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Healthy BMI Reduces GERD and C. Diff Infections from PPI Overuse: Clinical Review

Positive associations have been found between rising obesity/body mass index (BMI) levels and Clostridium difficile infections (CDI) rates. Additionally, recent studies point to changes in the human microbiome as a potential mechanism for increased rates of CDI, along with the obvious increase in CDI prevalence associated with the use of proton pump inhibitors (PPIs) for gastroesophageal reflux disease (GERD), a common occurrence in those with elevated BMI.

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