by Lewis Chang, PhD Decline in cognitive ability progresses over a long period of time and is a risk factor for dementia. The link between type 2 diabetes (T2D) and dementia has been well documented. Mechanistically, T2D may directly induce amyloid accumulation and indirectly increase microvascular disease of the central nervous system. However, the link between T2D and cognitive decline is much less clear. HbA1c, a biomarker that reflects blood glucose levels over a prior 2-3 month time frame, is…

15. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD In this short video, Dr. Charles Serhan discusses the differences between specialized pro-resolving mediators (SPMs) formulations for clinical application. He indicates that different product formulations must be assessed for efficacy for specific uses. Further, SPMs themselves are natural molecules and are not all created equally. They are tissue-specific, so some promote tissue regeneration while others are more effective at phagocytosis, for example.

12. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD Specialized pro-resolving mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. The precursors to SPMs are omega-3 essential fatty acids, EPA and DHA. In this short video with Dr. Charles Serhan of Harvard Medical School, Metagenics Institute inquires about whether it is possible for humans to consume too much EPA and DHA. Dr. Serhan responds that it may…

Specialized Pro-resolving Mediators (SPMs) in Real World Clinical Practice presented by Jennifer Stagg, ND Jennifer Stagg, ND, is a healthcare practitioner in Connecticut who actively uses nutritional solutions to help her patients achieve better health. She frequently sees patients who are experiencing chronic inflammation. In this webinar, she describes her experience seeing patients who have conditions that involve chronic inflammation and the solutions she uses to manage the underlying inflammation and the condition itself. We know that chronic inflammation is…

Real World Clinical Experiences with SPMs presented by Cory Rice, DO This presentation by Dr. Cory Rice is entitled “Specialized Pro-resolving Mediators in Real World Clinical Practice.” This is part of our peer-to-peer knowledge sharing series. Incorporating SPMs in clinical practice for patients with chronic disease, particularly those who need nutritional support for lifestyle medicine. Dr. Rice also provides several patient case studies in which he describes how SPMs have provided improved health outcomes to his patients. As we know,…

Over 75% of overeating can be attributed to emotional factors. Lifestyle habits can translate into an obese phenotype, but understanding the psychological underpinnings of food choices and obesity is crucial to effective obesity management. Deanna Minich, PhD, CNS, FACN, IFMCP is a Functional Medicine-trained clinician and researcher with a unique approach that combines physiology and psychology. In this talk titled “Scientific Understanding and Clinical Strategies for Eating Issues Related to Obesity,” Dr. Minich explores the role of mood in food…

Obesity, Comorbidities & Weight Change Patterns: Osama Hamdy, MD, PhD Obesity is on track to be the #1 killer in the US. Concurrent with the obesity epidemic is the rapidly growing diabetes epidemic. Environmental impact and lifestyle choices contribute to the high “diabesity” prevalence. Furthermore, epigenetic changes across generations are also playing a role. In this presentation “Obesity, Comorbidities & Weight Change Patterns,” Osama Hamdy, MD, PhD, FACE, of the Joslin Diabetes Center at Harvard, explores the evolution of dietary…

Inflammation & Resolution Physiology in Obesity: Joan Clària, PhD Unresolved, low-grade chronic inflammation triggers adipose dysfunction and is the culprit of obesity comorbidities. In this presentation “Inflammation & Resolution Physiology in Obesity,” Joan Clària, PhD explores how the resolution phase of the inflammatory response can be leveraged to resolve inflammation chronicity. He discusses in vitro and in vivo research demonstrating the distinct biological properties, pathways and actions of omega-3 PUFAs vs. specialized pro-resolving mediators (SPMs) in targeting unresolved, inflamed adipose tissue.…

by Bianca Garilli, ND Strokes are responsible for 1 out of every 20 deaths in the US – that’s ~ 140,000 Americans’ lives lost each year.1 Stroke is also a leading cause of serious, long-term disability.2 Diabetes mellitus is an independent risk factor for ischemic stroke, a form of stroke caused by inadequate blood supply (and therefore insufficient oxygen and nutrients) to a particular area of the brain. Ischemic strokes account for the majority of strokes (87%) in the US.2 Another subtype…

A large population-based study of patients with type 2 diabetes (T2D) indicates that achieving a greater number of “ABC” targets (A: HbA1c; B: blood pressure; C: LDL-cholesterol) incrementally reduced the risk of cardiovascular disease (CVD). However, not all ABC risk factors were of equal importance in CVD risk reduction.1 For adults with T2D, the American Diabetes Association (ADA) recommends maintaining optimal levels of all three ABC risk factors: HbA1c < 7%, blood pressure < 130/80 mm Hg, and LDL-C < 100 mg/dL.2 This…