by Bianca Garilli, ND Non-alcoholic fatty liver disease (NAFLD), the most common liver disorder in Western industrialized countries, can be categorized into two major groups – non-alcoholic fatty liver (NAFL), which is not associated with significant inflammation, and non-alcoholic steatohepatitis (NASH), which is associated with hepatic inflammation.1 Both of these conditions involve hepatic steatosis. The US prevalence of NAFLD is 10-46%.1,2 Worldwide, the prevalence is estimated to be between 6-35%, with some researchers noting up to 50% incidence in the…

by Lewis Chang, PhD A ketogenic diet is a dietary approach that promotes nutritional ketosis by restricting carbohydrates and increasing the intake of fat with adequate consumption of protein. According to systematic reviews and meta-analyses, ketogenic diets may prevent an increase in appetite on reduced calorie diets1 and help achieve long-term body weight reduction.2 Emerging studies have suggested that ketogenic diets may be beneficial in diabetes management and exercise performance.3,4 Compliance with ketogenic diets can be difficult because the amount…

by Bianca Garilli, ND Ketogenic protocols have become an important therapeutic option for a variety of health issues including weight management, cardiometabolic dysfunction, and epilepsy.1 The potential of the ketogenic diet (KD) to help optimize body mass has important implications for the reduction of metabolic syndrome and its related chronic disease aspects such as heart disease, fatty liver, and type 2 diabetes (T2D). Additionally, the ketogenic dietary approach has gained widespread attention within the professional sports performance and wellness communities…

by Bianca Garilli, ND Obesity, a preventable condition, has tripled worldwide since 1975, with 340 million children and adolescents between 5-19 years of age with overweight or obesity in 2016 according to the World Health Organization (WHO).1 In children and adolescents, BMI-for-age growth charts are used to determine weight status; >85th and <95th percentile is considered overweight, while ≥95th percentile is obese.2 In the US, overweight and obesity disproportionally affect children of low-income households, whereas the risk of overweight and…

There is a need to identify methods to complement and enhance compliance for the ketogenic diet in order to induce and sustain ketosis. Exogenous ketone supplementation, particularly with beta-hydroxybutyrate (βHB) salts, is one such method that has grown in commercial popularity, but clinical studies that test the efficacy and safety of exogenous ketones are lacking. A pilot study1 published in the Journal of Nutritional Health & Food Engineering assessed the circulating βHB blood (capillary) concentration in response to acute, oral βHB…

by Bianca Garilli, ND   Polyphenol Overview Polyphenols are naturally occurring secondary metabolites found in plants. In nature they protect against ultraviolet radiation and play a role in defending against pathogens. Over 8,000 polyphenolic compounds have been identified from a large variety of plant species.1 Based on the structure and number of phenol rings they contain, polyphenols are classified into 4 main groups: phenolic acids, flavonoids, stilbenes, and lignans.1 Phenolic Acids Phenolic acids are found extensively throughout the plant kingdom,…

by Ashley Jordan Ferira, PhD, RDN Autism spectrum disorder (ASD) is an urgent public health concern affecting approximately 1 in 59 US children.1-2 This complex neurodevelopmental syndrome is 4x more common in boys than girls and impacts all racial, ethnic, and socioeconomic backgrounds, although ASD is more common in white > black > Hispanic children.1 Other developmental, psychiatric, neurologic, chromosomal, and genetic diagnoses are known to co-occur with ASD,3-4 however, the genetic and epigenetic factors that impact autism pathogenesis are…