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Introduction Humans are constantly exposed to synthetic environmental chemicals found in household items, industrial products, pesticides, herbicides, plastics, flame retardants, paints, electrical equipment, cosmetics, and food preservatives. Many of these compounds are endocrine-disrupting chemicals (EDCs) that interfere with the endocrine system, including adipose tissue. EDCs may alter physiology during the whole life span of an individual, from fetal development to adulthood.1 Persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and bisphenol A (BPA) are the most well-known classes of…

Introduction Humans are constantly exposed to synthetic environmental chemicals found in household items, industrial products, pesticides, herbicides, plastics, flame retardants, paints, electrical equipment, cosmetics, and food preservatives. Many of these…

What is collagen? The most abundant structural protein in the body, collagen is responsible for the structure of skin, connective tissue, tendons, bones, and teeth. The major collagen types are I, II, and III, which form the structural fibrils of tissues.1     Download the PDF   Function As the main group of structural proteins of the extracellular matrix, collagen proteins form elastic molecular networks to strengthen tendons and elastic sheets that support skin and internal organs. They also function…

What is collagen? The most abundant structural protein in the body, collagen is responsible for the structure of skin, connective tissue, tendons, bones, and teeth. The major collagen types are…

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are long-chain omega-3 polyunsaturated fatty acids (PUFA). Biosynthesis of EPA and DHA from other fatty acids is poor, and as a result EPA and DHA are considered “conditionally essential” nutrients required in the diet for optimal health.1     Download the PDF   EPA and DHA nutrient gap On average, the daily intake of EPA and DHA, plus estimated EPA equivalents (endogenous biosynthesis from other fatty acids) from food and supplements, among American…

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are long-chain omega-3 polyunsaturated fatty acids (PUFA). Biosynthesis of EPA and DHA from other fatty acids is poor, and as a result EPA…

Lactobacillus rhamnosus GR-1® and Lactobacillus reuteri RC-14® are probiotic strains with clinically demonstrated effects on women’s urogenital health. The combination has shown positive benefits in women with bacterial vaginosis (BV), urinary tract infections (UTI), and vulvovaginal candidiasis (yeast).1     Download the PDF   L. rhamnosus GR-1 and L. reuteri RC-14 with Tinidazole in women diagnosed with BV In a randomized study of 64 women ages 16 to 51 years diagnosed with BV (confirmed by the Amsel criteria and the…

Lactobacillus rhamnosus GR-1® and Lactobacillus reuteri RC-14® are probiotic strains with clinically demonstrated effects on women’s urogenital health. The combination has shown positive benefits in women with bacterial vaginosis (BV),…

Introduction The development of probiotics targeted for their specific actions on host cells (including metabolism and intracellular signaling pathways) to confer targeted health benefits and outcomes represents a relatively recent advance in our understanding and use of beneficial bacteria for health. Lactobacillus salivarius UCC118 is a thoroughly researched probiotic selected for its effects on gut barrier function.     Download the PDF  

Introduction The development of probiotics targeted for their specific actions on host cells (including metabolism and intracellular signaling pathways) to confer targeted health benefits and outcomes represents a relatively recent…

Sulforaphane is a type of isothiocyanate and a metabolite of glucoraphanin—a phytonutrient found in cruciferous vegetables, such as broccoli, Brussels sprouts, and cabbage.1 Studies show that high consumption of cruciferous vegetables is associated with reduced risk of total and cardiovascular disease mortality.2     Download the PDF   Mechanism of Action Sulforaphane appears to be a potent activator of the cellular antioxidant pathway Keep1/Nrf2/ARE and other anti-inflammatory mechanisms, including inhibition of the Nfkb pathway (Figure 1).3-4 Sulforaphane works to protect…

Sulforaphane is a type of isothiocyanate and a metabolite of glucoraphanin—a phytonutrient found in cruciferous vegetables, such as broccoli, Brussels sprouts, and cabbage.1 Studies show that high consumption of cruciferous…

Ketosis is a natural metabolic state that occurs when there is an absence or shortage of dietary carbohydrates (sources of glucose) consumed as the main energy source for the body. While in ketosis, the body shifts to using fat as the primary energy source. The body increases the breakdown of fat into ketone bodies which are readily used by most tissues, including muscle and brain, as the main fuel.1     Download the PDF  

Ketosis is a natural metabolic state that occurs when there is an absence or shortage of dietary carbohydrates (sources of glucose) consumed as the main energy source for the body.…

Vitamin D Vitamin D is an essential, fat-soluble vitamin that acts as a steroid hormone and plays a central role in many components of our skeletal and extraskeletal health. Vitamin D is naturally present in some fish, mushrooms, and eggs; in select fortified foods such as milk products; and also in the form of dietary supplements and pharmaceuticals. It is also synthesized in the skin from 7-dehydrocholesterol when exposed to ultraviolet B (UVB) rays from sunlight.1     Download the…

Vitamin D Vitamin D is an essential, fat-soluble vitamin that acts as a steroid hormone and plays a central role in many components of our skeletal and extraskeletal health. Vitamin…

Recent discoveries have identified a class of lipid mediators, identified in circulation and tissues throughout the body,1,2 known as specialized pro-resolving mediators, which function as ”resolution agonists” and actively coordinate the resolution of inflammation1-3 However, some individuals exhibit insufficient levels of endogenous specialized pro-resolving mediators—thought to be related to lifestyle behaviors, dietary choices, age, or negative health conditions—in response to an inflammatory challenge.1-3 As a result, the resolution activities can be negatively impacted, leading to an unresolved chronic inflammatory response.…

Recent discoveries have identified a class of lipid mediators, identified in circulation and tissues throughout the body,1,2 known as specialized pro-resolving mediators, which function as ”resolution agonists” and actively coordinate…

Introduction Increasing evidence is now pointing to a crucial factor that links the intestinal microbiome with regulation of body weight and body fat mass. Dysbiosis—an imbalance within the microbiome—is now recognized to have wide clinical impacts, with links established to a diverse set of adverse health conditions including obesity. Genomic content and diversity in the microbiome has been shown to be different in obese individuals as compared with lean individuals.     Download the PDF   A growing body of…

Introduction Increasing evidence is now pointing to a crucial factor that links the intestinal microbiome with regulation of body weight and body fat mass. Dysbiosis—an imbalance within the microbiome—is now…

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