor in the Department of
- [Obesity Programs: Is Fat the Secret to Greater Success?](https://www.metagenicsinstitute.com/video/obesity-programs-fat-secret-greater-success/) - Diabetes, heart disease, and other metabolic issues are on the rise worldwide and are strongly associated with obesity. A growing body of research indicates that the ketogenic diet and keto-adaptation may play a role in mitigating metabolic dysfunction and related chronic disease concerns. In this talk, ketogenic diet researcher and expert Jeff Volek, PhD, RD
- [Food & Mood: Scientific Understanding and Clinical Strategies for Eating Issues Related to Obesity](https://www.metagenicsinstitute.com/video/scientific-understanding-clinical-strategies-eating-issues-related-obesity/) - Over 75% of overeating can be attributed to emotional factors. Lifestyle habits can translate into an obese phenotype, but understanding the psychological underpinnings of food choices and obesity is crucial to effective obesity management. Deanna Minich, PhD, CNS, FACN, IFMCP is a Functional Medicine-trained clinician and researcher with a unique approach that combines physiology and
- [Supplementing the Diet with SPMs](https://www.metagenicsinstitute.com/video/supplementing-diet-spms-charles-serhan-phd/) - 1. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD If already taking fish oils, is there a need to supplement with specialized pro-resolving mediators (SPMs)? In this video, Dr. Charles Serhan presents insights on inflammation from the Metagenics Lifestyle Summit in September 2015. Dr. Serhan is a distinguished researcher and
- [Supporting Endothelial Function with Targeted Nutrition: Video Animation](https://www.metagenicsinstitute.com/video/optimizing-endothelial-function-targeted-nutrition/) - Cardiovascular function can be strategically supported via targeted nutritional factors that support nitric oxide (NO) synthesis, which is essential for healthy endothelial function and blood flow. Arginine, citrulline, cocoa polyphenols, folate, vitamin C, and magnesium help protect and maintain NO synthesis, and therefore, preserve healthy endothelial function and blood flow. This endothelial health animation video
- [Novel Medical Nutrition Therapy for Glucose Control](https://www.metagenicsinstitute.com/video/novel-medical-nutrition-therapy-for-glucose-control/) - Robin Walsh, ND discusses the nutritional factors associated with the development of diabetes and obesity. Recent studies have shown that nearly 60% of the population has a genetic predisposition for developing diabetes. Dr. Walsh presents the many factors that lead to carbohydrate intolerance, insulin resistance and diabetic comorbidities. With the development of the 40:30:30 dietary approach created in
- [Precision Medicine: Tools for Patient Success](https://www.metagenicsinstitute.com/video/precision-medicine-tools-patient-success/) - The application of precision medicine in integrative healthcare Jennifer Stagg, ND Jennifer Stagg, ND discusses methods and application for precision medicine in an integrative healthcare setting. Dr. Stagg explores how you can utilize advances in genomics and epigenetics in health promotion and preventative care. She includes recent clinical case studies focused on incorporating genomic wellness testing, telomere length
- [Saturated Fat as Compared to Unsaturated Fats](https://www.metagenicsinstitute.com/video/saturated-fat-as-compared-to-unsaturated-fats/) - Dr. Frank Hu is a professor of nutrition, epidemiology, and medicine at the Harvard T.H. Chan School of Public Health and Harvard Medical School. In this presentation, he discusses the relationship between saturated and unsaturated fats, sources of carbohydrates, and risk of cardiovascular disease. There have been recent sensationalist headlines on the role of fat
- [An Overview of the Human Microbiome](https://www.metagenicsinstitute.com/video/overview-of-the-human-microbiome/) - In this video, Dr. Fergus Shanahan presents “An Overview of the Human Microbiome.” Originally delivered at ASPEN in 2015, this presentation provides a glimpse of success stories in the past with microbiome, as well as a glimpse into the future of using probiotics as preventive and treatment-focused therapies. He chooses to discuss the microbiome as
- [Role of Nutrition in Naturopathic Medicine-Practical Approach](https://www.metagenicsinstitute.com/video/role-of-nutrition-in-naturopathic-medicine-practical-approach/) - In this presentation Jaclyn Chasse, ND and President of AANP discusses the role of nutrition in naturopathic medicine and how it has significantly changed over the years for the naturopathic doctor. Dr Chasse points out a few of the key diets that are used in managing nutrition today, among them are the ketogenic diet, the Mediterranean diet and the Paleo
- [Nutritional Guidance for Cognitive Decline](https://www.metagenicsinstitute.com/video/nutritional-guidance-for-cognitive-decline/) - Dale E Bredesen, MD, is the director of the Easton Center for Alzheimer’s Disease Research at the University of California, Los Angeles (UCLA). He is also the principal investigator in Alzheimer’s Disease at the center. Dr. Bredesen has taken a novel approach to clinical management of cognitive decline by integrating nutrition and lifestyle medicine into
- [Healthy Fats and Prevention of Cardiometabolic Diseases](https://www.metagenicsinstitute.com/video/healthy-fats-and-prevention-of-cardiometabolic-diseases/) - There is extensive evidence showing that the intake of healthy fats can reduce incidence of cardiovascular disease (CVD). Dr. Frank Hu of the Harvard T.H. Chan School of Public Health and professor of medicine at Harvard Medical School discusses the evidence from several studies showing the benefits of healthy oils and fats for reduction of
- [The Microbiota-Gut-Brain Axis: Shared Neurochemistry and Its Potential Role in Infection and Behavior](https://www.metagenicsinstitute.com/video/microbiota-gut-brain-axis/) - The purported roles of the microbiota is ever emerging, and the associated technology is rapidly changing, but what do we know today? In this presentation, Mark Lyte, PhD, MS, MT (ASCP) discusses, “The Microbiota-Gut-Brain Axis: Shared Neurochemistry and Its Potential Role in Infection and Behavior.” Dr. Lyte reviews recent literature on the microbiome, taking a
- [Healthy Fats & Fatty Acids: Current Dietary Recommendations and Popular Opinions - Part II](https://www.metagenicsinstitute.com/video/healthy-fats-fatty-acids-current-dietary-recommendations-and-popular-opinions-part-ii/) - Part two of Dr. Penny Kris-Etherton’s presentation entitled Clinical Evidence Supporting the Role of Healthy Fats to Reduce Cardiovascular (CVD) Risk Factors is shown in this presentation. Here, Dr. Kris-Etherton discusses more clinical trial evidence regarding the support of unsaturated fatty acids, new research on minor fatty acids, and how these recommendations can be applied
- [Healthy Fats & Fatty Acids: Current Dietary Recommendations and Popular Opinions - Part I](https://www.metagenicsinstitute.com/video/healthy-fats-fatty-acids-current-dietary-recommendations-and-popular-opinions-part-i/) - This presentation is the first in a two-part series on healthy fats and fatty acids presented by Penny Kris-Etherton, PhD, RD of the Department of Nutritional Sciences at Penn State University. In this part of the presentation, she discusses current dietary recommendations and popular opinions. Published just before the release of the 2015 USDA Dietary
- [Role of Specialized Pro-Resolving Mediators in the Resolution of Chronic Inflammation](https://www.metagenicsinstitute.com/video/specialized-pro-resolving-mediators-in-the-resolution-of-chronic-inflammation/) - In this webinar Jennifer Stagg, ND presents an overview of the use of SPMs in clinical practice. Her research shows that the use of SPMs bring about an effective resolution response to chronic and acute inflammation. Dr Stagg presents the causes of most inflammation in both young and old and the symptoms that are associated with
- [The Reality of Carbohydrate Intolerance](https://www.metagenicsinstitute.com/video/carbohydrate-intolerance/) - This webinar is by Osama Hamdy, MD is the medical director of the obesity clinical program at the Joslin Diabetes Center in Boston. He is also a professor of medicine at Harvard Medical School and works in the inpatient clinic at Joslin. He also created Joslin’s Why Wait program. This presentation is entitled, “The Reality
- [The National Nutrition Fat Experiment "Was it Successful?"](https://www.metagenicsinstitute.com/video/nutrition-fat-experiment/) - This webinar is by Dr. Osama Hamdy, the medical director of the obesity clinical program at the Joslin Diabetes Center in Boston. He is also a professor of medicine at Harvard Medical School and works in the inpatient clinic at Joslin. He also created Joslin’s Why Wait program. This presentation is entitled, “The National Nutrition
- [Protein Intake: The Myth and the Facts](https://www.metagenicsinstitute.com/video/protein-intake-myth-facts/) - This presentation by Dr. Osama Hamdy of the Joslin Diabetes Center in Boston, MA discusses the myth and the facts of protein intake. In general, for diabetic patients with normal renal function, protein should make up 15-20% of total energy intake and high protein diets are generally not recommended for diabetes patients. Dr. Hamdy also
