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Cardiometabolic, Obesity

There is a need to identify methods to complement and enhance compliance for the ketogenic diet in order to induce and sustain ketosis. Exogenous ketone supplementation, particularly with beta-hydroxybutyrate (βHB) salts, is one such method that has grown in commercial popularity, but clinical studies that test the efficacy and safety of exogenous ketones are lacking. A pilot study1 published in the Journal of Nutritional Health & Food Engineering assessed the circulating βHB blood (capillary) concentration in response to acute, oral βHB…

There is a need to identify methods to complement and enhance compliance for the ketogenic diet in order to induce and sustain ketosis. Exogenous ketone supplementation, particularly with beta-hydroxybutyrate (βHB) salts, is one…

Dominic D’Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida In Q&A Part 2, Dominic D’Agostino, PhD focuses his discussion on the brain. Dr. D’Agostino explores misconceptions that exist regarding brain physiology, such as glucose dependency. He focuses on the neuroprotective effects of intermittent fasting, reducing glucose and insulin levels, and increasing ketone levels. Dr. D’Agostino shares how a targeted ketogenic approach can reduce neuroinflammation, enhance brain energy metabolism, and activate genetic changes that support…

Dominic D’Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida In Q&A Part 2, Dominic D’Agostino, PhD focuses his discussion on the brain. Dr. D’Agostino explores misconceptions that…

Dominic D’Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida In Q&A Part 1, Dr. Dominic D’Agostino shares his personal experience working with the US Navy to research the cellular and molecular mechanisms of oxygen toxicity seizures, which are a significant limitation for Navy SEAL fighters using special breathing apparatuses. This research allowed Dr. D’Agostino to unearth the unique benefits of nutritional ketosis to target energy metabolism pathways, thereby limiting seizures in Navy SEALs, even during…

Dominic D’Agostino, PhD; Assoc. Professor, Dept. of Molecular Pharmacology and Physiology, University of South Florida In Q&A Part 1, Dr. Dominic D’Agostino shares his personal experience working with the US Navy to research the…

Dominic D’Agostino, PhD is a researcher in neuroscience, molecular pharmacology, and physiology who has conducted mechanistic and clinical research on the ketogenic diet and its health benefits. The ketogenic diet is a high-fat, moderate-protein, low-carbohydrate dietary approach associated with meat eaters, but is the ketogenic diet feasible for vegetarians and even vegans? In this talk Dr. D’Agostino argues that anyone can potentially benefit from the ketogenic lifestyle. He shares targeted recipes and supporting nutrition science for vegetarians and vegans to…

Dominic D’Agostino, PhD is a researcher in neuroscience, molecular pharmacology, and physiology who has conducted mechanistic and clinical research on the ketogenic diet and its health benefits. The ketogenic diet is a high-fat,…

The ketogenic diet was originally studied and used in patients with seizure disorders, such as epilepsy. The ketogenic diet was shown to be superior to anticonvulsant drug therapies for seizure reduction or remission in a large portion this patient population. The underlying mechanisms mediating the profound impact of the ketogenic diet on seizure disorders include the suppression of oxidative stress and inflammation, in addition to the brain being fed ketones, which are a more efficient fuel source than glucose. In…

The ketogenic diet was originally studied and used in patients with seizure disorders, such as epilepsy. The ketogenic diet was shown to be superior to anticonvulsant drug therapies for seizure reduction or remission…

In this MAPS talk, Dr. Dominic D’Agostino examines the role of the ketogenic diet in metabolic health optimization. We know that metabolic health correlates with overall health in the body, so by optimizing metabolic health, defined by a set of biomarkers that reliably predict the physiological and metabolic state, we can potentially help delay the onset of many age-related chronic diseases. Dr. D’Agostino explains how the ketogenic diet may help manage many of these conditions, such as type 2 diabetes…

In this MAPS talk, Dr. Dominic D’Agostino examines the role of the ketogenic diet in metabolic health optimization. We know that metabolic health correlates with overall health in the body, so by optimizing…

Dominic D’Agostino, PhD is an expert on ketogenic science, having conducted research on the cellular, molecular, and physiological impacts of ketosis on the body. In part 2 of a 3-part discussion, Dr. D’Agostino examines the following facets of the ketogenic diet: Common myths surrounding the ketogenic diet Ketone testing How long should a patient be on the ketogenic diet? Nutritional ketosis and supplementation What conditions appear to be highly responsive to the ketogenic diet? Originally aired October 25, 2018

Dominic D’Agostino, PhD is an expert on ketogenic science, having conducted research on the cellular, molecular, and physiological impacts of ketosis on the body. In part 2 of a 3-part discussion, Dr. D’Agostino…

Dominic D’Agostino, PhD has conducted research on the ketogenic diet to ascertain the cellular, molecular, and physiological impacts that ketosis and its metabolic transition have on the body. In part 1 of a 3-part discussion series, Dr. D’Agostino provides research and clinical evidence to answer the following questions: What is the ketogenic diet? What are the optimal measurement indicators for optimal ketosis? What is the macronutrient profile of the ketogenic diet? What is intermittent fasting and what are the potential…

Dominic D’Agostino, PhD has conducted research on the ketogenic diet to ascertain the cellular, molecular, and physiological impacts that ketosis and its metabolic transition have on the body. In part 1 of a…

In Q&A Part 3, Dominic D’Agostino, PhD explains a conundrum: the evidence basis and clinical benefits of the ketogenic diet for certain chronic disease states are well known, however, there are many individuals who are unable or unwilling to implement a ketogenic diet. To address this issue, Dr. D’Agostino and others are researching the impact of exogenous ketone supplementation on raising ketone levels in the body. Dr. D’Agostino shares the latest research in this area and provides his expert perspective…

In Q&A Part 3, Dominic D’Agostino, PhD explains a conundrum: the evidence basis and clinical benefits of the ketogenic diet for certain chronic disease states are well known, however, there are many individuals…

In Q&A Part 2, Dominic D’Agostino, PhD focuses his discussion on the brain. Dr. D’Agostino explores misconceptions that exist regarding brain physiology, such as glucose dependency. He focuses on the neuroprotective effects of intermittent fasting, reducing glucose and insulin levels, and increasing ketone levels. Dr. D’Agostino shares how a targeted ketogenic approach can reduce neuroinflammation, enhance brain energy metabolism, and activate genetic changes that support brain protection and resilience. You will hear about the research technology Dr. D’Agostino and his…

In Q&A Part 2, Dominic D’Agostino, PhD focuses his discussion on the brain. Dr. D’Agostino explores misconceptions that exist regarding brain physiology, such as glucose dependency. He focuses on the neuroprotective effects of…

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