Robert Martindale, MD proposes that we have been so lost in trying to prevent inflammation that we have forgotten about the resolution of inflammation. Resolution is an active process. Anti-inflammation is not equivalent to Pro-Resolution. SPMs are lipid compounds isolated in many human tissues during inflammation. 1) Chemically synthesized in lab and in vivo 2) Injected into humans at physiologic doses 3) Inflammation resolves faster – mimics natural healing 4) Prevents transition to chronic inflammation 5) Increases bacterial and viral…

In this webinar, Dr. Osama Hamdy, the medical director of the obesity program at the Joslin Diabetes Center, discusses, “Dietary Fat: Should We Change Recommendations.” He begins with basic information on dietary fats. There are three types of lipids: free fatty acids, compound lipids (phospholipids, sterols/cholesterol). When we discuss fatty acids, we mean a chain of carbon atoms, one end called the alpha end, and one called the omega end. It is from that structure that we get the names of polyunsaturated…

Probiotics Video Animation This animation is designed for the educational use of clinicians and patients. The human gut is home to over 100 trillion bacterial cells, known as the gut microbiota. The bacteria are diverse and contain mostly “good” bacteria that help process the foods we consume and produce vitamins and short-chain fatty acids that help our bodies to function. The gut bacteria also produce metabolites that communicate with the brain and the rest of the body. They may influence…

Dr. Charles Serhan of Harvard Medical School discusses what excites him most about his research in inflammation resolution and specialized pro-resolving mediators, SPMs. He reveals that the opportunity for resolution of inflammation to leave the lab and enter clinical application is most exciting to him. Research and science about stimulating resolution of inflammation are now emerging for general practice. This is a concept that has been in development for many years and it is now ready for “prime time.” SPMs…

In Part 1 of this 2-part series, Jeff Volek, PhD, RD reviews the concept of ketogenesis, nutritional ketosis, and keto-adaptation. He discusses the utility of ketogenic diets in clinical practice and the potential benefits of the ketogenic approach to enhance physical performance, manage inflammation, and improve lifespan. Dr. Volek is a Professor in the Department of Human Sciences at The Ohio State University. For 20+ years, Dr. Volek has studied the effects of how diets extremely low in carbohydrates can induce…

Human Milk Oligosaccharides – Part 2 Presented by Lars Bode, PhD Lars Bode, PhD presents and overview of Human Milk Oligo Saccharides, what they are, their metabolism and how HMOs serve as prebiotics. HMOs are the third most abundant component in human milk and their composition follows a basic blueprint. There are more than 150 different HMOs identified. This video presentation includes a very informative Q&A session following the overview.

Human Milk Oligosaccharides – Part 1, Presented by Lars Bode, PhD Lars Bode, PhD presents an overview of human milk oligosaccharides (HMOs), what they are, their metabolism, and how they serve as prebiotics. HMOs are the third most abundant component in human milk, and their composition follows a basic blueprint. There are more than 150 different HMOs identified.  

Lars Bode, PhD: Potential Effects of HMOs on Adult Gut Microbiome Lars Bode, PhD discusses the health benefits of Human Milk Oligosaccharides (HMOs) and how research has shown ways HMOs can effect the adult microbiome. Positive effects are seen specifically in breastfed infants, where it has been identified to raise levels of two prime fucosyllactose (2′FL).

In this Clinical Minute, Nikky Contractor, PhD discusses oligosaccharides. 2’-fucosyllactose, also known as 2'-FL and pronounced “two F L,” is the most abundant human milk oligosaccharide (HMO) in human breast milk. Human milk contains many chemical structures that support the growth of beneficial bacteria in infants. The bacteria that are beneficial to infants are also beneficial in adults and support the growth of beneficial bacteria. 2'FL is also a “decoy receptor” that can bind with pathogenic bacteria and prevent binding…

Prebiotics and Quality Carbohydrates: Enhancing Digestive Health Prebiotics are non-digestible carbohydrates that selectively stimulate the growth and activity of beneficial gut bacteria. Some beneficial gut bacterial can metabolize prebiotics, which gives them a growth advantage. Some prebiotics have more specialized benefits and can play a protective role in gut function. This is especially true for selected oligosaccharides called two prime fucosyllactose, or 2’FL, that are naturally produced and are identical to oligosaccharides originally identified in breast milk, referred to as…