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Cognitive, Functional Medicine, Video

In this interview, George Kunos, MD, PhD discusses the involvement of endocannabinoid system (ECS) in regulating addiction and reward. Dr. Kunos also describes the role of CB1 receptors in regulating body weight and metabolic control, and highlights the critical differences of blocking CB1 receptors in the periphery versus the brain. George Kunos, MD, PhD is the Scientific Director of the National Institute on Alcohol Abuse and Alcoholism at the National Institutes of Health From the 16th International Conference on Bioactive…

In this interview, George Kunos, MD, PhD discusses the involvement of endocannabinoid system (ECS) in regulating addiction and reward. Dr. Kunos also describes the role of CB1 receptors in regulating body weight and…

Cognitive, Functional Medicine, Video

In this interview, Cecilia Hillard, PhD discusses endocannabinoid system (ECS) signaling in depressive disorders. Dr. Hillard describes the effect of exercise on the ECS, and how this may underpin some of the benefits of exercise in patients with depression and other mood disorders. Dr. Hillard discusses emerging results in patients with post-traumatic stress disorder (PTSD) which show a different picture, and ends with a discussion on what we know about the role that the endocannabinoid receptors (CB1 and CB2) play…

In this interview, Cecilia Hillard, PhD discusses endocannabinoid system (ECS) signaling in depressive disorders. Dr. Hillard describes the effect of exercise on the ECS, and how this may underpin some of the benefits…

Blogs, Digestive, Nutritionists

by Noelle Patno, PhD What is lactoferrin? Lactoferrin is an iron-binding glycoprotein found in most body fluids (including saliva, tears, bile, small intestine secretions, vaginal secretions, and more) and highly similar across species. First identified in bovine milk in 1939, it was later isolated from human milk in 1960 and other fluids as well as blood plasma (specifically, the immune cells called neutrophils). The highest concentration may be found in human colostrum at 8 mg/mL with breast milk levels at…

by Noelle Patno, PhD What is lactoferrin? Lactoferrin is an iron-binding glycoprotein found in most body fluids (including saliva, tears, bile, small intestine secretions, vaginal secretions, and more) and highly similar across species.…

Blogs, Digestive, Functional Medicine

by Noelle Patno, PhD Lactoferrin (LF) has been advocated by researchers1–3 as a potential method to prevent or treat COVID-19. These recent reviews promote a hypothesis that the natural, endogenous compound which has shown antiviral capabilities for other viruses including SARS-CoV may be effective against the SARS-CoV-2 virus as well. With over 70 years since the discovery of this glycoprotein, this iron-scavenging milk protein now deserves greater attention. The current literature demonstrates that LF has many anti-inflammatory, immunomodulatory, and even…

by Noelle Patno, PhD Lactoferrin (LF) has been advocated by researchers1–3 as a potential method to prevent or treat COVID-19. These recent reviews promote a hypothesis that the natural, endogenous compound which has…

Digestive, Podcasts, Video

This is a recording of a presentation given by Dr. Noelle Patno and Dr. Jennifer Ryan in June 2020, at the “Next Gen Microbiome and Probiotics” virtual conference. This presentation includes an overview of specific microbiota, F. prausnitzii and A. muciniphila, that have been described as next generation microbes and bioindicators of health. Challenges for delivering these microbiota directly as probiotic supplements are also explained. Dietary modification, prebiotics, and supplementation with specific strains of Lactobacillus and Bifidobacterium are described as…

This is a recording of a presentation given by Dr. Noelle Patno and Dr. Jennifer Ryan in June 2020, at the “Next Gen Microbiome and Probiotics” virtual conference. This presentation includes an overview…

Cardiometabolic, Musculoskeletal, Video

In this interview, Professor Charles Serhan, PhD, DSc describes new work highlighting the connection between specialized pro-resolving mediators (SPMs) and the vagus nerve. Dr. Serhan reflects back at his proudest moments of his career, and on the most exciting recent developments. Finally, Dr. Serhan delivers a message on the state of resolution science today, and what is needed to advance SPM-based therapies in the future. Charles Serhan, PhD, DSc is Director of the Center for Experimental Therapeutics and Reperfusion Injury…

In this interview, Professor Charles Serhan, PhD, DSc describes new work highlighting the connection between specialized pro-resolving mediators (SPMs) and the vagus nerve. Dr. Serhan reflects back at his proudest moments of his…

Blogs, Cardiometabolic, Musculoskeletal

As part of this conversation, Gabrielle Fredman, PhD describes what is meant by the failure of resolution, and the mechanisms that can drive this failure in atherosclerosis. Dr. Fredman ends by outlining the potential for specialized pro-resolving mediator (SPM) therapies in the management of vascular disease. Gabrielle Fredman, PhD is Associate Professor at Albany Medical College, Department of Molecular and Cellular Physiology. From the 16th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases, October 2019 in St…

As part of this conversation, Gabrielle Fredman, PhD describes what is meant by the failure of resolution, and the mechanisms that can drive this failure in atherosclerosis. Dr. Fredman ends by outlining the…

Blogs, Cognitive, Functional Medicine

by Milene Brownlow, PhD Nutritional psychiatry is a rapidly growing medical field studying the connection between the role food and diet quality plays in  how we feel.1 We intuitively understand the body-mind connection and how it affects our day-to-day. We get butterflies in our stomach when nervous, our heart races when we are excited, and our mindset quickly goes south when we have digestive problems. This connection has led researchers to investigate lifestyle modifications that may optimize mental and cognitive…

by Milene Brownlow, PhD Nutritional psychiatry is a rapidly growing medical field studying the connection between the role food and diet quality plays in  how we feel.1 We intuitively understand the body-mind connection…

Blogs, Cognitive, Foundational

by Molly Knudsen, MS, RDN From a culinary perspective, mushrooms are a very polarizing food. You either love or despise them, and you either order a meal based on their inclusion or veer far away from it. There are rarely feelings of indifference. However, the notion that medicinal mushrooms are beneficial for health isn’t as divisive as their presence on the dinnerplate. Typically taken in as an extract, fungal varieties considered to be a medicinal mushroom have been used in…

by Molly Knudsen, MS, RDN From a culinary perspective, mushrooms are a very polarizing food. You either love or despise them, and you either order a meal based on their inclusion or veer…

Articles, Functional Medicine

Chemicals used in food packaging that can lower antibody responses in humans will be phased out starting in 2021. JAMA reported on the FDA announcement that several manufacturing companies have agreed to a voluntary phase-out per- and poly-fluoroalkyl substances (PFAS), which are used to keep fats from soaking into paper and cardboard food packaging.1 These chemicals are immunotoxic to humans and animals, harming the immune system directly.2 Their effects range from a mild reduction in antibody response levels (measured from…

Chemicals used in food packaging that can lower antibody responses in humans will be phased out starting in 2021. JAMA reported on the FDA announcement that several manufacturing companies have agreed to a…

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