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Chronic Systemic Inflammation Leads to Chronic Disease

How does chronic inflammation reinforce and cause chronic disease? Inputs like a sedentary lifestyle, obesity, and aging are associated with chronic systems inflammation throughout the whole body. This infographic illustrates the cascade from the input to the system inflammation to the resultant disease state. Disease states associated with inflammation include type 2 diabetes, atherosclerosis, neurological diseases like Alzheimer’s disease, cancer, and arthritis.

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Handschin C, Spiegelman BM. The role of exercise and PGC1alpha in inflammation and chronic disease. Nature. 2008;454(7203):463-469.

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