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SPM Emerging Area: Inflammation Resolution and Surgery

Surgery is an inflammatory event. Several clinical conditions are associated with reduced levels of specialized pro-resolving mediators (SPMs), and many patients with these chronic conditions can be candidates for surgery and are at greater risks of reduced resolution capacity before going in for surgery. Further, circulating SPMs have been shown to drop immediately postsurgery, and higher levels of inflammation around the time of surgery has been associated with increased risk of complication and poorer outcomes.

In this document, we describe the scientific rationale for perioperative inflammation management and summarize emerging preclinical animal and cell data highlighting impact of SPMs in aspects of surgery recovery.

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