This animation features information on the role of inflammation in managing insults and injury to the body. Infection, wounds, poor diet, and aging are causes of acute inflammation. Acute inflammation helps the body to heal and helps tissue to return to homeostasis. When inflammation becomes chronic, however, as is common in many chronic diseases, it can destroy tissues and leave the body in poorer health. Science has now shown us that inflammation resolution is an active process that is controlled by specialized pro-resolving mediators (SPMs),…

During periods of over-nutrition, excess energy is stored in white adipose tissue (WAT); continuing expansion of WAT may lead to obesity. Obesity alters the cellular physiology of adipocytes, the cells of WAT. In the context of obesity, adipocytes secrete elevated levels of free fatty acids and adipokines, but decreased levels of adiponectin. These pathophysiologic changes have many effects. Elevated free fatty acids contribute to insulin resistance, oxidative stress, inflammation, and impaired arterial flow regulation Download the PDF

This research review discusses how the combination of undenatured type II collagen and tetrahydro iso-alpha acids help revitalize joint function and support an active lifestyle. Arthritis is not a single condition. In fact, there are more than 100 different forms of arthritis. The 2 most common types of arthritis, whose main feature is joint pain, are osteoarthritis (OA) and rheumatoid arthritis (RA). OA is a degenerative joint disease characterized by active bone remodeling, articular cartilage degradation, and synovial inflammation resulting…

Dyslipidemia is a prominent risk factor for atherosclerotic cardiovascular disease (CVD) and impacts over half of US adults. Lifestyle interventions, particularly those incorporating medical nutrition therapy, are essential in the management of dyslipidemia, to halt progression towards advanced CVD and metabolic disease. The primary objective of this multi-site, prospective case series was to measure changes in the plasma atherogenic lipid profile and metabolic syndrome-related variables in 24 overweight patients with dyslipidemia at baseline, 4 weeks after daily consumption of a…

This paper is entitled, “Supplementation with Specialized Pro-Resolving Mediators Reduces Inflammatory Biomarkers and Improves Reported Clinical Symptomology in Subjects with Chronic Inflammatory Conditions: Results from a Multi-Center Open-Case Series” Highlights: Inflammation has 2 phases: initiation and resolution. Many chronic health issues are linked to unresolved inflammation Specialized pro-resolving mediators (SPMs) are endogenous molecules essential for resolution of inflammation but may not be produced in required levels in certain condition Multi-center case study assessed effects of a proprietary SPM supplement (LM-O3)…

Effects of a novel hops extract & undenatured collagen combination in a case series of subjects with chronic arthritic joint discomfort According to the National Health Interview Survey, 30% of US adults have reported experiencing some type of joint pain during the preceding 30 days. Hops-derived tetrahydroiso-alpha acids (THIAA) –a mixture of co-, n-, and ad-congeners –have been shown to exhibit anti-inflammatory properties in vitro and to reduce bone cartilage degradation in a mouse model of RA. This case series provides…

by Ashley Jordan Ferira, PhD, RDN The importance of vitamin D in diverse organ systems and biochemical processes is ever-growing with novel research findings. From calcium absorption to extraskeletal health processes such as immune function- vitamin D is essential. The role of vitamin D in pain management is a newer area of investigation that has not been fully established. It is estimated that 25.3 million American adults experience pain every day, with nearly 40 million experiencing some form of extreme pain.1 Annual…

Coronary artery disease (CAD) is the most common form of heart disease and is a leading cause of death in the US among both men and women. CAD develops when plaque forms in the coronary arteries, limiting and blocking blood flow. Another cause of CAD, in addition to arterial plaques, is arterial inflammation.  A study by Tarec K. Elajami and colleagues found resolution of inflammation in the body may also lead to clot remodeling and reduce the incidence of CAD and coronary events in at risk…