In this presentation “Novel Clinical Insights on Inflammation: Resolving not Blocking,” Andrew Heyman, MD, MHSA shares clinical experiences and observations related to health conditions associated with increased inflammatory biomarkers. Dr. Heyman explores the role of specialized pro-resolving mediators (SPMs) in the clinical management of chronic inflammatory conditions, such as chronic pain and fibromyalgia, focusing on evidence from a multi-center case series investigation. Dr. Heyman concludes with insights on novel clinical targets for resolvins in neuroinflammation, in addition to providing a…

This presentation is the first in a two-part series on healthy fats and fatty acids presented by Penny Kris-Etherton, PhD, RD of the Department of Nutritional Sciences at Penn State University. In this part of the presentation, she discusses current dietary recommendations and popular opinions. Published just before the release of the 2015 USDA Dietary Guidelines, the presentation provides advice related to macronutrient balance for consumers, with special attention given to total fat, saturated fat, and cholesterol. Patients and practitioners…

In this webinar Jennifer Stagg, ND presents an overview of the use of SPMs in clinical practice. Her research shows that the use of SPMs bring about an effective resolution response to chronic and acute inflammation. Dr Stagg presents the causes of most inflammation in both young and old and the symptoms that are associated with its disease pathogenesis. Recorded at the AANP Pre-Conference in Salt Lake City, Utah at the 2016 American Association of Naturopathic Physicians Annual Convention & Exhibition. View the…

by Bianca Garilli, ND In the constant quest for improving performance, ultra-endurance athletes often alter exercise and dietary habits hoping to optimize peak physical and mental health. With this goal in mind, the ultra-endurance athlete community has turned its attention to the potential benefits of a low-carbohydrate diet. This is in stark contrast to the previously long-held approach of consuming a high-carbohydrate diet before, during and after exercise.1 Crucial to peak performance is the availability of adequate glycogen throughout the…

by Romilly Hodges, MS, CNS Dynamic Bone Bone is not a static entity in our body. Our body is continually actively forming bone, as well as breaking it down—a process called bone remodeling. Osteoblast cells are responsible for forming bone matrix, a collagen-proteoglycan mix that can bind mineral salts, mostly as calcium hydroxyapatite. Osteoclast cells are active in resorbing bone matrix by secreting cathepsin K proteases that catabolize bone collagen, and hydrogen ions that lower the surrounding pH and solubilize minerals. A healthy…

by Bianca Garilli, ND, IFMCP Endurance-trained athletes must maintain excellent physical fitness in order to regularly perform activities requiring large quantities of sustained energy. Nutrition plays a major role in their ability to achieve superior athletic goals. However, athletes often do not meet recommended nutritional requirements based on sport, age and sex.1 A study conducted in 146 endurance athletes from Lithuania found that 80.8% of endurance athletes used lower than recommended amounts of carbohydrates in their diet, while more than…

You try to eat well to feel good and stay healthy. While it’s optimal to get your daily nutritional needs from the foods you eat, it’s just plain difficult. There is conflicting information out there on the benefits of supplements, but the Dietary Guidelines for Americans 2015-2020 say that supplements may be useful for providing the nutrients you may be lacking from diet alone. Still on the fence? Consider these top five reasons to add a multivitamin to your daily regimen. 1. Healthy…

Cells of the immune system have been shown to produce specialized pro-resolving mediators (SPMs), a group of lipid molecules that coordinate the active resolution of inflammation. However, the capacity for non-immune cells types to biosynthesize SPMs is not well understood. In this publication, Chatterjee A et al. aimed to examine this ability by using freshly harvested segments of aortic branch as well as vascular smooth muscle cells and vascular endothelial cells all isolated from human volunteers perioperatively. The vascular cells…

15. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD In this short video, Dr. Charles Serhan discusses the differences between specialized pro-resolving mediators (SPMs) formulations for clinical application. He indicates that different product formulations must be assessed for efficacy for specific uses. Further, SPMs themselves are natural molecules and are not all created equally. They are tissue-specific, so some promote tissue regeneration while others are more effective at phagocytosis, for example.

12. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD Specialized pro-resolving mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. The precursors to SPMs are omega-3 essential fatty acids, EPA and DHA. In this short video with Dr. Charles Serhan of Harvard Medical School, Metagenics Institute inquires about whether it is possible for humans to consume too much EPA and DHA. Dr. Serhan responds that it may…