By: Yekta Dowlati, PhD Introduction Creatine is one of the most extensively studied dietary supplements, supporting its role in exercise performance, recovery, and clinical health. Despite this robust evidence base, discussions of creatine supplementation have historically centered on men, particularly athletes and bodybuilders.1 This has left a significant gap in the clinical dialogue on women’s health—despite the fact that women possess 70–80% lower endogenous creatine stores compared to men, and often consume less through diet.1 Emerging research now suggests that…

By: Yekta Dowlati, PhD The Hidden Crisis of Skeletal Decline Osteoporosis represents a major clinical and public health challenge, with an estimated one in two women experiencing an osteoporosis-related fracture in their lifetime. While fractures are often considered a problem of advanced age, the biological processes that predispose women to skeletal fragility accelerate dramatically during the menopausal transition. Bone is a dynamic tissue, continuously remodeled through the interplay of osteoclast-mediated resorption and osteoblast-mediated formation. This remodeling ensures that old, damaged…

By: Yekta Dowlati, PhD Vitamin C (ascorbic acid/ascorbate) is indispensable for immune defense, yet insufficiency remains widespread even in high-income nations. Data from the U.S. NHANES 2003–2006 survey revealed that 41.8% of adults had insufficient plasma Vitamin C levels, spanning deficiency (<11 µmol/L), hypovitaminosis (11–23 µmol/L), and inadequate concentrations (23–49 µmol/L).1 Notably, males, smokers, individuals with elevated BMI, and populations experiencing food insecurity were disproportionately affected. While scurvy is now rare, subclinical Vitamin C insufficiency exerts significant biological consequences. Inadequate…

By: Yekta Dowlati, PhD Pain is not merely a symptom; it is the consequence of disrupted immune resolution, tissue stress, metabolic dysfunction, and maladaptive neuroplasticity. The historical emphasis on symptom suppression through analgesics and anti-inflammatory drugs has overlooked the body’s own endogenous mechanisms for controlling inflammation and restoring homeostasis. As a result, conventional therapies often provide only temporary relief, while doing little to address the biological underpinnings of chronic pain. Emerging research in resolution biology, enzymatic signaling, and phytochemical immunomodulation…

Magnesium is a vital micronutrient involved in more than 600 enzymatic reactions, playing indispensable roles in energy metabolism, neuromuscular conduction, neurotransmitter synthesis, and cellular stress resilience.1,2 As the second most abundant intracellular cation after potassium, magnesium plays a critical role in maintaining ionic gradients, regulating intracellular hydration, and supporting cellular homeostasis under both physiological and stress conditions.3 Yet despite its ubiquity, magnesium deficiency, both overt and subclinical, is remarkably common and clinically underrecognized, especially in the context of chronic stress,…

By: Yekta Dowlati, PhD In today’s demanding world, restorative sleep, metabolic balance, and immune readiness are increasingly compromised—particularly in women navigating complex hormonal landscapes. Many experience chronic stress, disrupted sleep architecture, immune dysregulation, and emotional fatigue, all of which can erode physiological resilience over time.¹ The nighttime hours represent a biologically privileged window for recovery—a period when cortisol levels should decline, cellular repair mechanisms activate, and immune surveillance intensifies. However, disruptions in circadian rhythm, hormonal regulation, and stress responsiveness can…

by Yekta Dowlati, PhD In today’s fast-paced world, maintaining optimal health and vitality can feel overwhelming. With constant demands on energy, mood, digestion, and metabolism, many people struggle to feel their best. For women, these challenges can be even more complex due to hormonal fluctuations, evolving health needs, and busy lifestyles. But what if the key to lasting well-being lies in science-backed, natural ingredients? Research shows that targeted bioactive compounds—derived from plants and essential minerals—can support the body’s natural ability…