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Blogs, Cardiometabolic, Chiropractic, Foundational, Functional Medicine, Naturopathic

As the current pandemic rages on, several hundred clinical trials are recruiting and ongoing hoping to identify efficacious antiviral and anti-inflammatory strategies. In a new commentary published in the journal Cancer Metastasis and Reviews (Springer Nature publishing group),1 a group of prominent researchers proposed a promising, complementary direction worthy of consideration: targeting inflammation resolution. Who contributed to this commentary? The article was led by Dipak Panigrahy, MD, at Beth Israel Deaconess Medical Center of Harvard Medical School, who has had…

As the current pandemic rages on, several hundred clinical trials are recruiting and ongoing hoping to identify efficacious antiviral and anti-inflammatory strategies. In a new commentary published in the journal Cancer Metastasis and…

Blogs, Cardiometabolic, Foundational, Functional Medicine, Obesity

by Melissa Blake, ND Introduction The COVID-19 pandemic has raised many clinical questions that we do not yet have clear answers for. What does appear to be clear is the connection between metabolic health and disease risk. In particular, obesity poses a significant increased risk of infection and mortality, with statistics suggesting its presence in nearly half of hospitalized or deceased COVID-19 patients.1 As our waistlines expand, so too does the incidence of diabetes.2,3 Preexisting type 2 diabetes (T2D) has…

by Melissa Blake, ND Introduction The COVID-19 pandemic has raised many clinical questions that we do not yet have clear answers for. What does appear to be clear is the connection between metabolic…

Articles, Cardiometabolic, Foundational, Functional Medicine, Integrative

COVID-19 April 2, 2020 Update Currently, the diagnosis of SARS-CoV-2 infection heavily relies on RT-PCR-based viral RNA detection method. Although the test has high sensitivity (i.e., true positive rate), there are challenges with the test that may cause delay of a confirmed diagnosis, thereby impacting timing of treatment and ability to control further spread of the virus. Here are some variables: Test sample collected at different stage of infection: The viral RNA test has high sensitivity in the early stage…

COVID-19 April 2, 2020 Update Currently, the diagnosis of SARS-CoV-2 infection heavily relies on RT-PCR-based viral RNA detection method. Although the test has high sensitivity (i.e., true positive rate), there are challenges with…

Articles, Cardiometabolic, Foundational, Functional Medicine, Integrative

COVID-19 March 31, 2020 Update Keeping the immune system healthy is on most people’s minds during the current COVID-19 pandemic. According to epidemiological data, smoking increases susceptibility and severity of flu caused by the influenza virus.1 And experimental data have shown that cigarette smoke directly inhibits epithelial antiviral pathways and increases replication of influenza virus.2 There are also data showing higher mortality among smokers in the 2012 outbreak caused by a coronavirus known as MERS-CoV.3 However, as SARS-CoV-2 is a…

COVID-19 March 31, 2020 Update Keeping the immune system healthy is on most people’s minds during the current COVID-19 pandemic. According to epidemiological data, smoking increases susceptibility and severity of flu caused by…

Blogs, Cardiometabolic, Foundational, Functional Medicine

by Kara Fitzgerald, ND It looks like pyroptosis, a novel form of inflammatory cell death, may be a cause of the increased virulence of COVID-19 (although it was seen in SARS-CoV-1, too). Pyroptosis initiates the upregulation of inflammasome NLRP31 via caspase-1 proteases in the canonical pathway. Other caspases can also upregulate the inflammasome initiated by a variety of triggers. The end results of NLRP3 upregulation include IL-1β and IL-18 production and cell death. In COVID-19 patients, higher serum IL-1β (a…

by Kara Fitzgerald, ND It looks like pyroptosis, a novel form of inflammatory cell death, may be a cause of the increased virulence of COVID-19 (although it was seen in SARS-CoV-1, too). Pyroptosis…

Blogs, Cardiometabolic, Functional Medicine

by Lewis Chang, PhD 1 . What was observed among patients with COVID-19 infection? According to three recently published studies, the most common comorbidities in patients with COVID-19 are hypertension (high blood pressure) and diabetes; roughly 20-30% of them had hypertension, and 6-22% of them had diabetes.1-3 There are other comorbidities reported, such as coronary heart disease and cerebrovascular disease. But hypertension and diabetes appear to be the most common, at least based on currently available data. 2.  Do scientists…

by Lewis Chang, PhD 1 . What was observed among patients with COVID-19 infection? According to three recently published studies, the most common comorbidities in patients with COVID-19 are hypertension (high blood pressure)…

Blogs, Cardiometabolic, Functional Medicine

by Mark Houston, MD and Sara Gottfried, MD Abstract. Cardiovascular disease, the leading cause of death in the United States, is not a single disease. It encompasses three different pathophysiological processes that involve the heart or the blood vessels. When considering whether omega-3 fatty acids have any benefit for our cardiovascular system, there is an enormous amount of misinformation in the news and reputable medical journals. Several articles state that omega-3 fatty acids have no role in cardiovascular disease, but…

by Mark Houston, MD and Sara Gottfried, MD Abstract. Cardiovascular disease, the leading cause of death in the United States, is not a single disease. It encompasses three different pathophysiological processes that involve…

Studies show that 50-70% of men have their first heart attack before they have any chest pain.  There are two issues with the traditional treatment of LDL cholesterol. First, many people experience adverse effects with statin therapy, requiring alternative approaches via diet and supplements to get their LDL cholesterol levels under control. The second issue is LDL cholesterol evaluation. We need to be looking at LDL particle number and size as well as whether or not it’s been modified. LDL…

Studies show that 50-70% of men have their first heart attack before they have any chest pain.  There are two issues with the traditional treatment of LDL cholesterol. First, many people experience adverse…

Mark Houston, MD, MS, FAHA, FASH, DABC; Internist & Cardiovascular Specialist; Director, Hypertension Institute and Vascular Biology HDL cholesterol plays vital roles in lipid biology and coronary heart disease pathophysiology. The main function of HDL is to scavenge for and carry LDL cholesterol away from the arteries and back to the liver, for redistribution, metabolism, and excretion. A high HDL measurement was previously thought to represent high reverse cholesterol transport, conferring heart-protective benefits for patients. But newer research indicates a…

Mark Houston, MD, MS, FAHA, FASH, DABC; Internist & Cardiovascular Specialist; Director, Hypertension Institute and Vascular Biology HDL cholesterol plays vital roles in lipid biology and coronary heart disease pathophysiology. The main function…

Cardiometabolic, Functional Medicine, Video

Understand components and mechanisms of HDL particles, reverse cholesterol transport,  and how to treat dysfunctional HDL.  

Understand components and mechanisms of HDL particles, reverse cholesterol transport,  and how to treat dysfunctional HDL.  

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