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Intermittent Fasting: Examining Effects on Metabolism and Detoxification

Sara Gottfried, MD shares a simple solution that helped her break out of the fat storage mode

“Most of us are aware that for health and longevity we need to pay attention to what we’re eating, but few are taking into consideration the effects of our meal timing.” – Sara Gottfried, MD

In this podcast: 

02:09 Dr. Gottfried shares her own struggles with weight and the simple strategy that helped reverse her issues

03:00 Dr. Gottfried introduces the concept of periodic fasting, in particular time-restricted eating, and highlights the potential benefits

05:14 Dr. Gottfried explains the connection between higher body mass index and brain health

08:50 Dr. Gottfried describes how intermitting fasting helps flip the metabolic switch and defines metabolic flexibility

13:17 Dr. Gottfried outlines the nine cellular markers of aging

16:12 Dr. Gottfried shares findings from the Biosphere 2 experiment and problems associated with caloric restriction

19:36 Dr. Gottfried discusses the opportunity of intermittent energy restriction vs. continuous calorie energy restriction and reviews three of the most important IF protocols, beginning with the 5:2 protocol

32:34 Dr. Gottfried reviews the evidence for time-restricted eating

36:58 Dr. Gottfried shares clinical pearls to help implement intermittent fasting in practice


Hosted by
Sara Gottfried, MD

Get the inside scoop from Sara Gottfried, MD on the latest research on intermittent fasting, time-restricted eating, and the relationship to your metabolism and detoxification abilities. Explore several periodic fasting regimens and how to implement them.

Sara Gottfried, MD is a board-certified gynecologist and physician scientist. She graduated from Harvard Medical School and the Massachusetts Institute of Technology and completed residency at the University of California at San Francisco. Over the past two decades, Dr. Gottfried has seen more than 25,000 patients and specializes in identifying the underlying cause of her patients’ conditions to achieve true and lasting health transformations, not just symptom management.

Dr. Gottfried is a global keynote speaker who practices evidence-based integrative, precision, and Functional Medicine. She recently published a new book, Brain Body Diet, and has also authored three New York Times bestselling books: The Hormone Cure, The Hormone Reset Diet, and Younger.

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