Search Results for: SPM

This downloadable article discusses the relationship between bacterial infections and acute inflammation. Underlying mechanisms for how bacterial infections contribute to active resolution of acute inflammation are unknown. Here, we performed exudate leukocyte trafficking and mediator-metabololipidomics of murine peritoneal Escherichia coli infections with temporal identification of pro-inflammatory (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPMs). In self-resolving E. coli exudates (10(5) colony forming units, c.f.u.), the dominant SPMs identified were resolvin (Rv) D5 and protectin D1 (PD1), which at 12 h were…

Acute inflammation is normal and protective to the host, but when inflammation becomes chronic, it can damage tissues and be destructive to health. The resolution of inflammation involves several key steps: the termination of neutrophil recruitment, counterregulation of proinflammatory mediators, stimulation of macrophage-mediated clearance, and tissue remodeling. This review of the evidence by leading experts explains how the failure of inflammation resolution contributes to metabolic diseases and the pivotal role that specialized pro-resolving mediators (SPMs), resolvins, protectins, and maresins, play…

What tools exist to help prevent chronic inflammation and disease? In his talk “Start the Resolution: Stopping the Progression of Chronic Disease,” Robert Martindale, MD, PhD, Professor and Chief for the Division of GI and General Surgery at Oregon Health & Science University, explores the newest paradigm in metabolic mediation: inflammation resolution physiology. Dr. Martindale differentiates between anti-inflammatory and pro-resolution actions in the body. He delves into the unique roles that polyunsaturated fatty acids and a novel lipid mediator class,…

In the first part of an interview series, Charles Serhan, PhD, DSc answers the question “How and when did you determine the significant of resolution physiology to human health?” Dr. Serhan shares an edifying history of resolution physiology: from early microscope observations of leukocytic infiltration, to the turning point lipoxin discoveries in the 1990s, to the latest research insights and inquiries today. Once thought to be a passive event mediated by chemokines, resolution is now known to be an active…

Metabolic syndrome (MetS) is a chronic health condition comprised of a group of risk factors that raise the risk of developing cardiovascular disease, diabetes, and stroke. The National Institutes of Health (NIH) identified five risk factors that indicate that a patient may have MetS. These include a large waistline, elevated triglycerides, low HDL cholesterol, high blood pressure, and high fasting blood glucose. As prevalence and incidence of obesity increase globally, the risk of developing MetS increases as well. The NIH indicates that…

Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. The precursors to SPMs are Omega-3 essential fatty acids, EPA and DHA. In this short video with Dr. Charles Serhan of Harvard Medical School, MHICN inquires about whether it is possible for humans have excessive intake of SPMs. Dr. Serhan responds no as SPM operate under  a feed forward mechanism. 11. Insights from the Metagenics Lifestyle Summit 2015: Charles Serhan, PhD

The Dietary Guidelines for Americans 2015-2020 were released in January 2016 and have made significant updates for the consumer based on good science. However, the translation of the scientific basis of the recommendations to the Dietary Guidelines did not include some key scientific insights important to healthy lifestyles. Based on our ongoing commitment to creating safe, trusted, and effective medical nutrition solutions to prevent and manage chronic diseases, we conducted a detailed review in collaboration with our research partners at the Joslin Diabetes…

by Kara Fitzgerald, ND Allergy season is in high gear. The trees are budding and pollen is bursting forth in Connecticut. As our winters are warmer, we’re also seeing allergies kick in sooner, perhaps with a higher intensity than in years past. While most of us are cracking our windows open and emerging from the winter cocoon into the welcoming sun, our spring allergy patients step outside or crack their windows and they’re bombarded immediately with an almost invisible (to the non-sufferer)…

Specialized pro-resolving mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, Metagenics Institute asks Dr. Charles Serhan of Harvard Medical School about the significance of resolution physiology in the healthcare system today. Dr. Serhan responded that while resolution physiology has been known for decades, it has not been studied in detail of mechanisms until recently. Dr. Serhan’s work has shown that there is an organized progression to homeostasis from…

While inflammation is at the root of all sorts of poor outcomes and diseases it isn’t the fault of inflammation itself. Indeed, inflammation is a natural and protective response to specific insults and injuries. Healthy inflammation resolves naturally when you get a cut, for example. When inflammation becomes chronic, however, it can become destructive to the body’s tissues and systems. Long-term, chronic inflammation due to disease, a pro-inflammatory diet, or aging should be resolved as much as possible. Download the…