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Specialized pro-resolving mediators (SPMs) are a group of lipid mediators that function as “resolution agonists” and actively coordinate the resolution of inflammation. Compared with healthy individuals, patients with many chronic inflammatory conditions have reduced levels of SPMs in circulation and in affected tissues. This suggests that resolution support is needed to bring this critical resolution system into balance. In this document, we compile clinical evidence demonstrating resolution deficit in several human conditions (Table 1). We also summarize the emerging preclinical…

Specialized pro-resolving mediators (SPMs) are a group of lipid mediators that function as “resolution agonists” and actively coordinate the resolution of inflammation. Compared with healthy individuals, patients with many chronic inflammatory conditions have…

Surgery is an inflammatory event. Several clinical conditions are associated with reduced levels of specialized pro-resolving mediators (SPMs), and many patients with these chronic conditions can be candidates for surgery and are at greater risks of reduced resolution capacity before going in for surgery. Further, circulating SPMs have been shown to drop immediately postsurgery, and higher levels of inflammation around the time of surgery has been associated with increased risk of complication and poorer outcomes. In this document, we describe…

Surgery is an inflammatory event. Several clinical conditions are associated with reduced levels of specialized pro-resolving mediators (SPMs), and many patients with these chronic conditions can be candidates for surgery and are at…

Neuroinflammation is a driving factor in neurodegeneration and the adverse response to brain injury. For instance, individuals with Alzheimer’s disease have been shown to have reduced levels of specialized pro-resolving mediators (SPMs) in brain tissue, which are associated with cognitive function. In this document, we describe the scientific rationale for addressing inflammation for management of neurological conditions and summarize emerging preclinical animal and cell data highlighting impact of SPMs in neurodegenerative conditions as well as in cognitive and neurological response…

Neuroinflammation is a driving factor in neurodegeneration and the adverse response to brain injury. For instance, individuals with Alzheimer’s disease have been shown to have reduced levels of specialized pro-resolving mediators (SPMs) in…

Endometriosis is a painful chronic inflammatory disorder impacting 10-15% of women of reproductive age. Endometrial lesions are major drivers of inflammation, leading to disruption of hormone regulation and immune function. In patients with endometriosis, the levels of specialized pro-resolving mediators (SPMs; specifically, LXA4) in their endometrial tissues are reduced. Given the link between endometriosis and chronic unresolved inflammation, assessing the impact of SPMs and pro-resolving therapies is a promising area of research. In this document, we describe the scientific rationale…

Endometriosis is a painful chronic inflammatory disorder impacting 10-15% of women of reproductive age. Endometrial lesions are major drivers of inflammation, leading to disruption of hormone regulation and immune function. In patients with…

Fertility challenges impact millions of couples around the globe. This Female Fertility Assessment explores the hypothalamic-pituitary-gonadal (HPG) axis, menstrual cycle, and a variety of factors that can negatively impact female hormonal homeostasis and fertility. Assessment tools, screening labs, and genes relevant to female fertility are also detailed. For more information, download the infographic

Fertility challenges impact millions of couples around the globe. This Female Fertility Assessment explores the hypothalamic-pituitary-gonadal (HPG) axis, menstrual cycle, and a variety of factors that can negatively impact female hormonal homeostasis and…

Estrogen affects the growth, differentiation, and function of numerous tissues throughout the female body—not just those involved in reproduction. Various lifestyle and environmental factors can influence estrogen production, metabolism, and balance. These include poor diet, obesity, excess alcohol consumption, certain medications, life stages (e.g., perimenopause), and overexposure to certain chemicals. Genetics are also at play. In this infographic, you will learn about: The functions of estrogen in the body Modifiable lifestyle factors that impact estrogen levels The physiology of the…

Estrogen affects the growth, differentiation, and function of numerous tissues throughout the female body—not just those involved in reproduction. Various lifestyle and environmental factors can influence estrogen production, metabolism, and balance. These include…

Estrogen is the primary hormone responsible for sexual and reproductive development in women. Once puberty begins, the body uses estrogen to regulate the first half of the menstrual cycle and then metabolizes the hormone for elimination via urination and defecation. The end of perimenopause is typified by a significant reduction in estrogen. Dietary and lifestyle modifications that support a healthy weight, like consuming a nutrient-dense dietary pattern (e.g., increasing intake of fiber and phytoestrogens) and being physically active, have been…

Estrogen is the primary hormone responsible for sexual and reproductive development in women. Once puberty begins, the body uses estrogen to regulate the first half of the menstrual cycle and then metabolizes the…

In the Siberian Rhubarb and Menopause Research Review, the natural transition period of perimenopause and associated physiological changes are examined, with a focused look at vasomotor symptoms like hot flushes. Pharmacologic and natural treatments for menopausal symptoms are detailed, including the safety and efficacy research that spans 30+ years for a unique phytoestrogen extract from the roots of Siberian rhubarb (Rheum rhaponticum L.) called ERr 731®, a non-hormonal therapy. View the Research Review to learn more

In the Siberian Rhubarb and Menopause Research Review, the natural transition period of perimenopause and associated physiological changes are examined, with a focused look at vasomotor symptoms like hot flushes. Pharmacologic and natural…

A growing body of literature suggests an association between toxicant exposure and the etiology of a number of chronic conditions. Optimizing the body's ability to manage and excrete toxins is essential for health. Minimizing toxin exposure is only one part of a successful strategy to decrease susceptibility to toxicity-related conditions. The Detoxification and Health Research Review explores toxin classes, their health impact, and how low-allergy-potential, targeted nutrition can support balanced detoxification and health throughout life. View the Research Review to…

A growing body of literature suggests an association between toxicant exposure and the etiology of a number of chronic conditions. Optimizing the body's ability to manage and excrete toxins is essential for health.…

Human milk vs. other mammal milk is unique for its abundance of oligosaccharides, which are unique carbohydrate polymers. The Human Milk Oligosaccharides (HMO) Research Review examines the structure and functions of HMOs, which act as prebiotics, promoting the growth of beneficial gut microbiota and the production of short-chain fatty acids that create an environment that discourages the growth of potential pathogens. HMOs also serve as antiadhesive antimicrobials, thus reducing the risk of infections, and have also been shown to modulate…

Human milk vs. other mammal milk is unique for its abundance of oligosaccharides, which are unique carbohydrate polymers. The Human Milk Oligosaccharides (HMO) Research Review examines the structure and functions of HMOs, which…

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