This paper is entitled, “Supplementation with Specialized Pro-Resolving Mediators Reduces Inflammatory Biomarkers and Improves Reported Clinical Symptomology in Subjects with Chronic Inflammatory Conditions: Results from a Multi-Center Open-Case Series” Highlights: Inflammation has 2 phases: initiation and resolution. Many chronic health issues are linked to unresolved inflammation Specialized pro-resolving mediators (SPMs) are endogenous molecules essential for resolution of inflammation but may not be produced in required levels in certain condition Multi-center case study assessed effects of a proprietary SPM supplement (LM-O3)…

Type 2 diabetes is an increasing global health issue, which benefits from ongoing research in medical nutrition therapy. All attempts to introduce a modified diet, reduced caloric intake and physical activity have been shown to assistance patients experiencing glucose toxicity. Impaired glucose tolerance causes many health issues, including cardiovascular disease. This review covers the criteria for diagnosis of diabetes and prediabetes research completed by Osama Hamdy, MD, PhD, Medical Director of the Obesity Clinical Program, at the Joslin Diabetes Center.…

by Bianca Garilli, ND Diabetic peripheral neuropathy (DPN), a common complication of diabetes, leads to pain and loss of feeling in the hands, arms, feet and legs. The incidence of neuropathy is approximately 45% for patients with type 2 diabetes mellitus (T2D) and is responsible for more hospital admissions than all other diabetic complications combined; as well as accounting for 50-75% of non-traumatic amputations.1-2 The most common pharmaceutical treatments utilized in DPN cases include analgesics and anti-depressants along with physical therapy,…

A meta-analysis including 12 studies that included > 280,000 participants found that both obesity and underweight are associated with an increased risk for migraines.1 Prior research had indicated an association between higher weight and migraines and while exact mechanisms are not known, it has been postulated that overweight individuals may have increased adipose tissue secretion of pro-inflammatory cytokines, increased adipocytokines, and increased circulating sex hormones all of which may play a role in migraine development and severity. Studies have also shown patients…

Inflammation, pathogenic gut bacteria, and Candida species and markers of disease severity where analyzed in adults with stable mild, moderate and severe congestive heart failure (CHF). High levels of pathogenic bacteria including Campylobacter, Shigella, Salmonella, Yersinia enterocolitica, and Candida species were discovered in CHF patients when compared to normal control. Intestinal permeability (IP), right arterial pressure (RAP) and markers of inflammation, including C-reactive protein (CRP) was also greater in the CHF group. These results suggest that people with CHF have higher levels of gut dysbiosis and…

by Ashley Jordan Ferira, PhD, RDN Colorectal cancer (CRC) is the third leading cause of cancer-related death for men and women in the US.1 Chronic inflammation contributes to cancer development.2 Pro-inflammatory conditions, such as obesity and inflammatory bowel disease, have been associated with CRC risk.3-4 It is plausible that a dietary pattern that induces more inflammation could impact CRC risk. The relationship between dietary inflammatory potential and CRC risk was investigated by Dr. Frank Hu of Harvard University and his colleagues, evaluating data…

by Bianca Garilli, ND An article published in the New England Journal of Medicine  reviewed data collected from 1998-2012 from adults in the Swedish National Diabetes Register with type 1 diabetes (T1D) and type 2 diabetes (T2D).  Information was analyzed for various end points including overall mortality rate and incidence of cardiovascular disease (CVD) and coronary heart disease (CHD). Results from the study showed that during the observed time period the incidence rates of CVD and overall mortality rates decreased in both…

by Lewis Chang, PhD  An editorial written by three well-known cardiologists advocates for a paradigm shift in the management of coronary artery disease (CAD). They post: dietary saturated fat is not dangerous. The real danger, they propose, lies in the inflammatory processes that contribute to plaque buildup, plaque rupture, and the formation of blood clots.1 Aseem Malhotra, MD of the Academy of Medical Royal Colleges (Stevenage, UK), Rita Redberg, MD of UCSF School of Medicine (San Francisco, CA), and Pascal…

This video series is from conversations with Charles Serhan, PhD, DSc, during the recent 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases held Oct. 22-24, 2017 in Puerto Vallarta, Mexico. In this quick video, Dr. Serhan discusses ongoing research centers that are conducting research to assess SPMs efficacy in a variety of health conditions, as well as revealing additional human tissues where SPMs have been found. Charles Serhan, PhD, DSc is Director of the Center for…

Over the past several years, we have been instructed on the value of exercise and activity for our heart health. Statistics on the state of heart health in the US are sobering1: In the US, over 2000 people die from heart related illnesses every day (about one every 40 seconds) Every year over 735,000 Americans have a heart attack or myocardial infarct (MI) and of these, over 500,000 are ‘first’ heart attacks Coronary artery disease, the prime cause of MIs…