by Lewis Chang, PhD Ketosis is the metabolic state in which ketone bodies—alternative energy substrates to glucose—are produced from fat and utilized as the main energy source for the body. An important study found that nutritional ketosis induced by consumption of medium-chain triglycerides (MCT) oil helped increase the redox NAD+/NADH ratio in the brain of healthy young adults.1 Disturbed glucose metabolism and the resulting inadequate energy supply to the brain contributes to the pathophysiology of neurodegenerative diseases such as Alzheimer’s…

by Bianca Garilli, ND A reduction in muscle mass, strength, and function reduce the independence and health of aging adults. Sarcopenia, the loss of muscle tissue typically associated with the natural aging process, also increases the risk for morbidity and mortality through its association with chronic illnesses including cardiovascular disease, diabetes, and obesity. The greater the degree of sarcopenia, the higher the risk of these disease processes.1-2  Sarcopenia can be slowed through routine engagement in exercise, including strength or resistance…

by Lewis Chang, PhD The Mediterranean diet (MED), characterized by a high consumption of plant-based foods, less red meat, and using olive oil as the main source of fat, is one of the healthiest diets. A study found that MED might also prolong brain health and function in cognitively healthy middle-aged individuals.1 According to an earlier systematic review of cohort studies and randomized controlled trials, adherence to MED was associated with a lower risk of cognitive decline and Alzheimer’s disease…

by Bianca Garilli, ND Body mass index (BMI) is frequently utilized in clinical practice to assess for risk of cardiometabolic disease (CMD). High BMI measurements are associated with insulin resistance along with other markers of CMD such as elevated blood glucose and triglycerides, low HDL cholesterol, and elevated blood pressure.1 By way of review, a BMI > 30 indicates obesity, which is linked to increased risk of chronic illness, particularly CMD; a BMI 25-29 is considered overweight, and a BMI…

by Ashley Jordan Ferira, PhD, RDN There is a paradox occurring in American youth: obesity and dieting. National statistics confirm that pediatric overweight and obesity rates are high, steadily rising over the past few decades.1 In fact, over 20% of the 12-19 age group in the US are obese, with higher prevalence in Hispanics and blacks.1 Actual weight and the teenager’s perception of their weight can be incongruent. Furthermore, weight status misperception drives intent for weight change.3 American youth are…

by Bianca Garilli, ND Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the digestive tract and can be classified into two main conditions: ulcerative colitis (UC) and Crohn’s disease (CD). Both of these debilitating diseases involve similar symptoms including bloody diarrhea, abdominal pain and cramping, fever, fatigue, and unintended weight loss.1 The two disease processes, although overlapping in many ways, differ in their pathophysiology:1-2 CD: This disease can affect any part of the gastrointestinal (GI) tract and is…

by Bianca Garilli, ND, IFMCP The Global Breastfeeding Collective (GBC), co-led by UNICEF and WHO, has a mission to rally political, legal, financial, and public support for breastfeeding, which will benefit mothers, children, and society. Seven key priorities have been set forth by the GBC to increase the rate of breastfeeding globally; their most recent data from 2017 evaluated 194 nations and found that, “only 40 percent of children younger than six months are breastfed exclusively (given nothing but breastmilk)…

by Milene Brownlow, PhD It is estimated that 5.7 million Americans live with Alzheimer’s disease (AD).1 For decades, research efforts have targeted neuropathological features of the disease (amyloid plaques, tau dysregulation and tangle formation) with little success so far. Impaired brain glucose metabolism is an early hallmark of the disease.2 For instance, cerebral metabolic rate of glucose (CMRglu) utilization was found to be 13% lower in AD compared to healthy, young subjects.3 Conversely, brain ketone metabolism remains unchanged in mild…

by Lewis Chang, PhD Frailty, characterized by exhaustion, reduced physical activity capacity, slow gait speed, unintentional weight loss, and muscle weakness, is a major health concern associated with aging that increases the risk of disability, institutionalization, and death in older adults.1 It is important to identify modifiable risk factors associated with frailty so that prevention or early intervention strategies can be implemented accordingly. According to epidemiological evidence, certain dietary patterns or dietary components can influence the risk of frailty.2 However,…

by Bianca Garilli, ND and Ashley Jordan Ferira, PhD, RDN Poor diet quality is common in developed countries and is responsible for significant morbidity and mortality. The impact of dietary patterns and nutritional bioactives on mental health is important to understand since at least 16 million people in the US, or 7% of the population, experience at least one bout of depression per year.1 The worldwide prevalence of depression is estimated to be 300 million, with projections by the World…