Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School about the time of onset of action for SPMs following their ingestion. Dr. Serhan responds that, in a limited study of humans, the conversion of substrate is very fast. Within four hours, investigators could identify those patients who had taken pro-resolving mediators by testing the peripheral blood. Experiments…

Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School about where SPMs are most commonly stored in the body. Dr. Serhan responded that there is no evidence that SPMs are stored in the body at all. Preclinical and limited human data indicate that SPMs act rapidly at target cells. Afterward, they are inactivated. Watch the video for more…

Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School how SPMs can be used as preventive dietary supplements in healthy people. Dr. Serhan responded that pre-clinical models indicate that SPMs can regenerate tissue, expedite endogenous inflammatory resolution, and return to homeostasis after an insult or injury. Limited clinical findings indicate that SPMs are produced in fish and…

Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, Metagenics Institute asks Dr. Charles Serhan of Harvard Medical School about some parameters or markers that can be used to assess the efficacy of SPMs. Dr. Serhan responds that indices have been created to measure SPMs. Current tools include assessing pre- and post- levels of SPMs in blood, as well as the functional increase related to certain…

Specialized Pro-Resolving Mediators (SPMs) offer an exciting opportunity to treat and manage the inflammation often associated with chronic disease. In this short video, we ask Dr. Charles Serhan of Harvard Medical School about some situations under which SPM biosynthesis would be challenged. More specifically, what pharmacological interactions would make SPMs and inflammation resolution less effective? Dr. Serhan responded that a variety of pharmaceuticals have been tested with SPMs. It may be surprising that NSAIDs, which reduce the signs and symptoms…

In this video we ask Dr. Serhan, "What is the potential use of supplements enriched with SPMs for patients whose diets are deficient in essential fatty acids?" 3. Insights from the Metagenics Lifestyle Summit 2015: Charles Serhan, PhD

Frank Hu, MD, PhD at Nutrition Pro 2015: Translating Genetic Information in Nutrition Practice Dr. Frank Hu of the Harvard T.H. Chan School of Public Health discusses the role of genetic information, prediction of chronic disease, and nutrition interventions for improved health. This presentation comes from Nutrition Pro 2015 and contains valuable information for clinical translation of genetic information for improved nutrition practice. Genes play only a small role in our overall health outcomes. Other genetic determinants, such as…

Cardiovascular function can be strategically supported via targeted nutritional factors that support nitric oxide (NO) synthesis, which is essential for healthy endothelial function and blood flow. Arginine, citrulline, cocoa polyphenols, folate, vitamin C, and magnesium help protect and maintain NO synthesis, and therefore, preserve healthy endothelial function and blood flow. This endothelial health animation video shows how various nutritional factors impact the NO synthesis pathway. Understanding these biochemical insights will help leverage targeted, personalized nutrition therapies to optimize endothelial health…

Diabetes, heart disease, and other metabolic issues are on the rise worldwide and are strongly associated with obesity. A growing body of research indicates that the ketogenic diet and keto-adaptation may play a role in mitigating metabolic dysfunction and related chronic disease concerns. In this talk, ketogenic diet researcher and expert Jeff Volek, PhD, RD emphasizes a case method approach for managing chronic health issues—specifically, via carbohydrate restriction and ketosis. Dr. Volek is a Professor in the Department of Human…

This conversation took place at ASPEN Clinical Nutrition Week 2015 and was moderated by Robert Martindale, MD. In this video segment, he discusses the question, can over-supplementation of specialized pro-resolving mediators (SPMs) lead to pathway down-regulation. The conversation took place with Dr. Stephen McClave, Dr. Jesmond Dalli, and Dr. Todd Rice. The conversation is part of a series on inflammation entitled, Inflammation: Should we Block or Accelerate Its Resolution? Dr. Martindale asks if the body might down-regulate the production of…