Search Results for: spm

In this interview, Matthew Spite, PhD discusses his research on the intersection of inflammation resolution via specialized pro-resolving mediators (SPMs) and tissue repair.  He explains how their animal models demonstrate the ability of SPMs to promote tissue vascularization in cases of tissue injury or ischemia. Additionally, Dr. Spite elaborates on how Maresins can not only resolve inflammation but might also mitigate obesity, thus improving systematic metabolism. He is then asked to delve into his work concerning the role of Maresins…

In this interview, Edward Botchwey, PhD delves into the use of emerging technologies like metabolomics to identify insufficiencies in endogenous lipid mediators that may impact tissue healing. Dr. Botchwey outlines his research on synergizing bioengineering with traditional rehabilitation medicine, with the goal of delivering immunomodulatory compounds such as specialized pro-resolving mediators (SPMs) directly to the injured tissue to achieve satisfactory wound healing. Edward Botchwey, PhD, is a Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech…

In this interview, Dipak Panigraphy, MD discusses cytokine storms in both COVID-19 and cancer patients, emphasizing their potential to disrupt resolution of inflammation and contribute to unfavorable clinical outcomes. Dr. Panigraphy discusses how standard cancer treatments, including surgery and chemotherapy, may trigger cytokine storms, facilitating the spread of cancer in some patients. Lastly, he discusses his latest research, demonstrating the efficacy of specific specialized pro-resolving mediators (SPMs) molecules in promoting inflammation resolution and preventing treatment-induced metastasis in multiple preclinical cancer…

Patients with obesity suffer from chronic, low-grade inflammation.1 That’s partly due to dysfunctions in the ability to endogenously create specialized pro-resolving mediators (SPMs).1 SPMs communicate with immune cells, telling them the inflammatory process is no longer needed and to finish the job.2 However, in many conditions, including obesity, the capability to send these potent signaling molecules can diminish, and so too can their effects.1-3 As a result, inflammation smolders and further perpetuates a vast array of associated conditions such as…

As part of this conversation, Gabrielle Fredman, PhD describes what is meant by the failure of resolution, and the mechanisms that can drive this failure in atherosclerosis. Dr. Fredman ends by outlining the potential for specialized pro-resolving mediator (SPM) therapies in the management of vascular disease. Gabrielle Fredman, PhD is Associate Professor at Albany Medical College, Department of Molecular and Cellular Physiology. From the 16th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases, October 2019 in St…

In this Grand Rounds presentation, Niccolò Terrando, PhD shares scientific research on the role of specialized pro-resolving mediators (SPMs) in perioperative neurocognitive disorders. Dr. Terrando uses a preclinical mouse model to study postoperative neuroinflammation and elucidate the impact of SPMs in neuroglia activity and modulating memory.

Specialized pro-resolving mediators (SPMs) are a group of lipid mediators that function as “resolution agonists” and actively coordinate the resolution of inflammation. Compared with healthy individuals, patients with many chronic inflammatory conditions have reduced levels of SPMs in circulation and in affected tissues. This suggests that resolution support is needed to bring this critical resolution system into balance. In this document, we compile clinical evidence demonstrating resolution deficit in several human conditions (Table 1). We also summarize the emerging preclinical…

Endometriosis is a painful chronic inflammatory disorder impacting 10-15% of women of reproductive age. Endometrial lesions are major drivers of inflammation, leading to disruption of hormone regulation and immune function. In patients with endometriosis, the levels of specialized pro-resolving mediators (SPMs; specifically, LXA4) in their endometrial tissues are reduced. Given the link between endometriosis and chronic unresolved inflammation, assessing the impact of SPMs and pro-resolving therapies is a promising area of research. In this document, we describe the scientific rationale…

As the current pandemic rages on, several hundred clinical trials are recruiting and ongoing hoping to identify efficacious antiviral and anti-inflammatory strategies. In a new commentary published in the journal Cancer Metastasis and Reviews (Springer Nature publishing group),1 a group of prominent researchers proposed a promising, complementary direction worthy of consideration: targeting inflammation resolution. Who contributed to this commentary? The article was led by Dipak Panigrahy, MD, at Beth Israel Deaconess Medical Center of Harvard Medical School, who has had…