- [Medical Nutrition Therapy for Prevention and Management of Diabetes](https://www.metagenicsinstitute.com/video/medical-nutrition-therapy-diabetes/) - This webinar is by Osama Hamdy, MD, PhD and is entitled “Medical Nutrition Therapy for Prevention and Management of Diabetes.” Dr. Hamdy is the Medical director of the Obesity Clinical Program and Director of Inpatient Diabetes Management at the Joslin Diabetes Center and an Assistant Professor of Medicine at Harvard Medical School. This is the
- [Optimal Lifestyle Intervention for Patients with Diabetes: The Joslin Why WAIT Model](https://www.metagenicsinstitute.com/video/patient-diabetes-intervention/) - This webinar is entitled “Optimal Lifestyle Intervention for Patients with Diabetes: The Joslin Why WAIT Model.” It is delivered by Osama Hamdy, the Medical Director of the Obesity Clinical Program at the Joslin Diabetes Center in Boston, and also the creator of the Why WAIT program, clinically proven to support weight loss and glucose control
- [Nutrition Revolution in the Prevention and Management of Obesity and Diabetes](https://www.metagenicsinstitute.com/video/obesity-diabetes-management/) - This webinar Dr. Osama Hamdy, the medical director of the obesity program at the Joslin Diabetes Center. This presentation is entitled, “Nutrition Revolution in the Prevention and Management of Obesity and Diabetes” and discusses the pathology of diabetes, specifically why it is the result of carbohydrate intolerance and glucose toxicity. Furthermore, he discusses the role
- [The Role of Gluten-Digesting Enzymes in Supporting Digestive Health](https://www.metagenicsinstitute.com/video/the-role-of-gluten-digesting-enzymes-in-supporting-digestive-health/) - In this live talk, Dr. Karin Wertz walks us through what gluten is, where it is found, and what role it plays in health. From gluten sensitivities to IBS, Dr. Wertz discusses the health implications, research, and diagnosis currently being explored regarding gluten related diseases Foods that say they are gluten free may still contain
- [Synbiotic Effects-Do They Make a Difference?](https://www.metagenicsinstitute.com/video/synbiotic-effects-make-difference-gail-cresci-phd-rd/) - In this video, Gail Cresci, PhD, RD, LD, CNSC from the Cleveland Clinic discusses the microbiome and whether synbiotics, synergistic combination of pre- and probiotics, make a difference. She covers the rationale for synbiotic use, synbiotic approaches, supporting evidence for health outcomes. Presented at ASPEN Clinical Nutrition Week 2015. View the Slide Deck
- [Novel Pro-Resolving Mediators and Mechanisms in Inflammation](https://www.metagenicsinstitute.com/video/novel-pro-resolving-mediators-mechanisms-inflammation/) - Novel Pro-Resolving Mediators and Mechanisms in Inflammation presented by Jesmond Dalli, PhD for ASPEN Clinical Nutrition Week 2015 This presentation, entitled Novel Pro-Resolving Mediators and Mechanisms in Inflammation: Immunoresolvents is delivered by Dr. Jesmond Dalli and Dr. Charles N. Serhan. They are preeminent researchers in the field of inflammation resolution and share their insights at
- [Systems Epidemiology Approach To Understanding Nutrition And Obesity and Diabetes](https://www.metagenicsinstitute.com/video/nutrition-obesity-diabetes-frank-hu/) - In this presentation made at The New York Academy of Sciences, Frank Hu, MD, PhD, Professor of Nutrition and Epidemiology at Harvard School of Public Health and Harvard Medical School, provides an edifying overview of the relationship between nutrition and metabolic diseases. Dr. Hu delves deep into systems epidemiology, which integrates a wide range of
- [Pain Management: Symptomatic Relief of Inflammation](https://www.metagenicsinstitute.com/video/pain-management-symptomatic-relief-inflammation/) - Pain Management: Symptomatic Relief of Inflammation: Robert Bonakdar, MD Inflammation impacts numerous systems and can be challenging to treat. In this talk Robert Bonakdar, MD Director of Pain Management at Scripps Center for Integrative Medicine, discusses these pathways and ways to approach the inflammatory response upstream to prevent silent and chronic inflammatory states. Understanding inflammation, its
- [The Cardiometabolic Consequences of Obesity and Nutritional Strategies for Prevention](https://www.metagenicsinstitute.com/video/cardiometabolic-consequences-obesity-nutritional-strategies-prevention/) - The Cardiometabolic Consequences of Obesity and Nutritional Strategies for Prevention - Frank Hu, MD, PhD The prevalence of obesity in the US has reached epidemic proportions. In this presentation, “The Cardiometabolic Consequences of Obesity and Nutritional Strategies for Prevention,” Frank Hu, MD, PhD, reviews high-quality research demonstrating the dietary contributors to weight gain and the
- [Total Patient Care Management: Knowing the Predisposition of Chronic Disease](https://www.metagenicsinstitute.com/video/total-patient-care-management-knowing-predisposition-chronic-disease/) - Total Patient Care Management: Knowing the Predisposition of Chronic Disease - Robert Martindale, MD, PhD In this presentation, “Total Patient Care Management: Knowing the Predisposition of Chronic Disease,” Robert Martindale, MD, PhD of Oregon Health & Science University discusses how to get ahead of chronic disease in an aging population by reviewing current research and
- [Obesity, Comorbidities & Weight Change Patterns](https://www.metagenicsinstitute.com/video/obesity-comorbidities-weight-change-patterns/) - Obesity, Comorbidities & Weight Change Patterns: Osama Hamdy, MD, PhD Obesity is on track to be the #1 killer in the US. Concurrent with the obesity epidemic is the rapidly growing diabetes epidemic. Environmental impact and lifestyle choices contribute to the high “diabesity” prevalence. Furthermore, epigenetic changes across generations are also playing a role. In
- [Inflammation & Resolution Physiology in Obesity](https://www.metagenicsinstitute.com/video/inflammation-resolution-physiology-obesity/) - Inflammation & Resolution Physiology in Obesity: Joan Clària, PhD Unresolved, low-grade chronic inflammation triggers adipose dysfunction and is the culprit of obesity comorbidities. In this presentation “Inflammation & Resolution Physiology in Obesity,” Joan Clària, PhD explores how the resolution phase of the inflammatory response can be leveraged to resolve inflammation chronicity. He discusses in vitro and
- [SPMs Now: Role in Adaptive Immunity](https://www.metagenicsinstitute.com/video/spms-now-newly-discovered-role-adaptive-immunity/) - In the 3rd part of a new SPM interview series, Charles Serhan, PhD, DSc answers the question: “Are there any recent findings or results in resolvins research that have surprised you?” Dr. Serhan discusses the recently discovered resolution role of specialized pro-resolving mediators (SPMs) in the adaptive immune response, including the regulation of B cell
- [SPMs Now: Role of Resolvins in Cancer](https://www.metagenicsinstitute.com/video/spms-now-role-resolvins-cancer/) - In the 5th part of the SPM interview series with Charles Serhan, PhD, DSc, he explores the latest research to answer the question: “What is the role of resolvins in cancer?” Listen in as Dr. Serhan shares the impact resolvins have on tumor debris clearance, tumor burden and cytotoxic agent use in animal models, as
- [SPMs & the Future of Clinical Decision Making](https://www.metagenicsinstitute.com/video/spms-future-clinical-decision-making/) - In the 6th part of the SPM interview series, Charles Serhan, PhD, DSc provides insights into the query: “What role do you envision lipid mediators and active resolution will play in future clinical decision-making?” Dr. Serhan shares an edifying history on resolvins, from molecular work following their discovery in 2000, to the growing body of in
- [Gut Microbiome in Health and Disease: Module 2](https://www.metagenicsinstitute.com/video/gut-microbiome-health-disease-module-2/) - Gail Cresci, PhD, RD, LD, CNSc: The Gut Microbiome in Health and Disease 2-part series, "Therapeutic Manipulations of Gut Microbiota – Module 2" In this module Dr. Gail Cresci discusses the therapeutic manipulations of gut microbiota, including methods for managing peptic ulcers. Dr. Cresci explores the use of fecal microbiota transplants to manage recurrent C. difficile
- [Gut Microbiome in Health and Disease: Module 1](https://www.metagenicsinstitute.com/video/gut-microbiome-health-disease-module-1/) - Gail Cresci, PhD, RD, LD, CNSc: The Gut Microbiome in Health and Disease 2-part series, “Diversity of the Gut Microbiota and the Host – Module 1” In this module Dr. Gail Cresci discusses the diversity of the gut microbiome and its influences on the host, as well as the associations of gut dysbiosis and synbiosis.
- [Synbiotic Effects and Target Uses of Probiotics](https://www.metagenicsinstitute.com/video/synbiotic-effects-target-uses-probiotics/) - In this presentation Gail Cresci, PhD, RD reviews how digestive health is enhanced when the gut microbiome is rich in diverse micro flora. This diversity is supported when preferred energy sources for the bacteria are available and support the viability of microbiota. The importance of these combinations lies in the fact that a metabolic environment
- [How Our Microbes Make Us Who We Are](https://www.metagenicsinstitute.com/video/rob-knight-phd-microbes-make-us/) - Rob Knight, PhD is a pioneer in the study of microbiomes, in humans, animals, and the environment. He says “the three pounds of microbes that you carry around with you might be more important than every single gene you carry around in your genome.” Dr. Knight is the author of a popular TED book, Follow
