Specialized pro-resolving mediators (SPMs) are a group of lipid mediators that function as “resolution agonists” and actively coordinate the resolution of inflammation. Compared with healthy individuals, patients with many chronic inflammatory conditions have reduced levels of SPMs in circulation and in affected tissues. This suggests that resolution support is needed to bring this critical resolution system into balance.
In this document, we compile clinical evidence demonstrating resolution deficit in several human conditions (Table 1). We also summarize the emerging preclinical evidence highlighting the impact of specific SPMs in inflammation resolution in a range of focus areas (Table 2-8).