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GI Mucosal Adherence Mechanisms of a Probiotic Lactobacillus Strain 

Lactobacillus salivarius UCC118 is a well-characterized and evidence-based probiotic strain. A feeding study led by Fergus Shanahan, MD and his research group at the University College Cork was conducted in patients with ulcerative colitis.

This pilot-scale, open-label study aimed to determine the ability of L. salivarius UCC118 to adhere to human enterocyte epithelial cells. The bacterial strain was administered to patients with ulcerative colitis at ~109 CFU/day for 12 days. Biopsy specimen analyses demonstrated that the ingested bacteria effectively adhered to both inflamed and non-inflamed mucosa of the large bowel in significant numbers and adherence mechanisms were explored.

The results demonstrate the mechanistic evidence for UCC118’s gastrointestinal (GI) transit and adherence to intestinal mucosa.

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  1. Dunne C, Kelly P, O’Halloran S, et al. Mechanisms of adherence of a probiotic Lactobacillus strain during and after in vivo assessment in ulcerative colitis patients. Microb Ecol Health Dis. 2009;July:96-104.

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