- [Dietary Fat: Should We Change Recommendations?](https://www.metagenicsinstitute.com/video/dietary-fat-should-we-change-recommendations/) - In this webinar, Dr. Osama Hamdy, the medical director of the obesity program at the Joslin Diabetes Center, discusses, “Dietary Fat: Should We Change Recommendations.” He begins with basic information on dietary fats. There are three types of lipids: free fatty acids, compound lipids (phospholipids, sterols/cholesterol). When we discuss fatty acids, we mean a chain of carbon
- [What Excites You About the SPMs Research You Are Involved In?](https://www.metagenicsinstitute.com/video/excites-spms-research-involved/) - Dr. Charles Serhan of Harvard Medical School discusses what excites him most about his research in inflammation resolution and specialized pro-resolving mediators, SPMs. He reveals that the opportunity for resolution of inflammation to leave the lab and enter clinical application is most exciting to him. Research and science about stimulating resolution of inflammation are now
- [HMOs and Gut Protection: Video Animation](https://www.metagenicsinstitute.com/video/enhancing-digestive-health-hmos-gut-protection/) - Prebiotics and Quality Carbohydrates: Enhancing Digestive Health Prebiotics are non-digestible carbohydrates that selectively stimulate the growth and activity of beneficial gut bacteria. Some beneficial gut bacterial can metabolize prebiotics, which gives them a growth advantage. Some prebiotics have more specialized benefits and can play a protective role in gut function. This is especially true for
- [Clinical Minute Consult: Prebiotic Focus on Human Milk Oligosaccharides](https://www.metagenicsinstitute.com/video/clinical-minute-consult-prebiotic-focus-human-milk-oligosaccharides/) - In this Clinical Minute, Nikky Contractor, PhD discusses oligosaccharides. 2’-fucosyllactose, also known as 2'-FL and pronounced “two F L,” is the most abundant human milk oligosaccharide (HMO) in human breast milk. Human milk contains many chemical structures that support the growth of beneficial bacteria in infants. The bacteria that are beneficial to infants are also
- [Translating Genetic Information in Nutrition Practice](https://www.metagenicsinstitute.com/video/translating-genetic-information-in-nutrition-practice/) - Frank Hu, MD, PhD at Nutrition Pro 2015: Translating Genetic Information in Nutrition Practice Dr. Frank Hu of the Harvard T.H. Chan School of Public Health discusses the role of genetic information, prediction of chronic disease, and nutrition interventions for improved health. This presentation comes from Nutrition Pro 2015 and contains valuable information for clinical
- [Women’s Health: Turning Down the Heat on Menopausal Transition](https://www.metagenicsinstitute.com/video/womens-health-turning-heat-menopausal-transition/) - What do we know about hormones for menopause? What are the risks and the benefits for women? Erika Schwartz, MD Chief Medical Officer at the Age Management Institute discusses the state of science and uses of hormone therapy for health concerns and improving quality of life. Dr. Schwartz also discusses the importance of preventative and
- [Probiotics: From Basic Science to Clinical Application -  Eamonn Quigley, MD](https://www.metagenicsinstitute.com/video/probiotics-basic-science-clinical-application-eamonn-quigley-md/) - This presentation, entitled, “Probiotics: From Basic Science to Clinical Application” was delivered by Eamon M Quigley, MD at the ASPEN Symposium in February 2015. Dr. Quigley is the Chief of the Division of Gastroenterology and Hepatology at Houston Methodist Hospital in Texas. His presentation begins with a definition of probiotics and discussion of the health
- [Dawn of the Era of Treatable Alzheimer’s Disease](https://www.metagenicsinstitute.com/video/cognitive-health-dawn-era-treatable-alzheimers-disease/) - In this video presentation, Dale Bredesen, MD presents on advances in Alzheimer’s disease research. He proposes that we are entering the era of treatable Alzheimer’s disease. He also discusses mild cognitive impairment (MCI) and subjective cognitive impairment (SCI), conditions that can be precursors to Alzheimer’s disease. Indeed, the opportunity exists to improve our cognition regardless
- [Significance of Resolution Physiology to Human Health](https://www.metagenicsinstitute.com/video/significance-resolution-physiology-human-health-charles-serhan-phd/) - Specialized pro-resolving mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, Metagenics Institute asks Dr. Charles Serhan of Harvard Medical School about the significance of resolution physiology in the healthcare system today. Dr. Serhan responded that while resolution physiology has been known for decades,
- [SPMs Now: Therapeutic Research Areas](https://www.metagenicsinstitute.com/video/spms-now-therapeutic-research-areas/) - In the 2nd part of a new SPM interview series, Charles Serhan, PhD, DSc answers the question: “Can you describe some therapeutic areas where specialized pro-resolving mediators are currently being investigated for clinical use?” Dr. Serhan discusses the most current therapeutic research assessing SPM efficacy, including pulmonary, cardiometabolic, vascular, joint and cognitive health, as well
- [Nutritional Management of Homocysteine: Annalouise O’Connor, PhD](https://www.metagenicsinstitute.com/video/nutritional-management-homocysteine-annalouise-oconnor-phd/) - In this video presentation Annalouise O’Connor, PhD provides an in-depth overview of homocysteine, its function in the human body and why it is clinically important, as well as the risk factors for raised homocysteine. Dr O’Connor describes the link between homocysteine and methylation, and the pathways involved in homocysteine metabolism for the function of SAM
- [Medical Nutrition Therapy: Alison Monette, RD, ND](https://www.metagenicsinstitute.com/video/medical-nutrition-therapy-alison-monette-rd-nd/) - In this video Allison Monette, RD, ND discusses how medical nutrition therapy help patients with diabetes and why it is important for all clinicians to integrate nutrition and lifestyle medicine into their practices.
- [Is There a Potential to Consume Too Much of Precursor Omega-3s (EPA and DHA)?](https://www.metagenicsinstitute.com/video/potential-consume-much-precursor-omega-3s-epa-dha/) - 12. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD Specialized pro-resolving mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. The precursors to SPMs are omega-3 essential fatty acids, EPA and DHA. In this short video with Dr. Charles Serhan of Harvard
- [Data Regarding Pre- and Post-Operative SPM Use](https://www.metagenicsinstitute.com/video/data-regarding-pre-post-operative-spm-use/) - Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. Inflammation exists in other settings as well, such as pre- and post-operative settings where healing will be necessary. Metagenics Institute asks Dr. Charles Serhan of Harvard Medical School if there is any data regarding pre- and
- [Are there Concerns Regarding Potential Excessive Intake of Pro-resolving Mediators?](https://www.metagenicsinstitute.com/video/concerns-regarding-potential-excessive-intake-pro-resolving-mediators/) - Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. The precursors to SPMs are Omega-3 essential fatty acids, EPA and DHA. In this short video with Dr. Charles Serhan of Harvard Medical School, MHICN inquires about whether it is possible for humans have excessive intake
- [Insights on SPM Dosing](https://www.metagenicsinstitute.com/video/insights-spm-dosing/) - While SPMs offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease, it is crucial to consider the correct amount of SPM for various clinical conditions. In this short video with Dr. Charles Serhan of Harvard Medical School, MHICN inquires about the correct dose of SPM in humans. Dr. Serhan
- [Can SPM Over-Supplementation Downregulate Endogenous Production?](https://www.metagenicsinstitute.com/video/can-spm-supplementation-downregulate-endogenous-production/) - This conversation took place at ASPEN Clinical Nutrition Week 2015 and was moderated by Robert Martindale, MD. In this video segment, he discusses the question, can over-supplementation of specialized pro-resolving mediators (SPMs) lead to pathway down-regulation. The conversation took place with Dr. Stephen McClave, Dr. Jesmond Dalli, and Dr. Todd Rice. The conversation is part
- [Fish Oils vs SPMs: What's the Difference?](https://www.metagenicsinstitute.com/video/fish-oils-vs-spms-whats-difference/) - ASPEN 2015 Inflammation: Fish Oils vs SPMs: What's the Difference? - 1 https://vimeo.com/131679216 Roundtable Symposia from ASPEN Clinical Nutrition Week 2015 Participating Speakers are: Robert G. Martindale, MD, PhD Stephen McClave, MD Jesmond Dalli, PhD Todd Rice, MD ASPEN Clinical Nutrition Week in February 2015 provided an excellent opportunity for experts in clinical nutrition to
- [Markers to Assess the Efficacy of SPMs?](https://www.metagenicsinstitute.com/video/markers-assess-efficacy-spms/) - Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, Metagenics Institute asks Dr. Charles Serhan of Harvard Medical School about some parameters or markers that can be used to assess the efficacy of SPMs. Dr. Serhan responds that indices have been
- [Are there Opportunities in Inflammatory Bowel Disease (IBD) for Treating with SPMs](https://www.metagenicsinstitute.com/video/opportunities-inflammatory-bowel-disease-ibd/) - We know that many health conditions have underlying chronic inflammation that can make disease management and treatment more complex. Inflammatory bowel conditions, such as IBD or Crohn’s Disease are closely related to inflammation. In this short video with Dr. Serhan of Harvard Medical School, Metagenics Institute inquires about the opportunities to treat IBD and Crohn’s

