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Articles, Functional Medicine, Musculoskeletal

Most patients seeking pain relief rely on the following three families of drugs: opioids, gabapentinoids, and nonsteroidal anti-inflammatory agents (NSAIDs). These widely used drugs are associated with serious side effects.1 During the past decade there has been an increasing interest in cannabis-derived products for pain management with a better safety profile and adequate pain relief. However, we still know surprisingly little about the effectiveness of nonintoxicating cannabis-based products on pain—conventionally referred to as “industrial hemp.” A new preclinical study using…

Most patients seeking pain relief rely on the following three families of drugs: opioids, gabapentinoids, and nonsteroidal anti-inflammatory agents (NSAIDs). These widely used drugs are associated with serious side effects.1 During the past…

View this 2-minute preview of an upcoming webinar with Amy Coleman, MD. Webinar summary Amy Coleman, MD provides a high-level overview of the gut-skin connection. She discusses how leaky gut can lead to a number of inflammatory skin diseases including psoriasis and eczema. Dr. Coleman provides her steps to heal the gut and lead to skin relief. In her steps to heal the inflammatory response, she includes specific diets as well as bioactives to heal the mucosal lining and support…

View this 2-minute preview of an upcoming webinar with Amy Coleman, MD. Webinar summary Amy Coleman, MD provides a high-level overview of the gut-skin connection. She discusses how leaky gut can lead to…

Blogs, Digestive, Functional Medicine

by Melissa Blake, ND Immune resilience has never been more important or desired than in the past year. As a result of a global pandemic, patients and practitioners alike are seeking effective solutions to ensure a robust immune defense. Outside of the current COVID-19 concerns, respiratory tract infections (RTIs) pose a significant burden and are, in children, elderly, and immunocompromised individuals, the most prevalent diseases globally.1 A well-balanced gut microbiota is associated with protection against various diseases, including respiratory infections,…

by Melissa Blake, ND Immune resilience has never been more important or desired than in the past year. As a result of a global pandemic, patients and practitioners alike are seeking effective solutions…

Articles, Foundational, Functional Medicine

The ketogenic diet (KD) is a low-carbohydrate, high-fat, adequate-protein diet that has proven to be effective for the reversal of several chronic conditions including obesity, metabolic syndrome, and type-2 diabetes (T2DM) in trials of up to two years.1 However, the degree of therapeutic response to KD varies across individuals.2,3 For example, some KD dieters lose more weight than others, and, while most of them improve their blood lipids, so-called “high responders” experience abnormal increases in low-density lipoprotein cholesterol (LDL-C). Many…

The ketogenic diet (KD) is a low-carbohydrate, high-fat, adequate-protein diet that has proven to be effective for the reversal of several chronic conditions including obesity, metabolic syndrome, and type-2 diabetes (T2DM) in trials…

Blogs, Functional Medicine

by Anu Desai, PhD Messenger RNA (mRNA) is a single-stranded molecule of genetic code found in all living cells. As a chemical intermediary, mRNA carries instructions from deoxyribonucleic acid (DNA) in our chromosomes to cellular machinery in the cytoplasm of the cell to make proteins.1 Over the past decade, research and technological innovations progressed rapidly in the field of vaccine development enabling mRNA as a promising therapeutic tool. There has been research on mRNA vaccines for infectious agents, such as…

by Anu Desai, PhD Messenger RNA (mRNA) is a single-stranded molecule of genetic code found in all living cells. As a chemical intermediary, mRNA carries instructions from deoxyribonucleic acid (DNA) in our chromosomes…

Blogs, Functional Medicine, Musculoskeletal

by Michael Stanclift, ND Many of us have been using omega-3 fats, such as fish oil, for managing inflammatory conditions. Interestingly, fish oil and special molecules made from them called specialized pro-resolving mediators (SPMs) have big impacts on our immune system and play an important role in the activity of immune cells. The key lies in how fats such as the ones found in fish oil influence the behavior of the white blood cells (WBCs) of our immune system. Our…

by Michael Stanclift, ND Many of us have been using omega-3 fats, such as fish oil, for managing inflammatory conditions. Interestingly, fish oil and special molecules made from them called specialized pro-resolving mediators…

Blogs, Digestive, Functional Medicine

by Anu Desai, PhD Pollution and toxic elements Environmental pollution and toxins from plastics, pesticides, smoke, contaminated water, and food have the potential to greatly impact human health.1 These toxic loads cause inflammatory and autoimmune responses, including neurodegenerative conditions including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS).2-4 More recently, some efforts have been made to minimize the exposures to pollutants in the long run, such as: using BPA-free plastics, attempting to reduce greenhouse gasses, and incorporating clean-energy…

by Anu Desai, PhD Pollution and toxic elements Environmental pollution and toxins from plastics, pesticides, smoke, contaminated water, and food have the potential to greatly impact human health.1 These toxic loads cause inflammatory…

Foundational, Functional Medicine, Video

In this interview, Joan Claria, PhD discusses the discovery that a resolution deficit occurs in obesity. Dr. Claria outlines the important role that specialized pro-resolving mediators (SPMs) play in adipose tissue and metabolic health, and outlines future potential for SPM-based therapies in the management of fatty liver disease. Joan Claria, PhD is Professor at the Department of Biomedical Sciences at the School of Medicine of the University of Barcelona, Spain From the 16th International Conference on Bioactive Lipids in Cancer,…

In this interview, Joan Claria, PhD discusses the discovery that a resolution deficit occurs in obesity. Dr. Claria outlines the important role that specialized pro-resolving mediators (SPMs) play in adipose tissue and metabolic…

Functional Medicine, Musculoskeletal, Video

In this interview, Dipak Panigrahy, MD discusses the emerging impact of specialized pro-resolving mediators (SPMs) on tumor size and growth, highlighting his work with several preclinical models including pancreatic cancer and breast cancer.  Dr. Panigrahy outlines the reduction in metastases seen in preclinical cancer models, including pancreatic cancer, following treatments with various SPMs. Finally, Dr Panigrahy describes results in preclinical models showing that SPM treatment helps to clear tumor debris caused by standard of care cancer treatments. Dipak Panigrahy, MD,…

In this interview, Dipak Panigrahy, MD discusses the emerging impact of specialized pro-resolving mediators (SPMs) on tumor size and growth, highlighting his work with several preclinical models including pancreatic cancer and breast cancer.…

Foundational, Functional Medicine, Video

In this interview, Bruce Levy, MD describes the loss of inflammatory ‘breaking signals’ in the lung of patients with asthma. Dr. Levy highlights how this defective resolution phenotype negatively impacts both adaptive and innate immune responses in individuals with asthma, leaving them more vulnerable to infection. Bruce Levy, MD is the Chief of the Division of Pulmonary and Critical Care Medicine at Brigham and Women's Hospital, MA and Parker B. Francis Professor at Harvard Medical School From the 16th International…

In this interview, Bruce Levy, MD describes the loss of inflammatory ‘breaking signals’ in the lung of patients with asthma. Dr. Levy highlights how this defective resolution phenotype negatively impacts both adaptive and…

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