by Bianca Garilli, ND Insulin resistance (IR) develops as a response to long term elevation of insulin levels or hyperinsulinemia (HI) after exposure to chronic increases in blood sugar levels. Additionally, IR in conjunction with non-alcoholic fatty liver disease (NAFLD) and an increase in ectopic adipose storage including visceral adiposity tissue (VAT), are shown to increase the risk and further the progression of dyslipidemia, type 2 diabetes (T2D), obesity and cardiovascular disease (CVD). Recently, studies have indicated that elevations of…
by Bianca Garilli, ND Insulin resistance (IR) develops as a response to long term elevation of insulin levels or hyperinsulinemia (HI) after exposure to chronic increases in blood sugar levels. Additionally, IR in…
The struggle to find the best diet for weight management and metabolic health improvement has largely failed. This failure may imply that no diet fits all needs, which justifies a search for biomarkers that can predict success in weight loss and physiological response, and can allow the most efficient diet to be selected on an individual basis. Researchers from the Texas A&M University recently conducted a series of metabolic studies to understand how genetic differences in mice influence health responses to…
The struggle to find the best diet for weight management and metabolic health improvement has largely failed. This failure may imply that no diet fits all needs, which justifies a search for biomarkers…
by Lewis Chang, PhD Body mass index (BMI) is positively associated with cardiometabolic risk and insulin resistance in children according to a recent population-based study, but cardiorespiratory fitness may mitigate risk.1 Swedish researchers from the Department of Biosciences and Nutrition at Karolinska Institutet (Huddinge, Sweden) and colleagues from Spain and Chile conducted a pooled study including cross-sectional data from three projects (n=1247, aged 8-11 years old) to evaluate the impact of BMI on cardiometabolic risk and homeostatic model assessment of insulin…
by Lewis Chang, PhD Body mass index (BMI) is positively associated with cardiometabolic risk and insulin resistance in children according to a recent population-based study, but cardiorespiratory fitness may mitigate risk.1 Swedish researchers from…
by Bianca Garilli, ND Obesity has both genetic and environmental underpinnings. Research has elucidated key fat-regulating genes, one of which is the fat-mass and obesity-associated (FTO) gene located on chromosome 16q12.2. Single nucleotide polymorphisms (SNPs) on the FTO gene have been associated with an increased risk for obesity.1 Certain obesity-related SNPs have been shown to be specific to a person’s ethnic and racial makeup. As body mass index (BMI) continues to increase at an alarming rate across the globe, it is…
by Bianca Garilli, ND Obesity has both genetic and environmental underpinnings. Research has elucidated key fat-regulating genes, one of which is the fat-mass and obesity-associated (FTO) gene located on chromosome 16q12.2. Single nucleotide…
by Milene Brownlow, PhD It seems like we’re always on our way to a destination. Whether it’s a physical journey, such as traveling out of town, or a mental one, like getting ready for a job interview, we must prepare for the journey in order to get there. Entering a state of ketosis is no different. Strategic planning is important. What is “ketosis,” and how can you get there? Many people associate ketosis with a popular diet program and as…
by Milene Brownlow, PhD It seems like we’re always on our way to a destination. Whether it’s a physical journey, such as traveling out of town, or a mental one, like getting ready…
In Part 1 of this 2-part series, Jeff Volek, PhD, RD reviews the concept of ketogenesis, nutritional ketosis, and keto-adaptation. He discusses the utility of ketogenic diets in clinical practice and the potential benefits of the ketogenic approach to enhance physical performance, manage inflammation, and improve lifespan. Dr. Volek is a Professor in the Department of Human Sciences at The Ohio State University. For 20+ years, Dr. Volek has studied the effects of how diets extremely low in carbohydrates can induce…
In Part 1 of this 2-part series, Jeff Volek, PhD, RD reviews the concept of ketogenesis, nutritional ketosis, and keto-adaptation. He discusses the utility of ketogenic diets in clinical practice and the potential…
Ryan Lazarus, DC, MS, CNS, IFMCP If you had three wishes to improve your health, what would they be? Dr. Lazarus identifies the three main areas most patients desire improvement in: gain energy, lose weight, and improve the aging process. Dr. Lazarus discusses a therapeutic metabolic reboot via nutritional ketosis, when the body uses fat as alternative fuel by reducing overall calorie input, reducing carbohydrate intake, and maintaining adequate protein intake. He provides simple implementation strategies to help patients safely achieve ketosis…
Ryan Lazarus, DC, MS, CNS, IFMCP If you had three wishes to improve your health, what would they be? Dr. Lazarus identifies the three main areas most patients desire improvement in: gain energy, lose…
It is estimated that by 2050, 1 in 3 U.S. individuals will have type 2 diabetes(T2D) and cardiovascular disease (CVD) is the most common cause of death for in these patients. Prevention of CVD among individuals with T2D is therefore of great public health importance. The scientific statements from the American Diabetes Association (ADA), American Heart Association (AHA) and American College of Cardiology (ACC) regarding CVD prevention for patients with T2D, and risk factors for CVD, were recently synthesized and published in…
It is estimated that by 2050, 1 in 3 U.S. individuals will have type 2 diabetes(T2D) and cardiovascular disease (CVD) is the most common cause of death for in these patients. Prevention of…
by Ashley Jordan Ferira, PhD, RDN The latest findings from the landmark Swedish Obese Subjects (SOS) trial demonstrate that bariatric surgery significantly reduces the incidence of female-specific cancers, with the most pronounced cancer risk reductions seen for endometrial cancer and in women with high insulin levels pre-surgery.1-2 The health and economic burdens of obesity in the US, and globally, are immense. Based on the latest 2015-2016 National Health and Nutrition Examination Survey findings from the Centers for Disease Control and…
by Ashley Jordan Ferira, PhD, RDN The latest findings from the landmark Swedish Obese Subjects (SOS) trial demonstrate that bariatric surgery significantly reduces the incidence of female-specific cancers, with the most pronounced cancer…
by Bianca Garilli, ND Obesity is an established a predisposing factor for chronic disease processes including metabolic syndrome, type 2 diabetes (T2D), cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). These sequelae of obesity results from the relationship between excess adiposity, underlying inflammation and insulin resistance at the population level.1 More recently, however, research indicates there is more to learn about obesity as a risk factor for these disease processes on the individual level since the number of lean phenotypes suffering the same health conditions…
by Bianca Garilli, ND Obesity is an established a predisposing factor for chronic disease processes including metabolic syndrome, type 2 diabetes (T2D), cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). These sequelae of obesity…
Metagenics Institute is a trusted, peer-to-peer, evidence-based educational resource for nutrition and personalized medicine.
At Metagenics Institute, we translate credible research with scientific integrity into innovative and actionable clinical
decision-making. Metagenics Institute supports a diverse practitioner base to optimize patient outcomes by shifting existing paradigms in healthcare. Our mission is to transform healthcare by inspiring and educating practitioners, and their patients, about personalized lifestyle medicine.
