Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, Metagenics Institute asks Dr. Charles Serhan of Harvard Medical School about some parameters or markers that can be used to assess the efficacy of SPMs. Dr. Serhan responds that indices have been created to measure SPMs. Current tools include assessing pre- and post- levels of SPMs in blood, as well as the functional increase related to certain…

Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School about some situations under which SPM biosynthesis would be challenged. More specifically, what pharmacological interactions would make SPMs and inflammation resolution less effective? Dr. Serhan responded that a variety of pharmaceuticals have been tested with SPMs. It may be surprising that NSAIDs, which reduce the signs and symptoms…

In this video we ask Dr. Serhan, "What is the potential use of supplements enriched with SPMs for patients whose diets are deficient in essential fatty acids?" 3. Insights from the Metagenics Lifestyle Summit 2015: Charles Serhan, PhD

Frank Hu, MD, PhD at Nutrition Pro 2015: Translating Genetic Information in Nutrition Practice Dr. Frank Hu of the Harvard T.H. Chan School of Public Health discusses the role of genetic information, prediction of chronic disease, and nutrition interventions for improved health. This presentation comes from Nutrition Pro 2015 and contains valuable information for clinical translation of genetic information for improved nutrition practice. Genes play only a small role in our overall health outcomes. Other genetic determinants, such as…

Cardiovascular function can be strategically supported via targeted nutritional factors that support nitric oxide (NO) synthesis, which is essential for healthy endothelial function and blood flow. Arginine, citrulline, cocoa polyphenols, folate, vitamin C, and magnesium help protect and maintain NO synthesis, and therefore, preserve healthy endothelial function and blood flow. This endothelial health animation video shows how various nutritional factors impact the NO synthesis pathway. Understanding these biochemical insights will help leverage targeted, personalized nutrition therapies to optimize endothelial health…

Xanthohumol (XN) is a flavonoid found in hops, the flowers of the hop plant Humulus lupulus. XN exhibits anti-inflammatory and antioxidant properties. In collaboration with researchers at Oregon State University, a randomized, double-blind, cross-over study in healthy participants was conducted to determine if a protein matrix affected the bioavailability of XN when orally consumed. The circulating concentration of XN and its major metabolites were significantly higher when the spent hops-rice protein matrix preparation was consumed vs. the standard control spent…

by Robert Silverman, DC, MS, CNS   When your joints ache, don’t open the medicine cabinet for a pain pill. Instead, head to the grocery store to find healthful—and delicious—foods the support joint health instead. Sweet Potatoes The deep orange color of a sweet potato comes from the rich supply of beta-carotene it contains. Beta-carotene is the natural precursor of vitamin A (retinol). When you eat a sweet potato, your body converts some of the beta-carotene into vitamin A. The rest…

This conversation took place at ASPEN Clinical Nutrition Week 2015 and was moderated by Robert Martindale, MD. In this video segment, he discusses the question, can over-supplementation of specialized pro-resolving mediators (SPMs) lead to pathway down-regulation. The conversation took place with Dr. Stephen McClave, Dr. Jesmond Dalli, and Dr. Todd Rice. The conversation is part of a series on inflammation entitled, Inflammation: Should we Block or Accelerate Its Resolution? Dr. Martindale asks if the body might down-regulate the production of…

1. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD If already taking fish oils, is there a need to supplement with specialized pro-resolving mediators (SPMs)? In this video, Dr. Charles Serhan presents insights on inflammation from the Metagenics Lifestyle Summit in September 2015. Dr. Serhan is a distinguished researcher and professor at Harvard Medical School and Brigham and Women’s Hospital in Boston, MA. Dr. Serhan cites his research to answer a variety of questions on…

ASPEN 2015 Inflammation: Fish Oils vs SPMs: What's the Difference? - 1 Roundtable Symposia from ASPEN Clinical Nutrition Week 2015 Participating Speakers are: Robert G. Martindale, MD, PhD Stephen McClave, MD Jesmond Dalli, PhD Todd Rice, MD ASPEN Clinical Nutrition Week in February 2015 provided an excellent opportunity for experts in clinical nutrition to gather and discuss new clinical science from the field. In a series of discussions on Inflammation, Dr. Robert Martindale moderates conversation among several experts, including…