The ketogenic diet (KD) is a low-carbohydrate, high-fat, adequate-protein diet that has proven to be effective for the reversal of several chronic conditions including obesity, metabolic syndrome, and type-2 diabetes (T2DM) in trials of up to two years.1 However, the degree of therapeutic response to KD varies across individuals.2,3 For example, some KD dieters lose more weight than others, and, while most of them improve their blood lipids, so-called “high responders” experience abnormal increases in low-density lipoprotein cholesterol (LDL-C). Many…
The ketogenic diet (KD) is a low-carbohydrate, high-fat, adequate-protein diet that has proven to be effective for the reversal of several chronic conditions including obesity, metabolic syndrome, and type-2 diabetes (T2DM) in trials…
by Sara Gottfried, MD; Kari Hamrick, PhD, RD; Lewis Chang, PhD We all know that it’s time for mainstream science to investigate—rigorously and on a large scale—whether eating a particular diet can help reduce or reverse chronic disease. While we have growing evidence on the Mediterranean diet, we know little about the molecular benefits and risks of eating certain foods, not eating specific macronutrients, or other emerging condition-based protocols that involve nutritional modulation, particularly related to insulin and glucose signaling.…
by Sara Gottfried, MD; Kari Hamrick, PhD, RD; Lewis Chang, PhD We all know that it’s time for mainstream science to investigate—rigorously and on a large scale—whether eating a particular diet can help…
Host: Deanna Minich, PhD Guest: Rob Silverman, DC As literature and clinical discussions on the ketogenic diet continue to grow across the globe, Robert Silverman, DC and Deanna Minich, PhD are infusing nuance and pragmatism into an important discussion on the ketogenic diet approach (“keto”) in clinical practice. First, Dr. Silverman defines keto (in his clinical practice) as 75% fat, 20% protein, and 5% carbohydrates (< 50g per day) and differentiates “dirty” vs. “clean” keto. The latter focuses on healthy fats,…
Host: Deanna Minich, PhD Guest: Rob Silverman, DC As literature and clinical discussions on the ketogenic diet continue to grow across the globe, Robert Silverman, DC and Deanna Minich, PhD are infusing nuance and…
In recent years we have witnessed a groundswell of interest in the ketogenic diet. This concept of consuming certain types of high-fat foods (while reducing carbohydrates) to induce a physiological state called ketosis is a form of therapeutic nutrition that has been studied for decades in a variety of conditions. Cancer researchers have become very interested in the potential benefits a ketogenic approach might bring to oncology patients taking certain types of anti-cancer drugs. Why? Because initial experiments conducted in…
In recent years we have witnessed a groundswell of interest in the ketogenic diet. This concept of consuming certain types of high-fat foods (while reducing carbohydrates) to induce a physiological state called ketosis…
by Milene Brownlow, PhD; Sara Gottfried, MD; Nikky Contractor, PhD Here at Metagenics Institute, our goal is to keep you abreast of the latest scientific literature in health, nutrition, and personalized lifestyle medicine. As the ketogenic diet continues to grow in popularity in mainstream and clinical settings, we want to know what’s new and what patient populations or individuals may be uniquely positioned to benefit from a ketogenic dietary approach. In the past 10 years, citations for the ketogenic diet…
by Milene Brownlow, PhD; Sara Gottfried, MD; Nikky Contractor, PhD Here at Metagenics Institute, our goal is to keep you abreast of the latest scientific literature in health, nutrition, and personalized lifestyle medicine.…
Dominic D’Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida In Q&A Part 4, Dominic D’Agostino, PhD answers questions pertaining to healthy individuals utilizing the ketogenic diet. Dr. D’Agostino provides a reality check on the deleterious health effects of our environment and explains how the ketogenic dietary approach is a targeted nutritional intervention that can help address the healthcare crisis in America. Additionally, Dr. D’Agostino addresses common misconceptions surrounding the ketogenic diet and intermittent fasting,…
Dominic D’Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida In Q&A Part 4, Dominic D’Agostino, PhD answers questions pertaining to healthy individuals utilizing the ketogenic diet. Dr.…
Dominic D'Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida Dominic D’Agostino, PhD has been providing his expert perspective on all things keto in a series of discussions on the supporting science of the ketogenic diet. In the final part of this 3-part discussion, Dr. D’Agostino shares clinical and research insights on the ketogenic diet: Supporting science for the ketogenic diet and type 2 diabetes Utility of ketogenic diet for weight loss Considerations for a…
Dominic D'Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida Dominic D’Agostino, PhD has been providing his expert perspective on all things keto in a series of discussions…
In Q&A Part 4, Dominic D’Agostino, PhD answers questions pertaining to healthy individuals utilizing the ketogenic diet. Dr. D’Agostino provides a reality check on the deleterious health effects of our environment and explains how the ketogenic dietary approach is a targeted nutritional intervention that can help address the healthcare crisis in America. Additionally, Dr. D’Agostino addresses common misconceptions surrounding the ketogenic diet and intermittent fasting, leveraging science to dispel myths. Lastly, from a research and clinical perspective, Dr. D’Agostino explores…
In Q&A Part 4, Dominic D’Agostino, PhD answers questions pertaining to healthy individuals utilizing the ketogenic diet. Dr. D’Agostino provides a reality check on the deleterious health effects of our environment and explains…
Introduction Ketosis is a normal physiological process during which the body utilizes fat to produce ketone bodies as its main fuel.1 Ketosis occurs when there is an absence or shortage of carbohydrates in the diet or glycogen storage in the body, such as during overnight fasting or prolonged fasting, during extended exercise, or when following a ketogenic diet.1 Ketogenic diets are very low in dietary carbohydrate (<50 g per day) and high in fat, and provide an adequate amount of…
Introduction Ketosis is a normal physiological process during which the body utilizes fat to produce ketone bodies as its main fuel.1 Ketosis occurs when there is an absence or shortage of carbohydrates in…
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