## Newsletter Archives

- [Newsletter: Blood Sugar Management 8/14/23](https://www.metagenicsinstitute.com/newsletter-archives/newsletter-blood-sugar-management-8-14-23/)
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- [Newsletter: Heart Health 11/24/21](https://www.metagenicsinstitute.com/newsletter-archives/newsletter-heart-health-11-24-21/) - Heart Health
- [Newsletter: Probiotics and Gut Health 10/27/21](https://www.metagenicsinstitute.com/newsletter-archives/newsletter-probiotics-10-27-21/)
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- [Newsletter: Ketogenic Diet for a Healthy Brain 7/7/21](https://www.metagenicsinstitute.com/newsletter-archives/newsletter-ketogenic-diet-7-7-21/) - Ketogenic Diet for a Healthy Brain
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- [Newsletter: Probiotics 3/17/21](https://www.metagenicsinstitute.com/newsletter-archives/newsletter-probiotics-3-17-21/) - Probiotics
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- [Newsletter: Top 5 Metagenics Institute Blog Posts of 2020 12/23/20](https://www.metagenicsinstitute.com/newsletter-archives/newsletter-top-5-metagenics-institute-blog-posts-of-2020-12-23-20/)
- [Newsletter: Endocannabinoid System and Palmitoylethanolamide 11/18/20](https://www.metagenicsinstitute.com/newsletter-archives/newsletter-11-18-20-10-ready-to-use-tools-available-for-your-practice/)
- [Newsletter: Mediterranean Diet 9/30/20](https://www.metagenicsinstitute.com/newsletter-archives/newsletter-mediterranean-diet-9-30-20/)
- [Newsletter: Latest SPM Science Updates 10/21/20](https://www.metagenicsinstitute.com/newsletter-archives/newsletter-10-21-spm-updates/)
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- [Weekly Newsletter 10/31/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-10-31-18/)
- [Weekly Newsletter 10/24/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-10-24-18/)
- [Weekly Newsletter 10/17/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-10-17-18/)
- [Weekly Newsletter 10/10/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-10-10-18/)
- [Weekly Newsletter 10/3/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-10-3-18/)
- [Weekly Newsletter 9/26/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-9-26-18/)
- [Weekly Newsletter 9/19/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-9-19-18/)
- [Weekly Newsletter 9/12/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-9-12-18/)
- [Weekly Newsletter 9/5/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-9-5-18/)
- [Weekly Newsletter 8/29/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-8-29-18/)
- [Weekly Newsletter 8/22/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-8-22-18/)
- [Weekly Newsletter 8/15/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-8-15-18/)
- [Weekly Newsletter 8/8/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-8-8-18/)
- [Weekly Newsletter 8/1/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-8-1-18/)
- [Weekly Newsletter 7/25/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-7-25-18/)
- [Weekly Newsletter 7/18/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-7-18-18/)
- [Weekly Newsletter 7/11/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-7-11-18/)
- [Weekly Newsletter 7/4/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-7-4-18/)
- [Weekly Newsletter 6/27/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-6-27-18/)
- [Weekly Newsletter 6/20/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-6-20-18/)
- [Weekly Newsletter 6/13/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-6-13-18/)
- [Weekly Newsletter 6/6/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-6-6-18/)
- [Weekly Newsletter 5/30/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-5-30-18/)
- [Weekly Newsletter 5/23/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-5-23-18/)
- [Weekly Newsletter 5/16/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-5-16-18/)
- [Weekly Newsletter 5/9/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-5-9-18/)
- [Weekly Newsletter 4/25/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-4-25-18/)
- [Weekly Newsletter 4/11/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-4-11-18/)
- [Weekly Newsletter 5/2/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-5-2-18/)
- [Weekly Newsletter 4/18/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-4-18-18/)
- [Weekly Newsletter 4/4/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-4-4-18/)
- [Weekly Newsletter 3/28/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-3-28-18/)
- [Weekly Newsletter 3/21/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-3-21-18/)
- [Weekly Newsletter 3/14/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-3-14-18/)
- [Weekly Newsletter 3/7/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-3-7-18/)
- [Weekly Newsletter 2/28/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-2-28-18/)
- [Weekly Newsletter 2/21/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-2-21-18/)
- [Weekly Newsletter 2/14/18](https://www.metagenicsinstitute.com/newsletter-archives/weekly-newsletter-2-14-18/)

## Science Reviews

- [Science Review: Comprehensive Benefits of Probiotic Strains on Women’s Gut, Immunity, Mind, Urogenital and Overall Health](https://www.metagenicsinstitute.com/ce-education/science-sheets/comprehensive-benefits-of-probiotic-strains-on-womens-gut-immunity-mind-urogenital-and-overall-health/)
- [Science Review: Comprehensive Benefits of Probiotic Strains on Gut Health and Immunity](https://www.metagenicsinstitute.com/ce-education/science-sheets/comprehensive-benefits-of-probiotic-strains-on-gut-health-and-immunity/) - This review focuses on two extensively researched strains: Lactobacillus acidophilus NCFM® and Bifidobacterium lactis Bi-07.
- [Science Review: Comprehensive Analysis of Fast-Acting and Safe Plant-Based Pain Relief](https://www.metagenicsinstitute.com/ce-education/science-sheets/comprehensive-analysis-of-fast-acting-and-safe-plant-based-pain-relief/)
- [Science Review: Integrative Approaches to General Wellness and Gut Health: Prebiotics, Probiotics, and Postbiotics](https://www.metagenicsinstitute.com/ce-education/science-sheets/integrative-approaches-to-general-wellness-and-gut-health/) - The gut microbiota is pivotal to health, impacting everything from metabolic functions to the immune system.
- [Science Review: Everyday Synbiotic for Wellbeing, Gut Health, & Immunity](https://www.metagenicsinstitute.com/ce-education/science-sheets/synbiotic-gut-health-immunity/)
- [Science Review: Plant Bioactives for Improving Occasional Stress and Sleeplessness](https://www.metagenicsinstitute.com/ce-education/science-sheets/plant-bioactives-for-improving-occasional-stress-and-sleeplessness/) - Plant Bioactives are helpful tools to support a healthy circadian rhythm. It is crucial for proper brain function, functioning, and development.
- [Science Review: (Bacterial Vaginosis) Lactobacilli Strains and their Effect on Women’s Urogenital Health](https://www.metagenicsinstitute.com/ce-education/science-sheets/urogenital-health/) - During a six-week study of 544 adult women ages 18-58 with bacterial vaginosis., a restitution of balanced vaginal microbiota was seen in 61.5%
- [Science Review: SPM Supplementation for Chronic Pain](https://www.metagenicsinstitute.com/ce-education/science-sheets/spm-supplementation-for-chronic-pain/) - A survey was conducted in Italy with the goal of evaluating the effects and safety of a specific specialized pro-resolving mediators (SPM) supplement on people with chronic pain.
- [Science Review: Akkermansia muciniphila Next-Gen Bacteria for Metabolic Health](https://www.metagenicsinstitute.com/ce-education/science-sheets/akkermansia-muciniphila-for-metabolic-health/) - Akkermansia muciniphila supports various bodily functions, such as energy, lipid, and glucose metabolism as well as immune responses.
- [Science Review: Berberine Research and Clinical Applications](https://www.metagenicsinstitute.com/ce-education/science-sheets/berberine-research-and-clinical-applications/) - Berberine has been used in traditional Chinese and Ayurvedic medicine for centuries for the treatment of indigestion, dysentery, and a wide range of infections.
- [Science Review: ERr 731®](https://www.metagenicsinstitute.com/ce-education/science-sheets/science-review-err-731/) - ERr 731 has been clinically demonstrated through extensive research including randomized controlled trials to safely and effectively reduce menopausal symptoms.
- [Science Review: Fast-Acting and Safe Pain Relief](https://www.metagenicsinstitute.com/ce-education/science-sheets/rhuleave-k-nsaids-pain-relief/) - Rhuleave-K™ contains safe ingredients, curcumin and Boswellia serrata (Boswellia). This clinically proven combination has been shown to help alleviate pain within 63 minutes.
- [Science Review: Estrogen Metabolism](https://www.metagenicsinstitute.com/ce-education/science-sheets/estrogen-metabolism/) - Various lifestyle and environmental factors can influence estrogen production, metabolism, and balance. These include poor diet, obesity, excess alcohol consumption & high insulin levels.
- [Science Review: Vitamins D and K](https://www.metagenicsinstitute.com/ce-education/science-sheets/science-review-vitamins-d-k/) - Vitamin D is an essential fat-soluble vitamin that acts as a steroid hormone and plays a central role in many components of our skeletal & extraskeletal health.
- [Science Review: Probiotic Strains for the Common Cold](https://www.metagenicsinstitute.com/ce-education/science-sheets/probiotic-strains-common-cold/) - Specific probiotic strains Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 reduce the duration of the common cold by 2.4 days in one study.
- [Science Review: Lactobacilli Strains for Immune and GI Health](https://www.metagenicsinstitute.com/ce-education/science-sheets/lactobacilli-strains-bifidobacteria/) - Stool testing showed that Lactobacilli species increased significantly and Bifidobacterium species increased but the change was not statistically significant.
- [Science Review: Probiotic Research and Clinical Benefits](https://www.metagenicsinstitute.com/ce-education/science-sheets/probiotic-benefits/) - As public awareness of probiotics continues to expand, it is important for healthcare practitioners to increase their understanding of probiotic research & use.
- [Science Review: Vaccine Response Modifying Factors](https://www.metagenicsinstitute.com/ce-education/science-sheets/vaccine-response-review/) - Numerous COVID-19 vaccines are being tested around the world, and billions of people will receive a COVID-19 vaccine in hopes of returning some normalcy to their lives and communities.
- [Science Review: Quieting the Inflammasome](https://www.metagenicsinstitute.com/ce-education/science-sheets/quieting-the-inflammasome/) - Inflammasomes are protein complexes, built by “ready-to-go” parts within a cell. Danger signals, such as an infection can trigger inflammasome assembly in as little as 10 minutes
- [Science Review: The Endocannabinoid System](https://www.metagenicsinstitute.com/ce-education/science-sheets/the-endocannabinoid-system/) - The endocannabinoid system or ECS, is an important physiological system involved in regulating and balancing numerous functions and processes in the human body.
- [Science Review: The Ketogenic Diet for Weight Management](https://www.metagenicsinstitute.com/ce-education/science-sheets/ketogenic-weight-management/) - The consumption of very low amounts of carbohydrate (
- [Science Review: The Endocannabinoid System and Palmitoylethanolamide (PEA)](https://www.metagenicsinstitute.com/ce-education/science-sheets/ecs-and-pea/) - The endocannabinoid system (ECS) is an important biological system that regulates and balances a wide range of physiological functions in the body.
- [Science Review: Modulation of Inflammatory Responses by Select Plant-Derived Ingredients](https://www.metagenicsinstitute.com/ce-education/science-sheets/modulation-inflammatory-responses-select-plant-derived-ingredients/)
- [Science Review: Magnesium L-Threonate](https://www.metagenicsinstitute.com/ce-education/science-sheets/science-review-magnesium-l-threonate/)
- [Science Review: Bifidobacterium lactis 420](https://www.metagenicsinstitute.com/ce-education/science-sheets/science-review-bifidobacterium-lactis-420/)
- [Science Review: Specialized Pro-Resolving Mediators](https://www.metagenicsinstitute.com/ce-education/science-sheets/science-review-specialized-pro-resolving-mediators/)
- [Science Review: The Ketogenic Diet](https://www.metagenicsinstitute.com/ce-education/science-sheets/science-review-ketogenic-diet/)
- [Science Review: Lactobacillus salivarius UCC118](https://www.metagenicsinstitute.com/ce-education/science-sheets/lactobacillus-ucc118/)
- [Science Review: Clinical Applications of EPA and DHA Consumption](https://www.metagenicsinstitute.com/ce-education/science-sheets/omega-fatty-acid/)
- [Science Review: Collagen](https://www.metagenicsinstitute.com/ce-education/science-sheets/keto-collagen/)
- [Science Review: Environmental Chemical Exposure and Weight Management](https://www.metagenicsinstitute.com/ce-education/science-sheets/chemical-exposure-weight-management/)
- [Science Review: Metabolic Effects of Medium-Chain Triglycerides](https://www.metagenicsinstitute.com/ce-education/science-sheets/metabolic-medium-chain-triglycerides/)
- [Science Review: Intermittent Fasting (IF) and Emerging Clinical Applications](https://www.metagenicsinstitute.com/ce-education/science-sheets/intermittent-fasting/)
- [Science Review: Indole-3-carbinol (I3C) and 3,3’-diindolylmethane (DIM)](https://www.metagenicsinstitute.com/ce-education/science-sheets/indole-3-carbinol-dim/)
- [Science Review: Meal Replacements in Weight Loss & Maintenance](https://www.metagenicsinstitute.com/ce-education/science-sheets/meal-replacements-weight-loss/)
- [Science Review: Weight Loss Maintenance](https://www.metagenicsinstitute.com/ce-education/science-sheets/weight-loss-maintenance/)
- [Science Review: Sulforaphane](https://www.metagenicsinstitute.com/ce-education/science-sheets/sulforaphane/)
- [Science Review: 2’Fucosyllactose](https://www.metagenicsinstitute.com/ce-education/science-sheets/science-review-2fucosyllactose/)

