Oral digestive enzymes are a useful adjunctive therapy for individuals avoiding dietary gluten as a result of gluten sensitivity, intolerance or celiac disease. Aspergillus niger prolyl endoprotease (AN-PEP) is an extensively studied, gluten-digesting enzyme that is naturally occurring from the A. niger microorganism. It is resistant to the pH extremes and endogenous digestive enzymes found in the gastrointestinal tract. The AN-PEP Research Review examines the purpose, origin, actions (i.e., breaking down gluten peptides and intact gluten proteins), and clinical study efficacy.
