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Recent discoveries have identifed a class of lipid mediators, identifed in circulation and tissues throughout the body,1,2 known as specialized pro-resolving mediators, which function as ”resolution agonists” and actively coordinate the resolution of infammation.1-3 However, some individuals exhibit insufficient levels of endogenous specialized pro-resolving mediators—thought to be related to lifestyle behaviors, dietary choices, age, or negative health conditions—in response to an inflammatory challenge.1-3 As a result, the resolution activities can be negatively impacted, leading to an unresolved chronic inflammatory response.…

Recent discoveries have identifed a class of lipid mediators, identifed in circulation and tissues throughout the body,1,2 known as specialized pro-resolving mediators, which function as ”resolution agonists” and actively coordinate…

Introduction Increasing evidence is now pointing to a crucial factor that links the intestinal microbiome with regulation of body weight and body fat mass. Dysbiosis—an imbalance within the microbiome—is now recognized to have wide clinical impacts, with links established to a diverse set of adverse health conditions including obesity. Genomic content and diversity in the microbiome has been shown to be different in obese individuals as compared with lean individuals. A growing body of literature is supporting the use of…

Introduction Increasing evidence is now pointing to a crucial factor that links the intestinal microbiome with regulation of body weight and body fat mass. Dysbiosis—an imbalance within the microbiome—is now…

ERr 731® is a nonhormonal therapy to alleviate the uncomfortable symptoms of menopause, including hot flashes. With more than 30 years of safe, effective use in Europe (backed by decades of postmarketing surveillance data), ERr 731® has been clinically demonstrated, through extensive research, including randomized controlled trials, to safely and effectively reduce menopausal symptoms. 12-week randomized controlled trial (RCT) 109 perimenopausal women Heger M, et al. Menopause. 2006.1 At 12 weeks, ERr 731® group had a significant reduction in total…

ERr 731® is a nonhormonal therapy to alleviate the uncomfortable symptoms of menopause, including hot flashes. With more than 30 years of safe, effective use in Europe (backed by decades…

Magnesium L-threonate is the magnesium salt of a naturally occurring vitamin C metabolite L-threonic acid. Magnesium, a divalent cation, is important for neuronal activity as it is a co-factor for enzymes present in the neurons or glial cells.1,2 Magnesium and Cognitive Health Two observational studies found that individuals with a diet rich in magnesium have a lower risk of cognitive decline: 86% reduced risk in an Australian cohort of 1,400 elderly people between 60-72 years of developing mild cognitive impairment…

Magnesium L-threonate is the magnesium salt of a naturally occurring vitamin C metabolite L-threonic acid. Magnesium, a divalent cation, is important for neuronal activity as it is a co-factor for…

Inflammatory Immune Responses Inflammation is an essential biological response that may be triggered by a variety of stimuli, including tissue injury, pathogens, toxins, and oxidative stress. Inflammation underlies many normal physiologic processes, yet it also underlies many pathologic states—especially when inflammatory responses become excessive or chronic. Inflammation initiation pathways involve several enzymes, transcription factors, and signaling molecules (i.e., chemokines and cytokines) that can be modulated by a variety of agents, including select botanical ingredients. Mechanisms of Immunomodulation by Curcumin, Xanthohumol,…

Inflammatory Immune Responses Inflammation is an essential biological response that may be triggered by a variety of stimuli, including tissue injury, pathogens, toxins, and oxidative stress. Inflammation underlies many normal…

Human milk oligosaccharides (HMOs) are among the most abundant components in breast milk,1 and a growing body of research has shown they have diverse functions and are known to confer numerous health benefits and advantages to nursing infants. Emerging research has also shown that HMOs can promote health in adults, including those with gastrointestinal (GI) dysfunction. Out of approximately 200 distinct HMO structures identified to date, 2’Fucosyllactose (2’-FL) is the most abundantly produced HMO, with an average of 2.4 grams produced…

Human milk oligosaccharides (HMOs) are among the most abundant components in breast milk,1 and a growing body of research has shown they have diverse functions and are known to confer numerous…

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