Akkermansia muciniphila is a unique mucin-loving keystone species residing in the human gastrointestinal tract, purportedly offering health benefits, especially in the realms of metabolic health and obesity.1 Clinical investigations exploring A. muciniphila supplementation in overweight and obese cohorts seek to elucidate its potential impact on metabolic parameters, adiposity, and other health metrics. Studies consistently show reduced abundance in obesity, type 2 diabetes, high blood pressure, and other metabolic conditions.2 Intervention studies in animals demonstrated A. muciniphila administration reversed high-fat diet-induced metabolic disorders,…

by Melissa Blake, ND Introduction The COVID-19 pandemic has raised many clinical questions that we do not yet have clear answers for. What does appear to be clear is the connection between metabolic health and disease risk. In particular, obesity poses a significant increased risk of infection and mortality, with statistics suggesting its presence in nearly half of hospitalized or deceased COVID-19 patients.1 As our waistlines expand, so too does the incidence of diabetes.2,3 Preexisting type 2 diabetes (T2D) has…

Host: Deanna Minich, PhD Guest: Erik Lundquist, MD In this discussion, Erik Lundquist, MD and Deanna Minich, PhD explore thyroid physiology, assessment, and clinical pearls for treating patients with thyroid dysfunction or disorders. The crux of the discussion is treating the individual patient, not the labs. You will learn valuable insights and effective clinical strategies that Dr. Lundquist utilizes every day in his clinic to provide personalized support to patients with thyroid disorders. Dr. Lundquist shares that in his medical school…

by Sara Gottfried, MD, and Kari Hamrick, PhD, RD Polycystic ovary syndrome (PCOS) is a problem of hormone dysregulation that can lead to irregular menstrual cycles, high androgens, and its downstream sequelae such as acne and hirsutism, infertility, weight gain, and cardiovascular disease. As practitioners and their affected female patients anguish over the root cause and solutions, one part is very clear: up to 85% of women with PCOS are insufficient in vitamin D.1 For our patients with PCOS, correcting…

Host: Deanna Minich, PhD Guest: Kara Fitzgerald, ND In this discussion, Kara Fitzgerald, ND and Deanna Minich, PhD explore the active process of inflammation resolution and how to provide clinical support to quench inflammation chronicity in your patients. Dr. Fitzgerald thinks of inflammation broadly, as a complex immune response to a variety of inputs. The offensive input could be a pathogenic insult like a bacterial or viral infection, and the inflammatory response is acute and protective to the patient. But when…

by Lewis Chang, PhD and Noelle Patno, PhD New research continues to demonstrate that the benefits of probiotics are strain-specific,1 and their effects go beyond supporting digestive health. A recent example is the strain Bifidobacterium animalis ssp. lactis 420 (B420), which was previously shown in a 6-month randomized clinical trial to support weight management in adults affected by overweight or obesity.2 Recently, new data analysis from that study found other potentially beneficial metabolic benefits associated with B420.3 The original trial…

by Sara Gottfried, MD and Bianca Garilli, ND, IFMCP Introduction We’re just starting to understand the full spectrum of toxic threats to the human body, including obesity. What’s clear is that the body doesn’t know what to do with our myriad exposures to toxins. They clog the liver, then get stored in fat, and ultimately back up into the brain. Since the brain is almost two-thirds fat (the fattiest organ in the body), it makes sense that it’s likely the…

Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Deborah Maragopoulos, MN, FNP "The hypothalamus is like the CEO of your entire body. Everything else are workers." – Deborah Maragopoulos, MN, FNP In this edifying discussion, Deborah Maragopoulos, FNP and Deanna Minich, PhD explore the neuro-immune-endocrine system and how the hypothalamus, specifically, is at the core of many patients’ chronic health issues, from mood and metabolic disorders to insomnia and autoimmunity. Over 30+ years of working in healthcare, Deborah explains that her…