In this interview, Edward Botchwey, PhD delves into the use of emerging technologies like metabolomics to identify insufficiencies in endogenous lipid mediators that may impact tissue healing. Dr. Botchwey outlines his research on synergizing bioengineering with traditional rehabilitation medicine, with the goal of delivering immunomodulatory compounds such as specialized pro-resolving mediators (SPMs) directly to the injured tissue to achieve satisfactory wound healing. Edward Botchwey, PhD, is a Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech…

In this interview, Dipak Panigraphy, MD discusses cytokine storms in both COVID-19 and cancer patients, emphasizing their potential to disrupt resolution of inflammation and contribute to unfavorable clinical outcomes. Dr. Panigraphy discusses how standard cancer treatments, including surgery and chemotherapy, may trigger cytokine storms, facilitating the spread of cancer in some patients. Lastly, he discusses his latest research, demonstrating the efficacy of specific specialized pro-resolving mediators (SPMs) molecules in promoting inflammation resolution and preventing treatment-induced metastasis in multiple preclinical cancer…

Akkermansia muciniphila is a unique mucin-loving keystone species residing in the human gastrointestinal tract, purportedly offering health benefits, especially in the realms of metabolic health and obesity.1 Clinical investigations exploring A. muciniphila supplementation in overweight and obese cohorts seek to elucidate its potential impact on metabolic parameters, adiposity, and other health metrics. Studies consistently show reduced abundance in obesity, type 2 diabetes, high blood pressure, and other metabolic conditions.2 Intervention studies in animals demonstrated A. muciniphila administration reversed high-fat diet-induced metabolic disorders,…

by Kyle Perkovich, BS In the intricate ecosystem of the human gut, a new frontier is emerging, marked by the strategic paring of probiotics and prebiotics working synergistically to help provide optimal gut health and well-being. This combination, known as synbiotics, is gaining prominence for its potential to enhance gut health and immune function. As research has advanced, the role of our gut microbiota has become increasingly recognized as a vital part of overall health, influencing not only proper digestion,…

by Lewis Chang, PhD Not all heroes are muscle-bound and wear capes. There is a tiny, almost invisible, hero that lives in our gut and promotes our health and wellbeing. Its name, Akkermansia muciniphila, may be a mouthful, but it’s time to get to know this hero better, as its health-promoting effects have earned it the reputation as a next-generation beneficial bacteria.1 Gut health is intricately connected to human health in ways that surprise us. Our gut is home to…

Metabolic detoxification (detox)—or biotransformation—is a physiological function that removes toxic substances of endogenous or exogenous origin from the body. Because the function and regulation of this process varies from person to person, different people can have a different sensitivity to toxic substances and their effects on the development of a variety of diseases such as liver conditions, fertility problems, and cancer. Along with sex, age, and lifestyle, genetics play an important role in this variability. But do we actually know…

by Michael Stanclift, ND It goes by many names, ubiquinol (“yoo-bik-quin-ol”), ubiquinone (“yoo-bik-quin-ohn”), coenzyme Q10, or everybody’s favorite nickname, CoQ10. It’s found all over the body, in our mitochondria, which gives you an idea of how important it is to our health. CoQ10 is a fat-soluble antioxidant that we get by eating oily fish, organ meats, and whole grains, and CoQ10’s job is to help us make energy and protect our cells from free radicals. A wide range of medical…

by Joseph Lamb, MD “In 1982, while on sabbatical at the Linus Pauling Institute, I became convinced from the discussions I had with Dr. Pauling and many other luminaries that visited the Institute that the only way to really differentiate disease care from health care was through the development of a system that quantified health in terms of function and not the absence of disease.” —Jeffrey Bland, PhD President, Personalized Lifestyle Medicine Institute We all likely agree with Dr. Bland…

by Melissa Blake, ND Metabolic detoxification is a complex set of coordinating systems working together to neutralize and eliminate toxic substances from the body. It is an amazing and intricate design. As suggested by design expert Irene Au, just like any good design, “when it works, no one notices, but when it doesn’t, it sure stinks.” Patients know far too well just how much it does stink. Excess toxic burden (too much in, not enough out) has been associated with…

In this brief hallway chat, Mimi Guarneri, MD addresses how to manage stress and aging using integrative medicine and lifestyle approaches. Dr. Guarneri also answers a few questions on how to personalize use of phytonutrients (e.g., quercetin) and bioactives (e.g., omega-3) for gut and heart health, with the proper use of biomarkers and elimination diet protocols. Download the transcript