## Clinical Tools

- [Phytonutrients: Research Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/phytonutrients-research-review/) - Only in the past few decades has research revealed that plants produce a wide variety of phytochemicals, commonly referred to as phytonutrients.
- [Detoxification and Health: Research Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/detoxification-health-research-review/) - This Research Review explores toxin classes, their health impact, and how targeted nutrition can support balanced detoxification and health throughout life.
- [Vaccine Response Modifying Factors](https://www.metagenicsinstitute.com/ce-education/clinical-tools/vaccine-response/) - In the following paper we present information from peer-reviewed publications to educate providers on how factors such as age, sex, sleep, and mood can affect responses to vaccines. 
- [Infographic: The 3 Phases of Detoxification](https://www.metagenicsinstitute.com/ce-education/clinical-tools/3-phases-detoxification/) - The 3 phases of detox are the generation of water-soluble intermediaries, the neutralization of toxic water-soluble intermediaries, and the excretion of the neutralized intermediaries.
- [Diabetes Prevention Program Meal Plan: 1200/1500/1800](https://www.metagenicsinstitute.com/ce-education/clinical-tools/diabetes-prevention-program-meal-plan-1200-1500-1800/) - Part of the Diabetes Prevention Program: Tips and guidelines for diabetes prevention and treatment, including meal plans with caloric intake and suggested options for managing glycemic index Several studies have demonstrated the reduction in the development of diabetes with moderate weight loss that is sustained over a long period of time. Structured, intensive lifestyle programs
- [Modulation of Inflammatory Responses by Select Plant-Derived Ingredients: Slide Deck](https://www.metagenicsinstitute.com/ce-education/clinical-tools/modulation-inflammatory-responses-select-plant-derived-ingredients/) - Several figures delve into the biologic mechanisms of action of these constituents as they relate to local and systemic inflammation and pain.
- [Clinical Studies of Proprietary Specialized Pro-Resolving Mediators (SPM) Formula at a Glance](https://www.metagenicsinstitute.com/ce-education/clinical-tools/spm-clinical-studies/) - This document provides a summary of seven human clinical studies of a proprietary specialized pro-resolving mediators (SPM) formula.
- [Specialized Pro-Resolving Mediators a Novel Nutritional Approach to Resolve Inflammation: Brief Research Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/specialized-pro-resolving-mediators-novel-nutritional-approach-resolve-inflammation-brief-research-review/) - This research review on Specialized Pro-resolving Mediators (SPMs) covers a novel nutritional approach to resolve inflammation.
- [Specialized Pro-Resolving Mediators (SPMs): Research Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/specialized-pro-resolving-mediators-spms-research-review/) - Specialized pro-resolving mediators (SPMs) are produced from long-chain polyunsaturated fats, especially EPA and DHA.
- [Specialized Pro-Resolving Mediators  Emerging Area: Inflammation Resolution and Endometriosis](https://www.metagenicsinstitute.com/ce-education/clinical-tools/spm-endometriosis/) - In patients with endometriosis, the levels of specialized pro-resolving mediators (SPMs; specifically, LXA4) in their endometrial tissues are reduced.
- [Rhuleave-K™ for Modulation of Inflammation Resolution](https://www.metagenicsinstitute.com/ce-education/clinical-tools/rhuleave-k-inflammation-resolution/) - Rhuleave-K combines the plant extracts of Boswellia and curcumin in a highly-absorbable, rapid onset form offering comparable analgesia to acetaminophen.
- [Practitioner Guide: Restoring Vaginal Health](https://www.metagenicsinstitute.com/ce-education/clinical-tools/restoring-vaginal-health/) - Probiotics are healthy bacterial strains that not only improve the digestive system but also prevent & address urogenital infections and maintain vaginal health
- [Lactobacilli Strains for Immune and GI Health](https://www.metagenicsinstitute.com/ce-education/clinical-tools/lactobacilli-strains-immune-health/) - This summary of clinical trials includes research on one or more of the Lactobacilli strains acidophilus NCFM, Lactobacillus rhamnosus GG and HN001, and Lp-115.
- [Infographic: Hormone Function and Estrogen Dysregulation](https://www.metagenicsinstitute.com/ce-education/clinical-tools/estrogen-function/) - This downloadable infographic is a clinical tool that provides information on estrogen functions, HPG axis physiology, and factors that impact estrogen levels.
- [IHS 2018 Pre-Conference: Gut-Brain Axis & Cognitive Health](https://www.metagenicsinstitute.com/ce-education/clinical-tools/integrative-healthcare-symposium-ihs-2018-pre-conference-gut-brain-axis-cognitive-health/) - Navigating the Gut-Brain Axis to Optimize Cognitive Health Across the Lifespan.
- [Resolvins, SPMs and their Potential Roles in Metabolic Diseases](https://www.metagenicsinstitute.com/ce-education/clinical-tools/resolvins-spms-potential-roles-metabolic-diseases/) - Patients with a variety of inflammatory conditions & metabolic diseases can benefit from SPMs and improved inflammation resolution.
- [Management of Inflammatory Diseases with SPMs](https://www.metagenicsinstitute.com/ce-education/clinical-tools/management-inflammatory-diseases-spms/) - Acute inflammation is essential to health—and, so too, is its resolution. Pathologists divide acute inflammation into 2 parts: Initiation & Resolution.
- [Probiotic Strains for the Common Cold](https://www.metagenicsinstitute.com/ce-education/clinical-tools/probiotics-reduce-common-cold/) - Specific probiotic strains Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 reduce the duration of the common cold by 2.4 days in one study.
- [Lactobacillus plantarum 299v Beneficial for GI Function & Health: Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/lactobacillus-plantarum-299v-beneficial-gastrointestinal-function/) - In a large review of various Lactobacillus species, researchers found Lactobacilli efficacious for the treatment of some cancers, vaginal disorders & H. pylori.
- [Siberian Rhubarb and Menopause: Research Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/err731-menopause-research-review/) - In the Siberian Rhubarb and Menopause Research Review, the natural transition period of perimenopause and associated physiological changes are examined, with a focused look at vasomotor symptoms.
- [Sulforaphane and Its Many Uses: Slide Deck](https://www.metagenicsinstitute.com/ce-education/clinical-tools/sulforaphane-many-uses/) - Sulforaphane found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage has been associated with the up-regulation of antioxidant and detoxification enzymes in the body. Recent studies revealed an anti-inflammatory response in patients supplementing with sulforaphane. Clinical studies showed increased detoxification of carcinogens, an indirect increase of anti-oxidative cellular potential, and inhibition of
- [Xanthohumol: Research Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/xanthohumol-research-review/) - This Research Review explores the sources, bioavailability, and known biological effects of xanthohumol, with a focus on its anti-inflammatory properties.
- [The Science of Inflammation Resolution: Specialized Pro-Resolving Mediators Evidence Summary](https://www.metagenicsinstitute.com/ce-education/clinical-tools/spm-evidence-summary/) - Summary of the emerging preclinical evidence highlighting the impact of Specialized pro-resolving mediators in inflammation resolution in a range of focus areas
- [Highlights of the Body’s Detoxification Processes: Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/highlights-bodys-detoxification-processes/) - Detoxification in the body is often viewed as the removal of toxic or unneeded substances. While this is true, detoxification processes are more accurately described as highly coordinated metabolic processes which remove environmental toxin metabolites, as well as metabolites from daily consumption and biotransformation processes. These metabolic processes are operating throughout numerous body systems continuously,
- [SPM Emerging Area: Inflammation Resolution and Surgery](https://www.metagenicsinstitute.com/ce-education/clinical-tools/nflammation-resolution-surgery/) - The scientific rationale for perioperative inflammation management and emerging preclinical animal & cell data highlighting impact of SPMs in surgery recovery.
- [SPM Emerging Area: Inflammation Resolution and Neurological Conditions](https://www.metagenicsinstitute.com/ce-education/clinical-tools/spms-neurological-conditions/) - Individuals with Alzheimer’s disease have been shown to have reduced levels of SPMs in brain tissue, which are associated with cognitive function.
- [EPA and DHA: Research Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/epa-dha-research-review/) - EPA & DHA are long-chain polyunsaturated omega-3 fatty acids derived from marine sources, such as oily fish and fish oil.
- [Human Milk Oligosaccharides (HMOs): Research Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/human-milk-oligosaccharides-hmos-research-review/) - Human milk vs. other mammal milk is unique for its abundance of oligosaccharides, which are unique carbohydrate polymers. The Human Milk Oligosaccharides (HMO) Research Review examines the structure and functions of HMOs, which act as prebiotics, promoting the growth of beneficial gut microbiota and the production of short-chain fatty acids that create an environment that
- [MAPS Slide Deck Presentations: April 26-28, 2018 - Miami, FL](https://www.metagenicsinstitute.com/ce-education/clinical-tools/maps-slide-deck-presentations-april-26-2018-miami-fl/) - MAPS Slide Deck Presentations Dominic D'Agostino, PhD – Plant-Centric Keto Diet Dr. Dominic D’Agostino is Associate Professor of Molecular Pharmacology and Physiology at University of South Florida in Tampa, FL. View the slides Bridget Briggs, MD – Achieving Hormone Balance in Women’s Health: Address Your Patients’ Symptoms with Simple Detox Protocols Dr. Bridget Briggs is
- [Probiotic Strains LGG® and BB-12®: Research Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/probiotic-strains-lgg-bb-12-research-review/) - Probiotics from the Lactobacilli and Bifidobacteria genera are some of the most commonly studied and used. Two specific probiotic strains, Lactobacillus rhamnosus GG (LGG®)* and Bifidobacterium animalis subsp. lactis BB-12 (BB-12®)*, have been extensively researched for safety and efficacy, particularly in the pediatric population. The LGG® and BB-12® Research Review examines the clinical evidence for
