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In Q&A Part 1, Dr. Dominic D’Agostino shares his personal experience working with the US Navy to research the cellular and molecular mechanisms of oxygen toxicity seizures, which are a significant limitation for Navy SEAL fighters using special breathing apparatuses. This research allowed Dr. D’Agostino to unearth the unique benefits of nutritional ketosis to target energy metabolism pathways, thereby limiting seizures in Navy SEALs, even during times of oxidative stress. Dr. D’Agostino discusses the evidence basis for the ketogenic diet,…

In Q&A Part 1, Dr. Dominic D’Agostino shares his personal experience working with the US Navy to research the cellular and molecular mechanisms of oxygen toxicity seizures, which are a significant limitation for…

Obesity

by Christopher Keroack, MD, IFMCP Excess adiposity remains one of the leading healthcare concerns in America. Two-thirds of our nation is overweight and one-third is obese.1 As a healthcare force, we recognize that lifestyle factors like nutrition and physical activity are major contributors to this epidemic. Because of this, novel approaches to nutrition have come about in the last decade to address this epidemic…some helpful, others not so much. Along with Hippocrates, the father of healthcare who said, “There are…

by Christopher Keroack, MD, IFMCP Excess adiposity remains one of the leading healthcare concerns in America. Two-thirds of our nation is overweight and one-third is obese.1 As a healthcare force, we recognize that…

Cognitive

by Lewis Chang, PhD Ketosis is the metabolic state in which ketone bodies—alternative energy substrates to glucose—are produced from fat and utilized as the main energy source for the body. An important study found that nutritional ketosis induced by consumption of medium-chain triglycerides (MCT) oil helped increase the redox NAD+/NADH ratio in the brain of healthy young adults.1 Disturbed glucose metabolism and the resulting inadequate energy supply to the brain contributes to the pathophysiology of neurodegenerative diseases such as Alzheimer’s…

by Lewis Chang, PhD Ketosis is the metabolic state in which ketone bodies—alternative energy substrates to glucose—are produced from fat and utilized as the main energy source for the body. An important study…

Cardiometabolic, Cognitive, Foundational, Obesity

Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Christopher Keroack, MD, IFMCP You may have heard about the ketogenic diet. This high-fat, low-carbohydrate, moderate-protein dietary pattern has experienced a revival of sorts in the mainstream media and dieting world. But, before “keto” was a contemporary fad, how was it used? In fact, there is ~100 years of science supporting the ketogenic diet. To shed light on its history of use and elucidate practical areas of clinical application, Drs. Deanna Minich and Christopher…

Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Christopher Keroack, MD, IFMCP You may have heard about the ketogenic diet. This high-fat, low-carbohydrate, moderate-protein dietary pattern has experienced a revival of sorts in the mainstream…

Cognitive

by Milene Brownlow, PhD This 3-part blog series explores the history (Part 1), mechanisms and evidence (Part 2) underlying the neuroprotective effects of the ketogenic diet. In the final part 3, let’s investigate the current scientific evidence in support of the ketogenic diet (KD) as a therapeutic approach for specific neurological disorders. Preclinical study evidence In rodents, diet-induced ketosis has been shown to reverse motor deficits in a model of amyotrophic lateral sclerosis (ALS),1 reduce lesion volume after traumatic brain…

by Milene Brownlow, PhD This 3-part blog series explores the history (Part 1), mechanisms and evidence (Part 2) underlying the neuroprotective effects of the ketogenic diet. In the final part 3, let’s investigate…

Cognitive

by Milene Brownlow, PhD In addition to their original use as an anticonvulsant treatment (explored in Part 1 of this blog series), ketogenic diets (KDs) are increasingly viewed as a promising metabolic therapy for other neurological conditions. But first, an important question: Are KDs neuroprotective because of the reduction in glucose and insulin levels or due to the presence of ketones? Answer: Both. On the one hand, chronic consumption of refined sugar and starches results in systemic inflammation in the…

by Milene Brownlow, PhD In addition to their original use as an anticonvulsant treatment (explored in Part 1 of this blog series), ketogenic diets (KDs) are increasingly viewed as a promising metabolic therapy…

Scott Bergman, DC, CTN, DAAIM; Ryan Lazarus, DC, MS, CNS, IFMCP; and Jeff Volek, PhD, RD Three key opinion leaders touch on the biological science behind ketosis as well as emerging scientific research that suggests the epigenetic benefits of a ketogenic lifestyle. To monitor progress during a ketogenic lifestyle plan, they explain how to check for ketone levels, the optimal range for ketosis, and which biomarkers to measure. To help supplement a meal plan, easy-to-consume exogenous ketones and MCT oil…

Scott Bergman, DC, CTN, DAAIM; Ryan Lazarus, DC, MS, CNS, IFMCP; and Jeff Volek, PhD, RD Three key opinion leaders touch on the biological science behind ketosis as well as emerging scientific research…

Scott Bergman, DC, CTN, DAAIM; Ryan Lazarus, DC, MS, CNS, IFMCP; and Jeff Volek, PhD, RD Three key opinion leaders explain the impact the ketogenic diet may have on various health conditions such as epilepsy, obesity, insulin resistance, and neurological disorders. They also explain why keto can be beneficial for athletes and how it may help increase focus and athletic performance. These Q&A insights will provide you with clinical pearls on how to distinguish the appropriate patient for a ketogenic…

Scott Bergman, DC, CTN, DAAIM; Ryan Lazarus, DC, MS, CNS, IFMCP; and Jeff Volek, PhD, RD Three key opinion leaders explain the impact the ketogenic diet may have on various health conditions such…

Scott Bergman, DC, CTN, DAAIM; Ryan Lazarus, DC, MS, CNS, IFMCP; and Jeff Volek, PhD, RD Three key opinion leaders share their take on the philosophy behind the ketogenic diet and its therapeutic benefits, including macronutrient ratios, the process of ketosis, and the history of ketosis for human survival. They also provide thoughtful responses to the common misconceptions of keto as well as historical, experiential evidence for long-term use. The insights from this expert Q&A discussion will provide you with…

Scott Bergman, DC, CTN, DAAIM; Ryan Lazarus, DC, MS, CNS, IFMCP; and Jeff Volek, PhD, RD Three key opinion leaders share their take on the philosophy behind the ketogenic diet and its therapeutic…

Cardiometabolic, Cognitive, Foundational, Obesity

Although the ketogenic diet has been used clinically since the early 20th century, with specific therapeutic use for seizure mitigation in children with intractable epilepsy, the “keto diet” is now discussed more broadly, having even entered colloquial use. With the ketogenic diet’s recent rise in mainstream popularity and increased clinical exposure, we compiled a Q&A with Mark Kaye, DC to answer specific questions from healthcare practitioners. Does a ketogenic lifestyle work for hypothyroid patients? Contributing factors to low thyroid function…

Although the ketogenic diet has been used clinically since the early 20th century, with specific therapeutic use for seizure mitigation in children with intractable epilepsy, the “keto diet” is now discussed more broadly,…

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