As the widespread adoption of GLP-1 receptor agonists reshapes the treatment landscape for obesity and metabolic disease, a new and arguably more intricate challenge is emerging: guiding patients through the phase that follows with GLP-1 nutritional support. The discontinuation of GLP-1 therapy is not merely the end of pharmacologic appetite suppression; it represents a critical metabolic inflection point, where compensatory physiology can rapidly unravel previous progress if left unchecked.1,2 What follows is far from benign. Appetite mechanisms recalibrate, often overshooting…
As the widespread adoption of GLP-1 receptor agonists reshapes the treatment landscape for obesity and metabolic disease, a new and arguably more intricate challenge is emerging: guiding patients through the phase that follows…
By: Yekta Dowlati, PhD GLP-1 receptor agonists (GLP-1 RAs), including semaglutide and liraglutide, have redefined therapeutic strategies for type 2 diabetes and obesity by harnessing incretin biology to achieve profound metabolic benefits.1 These agents enhance glucose-dependent insulin secretion, suppress glucagon, delay gastric emptying, and reduce appetite through central and peripheral pathways. However, the same physiological mechanisms that underpin their efficacy are intrinsically linked to gastrointestinal (GI) side effects—an area of growing clinical significance.2 Nausea, early satiety, bloating, diarrhea, and constipation…
By: Yekta Dowlati, PhD GLP-1 receptor agonists (GLP-1 RAs), including semaglutide and liraglutide, have redefined therapeutic strategies for type 2 diabetes and obesity by harnessing incretin biology to achieve profound metabolic benefits.1 These…
By: Yekta Dowlati, PhD The therapeutic landscape for obesity and type 2 diabetes mellitus (T2DM) has been revolutionized by glucagon-like peptide-1 receptor agonists (GLP-1 RAs), with weight reductions approaching magnitudes once exclusive to bariatric surgery. Yet, alongside dramatic fat mass loss, emerging data underscore a concerning reality: a substantial fraction of weight shed on GLP-1 RAs is lean mass — up to 40% in some trials.1,2 As muscle quantity and quality are integral to metabolic resilience, physical function, and…
By: Yekta Dowlati, PhD The therapeutic landscape for obesity and type 2 diabetes mellitus (T2DM) has been revolutionized by glucagon-like peptide-1 receptor agonists (GLP-1 RAs), with weight reductions approaching magnitudes once exclusive…
By: Yekta Dowlati, PhD The advent of GLP-1 receptor agonists (GLP-1 RAs) marks a transformative era in obesity and type 2 diabetes management. As of 2024, 6% of adults in the United States are currently using GLP-1 medications, with 12% reporting either current or previous use.1 Among those who have been diagnosed with overweight or obesity by a healthcare provider, this figure increases to 22%.1 These agents—such as semaglutide and tirzepatide—deliver clinically meaningful weight loss, improved glycemic control, and cardiovascular…
By: Yekta Dowlati, PhD The advent of GLP-1 receptor agonists (GLP-1 RAs) marks a transformative era in obesity and type 2 diabetes management. As of 2024, 6% of adults in the United States…
by Yekta Dowlati, PhD In today’s fast-paced world, maintaining optimal health and vitality can feel overwhelming. With constant demands on energy, mood, digestion, and metabolism, many people struggle to feel their best. For women, these challenges can be even more complex due to hormonal fluctuations, evolving health needs, and busy lifestyles. But what if the key to lasting well-being lies in science-backed, natural ingredients? Research shows that targeted bioactive compounds—derived from plants and essential minerals—can support the body’s natural ability…
by Yekta Dowlati, PhD In today’s fast-paced world, maintaining optimal health and vitality can feel overwhelming. With constant demands on energy, mood, digestion, and metabolism, many people struggle to feel their best. For…
by Kyle Perkovich, BS The gut, often referred to as the body’s “second brain,” is central to overall health, influencing everything from digestion to immune function, metabolism, and even mental health.1-3 Emerging research consistently demonstrates that a balanced and diverse gut microbiome is essential for overall health and a key aspect of every patient’s wellness. The gut microbiome – a complex ecosystem containing trillions of bacteria and other microorganisms – helps regulate digestion and communicates with various body systems through neurotransmitters,…
by Kyle Perkovich, BS The gut, often referred to as the body’s “second brain,” is central to overall health, influencing everything from digestion to immune function, metabolism, and even mental health.1-3 Emerging research consistently…
In this interview, Valerio Chiurchiu, PhD addresses the crucial role of SPMs in neuroinflammation and brain health. He explains their critical function in resolving neuroinflammation and maintaining brain homeostasis, particularly highlighting their impact on neurodegenerative diseases such as MS and Parkinsons Disease. Dr. Chiurchiu also covers the therapeutic potential of SPMs for neurological disorders and discusses the challenges of translating these findings into clinical practice. Valerio Chiurchiu, PhD, is the head of the laboratory for Neuroinflammation and Resolution at CNR…
In this interview, Valerio Chiurchiu, PhD addresses the crucial role of SPMs in neuroinflammation and brain health. He explains their critical function in resolving neuroinflammation and maintaining brain homeostasis, particularly highlighting their impact…
In this interview, Dr. Ru-Rong Ji delves into the pain-relieving properties of SPMs, discussing their effectiveness in mitigating both inflammatory and neuropathic pain. He emphasizes the significance of SPMs in resolution pharmacology and their potential to reduce opioid dependency. Dr. Ji describes the successful application of SPMs in animal studies and their promising prospects for human therapy. Ru-Rong Ji, PhD, is a Professor of Anesthesiology, Neurobiology and Cell Biology and the Director of the Center for Translational Pain Medicine at…
In this interview, Dr. Ru-Rong Ji delves into the pain-relieving properties of SPMs, discussing their effectiveness in mitigating both inflammatory and neuropathic pain. He emphasizes the significance of SPMs in resolution pharmacology and…
In this interview, Robert Martindale, MD, PhD, sheds light on the benefits of immunonutrition and SPMs in patient recovery post-surgery. He highlights how these nutritional strategies help modulate the immune response and improve outcomes for surgical and critical care patients. Dr. Martindale addresses the challenges of integrating such approaches into patient care. He also explores how nutritional interventions can influence metabolic balance and accelerate recovery, expressing enthusiasm for ongoing research in this field. Robert Martindale, MD, PhD, is a Professor…
In this interview, Robert Martindale, MD, PhD, sheds light on the benefits of immunonutrition and SPMs in patient recovery post-surgery. He highlights how these nutritional strategies help modulate the immune response and improve…
In this interview, Olga Baker, PhD, DDS, focuses on the treatment of Sjogren’s syndrome, discussing the limitations of current methods and the potential of SPMs like resolvin D1 to reduce inflammation and aid tissue restoration. Dr. Baker also expresses optimism about the future of research in this field, highlighting the importance of translating findings from animal models to human treatments. Olga Baker, PhD, DDS, is a Professor of Otolaryngology at the University of Missouri, School of Medicine.
In this interview, Olga Baker, PhD, DDS, focuses on the treatment of Sjogren’s syndrome, discussing the limitations of current methods and the potential of SPMs like resolvin D1 to reduce inflammation and aid…
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