In this video presentation Annalouise O’Connor, PhD provides an in-depth overview of homocysteine, its function in the human body and why it is clinically important, as well as the risk factors for raised homocysteine. Dr O’Connor describes the link between homocysteine and methylation, and the pathways involved in homocysteine metabolism for the function of SAM and SAH. During the presentation, she covers specific nutritional supplementation for the management of raised homocysteine.