by Bianca Garilli, ND   Polyphenol Overview Polyphenols are naturally occurring secondary metabolites found in plants. In nature they protect against ultraviolet radiation and play a role in defending against pathogens. Over 8,000 polyphenolic compounds have been identified from a large variety of plant species.1 Based on the structure and number of phenol rings they contain, polyphenols are classified into 4 main groups: phenolic acids, flavonoids, stilbenes, and lignans.1 Phenolic Acids Phenolic acids are found extensively throughout the plant kingdom,…

by Ashley Jordan Ferira, PhD, RDN Autism spectrum disorder (ASD) is an urgent public health concern affecting approximately 1 in 59 US children.1-2 This complex neurodevelopmental syndrome is 4x more common in boys than girls and impacts all racial, ethnic, and socioeconomic backgrounds, although ASD is more common in white > black > Hispanic children.1 Other developmental, psychiatric, neurologic, chromosomal, and genetic diagnoses are known to co-occur with ASD,3-4 however, the genetic and epigenetic factors that impact autism pathogenesis are…

Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Mark Houston, MD, MS, FAHA, FASH, DABC Drs. Mark Houston and Deanna Minich delve into the science and proper clinical use of omega-3 fatty acids for the prevention and treatment of heart-related conditions. Dr. Houston vets the methodology and validity of 3 major meta-analyses related to omega-3s and heart health outcomes,1-3 helping to demystify the seemingly complex science and conflicting conclusions, so you can understand the data. Drs. Houston and Minich also discuss food…

by Lewis Chang, PhD Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) in which the immune system attacks and damages the myelin sheaths of nerve fibers in the brain and spinal cord.1 Common symptoms include cognitive difficulties, vision problems, fatigue, pain, motor problems, bladder dysfunction, and sexual problems. However, symptoms and their severity vary greatly from patient to patient depending on the location of affected nerve fibers. What triggers MS is still unknown, but a…

by Bianca Garilli, ND Physical inactivity prevalence among adolescents aged 11-17 years was estimated to be 81% globally in 2010, where insufficient physical activity (PA) was measured as < 60 minutes of moderate-to-vigorous-intensity PA daily per WHO guidelines.1 As part of the 60 minute/day exercise recommendation, the US Department of Health and Human Services recommends that aerobic activity should be incorporated at least 3 days/week, muscle-strengthening at least 3 days/week, and bone-strengthening activities at least 3 days/week.2 It is well…

by Ashley Jordan Ferira, PhD, RDN Mild traumatic brain injury (TBI), AKA “concussion,” results from an impact to the head (e.g. bump, blow, jolt) that disrupts normal brain function or consciousness.1 Concussions in youth are more common than you may think. In 2016, 19.5% of US adolescents reported at least 1 diagnosed concussion during their lifetime, with 5.5% reporting >1 concussion.2 In addition to competitive sports participation (particularly contact sports), other characteristics associated with a higher concussion rates include being…

by Christopher Moulton, PhD Depression is one of the most common mood disorders in the US and worldwide. In 2016 an estimated 16.2 million adults, or 6.7% of US adults, suffered at least one major depressive episode,1 while globally more than 300 million are afflicted.2 Further, depression is comorbid with numerous chronic disease states including cardiovascular disease,3 type 2 diabetes,4 inflammatory bowel disease,5 and cognitive decline.6 Current frontline therapies such as psychotherapy and antidepressant medications present challenges related to treatment…

by Bianca Garilli, ND For women, the pre- and post-menopausal years represent a time of major change in many aspects of life including spiritual, emotional, and physical. From a physical perspective, shifting levels of sex hormones such as dehydroepiandrosterone (DHEA), testosterone, and estrogen play critical roles in the transition in and through menopause. It’s during this chapter of a woman’s life that the number of ovarian follicles begin to decline. Their eventual depletion cause the ovaries to no longer respond…

by Lewis Chang, PhD Ketosis is the metabolic state in which ketone bodies—alternative energy substrates to glucose—are produced from fat and utilized as the main energy source for the body. An important study found that nutritional ketosis induced by consumption of medium-chain triglycerides (MCT) oil helped increase the redox NAD+/NADH ratio in the brain of healthy young adults.1 Disturbed glucose metabolism and the resulting inadequate energy supply to the brain contributes to the pathophysiology of neurodegenerative diseases such as Alzheimer’s…

Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Christopher Keroack, MD, IFMCP You may have heard about the ketogenic diet. This high-fat, low-carbohydrate, moderate-protein dietary pattern has experienced a revival of sorts in the mainstream media and dieting world. But, before “keto” was a contemporary fad, how was it used? In fact, there is ~100 years of science supporting the ketogenic diet. To shed light on its history of use and elucidate practical areas of clinical application, Drs. Deanna Minich and Christopher…