Chronic inflammation is linked to many chronic diseases. The innate inflammatory response is comprised of two distinct, active phases: initiation and resolution. The resolution phase is coordinated by specialized pro-resolving mediators (SPMs). In this slide deck, you will learn about the history of SPM discovery, lipid mediator biosynthesis pathways, and hallmark activities of SPMs in inflammation resolution. Areas where lipid mediator synthesis dysregulation exist are highlighted, and emerging areas of clinical pro-resolution research evidence are explored.