In this interview, George Kunos, MD, PhD discusses the involvement of endocannabinoid system (ECS) in regulating addiction and reward. Dr. Kunos also describes the role of CB1 receptors in regulating body weight and metabolic control, and highlights the critical differences of blocking CB1 receptors in the periphery versus the brain. George Kunos, MD, PhD is the Scientific Director of the National Institute on Alcohol Abuse and Alcoholism at the National Institutes of Health From the 16th International Conference on Bioactive…
In this interview, George Kunos, MD, PhD discusses the involvement of endocannabinoid system (ECS) in regulating addiction and reward. Dr. Kunos also describes the role of CB1 receptors in regulating body weight and…
In this interview, Cecilia Hillard, PhD discusses endocannabinoid system (ECS) signaling in depressive disorders. Dr. Hillard describes the effect of exercise on the ECS, and how this may underpin some of the benefits of exercise in patients with depression and other mood disorders. Dr. Hillard discusses emerging results in patients with post-traumatic stress disorder (PTSD) which show a different picture, and ends with a discussion on what we know about the role that the endocannabinoid receptors (CB1 and CB2) play…
In this interview, Cecilia Hillard, PhD discusses endocannabinoid system (ECS) signaling in depressive disorders. Dr. Hillard describes the effect of exercise on the ECS, and how this may underpin some of the benefits…
This is a recording of a presentation given by Dr. Noelle Patno and Dr. Jennifer Ryan in June 2020, at the “Next Gen Microbiome and Probiotics” virtual conference. This presentation includes an overview of specific microbiota, F. prausnitzii and A. muciniphila, that have been described as next generation microbes and bioindicators of health. Challenges for delivering these microbiota directly as probiotic supplements are also explained. Dietary modification, prebiotics, and supplementation with specific strains of Lactobacillus and Bifidobacterium are described as…
This is a recording of a presentation given by Dr. Noelle Patno and Dr. Jennifer Ryan in June 2020, at the “Next Gen Microbiome and Probiotics” virtual conference. This presentation includes an overview…
In this interview, Professor Charles Serhan, PhD, DSc describes new work highlighting the connection between specialized pro-resolving mediators (SPMs) and the vagus nerve. Dr. Serhan reflects back at his proudest moments of his career, and on the most exciting recent developments. Finally, Dr. Serhan delivers a message on the state of resolution science today, and what is needed to advance SPM-based therapies in the future. Charles Serhan, PhD, DSc is Director of the Center for Experimental Therapeutics and Reperfusion Injury…
In this interview, Professor Charles Serhan, PhD, DSc describes new work highlighting the connection between specialized pro-resolving mediators (SPMs) and the vagus nerve. Dr. Serhan reflects back at his proudest moments of his…
As part of this conversation, Gabrielle Fredman, PhD describes what is meant by the failure of resolution, and the mechanisms that can drive this failure in atherosclerosis. Dr. Fredman ends by outlining the potential for specialized pro-resolving mediator (SPM) therapies in the management of vascular disease. Gabrielle Fredman, PhD is Associate Professor at Albany Medical College, Department of Molecular and Cellular Physiology. From the 16th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases, October 2019 in St…
As part of this conversation, Gabrielle Fredman, PhD describes what is meant by the failure of resolution, and the mechanisms that can drive this failure in atherosclerosis. Dr. Fredman ends by outlining the…
In this Clinical Minute, Nikky Contractor, PhD discusses the most important factors for healthcare provider to consider when selecting a probiotic for their patient. Important strategies include: Make sure that the probiotic has been identified by its genus, species, and strain. Ensure that probiotics are used in a targeted way for a particular condition. Understand the clinical research that supports the use of a particular probiotic for a specific condition.
In this Clinical Minute, Nikky Contractor, PhD discusses the most important factors for healthcare provider to consider when selecting a probiotic for their patient. Important strategies include: Make sure that the probiotic has been…
Studies show that 50-70% of men have their first heart attack before they have any chest pain. There are two issues with the traditional treatment of LDL cholesterol. First, many people experience adverse effects with statin therapy, requiring alternative approaches via diet and supplements to get their LDL cholesterol levels under control. The second issue is LDL cholesterol evaluation. We need to be looking at LDL particle number and size as well as whether or not it’s been modified. LDL…
Studies show that 50-70% of men have their first heart attack before they have any chest pain. There are two issues with the traditional treatment of LDL cholesterol. First, many people experience adverse…
HDL cholesterol plays vital roles in lipid biology and coronary heart disease pathophysiology. The main function of HDL is to scavenge for and carry LDL cholesterol away from the arteries and back to the liver, for redistribution, metabolism, and excretion. A high HDL measurement was previously thought to represent high reverse cholesterol transport, conferring heart-protective benefits for patients. But newer research indicates a more complicated HDL picture—where five different HDL forms and unique functionalities are at play. In this MAPS…
HDL cholesterol plays vital roles in lipid biology and coronary heart disease pathophysiology. The main function of HDL is to scavenge for and carry LDL cholesterol away from the arteries and back to…
Understand components and mechanisms of HDL particles, reverse cholesterol transport, and how to treat dysfunctional HDL.
Understand components and mechanisms of HDL particles, reverse cholesterol transport, and how to treat dysfunctional HDL.
In recent years we have witnessed a groundswell of interest in the ketogenic diet. This concept of consuming certain types of high-fat foods (while reducing carbohydrates) to induce a physiological state called ketosis is a form of therapeutic nutrition that has been studied for decades in a variety of conditions. Cancer researchers have become very interested in the potential benefits a ketogenic approach might bring to oncology patients taking certain types of anti-cancer drugs. Why? Because initial experiments conducted in…
In recent years we have witnessed a groundswell of interest in the ketogenic diet. This concept of consuming certain types of high-fat foods (while reducing carbohydrates) to induce a physiological state called ketosis…