Acute inflammation is normal and protective to the host, but when inflammation becomes chronic, it can damage tissues and be destructive to health. The resolution of inflammation involves several key steps: the termination of neutrophil recruitment, counterregulation of proinflammatory mediators, stimulation of macrophage-mediated clearance, and tissue remodeling.
This review of the evidence by leading experts explains how the failure of inflammation resolution contributes to metabolic diseases and the pivotal role that specialized pro-resolving mediators (SPMs), resolvins, protectins, and maresins, play in inflammation resolution. Patients with a variety of inflammatory conditions can benefit from SPMs and improved inflammation resolution.
Spite M, Clària J, Serhan CN. Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 2014;19(1):21-36.