- [B. animalis ssp. lactis 420 Probiotic and Body Weight Regulation: Slide Deck](https://www.metagenicsinstitute.com/ce-education/clinical-tools/b-animalis-ssp-lactis-420-body-weight-regulation/) - Over the past decade, increasing evidence has linked the intestinal microbiome with regulation of body weight and body fat mass. Preclinical research on the probiotic strain Bifidobacterium animalis ssp. lactis 420 (B420) demonstrates improved intestinal barrier function, satiety signaling, body weight, and body fat regulation. A 6-month clinical study in obese men and women demonstrated
- [Infographic: Female Fertility Assessment](https://www.metagenicsinstitute.com/ce-education/clinical-tools/fertility-hormones/) - This clinical tool explores the HPG axis, menstrual cycle, and factors that can negatively impact female hormones and fertility, plus assessment tools.
- [Infographic: Estrogen Metabolism and Nutritional Influences](https://www.metagenicsinstitute.com/ce-education/clinical-tools/estrogen-metabolism/) - This downloadable infographic is a clinical tool that helps you learn estrogen metabolism and detoxification, the estrobolome, and the impact of nutrition.
- [Chronic Systemic Inflammation Leads to Chronic Disease](https://www.metagenicsinstitute.com/ce-education/clinical-tools/chronic-systemic-inflammation-leads-chronic-disease/) - How does chronic inflammation reinforce and cause chronic disease? Inputs like a sedentary lifestyle, obesity, and aging are associated with chronic systems inflammation throughout the whole body. This infographic illustrates the cascade from the input to the system inflammation to the resultant disease state. Disease states associated with inflammation include type 2 diabetes, atherosclerosis, neurological
- [Specialized Pro-Resolving Mediators and Inflammation Resolution: Slide Deck](https://www.metagenicsinstitute.com/ce-education/clinical-tools/specialized-pro-resolving-mediators-inflammation-resolution-clinical-tool/) - Chronic inflammation is linked to many chronic diseases. The innate inflammatory response is comprised of two distinct, active phases: initiation and resolution. The resolution phase is coordinated by specialized pro-resolving mediators (SPMs). In this slide deck, you will learn about the history of SPM discovery, lipid mediator biosynthesis pathways, and hallmark activities of SPMs in
- [Infographic: Thyroid Function and Hypothyroidism](https://www.metagenicsinstitute.com/ce-education/clinical-tools/infographic-thyroid-function-hypothyroidism/) - Did you know?... Over 12% of the US population will develop a thyroid condition during their lifetime Up to 60% of individuals with thyroid disease are unaware of their condition Hypothyroidism is the 2nd most common endocrine disorder affecting women of reproductive age Thyroid hormone (TH) is essential for life and has numerous, critical functions
- [Food Talk, Unique Food Messages Influencing Heart Health and Diabetes: Clinical Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/food-talk-unique-food-messages-influencing-heart-health-diabetes/) - This clinical review covers the influence of various diets on overall health and how diet directly impacts cardiometabolic disease. Cardiometabolic disease, including coronary heart disease (CHD), stroke and type 2 diabetes (T2D), accounts for nearly 1 in 4 deaths annually in the United States, amounting to 702,308 deaths in 2012. This includes 371,266 CHD related deaths, 128,294
- [Resolution of Inflammation Reduces the Negative Effects of Inflammaging: Infographic](https://www.metagenicsinstitute.com/ce-education/clinical-tools/resolution-inflammation-reduces-negative-effects-inflammaging-infographic/) - Inflammaging is a term that describes how immune system function deteriorates as we age. In individuals, it is determined by a variety of interrelated genetic and environmental factors, also known as epigenetics. This infographic shows how our bodies can become susceptible to inflammating and its effects. When we are young, we typically have good resolution
- [Osher Center for Integrative Medicine 2018 Annual Integrative Medicine Pre-Conference](https://www.metagenicsinstitute.com/ce-education/clinical-tools/2018-annual-integrative-medicine-pre-conference/) - Osher Center for Integrative Medicine 2018 Annual Integrative Medicine Pre-Conference: Personalizing Cognitive Health for Optimal Outcomes Metagenics Institute sponsored the pre-conference “Personalizing Cognitive Health for Optimal Outcomes,” which took place on April 26, 2018 in Miami, FL at The University of Miami Miller School of Medicine’s Osher Center for Integrative Medicine’s Annual Integrative Medicine Conference.
- [The Role of Specialized Pro-Resolving Mediators (SPMs) on Inflammation](https://www.metagenicsinstitute.com/ce-education/clinical-tools/role-specialized-pro-resolving-mediators-spms-inflammation/) - Inflammation is a core defect of many common chronic diseases, but existing anti-inflammatory treatments are often ineffective in stopping inflammation and may actually contribute to delay resolution. In fact, inflammation is a natural process that arises and subsides, leaving tissue repaired and functioning as it was prior to injury and inflammatory response. SPMs are bioactive
- [A. niger Prolyl Endoprotease (AN-PEP) Enzyme: Research Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/niger-prolyl-endoprotease-pep-enzyme-research-review/) - Oral digestive enzymes are a useful adjunctive therapy for individuals avoiding dietary gluten as a result of gluten sensitivity, intolerance or celiac disease. Aspergillus niger prolyl endoprotease (AN-PEP) is an extensively studied, gluten-digesting enzyme that is naturally occurring from the A. niger microorganism. It is resistant to the pH extremes and endogenous digestive enzymes found
- [Inflammation is a Natural and Protective Response to Specific Insults](https://www.metagenicsinstitute.com/ce-education/clinical-tools/inflammation-natural-protective-response-specific-insults/) - While inflammation is at the root of all sorts of poor outcomes and diseases it isn’t the fault of inflammation itself. Indeed, inflammation is a natural and protective response to specific insults and injuries. Healthy inflammation resolves naturally when you get a cut, for example. When inflammation becomes chronic, however, it can become destructive to
- [Specialized Pro-Resolving Mediators (SPMs) Inflammation Resolution – Clinical Discussion](https://www.metagenicsinstitute.com/ce-education/clinical-tools/specialized-pro-resolving-mediators-spms-inflammation-resolution-clinical-discussion/) - Introducing a Novel Nutritional Therapy & Pathway for Addressing Resolution of Inflammation 1. Novel Solution and Pathway to Support Inflammatory Responses New Clinical Benefits to Resolve Inflammation Fills a Gap in Managing Inflammatory Responses 2. Independent yet Complementary Solutions to Managing Inflammatory Conditions Not Blocking, inhibiting or suppressing inflammation Resolves’ inflammation to avoid prolongation to chronic health
- [Multimodal Management of Patients with Moderate Alzheimer’s Disease: Slide Deck](https://www.metagenicsinstitute.com/ce-education/clinical-tools/multimodal-clinical-management-approach-patients-moderate-alzheimers-disease/) - In 2015, Xu Wang, PhD and colleagues conducted the first comprehensive systematic review and meta-analysis of risk and protective factors for Alzheimer’s Disease that could be modified via personal, clinical and public strategy. Their findings suggested an effective diet, relevant medications, appropriate biochemical exposures, psychological condition, preexisting disease and life-style changes may be promising options
- [Clinical Evidence Supporting the Role of Healthy Fats to Reduce CVD Risk: Slide Deck](https://www.metagenicsinstitute.com/ce-education/clinical-tools/clinical-evidence-supporting-role-healthy-fats-reduce-cvd-risk/) - There is extensive evidence showing that the intake of healthy fats can reduce incidence of cardiovascular disease (CVD). Penny Kris-Etherton, PhD, RD, FAH, FAHA, FNLA, FASN, CLS from Penn State University shows evidence from several studies showing the benefits of healthy oils and fats for reduction of CVD incidence and CVD risk factors. There is
- [Prediabetes Risk Assessment Tool](https://www.metagenicsinstitute.com/ce-education/clinical-tools/prediabetes-risk-assessment/) - The Ad Council, the Centers for Disease Control and Prevention, the American Medical Association, and the American Diabetes Association have joined forces on a new initiative to shed light on the prevalence of prediabetes among Americans. Prediabetes is a condition when individuals have elevated blood glucose, but not high enough to be diagnosed with type
- [Therapeutic Benefit of IMO Prebiotic Fibers in IBD: Clinical Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/therapeutic-benefit-isomalto-oligosaccharide-fiber-inflammatory-bowel-disease/) - IMOs are partially indigestible prebiotics made from maltose, a disaccharide found commonly in commercial products, barley, grains, miso, soy sauce, and starchy vegetables. Isomalto-oligosaccharides (IMOs) are short-chain carbohydrate starch-based oligosaccharides composed of branched alpha-1-4, and or alpha 1,6-glucosidic linkages. IMOs have therapeutic potential in the management of inflammatory bowel disease (IBD), and other digestive disorders,
- [Healthy BMI Reduces GERD and C. Diff Infections from PPI Overuse: Clinical Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/healthy-bmi-reduces-gerd-c-diff-infections-implicated-ppi-overuse/) - Positive associations have been found between rising obesity/body mass index (BMI) levels and Clostridium difficile infections (CDI) rates. Additionally, recent studies point to changes in the human microbiome as a potential mechanism for increased rates of CDI, along with the obvious increase in CDI prevalence associated with the use of proton pump inhibitors (PPIs) for gastroesophageal reflux disease
- [A Review of Factors Associated with Long-Term Weight Loss Success: Clinical Review](https://www.metagenicsinstitute.com/ce-education/clinical-tools/review-factors-associated-long-term-weight-loss-success/) - Maintaining a healthy weight is not easy, but it is possible. This clinical review covers various factors influencing successful long-term weight loss maintenance. The World Health Organization’s statistics indicate that most of the world’s population now lives in a country in which overweight and obesity contribute to more mortality than underweight. This trend has led to

