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Metagenics Institute Presents:
A Deep Dive into SPMs

There is a growing body of research on the use of specialized pro-resolving mediators (SPMs) as a key therapy for many different conditions. Unsure of how to use them in your clinical practice? Scroll down for the latest articles, videos, and tools available on this exciting therapy option.

1. Rethink Inflammation— How the scientific discovery of SPMs helped refine and reframe how clinicians manage inflammation

Overview article – (3200 words/20 minute read)


2. SPMs and Inflammation Resolution—Master Class On the two distinct phases of an inflammatory response, biosynthesis and functions of SPMs, and practice-based research results with SPMs

Slide deck

3. The Science and Clinical Application of SPMs—Webinar From SPM basic science to the clinical application of SPMs, presented by Erik Lundquist, MD

On-demand webinar replay from 2020 – (1 hour, 22 minutes)


4. Brief Science Review— Concise review of the science and potential clinical applications of SPMs

Downloadable PDF – (2 pages/10 minute read)

5. Evidence Summary— Current clinical evidence demonstrating inflammation resolution deficits in human conditions, and emerging preclinical evidence highlighting the impact of SPMs

Downloadable PDF (13 pages/60 minute read)


6. Inflammation Resolution & SPMs— The basics of SPMs for visual learners

Video animation (5 minutes)


Check out these blog posts:

Omega-3 Fats and SPMs as Powerful Immune Influencers

A deeper dive on omega-3 fats, omega-6 fats, and SPMs

SPMs to Combat Inflammatory States

A short read on how SPMs resolve inflammatory states

SPMs and Osteoarthritis (OA)

A short read on SPMs as an integral part of OA management

Additional videos:

SPMs & the Future of Clinical Decision Making

Hear directly from Charles Serhan, PhD, DSc, who pioneered SPM research

Role of SPMs in the Resolution of Chronic Inflammation

Overview of the use of SPMs in clinical practice, presented by Jennifer Stagg, ND

More clinical tools:

Clinical Studies of a Proprietary SPM Formula

Summary of seven human clinical studies of a SPM formula involving different patient types

SPM Emerging Area: Surgery

The scientific rationale for perioperative inflammation management with SPMs

SPM Emerging Area: Endometriosis

The scientific rationale of endometriosis management with SPMs