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Blogs, Digestive, Functional Medicine

by Melissa Blake, ND Introduction As clinicians, we all want to make effective, safe recommendations, and the evidence of safety is an essential consideration prior to prescribing an intervention. Safety of probiotics is no exception.  With evidence mounting on the many benefits and overall safety profile, it’s not surprising that probiotic supplementation quadrupled between 2007 and 2012.1 With a few considerations, probiotic therapy is generally accepted as safe and well-tolerated, particularly in healthy people. However, few studies have specifically addressed…

by Melissa Blake, ND Introduction As clinicians, we all want to make effective, safe recommendations, and the evidence of safety is an essential consideration prior to prescribing an intervention. Safety of probiotics is…

Blogs, Digestive, Functional Medicine

by Sara Gottfried, MD and Noelle Patno, PhD As our understanding of the gut microbiome expands, many questions remain about the clinical relevance—particularly how emerging concepts translate into the front lines of patient care, including best practices for probiotics. What is a probiotic? Why use one, and what are the most well-substantiated clinical situations in which they affect patient outcomes? What is the mechanism of action for probiotics? How do we know probiotics “work” in our patients? How can I…

by Sara Gottfried, MD and Noelle Patno, PhD As our understanding of the gut microbiome expands, many questions remain about the clinical relevance—particularly how emerging concepts translate into the front lines of patient…

Aberrant DNA methylation patterns underlie disease and aging. While some DNA methylation marks are durable and not subject to environmental influence, in many other biological areas, DNA methylation is malleable, which unlocks the opportunity for epigenetic impact—modifying gene expression. In this MAPS talk, Dr. Kara Fitzgerald shares vanguard research and pragmatic clinical insights on the modifiable nutrition-related and lifestyle factors that can either negatively or positively influence the methylome and, therefore, the health and longevity of patients. The full video…

Aberrant DNA methylation patterns underlie disease and aging. While some DNA methylation marks are durable and not subject to environmental influence, in many other biological areas, DNA methylation is malleable, which unlocks the…

Blogs, Cardiometabolic, Functional Medicine

by Mark Houston, MD and Sara Gottfried, MD Abstract. Hypertension is the most common and modifiable risk factor for cardiovascular disease. Rather than a disease, hypertension is a manifestation of an abnormal vascular system. Therein is both the problem and opportunity: we need a systems biology approach to address the root cause of hypertension and reduce our patient’s risk of cardiovascular disease. In 2017, new guidelines lowered the criteria for the diagnosis of hypertension from 140/90 to 130/80. As more patients…

by Mark Houston, MD and Sara Gottfried, MD Abstract. Hypertension is the most common and modifiable risk factor for cardiovascular disease. Rather than a disease, hypertension is a manifestation of an abnormal vascular system.…

Blogs, Digestive, Functional Medicine

by Melissa Blake, ND Introduction The use of probiotics has grown substantially over the last several years. Propelled by development in sequencing methods and analytical techniques, we are now able to identify and study specific probiotic strains. This had led to a significant increase in the understanding of the importance of a healthy microbiome and the various ways probiotic strains may influence human health.1 With this increase in demand and knowledge of potential benefit, it is important for healthcare practitioners…

by Melissa Blake, ND Introduction The use of probiotics has grown substantially over the last several years. Propelled by development in sequencing methods and analytical techniques, we are now able to identify and…

According to the World Health Organization, 350,000,000 people suffer from depression—that is 5% of the world’s population. Betty Murray explains that 47% of our population has a mutation in the 5-MTHFR gene and that this genetic variance contributes to anxiety and depression. She dives into pertinent biochemical pathways and provides insights to improve the recognition of this genetic polymorphism in patients and shares how to overcome its limitations. The full video for the preview above is available for practitioners only.…

According to the World Health Organization, 350,000,000 people suffer from depression—that is 5% of the world’s population. Betty Murray explains that 47% of our population has a mutation in the 5-MTHFR gene and…

Blogs, Foundational, Functional Medicine, Musculoskeletal

by Kari Hamrick, PhD, RD and Elnaz Karimian-Azari, PhD Introduction Since 2016, the US Department of Health and Human Services has brought a new level of awareness to the opioid crisis in America by declaring it a nationwide Public Health Emergency.1 In the US, it is approximated that 2.5 million people have been diagnosed with an opioid use disorder (OUD), and 4 in 5 new heroin users started out misusing opioid prescription pain medication.2 As part of the efforts aimed…

by Kari Hamrick, PhD, RD and Elnaz Karimian-Azari, PhD Introduction Since 2016, the US Department of Health and Human Services has brought a new level of awareness to the opioid crisis in America…

Blogs, Cardiometabolic, Functional Medicine, Integrative, Naturopathic, Nutritionists

by Mark Houston, MD and Sara Gottfried, MD In the past, most of the emphasis on treating dyslipidemia and dyslipidemia-induced heart disease such as coronary heart disease (CHD) and myocardial infarction (MI) was directed toward low-density lipoprotein (LDL) cholesterol (LDL-C). The mainstay in the traditional cardiovascular community for treating LDL-C has been to prescribe statins. Herein a two-fold problem emerges. First, many people cannot take statins due to their adverse effects; others choose not to take them. Second, evaluation of…

by Mark Houston, MD and Sara Gottfried, MD In the past, most of the emphasis on treating dyslipidemia and dyslipidemia-induced heart disease such as coronary heart disease (CHD) and myocardial infarction (MI) was…

Blogs, Foundational, Functional Medicine

by Sara Gottfried, MD and Kari Hamrick, PhD, RD Did you grow up with parents who told you that breakfast is the most important meal of the day?  The word “breakfast” comes from breaking the overnight fasting period, and replenishing the body with a supply of glucose and other nutrients. It implies a period of metabolic rest that we know from ancestral health is beneficial, but in recent time, that period has shortened. While physicians and dietitians have touted the…

by Sara Gottfried, MD and Kari Hamrick, PhD, RD Did you grow up with parents who told you that breakfast is the most important meal of the day?  The word “breakfast” comes from…

Blogs, Cardiometabolic, Functional Medicine

 by Mark Houston, MD and Sara Gottfried, MD A precision and personalized medicine approach to dyslipidemia and dyslipidemia- induced cardiovascular disease—including high LDL cholesterol, elevated triglycerides, low high-density lipoprotein (HDL) and HDL function, and other related cardiometabolic conditions such as insulin resistance and metabolic syndrome—is completely different from the conventional medicine approach. In this article, we will review the major paradigm shift that has emerged in the past 10 to 15 years regarding HDL, which is best known for its…

 by Mark Houston, MD and Sara Gottfried, MD A precision and personalized medicine approach to dyslipidemia and dyslipidemia- induced cardiovascular disease—including high LDL cholesterol, elevated triglycerides, low high-density lipoprotein (HDL) and HDL function,…

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