Search Results for: SPM

This document provides a summary of seven human clinical studies of a proprietary specialized pro-resolving mediators (SPM) formula. These studies involved different participants or patient types, including healthy volunteers, competitive athletes, and patients with chronic inflammatory conditions, fibromyalgia or chronic pain. Page 1 contains information of the study investigators and hyperlinks to additional educational materials. Pages 2-9 are excerpts from each study. Page 10 tabulates SPM dosage information from these studies in one table for easy viewing. Pages 11-13 provide…

In this interview, Joan Claria, PhD discusses the discovery that a resolution deficit occurs in obesity. Dr. Claria outlines the important role that specialized pro-resolving mediators (SPMs) play in adipose tissue and metabolic health, and outlines future potential for SPM-based therapies in the management of fatty liver disease. Joan Claria, PhD is Professor at the Department of Biomedical Sciences at the School of Medicine of the University of Barcelona, Spain From the 16th International Conference on Bioactive Lipids in Cancer,…

In this interview, Dipak Panigrahy, MD discusses the emerging impact of specialized pro-resolving mediators (SPMs) on tumor size and growth, highlighting his work with several preclinical models including pancreatic cancer and breast cancer.  Dr. Panigrahy outlines the reduction in metastases seen in preclinical cancer models, including pancreatic cancer, following treatments with various SPMs. Finally, Dr Panigrahy describes results in preclinical models showing that SPM treatment helps to clear tumor debris caused by standard of care cancer treatments. Dipak Panigrahy, MD,…

In this interview, Professor Charles Serhan, PhD, DSc describes new work highlighting the connection between specialized pro-resolving mediators (SPMs) and the vagus nerve. Dr. Serhan reflects back at his proudest moments of his career, and on the most exciting recent developments. Finally, Dr. Serhan delivers a message on the state of resolution science today, and what is needed to advance SPM-based therapies in the future. Charles Serhan, PhD, DSc is Director of the Center for Experimental Therapeutics and Reperfusion Injury…

Surgery is an inflammatory event. Several clinical conditions are associated with reduced levels of specialized pro-resolving mediators (SPMs), and many patients with these chronic conditions can be candidates for surgery and are at greater risks of reduced resolution capacity before going in for surgery. Further, circulating SPMs have been shown to drop immediately postsurgery, and higher levels of inflammation around the time of surgery has been associated with increased risk of complication and poorer outcomes. In this document, we describe…

Neuroinflammation is a driving factor in neurodegeneration and the adverse response to brain injury. For instance, individuals with Alzheimer’s disease have been shown to have reduced levels of specialized pro-resolving mediators (SPMs) in brain tissue, which are associated with cognitive function. In this document, we describe the scientific rationale for addressing inflammation for management of neurological conditions and summarize emerging preclinical animal and cell data highlighting impact of SPMs in neurodegenerative conditions as well as in cognitive and neurological response…

by Sara Gottfried, MD; Annalouise O’Connor, PhD, RD; Lewis Chang, PhD If we go back a few decades, scientists and clinicians considered the leading public health killers—such as heart disease, cancer, Alzheimer’s disease, diabetes—to be separate diseases. Now we know they have a common root cause: inflammation, the process by which the body’s white blood cells are recruited and activated for a specific purpose. Acute inflammation is triggered to help fight an infection or illness, or to heal an injury,…

In this Grand Rounds presentation, Niccolò Terrando, PhD shares scientific research on the role of specialized pro-resolving mediators (SPMs) in perioperative neurocognitive disorders. Dr. Terrando uses a preclinical mouse model to study postoperative neuroinflammation and elucidate the impact of SPMs in neuroglia activity and modulating memory. Perioperative neurocognitive disorders (PND) encompass complications like postoperative delirium and longer-lasting postoperative cognitive dysfunction, which often negatively impact recovery in older adults. These complications can lead to significant, long-term morbidity for the patient and…

Inflammation is an immune response to insults like injuries, infections, or unhealthy dietary patterns. It is critical to control and resolve inflammation to prevent chronic inflammatory conditions. Specialized pro-resolving mediators (SPMs) are produced from long-chain polyunsaturated fats, especially EPA and DHA. This SPM Research Review examines the benefits of resolution-based nutrition and how SPMs, unique lipid mediators, play an indispensable role in switching an inflammatory response in the direction of resolution and homeostasis. View the Research Review to learn more