by Christopher Keroack, MD, IFMCP Excess adiposity remains one of the leading healthcare concerns in America. Two-thirds of our nation is overweight and one-third is obese.1 As a healthcare force, we recognize that lifestyle factors like nutrition and physical activity are major contributors to this epidemic. Because of this, novel approaches to nutrition have come about in the last decade to address this epidemic…some helpful, others not so much. Along with Hippocrates, the father of healthcare who said, “There are…

by Lewis Chang, PhD Ketosis is the metabolic state in which ketone bodies—alternative energy substrates to glucose—are produced from fat and utilized as the main energy source for the body. An important study found that nutritional ketosis induced by consumption of medium-chain triglycerides (MCT) oil helped increase the redox NAD+/NADH ratio in the brain of healthy young adults.1 Disturbed glucose metabolism and the resulting inadequate energy supply to the brain contributes to the pathophysiology of neurodegenerative diseases such as Alzheimer’s…

Host: Deanna Minich, PhD, CNS, FACN, IFMCP Guest: Christopher Keroack, MD, IFMCP You may have heard about the ketogenic diet. This high-fat, low-carbohydrate, moderate-protein dietary pattern has experienced a revival of sorts in the mainstream media and dieting world. But, before “keto” was a contemporary fad, how was it used? In fact, there is ~100 years of science supporting the ketogenic diet. To shed light on its history of use and elucidate practical areas of clinical application, Drs. Deanna Minich and Christopher…

by Annalouise O’Connor, PhD, RD Dyslipidemia is defined as an abnormal level of lipids in the blood and is often described most simplistically as greater levels of total or low-density lipoprotein (LDL), the “bad” cholesterol or particle number, or lower levels of high-density lipoprotein (HDL), the “good” cholesterol. Dyslipidemia is linked with cardiovascular risk and is highly prevalent: The minority of adults (46.6%) in the US have on-target total cholesterol levels (<200mg/dL).1 With cardiovascular disease (CVD) responsible for one in every…

by Lewis Chang, PhD The Mediterranean diet (MED), characterized by a high consumption of plant-based foods, less red meat, and using olive oil as the main source of fat, is one of the healthiest diets. A study found that MED might also prolong brain health and function in cognitively healthy middle-aged individuals.1 According to an earlier systematic review of cohort studies and randomized controlled trials, adherence to MED was associated with a lower risk of cognitive decline and Alzheimer’s disease…

by Milene Brownlow, PhD This 3-part blog series explores the history (Part 1), mechanisms and evidence (Part 2) underlying the neuroprotective effects of the ketogenic diet. In the final part 3, let’s investigate the current scientific evidence in support of the ketogenic diet (KD) as a therapeutic approach for specific neurological disorders. Preclinical study evidence In rodents, diet-induced ketosis has been shown to reverse motor deficits in a model of amyotrophic lateral sclerosis (ALS),1 reduce lesion volume after traumatic brain…

by Milene Brownlow, PhD In addition to their original use as an anticonvulsant treatment (explored in Part 1 of this blog series), ketogenic diets (KDs) are increasingly viewed as a promising metabolic therapy for other neurological conditions. But first, an important question: Are KDs neuroprotective because of the reduction in glucose and insulin levels or due to the presence of ketones? Answer: Both. On the one hand, chronic consumption of refined sugar and starches results in systemic inflammation in the…

by Lewis Chang, PhD A Mediterranean diet, which emphasizes predominantly plant-based foods, less red meat, and using olive oil as the main source of fat, is known for its health-promoting properties.1 However, the 21 countries that border the Mediterranean Sea are ethnically and culturally diverse; therefore, a Mediterranean diet is not one eating pattern but can vary in its execution from country to country. For example, Spaniards on average consume more red meat than Greeks.2 In terms of red meat,…

by Bianca Garilli, ND Body mass index (BMI) is frequently utilized in clinical practice to assess for risk of cardiometabolic disease (CMD). High BMI measurements are associated with insulin resistance along with other markers of CMD such as elevated blood glucose and triglycerides, low HDL cholesterol, and elevated blood pressure.1 By way of review, a BMI > 30 indicates obesity, which is linked to increased risk of chronic illness, particularly CMD; a BMI 25-29 is considered overweight, and a BMI…

by Ashley Jordan Ferira, PhD, RDN There is a paradox occurring in American youth: obesity and dieting. National statistics confirm that pediatric overweight and obesity rates are high, steadily rising over the past few decades.1 In fact, over 20% of the 12-19 age group in the US are obese, with higher prevalence in Hispanics and blacks.1 Actual weight and the teenager’s perception of their weight can be incongruent. Furthermore, weight status misperception drives intent for weight change.3 American youth are…