In Q&A Part 1, Dr. Dominic D’Agostino shares his personal experience working with the US Navy to research the cellular and molecular mechanisms of oxygen toxicity seizures, which are a significant limitation for Navy SEAL fighters using special breathing apparatuses. This research allowed Dr. D’Agostino to unearth the unique benefits of nutritional ketosis to target energy metabolism pathways, thereby limiting seizures in Navy SEALs, even during times of oxidative stress. Dr. D’Agostino discusses the evidence basis for the ketogenic diet, not only for neuroprotection, but in metabolic disorders and cancer pathology. Dr. D’Agostino also explains how to utilize a ketogenic food plan to achieve a ketogenic state.
Originally aired September 13, 2018
Dominic D’Agostino, PhD is a neuroscience, molecular pharmacology, and physiology researcher with a vast array of professional, academic, and personal pursuits and achievements. As a tenured Associate Professor at the University of South Florida, Dr. D’Agostino teaches students at the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on neuropharmacology, medical biochemistry, physiology, cell metabolism, and signaling.
Dr. D’Agostino’s laboratory develops and tests metabolic-based strategies for targeting CNS oxygen toxicity (seizures), epilepsy, neurodegenerative diseases, and cancer. The main focus of his lab over the last decade has been understanding the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation. Dr. D’Agostino is also a Research Scientist at the Florida Institute for Human and Machine Cognition (IHMC), assisting with environmental medicine research efforts to optimize the safety, health, and resilience of the warfighter and astronaut. Dr. D’Agostino was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22). His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private sources, and foundations.
Dr. D’Agostino received his PhD in Physiology and Neuroscience from Rutgers University and Robert Wood Johnson Medical School and completed postdoctoral fellowships in molecular pharmacology and physiology at University of South Florida and in neuroscience at Boonshoft School of Medicine at Wright State University.
Watch a preview of the video series below.