## Accredited Continuing Education

- [American Association of Naturopathic Physicians (AANP)](https://www.metagenicsinstitute.com/ce-education/accredited-continuing-education/american-association-naturopathic-physicians-aanp/) - How to register for the American Association of Naturopathic Physicians (AANP) Continuing Education Follow these 5 easy steps: Step 1: Register and login on Metagenics Institute Step 2: Select one of the 3 modules you wish to start by clicking on the link in the list below Step 3: Once you have listened to the entire presentation,

## Nutrition Masters Courses

- [Nutrition Masters Course: Inflammation and Targeted Nutrition](https://www.metagenicsinstitute.com/ce-education/nutrition-master-courses/nutrition-masters-course-inflammation-targeted-nutrition/) - The science behind specialized pro-resolving mediators (SPMs) and their critical role in inflammation resolution is examined, along with emerging areas of SPM research.
- [Nutrition Masters Course: Omega-3 Fatty Acids](https://www.metagenicsinstitute.com/ce-education/nutrition-master-courses/nutrition-masters-course-omega-3-fatty-acids/) - In this Nutrition Masters Course on Omega-3 Fatty Acids, the biochemistry, functions, sources, recommendations, and status (i.e., nutrient gaps) are explored.
- [Nutrition Masters Course: The Endocannabinoid System (ECS)](https://www.metagenicsinstitute.com/ce-education/nutrition-master-courses/endocannabinoid-system-course/) - The Nutrition Masters Course on the endocannabinoid system (ECS) explores the ECS, a critical homeostatic regulator in the body.
- [Nutrition Masters Course: Probiotics](https://www.metagenicsinstitute.com/ce-education/nutrition-master-courses/probiotics/) - The piece begins with a brief history of intestinal microbiome science, including pioneering researchers in the fields of microbiology and immunology.
- [Nutrition Masters Course: Targeted Nutrition Therapy](https://www.metagenicsinstitute.com/ce-education/nutrition-master-courses/targeted-nutrition/) - This Nutrition Masters Course provides evidence basis for targeted nutrition therapy approaches for blood glucose management, dyslipidemia and gut health.
- [Nutrition Masters Course: Addressing HDL Dysfunction Through Functional Nutrition](https://www.metagenicsinstitute.com/ce-education/nutrition-master-courses/hdl-dysfunction/) - What happens when HDL particles become dysfunctional and why dysfunctional HDL is a cardiovascular risk easily overlooked?
- [Nutrition Masters Course: Ketogenic Program](https://www.metagenicsinstitute.com/ce-education/nutrition-master-courses/nutrition-masters-course-ketogenic-program/) - In this Nutrition Masters Course on the Ketogenic Program, you will glean insights on the ketogenic diet through an evidence-based research approach. First, the impact of dietary macronutrient composition in human health, with a focus on low-carbohydrate implementation, will be explored. Next, the physiology and mechanisms supporting ketogenic approaches and nutritional ketosis, along with the
- [Nutrition Masters Course: Estrogen Balance, Clearance, and Health](https://www.metagenicsinstitute.com/ce-education/nutrition-master-courses/estrogen-balance/) - Master key concepts on estrogen & health with this clinical tool—Nutrition Masters Course on estrogen balance, clearance, & health from Metagenics Institute.
- [Nutrition Masters Course: Perinatal Management in the 21st Century](https://www.metagenicsinstitute.com/ce-education/nutrition-master-courses/perinatal-care/) - Master key concepts on perinatal health with this Nutrition Masters Course on hormonal & nutritional concepts for preconception, prenatal, and postpartum care.

