In this interview, Janos Filep, MD, PhD, discusses the role of aspirin-triggered resolvins and lipoxins in infection control, especially in sepsis. Dr. Filep is exploring how these molecules can restore immune function in patients with compromised phagocytosis. He also investigates the interaction between IFN-β and these mediators in clearing lung infections and outlines the challenges in developing therapies based on aspirin-triggered SPMs for infectious diseases. Janos Filep, MD, PhD, is a Professor of Pathology and Cell Biology at the University…
In this interview, Janos Filep, MD, PhD, discusses the role of aspirin-triggered resolvins and lipoxins in infection control, especially in sepsis. Dr. Filep is exploring how these molecules can restore immune function in…
In this interview, Gabrielle Fredman, PhD delves into the role of SPMs, particularly resolvin D2, in the resolution of chronic inflammation in cardiovascular conditions such as atherosclerosis. She discusses how RvD2 facilitates the resolution of inflammation and the reduction of plaque formation, focusing on how it corrects imbalances in lipid mediators that fuel atherosclerosis. Looking ahead, Dr. Fredman's research will concentrate on understanding the mechanisms that may become dysregulated with aging, and how Resolvins could contribute to organ protection as…
In this interview, Gabrielle Fredman, PhD delves into the role of SPMs, particularly resolvin D2, in the resolution of chronic inflammation in cardiovascular conditions such as atherosclerosis. She discusses how RvD2 facilitates the…
In this interview, Bruce Levy, MD discusses the scientific basis of SPMs in respiratory health, emphasizing their role in lung inflammation resolution, particularly for asthma and RSV infections. He notes the impact of lipoxin deficiency on asthma severity and how supplementation with these mediators offers therapeutic potential, promoting tissue repair and reducing lung damage. Dr. Levy stresses the importance of dietary strategies in enhancing SPM functionality and overall respiratory health, underscoring the need for innovative therapeutic approaches to address severe…
In this interview, Bruce Levy, MD discusses the scientific basis of SPMs in respiratory health, emphasizing their role in lung inflammation resolution, particularly for asthma and RSV infections. He notes the impact of…
In this interview, Alpdogan Kantarci, DDS, PhD, discusses the impact of SPMs on periodontal health and systemic inflammation. He reviews his research on SPMs and their role in linking oral inflammation to Alzheimer's disease, emphasizing their therapeutic potential. Dr. Kantarci also highlights the importance of nutrition in managing these conditions. Looking ahead, he discusses his plans for future research aimed at translating these findings into clinical practice, with the potential to improve treatment strategies for both oral and neurodegenerative diseases.…
In this interview, Alpdogan Kantarci, DDS, PhD, discusses the impact of SPMs on periodontal health and systemic inflammation. He reviews his research on SPMs and their role in linking oral inflammation to Alzheimer's…
by Kyle Perkovich, BS Premenstrual syndrome, or PMS can feel like an unavoidable struggle, but the right approach can help make it more manageable. During the luteal phase of the menstrual cycle, hormonal fluctuations trigger the common symptoms of PMS, leading to mood changes and physical discomfort.1 While various options exist for those seeking to combat these symptoms, natural supplements are increasingly recognized for their ability to provide relief. Many conventional treatments focus on masking the symptoms, but a growing body…
by Kyle Perkovich, BS Premenstrual syndrome, or PMS can feel like an unavoidable struggle, but the right approach can help make it more manageable. During the luteal phase of the menstrual cycle, hormonal fluctuations…
by Kyle Perkovich, BS The pursuit of effective, natural remedies for sleep disturbances and anxiety is increasingly critical. Among various options, kava—a traditional herbal ingredient rooted in Pacific Island cultures—stands out for its potential therapeutic benefits. Known scientifically as Piper methysticum, kava has been celebrated for centuries for its sedative properties1. Only in recent years has it garnered attention from the scientific community for its potential in enhancing sleep quality and mitigating anxiety. This exploration into kava's therapeutic capabilities aims…
by Kyle Perkovich, BS The pursuit of effective, natural remedies for sleep disturbances and anxiety is increasingly critical. Among various options, kava—a traditional herbal ingredient rooted in Pacific Island cultures—stands out for its…
by Yekta Dowlati, PhD Iron is a vital nutrient that serves as a fundamental component of heme and various coenzymes, playing critical roles in essential biochemical pathways. It is integral to the transport of oxygen via hemoglobin, supports mitochondrial oxidative phosphorylation for energy production, and is necessary for the synthesis of DNA.1 In female individuals, physiological changes during the menstrual, gestational, and lactational phases result in dynamic requirements for iron homeostasis. Sufficient iron consumption is essential for maintaining overall health…
by Yekta Dowlati, PhD Iron is a vital nutrient that serves as a fundamental component of heme and various coenzymes, playing critical roles in essential biochemical pathways. It is integral to the transport…
by Yekta Dowlati, PhD According to the World Health Organization (WHO), approximately 2 billion adults globally are overweight, with 650 million classified as obese. Projections suggest that, if current trends persist, the number of overweight adults could reach 2.7 billion by 2025, with the obese population surpassing 1 billion.1,2 Obesity, a complex condition, emerges from an interplay of genetic, societal, and environmental factors and induces metabolic alterations, including changes in gut microbiota, systemic inflammation, and intestinal barrier dysfunction.3,4 Approximately 31%…
by Yekta Dowlati, PhD According to the World Health Organization (WHO), approximately 2 billion adults globally are overweight, with 650 million classified as obese. Projections suggest that, if current trends persist, the number…
by Kyle Perkovich, BS Sleep determines everything – how we feel throughout the day, our mental and physical performance, and various aspects of our overall health.1 However, an estimated 50 to 70 million Americans struggle with sleep disorders, and one out of every three adults does not get the proper amount of sleep for their health.2 Trouble sleeping can occur for a variety of reasons, such as physiological, psychological, and environmental factors, and it effects all ages.3 This widespread issue is…
by Kyle Perkovich, BS Sleep determines everything – how we feel throughout the day, our mental and physical performance, and various aspects of our overall health.1 However, an estimated 50 to 70 million…
In this interview, Magnus Back, MD, PhD delves into the involvement of specialized pro-resolving mediators (SPMs) in the progression of aortic valve stenosis, and the reduced accumulation of omega-3. He also talks about his research on resolvins, their receptors, and ways to facilitate the resolution of inflammation without inducing immunosuppression. Additionally, Dr. Back discusses his recent work on the use of SPMs in treating hospitalized COVID-19 patients. Magnus Back, MD, PhD, is a Professor of Cardiology at Karolinska Institute. From…
In this interview, Magnus Back, MD, PhD delves into the involvement of specialized pro-resolving mediators (SPMs) in the progression of aortic valve stenosis, and the reduced accumulation of omega-3. He also talks about…
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