by Bianca Garilli, ND For women, the pre- and post-menopausal years represent a time of major change in many aspects of life including spiritual, emotional, and physical. From a physical perspective, shifting levels of sex hormones such as dehydroepiandrosterone (DHEA), testosterone, and estrogen play critical roles in the transition in and through menopause. It’s during this chapter of a woman’s life that the number of ovarian follicles begin to decline. Their eventual depletion cause the ovaries to no longer respond…

by Lewis Chang, PhD Ketosis is the metabolic state in which ketone bodies—alternative energy substrates to glucose—are produced from fat and utilized as the main energy source for the body. An important study found that nutritional ketosis induced by consumption of medium-chain triglycerides (MCT) oil helped increase the redox NAD+/NADH ratio in the brain of healthy young adults.1 Disturbed glucose metabolism and the resulting inadequate energy supply to the brain contributes to the pathophysiology of neurodegenerative diseases such as Alzheimer’s…

Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Christopher Keroack, MD, IFMCP You may have heard about the ketogenic diet. This high-fat, low-carbohydrate, moderate-protein dietary pattern has experienced a revival of sorts in the mainstream media and dieting world. But, before “keto” was a contemporary fad, how was it used? In fact, there is ~100 years of science supporting the ketogenic diet. To shed light on its history of use and elucidate practical areas of clinical application, Drs. Deanna Minich and Christopher…

by Annalouise O’Connor, PhD, RD Dyslipidemia is defined as an abnormal level of lipids in the blood and is often described most simplistically as greater levels of total or low-density lipoprotein (LDL), the “bad” cholesterol or particle number, or lower levels of high-density lipoprotein (HDL), the “good” cholesterol. Dyslipidemia is linked with cardiovascular risk and is highly prevalent: The minority of adults (46.6%) in the US have on-target total cholesterol levels (<200mg/dL).1 With cardiovascular disease (CVD) responsible for one in every…

by Lewis Chang, PhD The Mediterranean diet (MED), characterized by a high consumption of plant-based foods, less red meat, and using olive oil as the main source of fat, is one of the healthiest diets. A study found that MED might also prolong brain health and function in cognitively healthy middle-aged individuals.1 According to an earlier systematic review of cohort studies and randomized controlled trials, adherence to MED was associated with a lower risk of cognitive decline and Alzheimer’s disease…

by Milene Brownlow, PhD In addition to their original use as an anticonvulsant treatment (explored in Part 1 of this blog series), ketogenic diets (KDs) are increasingly viewed as a promising metabolic therapy for other neurological conditions. But first, an important question: Are KDs neuroprotective because of the reduction in glucose and insulin levels or due to the presence of ketones? Answer: Both. On the one hand, chronic consumption of refined sugar and starches results in systemic inflammation in the…

by Bianca Garilli, ND Introduction You’re sitting in a relaxing chair at the bookstore with no acute stress or problems, when out of the blue your heart begins to race, flutter, and skip beats. This is not the first time this has happened and you wonder if you might be experiencing a medical emergency. Should you be concerned and call 911, or simply ignore the strange fluttering feelings and continue reading? The answer, as is often the case in medicine:…

Christopher Bump, DC covers real world experiences supplementing with Specialized Pro-Resolving Mediators and reviews typical everyday patients he has treated with SPMs and the positive results each individual has experienced from insomnia to periodontal pain. View the slides

by Bianca Garilli, ND  History of breast milk: then and now The “breast is best” and “liquid gold” taglines made their return to conventional pediatric conversations in recent years, diverging from a previous school of thought that led Western mothers to believe their naturally produced, free breast milk was inferior to factory made synthetic formulas with a price tag. Interestingly enough, this was not the first time natural breastfeeding had gone out of vogue. A brief history of infant feeding…

by Milene Brownlow, PhD It is estimated that 5.7 million Americans live with Alzheimer’s disease (AD).1 For decades, research efforts have targeted neuropathological features of the disease (amyloid plaques, tau dysregulation and tangle formation) with little success so far. Impaired brain glucose metabolism is an early hallmark of the disease.2 For instance, cerebral metabolic rate of glucose (CMRglu) utilization was found to be 13% lower in AD compared to healthy, young subjects.3 Conversely, brain ketone metabolism remains unchanged in mild…