15. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD In this short video, Dr. Charles Serhan discusses the differences between specialized pro-resolving mediators (SPMs) formulations for clinical application. He indicates that different product formulations must be assessed for efficacy for specific uses. Further, SPMs themselves are natural molecules and are not all created equally. They are tissue-specific, so some promote tissue regeneration while others are more effective at phagocytosis, for example.

12. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD Specialized pro-resolving mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. The precursors to SPMs are omega-3 essential fatty acids, EPA and DHA. In this short video with Dr. Charles Serhan of Harvard Medical School, Metagenics Institute inquires about whether it is possible for humans to consume too much EPA and DHA. Dr. Serhan responds that it may…

Over 75% of overeating can be attributed to emotional factors. Lifestyle habits can translate into an obese phenotype, but understanding the psychological underpinnings of food choices and obesity is crucial to effective obesity management. Deanna Minich, PhD, CNS, FACN, IFMCP is a Functional Medicine-trained clinician and researcher with a unique approach that combines physiology and psychology. In this talk titled “Scientific Understanding and Clinical Strategies for Eating Issues Related to Obesity,” Dr. Minich explores the role of mood in food…

Obesity, Comorbidities & Weight Change Patterns: Osama Hamdy, MD, PhD Obesity is on track to be the #1 killer in the US. Concurrent with the obesity epidemic is the rapidly growing diabetes epidemic. Environmental impact and lifestyle choices contribute to the high “diabesity” prevalence. Furthermore, epigenetic changes across generations are also playing a role. In this presentation “Obesity, Comorbidities & Weight Change Patterns,” Osama Hamdy, MD, PhD, FACE, of the Joslin Diabetes Center at Harvard, explores the evolution of dietary…

Inflammation & Resolution Physiology in Obesity: Joan Clària, PhD Unresolved, low-grade chronic inflammation triggers adipose dysfunction and is the culprit of obesity comorbidities. In this presentation “Inflammation & Resolution Physiology in Obesity,” Joan Clària, PhD explores how the resolution phase of the inflammatory response can be leveraged to resolve inflammation chronicity. He discusses in vitro and in vivo research demonstrating the distinct biological properties, pathways and actions of omega-3 PUFAs vs. specialized pro-resolving mediators (SPMs) in targeting unresolved, inflamed adipose tissue.…

In this video Allison Monette, RD, ND discusses how medical nutrition therapy help patients with diabetes and why it is important for all clinicians to integrate nutrition and lifestyle medicine into their practices.

In this video presentation Annalouise O’Connor, PhD provides an in-depth overview of homocysteine, its function in the human body and why it is clinically important, as well as the risk factors for raised homocysteine. Dr O’Connor describes the link between homocysteine and methylation, and the pathways involved in homocysteine metabolism for the function of SAM and SAH. During the presentation, she covers specific nutritional supplementation for the management of raised homocysteine.

What tools exist to help prevent chronic inflammation and disease? In his talk “Start the Resolution: Stopping the Progression of Chronic Disease,” Robert Martindale, MD, PhD, Professor and Chief for the Division of GI and General Surgery at Oregon Health & Science University, explores the newest paradigm in metabolic mediation: inflammation resolution physiology. Dr. Martindale differentiates between anti-inflammatory and pro-resolution actions in the body. He delves into the unique roles that polyunsaturated fatty acids and a novel lipid mediator class,…

Osama Hamdy, MD, PhD is the Medical Director of the Obesity Clinical Program at the Joslin Diabetes Center in Boston and Professor of Medicine at Harvard Medical School. Dr. Hamdy  works in the inpatient clinic at Joslin and is the creator of the Joslin’s "Why Wait program." This presentation entitled “The Reality of Carbohydrate Intolerance” by Dr. Hamdy focuses on the clinical management of obese and diabetic patients. The video reviews the day to day practices that cause the epidemic…

In the first part of an interview series, Charles Serhan, PhD, DSc answers the question “How and when did you determine the significant of resolution physiology to human health?” Dr. Serhan shares an edifying history of resolution physiology: from early microscope observations of leukocytic infiltration, to the turning point lipoxin discoveries in the 1990s, to the latest research insights and inquiries today. Once thought to be a passive event mediated by chemokines, resolution is now known to be an active…