## Seminars

- [The Gut-GLP-1 Connection: Unlocking Mechanisms for Better Metabolic Health](https://www.metagenicsinstitute.com/ce-education/seminars/the-gut-glp-1-connection-unlocking-mechanisms-for-better-metabolic-health/) - The gut microbiome plays a crucial role in maintaining a healthy weight for individuals. Dysbiosis, a disruption of the gastrointestinal microbial composition by various stresses.

## Event Content

- [HDL Dysfunction: Wolf in Sheep’s Clothing: Mark Houston, MD – IHS 2020](https://www.metagenicsinstitute.com/ce-education/events/hdl-dysfunction-wolf-in-sheeps-clothing-mark-houston-md-ihs-2020/)
- [HDL Dysfunction Assessment and Protocol](https://www.metagenicsinstitute.com/ce-education/events/hdl-dysfunction-assessment-and-protocol/)

## Brain Body Protocol

- [SIBO Protocol](https://www.metagenicsinstitute.com/brain_body_protocol/sibo-protocol/)
- [Anxiety Protocol](https://www.metagenicsinstitute.com/brain_body_protocol/anxiety-protocol/)
- [Burnout Protocol](https://www.metagenicsinstitute.com/brain_body_protocol/burnout-protocol/)
- [Depression Protocol](https://www.metagenicsinstitute.com/brain_body_protocol/depression-protocol/)
- [Cognitive Decline Protocol](https://www.metagenicsinstitute.com/brain_body_protocol/cognitive-decline-protocol/)
- [Case Studies](https://www.metagenicsinstitute.com/brain_body_protocol/case-studies/)

## SPM Protocol

- [Immune Response Protocol](https://www.metagenicsinstitute.com/spm_protocol/immune-response-protocol/)
- [SPM and Fibromyalgia: Patient Brochure](https://www.metagenicsinstitute.com/spm_protocol/specialized-pro-resolving-mediators-spms-and-fibromyalgia-new-case-studies/)
- [SPM and Fibromyalgia Case Study: Group Summary](https://www.metagenicsinstitute.com/spm_protocol/case-study-group-summary/)

## Online Courses

- [Check back for future courses as they become available!](https://www.metagenicsinstitute.com/online-courses/check-back-for-future-courses-as-they-become-available/)

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- [Keto Diet](https://www.metagenicsinstitute.com/tag/keto-diet/)
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- [Vitamin K](https://www.metagenicsinstitute.com/tag/vitamin-k/)
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- [Vitamin C](https://www.metagenicsinstitute.com/tag/vitamin-c/)
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- [Cytokine storm](https://www.metagenicsinstitute.com/tag/cytokine-storm/)
- [GI issues](https://www.metagenicsinstitute.com/tag/gi-issues/)
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- [Green Tea Extract](https://www.metagenicsinstitute.com/tag/green-tea-extract/)
- [EGCG](https://www.metagenicsinstitute.com/tag/egcg/)
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- [Neurologic](https://www.metagenicsinstitute.com/tag/neurologic/)
- [brain health](https://www.metagenicsinstitute.com/tag/brain-health/)
- [mental health](https://www.metagenicsinstitute.com/tag/mental-health/)
- [SARS-CoV-2](https://www.metagenicsinstitute.com/tag/sars-cov-2/)
- [Central Nervous System](https://www.metagenicsinstitute.com/tag/central-nervous-system/)
- [Akkermansia muciniphila](https://www.metagenicsinstitute.com/tag/akkermansia-muciniphila/)
- [antibody testing](https://www.metagenicsinstitute.com/tag/antibody-testing/)
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- [Neuroinflammation](https://www.metagenicsinstitute.com/tag/neuroinflammation/)
- [Alzheimer’s disease](https://www.metagenicsinstitute.com/tag/alzheimers-disease/)
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- [antibacterial](https://www.metagenicsinstitute.com/tag/antibacterial/)
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- [nighttime hormonal renewal](https://www.metagenicsinstitute.com/tag/nighttime-hormonal-renewal/)
- [GLP-1 Therapy](https://www.metagenicsinstitute.com/tag/glp-1-therapy/)
- [Semaglutide](https://www.metagenicsinstitute.com/tag/semaglutide/)
- [tirzepatide](https://www.metagenicsinstitute.com/tag/tirzepatide/)
- [hepatic reslience](https://www.metagenicsinstitute.com/tag/hepatic-reslience/)
- [appetite](https://www.metagenicsinstitute.com/tag/appetite/)
- [GLP-1 nutritional support](https://www.metagenicsinstitute.com/tag/glp-1-nutritional-support/)
- [Muscle Recovery](https://www.metagenicsinstitute.com/tag/muscle-recovery/)
- [Magnesium glycinate](https://www.metagenicsinstitute.com/tag/magnesium-glycinate/)
- [magnesium citrate](https://www.metagenicsinstitute.com/tag/magnesium-citrate/)
- [magnesium deficiency](https://www.metagenicsinstitute.com/tag/magnesium-deficiency/)
- [magnesium supplements](https://www.metagenicsinstitute.com/tag/magnesium-supplements/)
- [botanical](https://www.metagenicsinstitute.com/tag/botanical/)
- [chronic pain](https://www.metagenicsinstitute.com/tag/chronic-pain/)
- [bone health](https://www.metagenicsinstitute.com/tag/bone-health/)
- [Calcium](https://www.metagenicsinstitute.com/tag/calcium/)
- [osteoporosis](https://www.metagenicsinstitute.com/tag/osteoporosis/)
- [creatine](https://www.metagenicsinstitute.com/tag/creatine/)
- [science](https://www.metagenicsinstitute.com/tag/science/)
- [reproductive health](https://www.metagenicsinstitute.com/tag/reproductive-health/)
- [b vitamins](https://www.metagenicsinstitute.com/tag/b-vitamins/)
- [redox](https://www.metagenicsinstitute.com/tag/redox/)
- [holiday](https://www.metagenicsinstitute.com/tag/holiday/)
- [detoxification](https://www.metagenicsinstitute.com/tag/detoxification/)
- [green tea](https://www.metagenicsinstitute.com/tag/green-tea/)
- [polyphenols](https://www.metagenicsinstitute.com/tag/polyphenols/)
- [milk thistle](https://www.metagenicsinstitute.com/tag/milk-thistle/)
- [glycine](https://www.metagenicsinstitute.com/tag/glycine/)
- [glutamine](https://www.metagenicsinstitute.com/tag/glutamine/)
- [elimination](https://www.metagenicsinstitute.com/tag/elimination/)
- [New Year](https://www.metagenicsinstitute.com/tag/new-year/)
- [juice cleanse](https://www.metagenicsinstitute.com/tag/juice-cleanse/)
- [hydration](https://www.metagenicsinstitute.com/tag/hydration/)

## Media Types

- [Articles](https://www.metagenicsinstitute.com/media-type/articles/)
- [Blogs](https://www.metagenicsinstitute.com/media-type/blogs/)
- [Grand Rounds](https://www.metagenicsinstitute.com/media-type/grand-rounds/)
- [MAPS](https://www.metagenicsinstitute.com/media-type/maps/)
- [Podcasts](https://www.metagenicsinstitute.com/media-type/podcasts/)
- [Publications](https://www.metagenicsinstitute.com/media-type/publications/)
- [Pulse Patrol](https://www.metagenicsinstitute.com/media-type/pulse-patrol/)
- [Roundtables](https://www.metagenicsinstitute.com/media-type/round-tables/)
- [Video](https://www.metagenicsinstitute.com/media-type/video/)

## Practitioner Specialties

- [Chiropractic](https://www.metagenicsinstitute.com/practitioner-specialties/chiropractic/)
- [Functional Medicine](https://www.metagenicsinstitute.com/practitioner-specialties/functional-medicine/)
- [Integrative](https://www.metagenicsinstitute.com/practitioner-specialties/integrative/)
- [Naturopathic](https://www.metagenicsinstitute.com/practitioner-specialties/naturopathic/)
- [Nutritionists](https://www.metagenicsinstitute.com/practitioner-specialties/nutritionists/)
- [Bariatric](https://www.metagenicsinstitute.com/practitioner-specialties/bariatric/)

## Health Categories

- [Cardiometabolic](https://www.metagenicsinstitute.com/health-category/cardiometabolic/)
- [Cognitive](https://www.metagenicsinstitute.com/health-category/cognitive/)
- [Digestive](https://www.metagenicsinstitute.com/health-category/digestive/)
- [Foundational](https://www.metagenicsinstitute.com/health-category/foundational/)
- [Musculoskeletal](https://www.metagenicsinstitute.com/health-category/musculoskeletal/)
- [Obesity](https://www.metagenicsinstitute.com/health-category/obestiy/)

## CE &amp; Education

- [MAPS](https://www.metagenicsinstitute.com/ce_education/maps/)
- [Publications](https://www.metagenicsinstitute.com/ce_education/publications/)