Search Results for: spm

Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School about where SPMs are most commonly stored in the body. Dr. Serhan responded that there is no evidence that SPMs are stored in the body at all. Preclinical and limited human data indicate that SPMs act rapidly at target cells. Afterward, they are inactivated. Watch the video for more…

Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School how SPMs can be used as preventive dietary supplements in healthy people. Dr. Serhan responded that pre-clinical models indicate that SPMs can regenerate tissue, expedite endogenous inflammatory resolution, and return to homeostasis after an insult or injury. Limited clinical findings indicate that SPMs are produced in fish and…

Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, Metagenics Institute asks Dr. Charles Serhan of Harvard Medical School about some parameters or markers that can be used to assess the efficacy of SPMs. Dr. Serhan responds that indices have been created to measure SPMs. Current tools include assessing pre- and post- levels of SPMs in blood, as well as the functional increase related to certain…

Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School about some situations under which SPM biosynthesis would be challenged. More specifically, what pharmacological interactions would make SPMs and inflammation resolution less effective? Dr. Serhan responded that a variety of pharmaceuticals have been tested with SPMs. It may be surprising that NSAIDs, which reduce the signs and symptoms…

In this video we ask Dr. Serhan, "What is the potential use of supplements enriched with SPMs for patients whose diets are deficient in essential fatty acids?" 3. Insights from the Metagenics Lifestyle Summit 2015: Charles Serhan, PhD

This conversation took place at ASPEN Clinical Nutrition Week 2015 and was moderated by Robert Martindale, MD. In this video segment, he discusses the question, can over-supplementation of specialized pro-resolving mediators (SPMs) lead to pathway down-regulation. The conversation took place with Dr. Stephen McClave, Dr. Jesmond Dalli, and Dr. Todd Rice. The conversation is part of a series on inflammation entitled, Inflammation: Should we Block or Accelerate Its Resolution? Dr. Martindale asks if the body might down-regulate the production of…

1. Insights from the Metagenics Lifestyle Summit 2015 in Phoenix, AZ: Charles Serhan, PhD If already taking fish oils, is there a need to supplement with specialized pro-resolving mediators (SPMs)? In this video, Dr. Charles Serhan presents insights on inflammation from the Metagenics Lifestyle Summit in September 2015. Dr. Serhan is a distinguished researcher and professor at Harvard Medical School and Brigham and Women’s Hospital in Boston, MA. Dr. Serhan cites his research to answer a variety of questions on…

ASPEN 2015 Inflammation: Fish Oils vs SPMs: What's the Difference? - 1 Roundtable Symposia from ASPEN Clinical Nutrition Week 2015 Participating Speakers are: Robert G. Martindale, MD, PhD Stephen McClave, MD Jesmond Dalli, PhD Todd Rice, MD ASPEN Clinical Nutrition Week in February 2015 provided an excellent opportunity for experts in clinical nutrition to gather and discuss new clinical science from the field. In a series of discussions on Inflammation, Dr. Robert Martindale moderates conversation among several experts, including…

This animation features information on the role of inflammation in managing insults and injury to the body. Infection, wounds, poor diet, and aging are causes of acute inflammation. Acute inflammation helps the body to heal and helps tissue to return to homeostasis. When inflammation becomes chronic, however, as is common in many chronic diseases, it can destroy tissues and leave the body in poorer health. Science has now shown us that inflammation resolution is an active process that is controlled by specialized pro-resolving mediators (SPMs),…

This paper is entitled, “Supplementation with Specialized Pro-Resolving Mediators Reduces Inflammatory Biomarkers and Improves Reported Clinical Symptomology in Subjects with Chronic Inflammatory Conditions: Results from a Multi-Center Open-Case Series” Highlights: Inflammation has 2 phases: initiation and resolution. Many chronic health issues are linked to unresolved inflammation Specialized pro-resolving mediators (SPMs) are endogenous molecules essential for resolution of inflammation but may not be produced in required levels in certain condition Multi-center case study assessed effects of a proprietary SPM supplement (LM-O3)…